YLL003W / SFI1

Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLL003W / SFI1

Click on Significant Values for Screen Details ID:SGTC_108|Compound:0509-0257|FD-Score:-2.94|P-value:7.29E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.37|P-value:1.09E-6 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.11|P-value:3.72E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.82|P-value:1.71E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:3.91|P-value:1.11E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:-4.12|P-value:3.96E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:3.58|P-value:5.31E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-2.91|P-value:8.08E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:2.87|P-value:9.21E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:2.90|P-value:8.50E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.14|P-value:3.67E-6 ID:SGTC_814|Compound:3342-0569|FD-Score:3.48|P-value:8.07E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:3.99|P-value:7.76E-6 ID:SGTC_1027|Compound:k015-0025|FD-Score:2.86|P-value:9.76E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.52|P-value:6.75E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.42|P-value:1.07E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-2.85|P-value:9.89E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.44|P-value:9.62E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-3.28|P-value:1.86E-4 ID:SGTC_1749|Compound:st037932|FD-Score:4.08|P-value:4.97E-6 ID:SGTC_1750|Compound:st081859|FD-Score:-3.12|P-value:3.63E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.01|P-value:5.46E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.01|P-value:5.59E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.26|P-value:2.06E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.26|P-value:2.02E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.66|P-value:3.63E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.69|P-value:3.12E-5 ID:SGTC_2128|Compound:5255449|FD-Score:-3.58|P-value:5.33E-5 ID:SGTC_2287|Compound:7945887|FD-Score:2.86|P-value:9.79E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.71|P-value:2.88E-5 ID:SGTC_2303|Compound:7774051|FD-Score:2.95|P-value:6.86E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.15|P-value:3.17E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.81|P-value:9.10E-8 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.25|P-value:2.16E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.03|P-value:5.14E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.38|P-value:1.26E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.93|P-value:1.02E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:2.89|P-value:8.73E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.23|P-value:2.30E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.37|P-value:1.31E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.34|P-value:1.47E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:-2.85|P-value:0.00100 ID:SGTC_2736|Compound:butenafine|FD-Score:3.62|P-value:4.42E-5 ID:SGTC_2854|Compound:9024559|FD-Score:-2.91|P-value:8.02E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.80|P-value:1.88E-5 ID:SGTC_2967|Compound:9089538|FD-Score:-3.06|P-value:4.65E-4 ID:SGTC_3065|Compound:9113888|FD-Score:2.89|P-value:8.69E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-4.56|P-value:3.86E-7 ID:SGTC_3335|Compound:9143315|FD-Score:-3.59|P-value:4.95E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:-2.94|P-value:7.29E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.37|P-value:1.09E-6 ID:SGTC_395|Compound:anisomycin|FD-Score:-3.11|P-value:3.72E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.82|P-value:1.71E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:3.91|P-value:1.11E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:-4.12|P-value:3.96E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:3.58|P-value:5.31E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-2.91|P-value:8.08E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:2.87|P-value:9.21E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:2.90|P-value:8.50E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.14|P-value:3.67E-6 ID:SGTC_814|Compound:3342-0569|FD-Score:3.48|P-value:8.07E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:3.99|P-value:7.76E-6 ID:SGTC_1027|Compound:k015-0025|FD-Score:2.86|P-value:9.76E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.52|P-value:6.75E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.42|P-value:1.07E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-2.85|P-value:9.89E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.44|P-value:9.62E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-3.28|P-value:1.86E-4 ID:SGTC_1749|Compound:st037932|FD-Score:4.08|P-value:4.97E-6 ID:SGTC_1750|Compound:st081859|FD-Score:-3.12|P-value:3.63E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.01|P-value:5.46E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.01|P-value:5.59E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.26|P-value:2.06E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.26|P-value:2.02E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.66|P-value:3.63E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.69|P-value:3.12E-5 ID:SGTC_2128|Compound:5255449|FD-Score:-3.58|P-value:5.33E-5 ID:SGTC_2287|Compound:7945887|FD-Score:2.86|P-value:9.79E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.71|P-value:2.88E-5 ID:SGTC_2303|Compound:7774051|FD-Score:2.95|P-value:6.86E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.15|P-value:3.17E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.81|P-value:9.10E-8 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.25|P-value:2.16E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.03|P-value:5.14E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.38|P-value:1.26E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.93|P-value:1.02E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:2.89|P-value:8.73E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.23|P-value:2.30E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.37|P-value:1.31E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.34|P-value:1.47E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:-2.85|P-value:0.00100 ID:SGTC_2736|Compound:butenafine|FD-Score:3.62|P-value:4.42E-5 ID:SGTC_2854|Compound:9024559|FD-Score:-2.91|P-value:8.02E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.80|P-value:1.88E-5 ID:SGTC_2967|Compound:9089538|FD-Score:-3.06|P-value:4.65E-4 ID:SGTC_3065|Compound:9113888|FD-Score:2.89|P-value:8.69E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-4.56|P-value:3.86E-7 ID:SGTC_3335|Compound:9143315|FD-Score:-3.59|P-value:4.95E-5

Top fitness defect scores for YLL003W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2519 cryptotanshinone 4.81 88.0 µM 9.10E-8 heme biosynthesis & mitochondrial translocase 11 7.39E-7 0.08
2 SGTC_116 0155-0182 4.37 31.8 µM 1.09E-6 mitochondrial response to ROS 3 6.22E-6 0.63
3 SGTC_769 0302-0231 4.14 76.0 µM 3.67E-6 8 1.76E-5 0.03
4 SGTC_1749 st037932 4.08 54.2 µM 4.97E-6 7 2.28E-5 0.04
5 SGTC_830 4076-0286 3.99 57.8 µM 7.76E-6 translation 4 3.34E-5 0.10
6 SGTC_2566 crystal violet carbinol 3.93 226.0 nM 1.02E-5 19 4.20E-5 0.01
7 SGTC_598 3937-0236 3.91 20.2 µM 1.11E-5 ERG2 2 4.55E-5 0.07
8 SGTC_2299 7976368 3.71 114.9 µM 2.88E-5 10 1.03E-4 0.05
9 SGTC_2122 5258151 3.69 111.7 µM 3.12E-5 8 1.10E-4 0.16
10 SGTC_2084 5306078 3.66 60.6 µM 3.63E-5 5 1.26E-4 0.05
11 SGTC_2736 butenafine 3.62 14.7 µM 4.42E-5 8 1.49E-4 0.13
12 SGTC_676 falcarinol 3.58 140.0 µM 5.31E-5 15 1.74E-4 0.23
13 SGTC_1125 tnp00248 3.52 1.3 µM 6.75E-5 14 2.14E-4 0.03
14 SGTC_814 3342-0569 3.48 96.0 µM 8.07E-5 4 2.49E-4 0.03
15 SGTC_1628 st004252 3.44 77.7 µM 9.62E-5 7 2.90E-4 0.04
16 SGTC_1317 1273-0028 3.42 910.0 nM 1.07E-4 azole & statin 19 3.17E-4 0.04
17 SGTC_2533 agelasine 3.38 13.7 µM 1.26E-4 ERG2 22 3.66E-4 0.07
18 SGTC_2703 st077852 3.34 53.4 µM 1.47E-4 12 4.16E-4 0.09
19 SGTC_2046 4110841 3.26 106.0 µM 2.02E-4 iron homeostasis 18 5.49E-4 0.00
20 SGTC_2034 5197015 3.26 53.1 µM 2.06E-4 SWF1 & branched chain AA biosynthesis 8 5.59E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.01E-10 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.107 4.23E-10 YLR188W MDL1 hom Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress
0.102 2.71E-9 YLL026W HSP104 hom Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.098 1.35E-8 YPR133W-A TOM5 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore
0.095 3.06E-8 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.085 9.04E-7 YIL050W PCL7 hom Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated
0.082 2.11E-6 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.082 2.20E-6 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.080 3.68E-6 YDL154W MSH5 hom Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans
0.079 4.71E-6 YBR103W SIF2 hom WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
0.078 5.66E-6 YPL217C BMS1 het GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p
0.078 6.25E-6 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.078 6.91E-6 YGR088W CTT1 hom Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
0.076 1.13E-5 YER053C-A YER053C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.076 1.14E-5 YNL277W-A_p YNL277W-A_p hom Putative protein of unknown function