YLL004W / ORC3

Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLL004W / ORC3

Click on Significant Values for Screen Details ID:SGTC_94|Compound:0334-0113|FD-Score:-3.05|P-value:9.90E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.02|P-value:9.41E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:3.05|P-value:8.49E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.23|P-value:4.40E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.55|P-value:1.32E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-9.84|P-value:5.65E-24 ID:SGTC_430|Compound:0958-0115|FD-Score:3.47|P-value:1.75E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.49|P-value:2.46E-6 ID:SGTC_641|Compound:4092-0595|FD-Score:3.23|P-value:4.41E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.45|P-value:2.35E-6 ID:SGTC_654|Compound:1124-0271|FD-Score:5.96|P-value:4.88E-10 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.07|P-value:9.18E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.07|P-value:7.79E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.58|P-value:1.17E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.19|P-value:5.07E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:-3.35|P-value:3.39E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.23|P-value:4.47E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.04|P-value:8.79E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:5.46|P-value:1.01E-8 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.91|P-value:2.87E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.37|P-value:2.63E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.62|P-value:9.96E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.32|P-value:3.16E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.50|P-value:1.59E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.03|P-value:8.98E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.52|P-value:1.46E-4 ID:SGTC_1798|Compound:st045719|FD-Score:4.20|P-value:7.93E-6 ID:SGTC_1803|Compound:st050068|FD-Score:3.15|P-value:5.79E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.36|P-value:2.72E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.07|P-value:7.73E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.84|P-value:3.91E-5 ID:SGTC_2134|Compound:5324836|FD-Score:-4.49|P-value:2.52E-6 ID:SGTC_2195|Compound:6536160|FD-Score:3.29|P-value:3.55E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.42|P-value:2.57E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-5.66|P-value:4.08E-9 ID:SGTC_2483|Compound:5729050|FD-Score:3.77|P-value:5.26E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.44|P-value:2.02E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.09|P-value:7.26E-4 ID:SGTC_2712|Compound:st079126|FD-Score:-3.16|P-value:6.83E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.79|P-value:4.38E-7 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.48|P-value:2.67E-6 ID:SGTC_3299|Compound:9121982|FD-Score:3.43|P-value:2.08E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.05|P-value:9.90E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.02|P-value:9.41E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:3.05|P-value:8.49E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.23|P-value:4.40E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.55|P-value:1.32E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-9.84|P-value:5.65E-24 ID:SGTC_430|Compound:0958-0115|FD-Score:3.47|P-value:1.75E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.49|P-value:2.46E-6 ID:SGTC_641|Compound:4092-0595|FD-Score:3.23|P-value:4.41E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.45|P-value:2.35E-6 ID:SGTC_654|Compound:1124-0271|FD-Score:5.96|P-value:4.88E-10 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.07|P-value:9.18E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.07|P-value:7.79E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.58|P-value:1.17E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.19|P-value:5.07E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:-3.35|P-value:3.39E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.23|P-value:4.47E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.04|P-value:8.79E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:5.46|P-value:1.01E-8 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.91|P-value:2.87E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.37|P-value:2.63E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.62|P-value:9.96E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.32|P-value:3.16E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.50|P-value:1.59E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.03|P-value:8.98E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.52|P-value:1.46E-4 ID:SGTC_1798|Compound:st045719|FD-Score:4.20|P-value:7.93E-6 ID:SGTC_1803|Compound:st050068|FD-Score:3.15|P-value:5.79E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.36|P-value:2.72E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.07|P-value:7.73E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.84|P-value:3.91E-5 ID:SGTC_2134|Compound:5324836|FD-Score:-4.49|P-value:2.52E-6 ID:SGTC_2195|Compound:6536160|FD-Score:3.29|P-value:3.55E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.42|P-value:2.57E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-5.66|P-value:4.08E-9 ID:SGTC_2483|Compound:5729050|FD-Score:3.77|P-value:5.26E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.44|P-value:2.02E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.09|P-value:7.26E-4 ID:SGTC_2712|Compound:st079126|FD-Score:-3.16|P-value:6.83E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.79|P-value:4.38E-7 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.48|P-value:2.67E-6 ID:SGTC_3299|Compound:9121982|FD-Score:3.43|P-value:2.08E-4

Top fitness defect scores for YLL004W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_654 1124-0271 5.96 80.9 µM 4.88E-10 2 1.28E-9 2.04
2 SGTC_1002 4049-0206 5.46 172.0 µM 1.01E-8 1 2.32E-8 1.06
3 SGTC_2752 diclazuril 4.79 33.1 µM 4.38E-7 4 8.45E-7 0.27
4 SGTC_651 3253-0966 4.45 34.4 µM 2.35E-6 calcium & mitochondrial duress 2 4.20E-6 0.46
5 SGTC_1798 st045719 4.20 61.0 µM 7.93E-6 3 1.34E-5 0.31
6 SGTC_1022 4477-0945 3.91 21.3 µM 2.87E-5 5 4.56E-5 0.01
7 SGTC_2122 5258151 3.84 111.7 µM 3.91E-5 6 6.13E-5 0.04
8 SGTC_2483 5729050 3.77 27.2 µM 5.26E-5 12 8.14E-5 0.06
9 SGTC_1193 1488-0126 3.62 41.5 µM 9.96E-5 5 1.50E-4 0.14
10 SGTC_766 1391-0721 3.58 126.0 µM 1.17E-4 5 1.75E-4 0.08
11 SGTC_333 3486-0131 3.55 40.1 µM 1.32E-4 amide catabolism 6 1.96E-4 0.15
12 SGTC_1765 st044815 3.52 90.4 µM 1.46E-4 13 2.15E-4 0.04
13 SGTC_1627 st003713 3.50 25.6 µM 1.59E-4 calcium & mitochondrial duress 12 2.35E-4 0.08
14 SGTC_430 0958-0115 3.47 16.4 µM 1.75E-4 13 2.57E-4 0.02
15 SGTC_2488 5268135 3.44 45.7 µM 2.02E-4 13 2.94E-4 0.05
16 SGTC_3299 9121982 3.43 43.1 µM 2.08E-4 8 3.03E-4 0.00
17 SGTC_1162 k048-0130 3.37 20.1 µM 2.63E-4 Golgi 14 3.79E-4 0.20
18 SGTC_1834 st055981 3.36 52.8 µM 2.72E-4 RPP1 & pyrimidine depletion 16 3.90E-4 0.07
19 SGTC_1272 0839-0021 3.32 27.0 µM 3.16E-4 14 4.51E-4 0.05
20 SGTC_2195 6536160 3.29 144.2 µM 3.55E-4 60S ribosome export 8 5.04E-4 0.17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 4.00E-10 YDR142C PEX7 hom Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)
0.092 1.00E-7 YLR018C POM34 hom Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication
0.089 2.54E-7 YPR050C_d YPR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W
0.087 3.87E-7 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.086 5.97E-7 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.086 6.37E-7 YGL188C-A_p YGL188C-A_p hom Putative protein of unknown function
0.084 1.04E-6 YMR293C HER2 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
0.084 1.22E-6 YGL140C_p YGL140C_p hom Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
0.083 1.62E-6 YHR067W HTD2 hom Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
0.082 2.23E-6 YPL005W AEP3 hom Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA
0.081 2.90E-6 YLR404W FLD1 hom Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy
0.080 3.43E-6 YBR045C GIP1 hom Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
0.079 4.67E-6 YDL056W MBP1 hom Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
0.079 4.88E-6 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 4.94E-6 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity