YLL005C / SPO75

Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL005C / SPO75

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:-2.99|P-value:4.78E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.37|P-value:7.67E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:2.95|P-value:4.52E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-2.89|P-value:7.20E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.06|P-value:3.65E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.78|P-value:1.09E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:3.03|P-value:3.33E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.48|P-value:5.91E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.14|P-value:2.64E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:2.82|P-value:7.58E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.46|P-value:6.75E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.22|P-value:1.93E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.19|P-value:1.69E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:4.47|P-value:2.61E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.49|P-value:5.70E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:4.44|P-value:3.14E-7 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.23|P-value:1.41E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:-4.20|P-value:1.67E-6 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.14|P-value:2.09E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:2.98|P-value:3.96E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.01|P-value:3.55E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.04|P-value:3.96E-4 ID:SGTC_1523|Compound:st012844|FD-Score:5.68|P-value:1.02E-10 ID:SGTC_1779|Compound:st039427|FD-Score:4.04|P-value:2.86E-6 ID:SGTC_1850|Compound:st056238|FD-Score:-3.00|P-value:4.62E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.14|P-value:2.09E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.14|P-value:2.04E-4 ID:SGTC_2060|Compound:5238662|FD-Score:6.37|P-value:5.11E-13 ID:SGTC_2242|Compound:6630449|FD-Score:2.87|P-value:6.23E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:2.82|P-value:7.60E-4 ID:SGTC_2278|Compound:7948257|FD-Score:4.25|P-value:9.41E-7 ID:SGTC_2370|Compound:9071495|FD-Score:2.96|P-value:4.31E-4 ID:SGTC_2374|Compound:9071832|FD-Score:4.24|P-value:9.75E-7 ID:SGTC_2378|Compound:9074213|FD-Score:-3.40|P-value:8.84E-5 ID:SGTC_2385|Compound:9074692|FD-Score:-4.43|P-value:4.84E-7 ID:SGTC_2387|Compound:9077560|FD-Score:-3.24|P-value:1.71E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-4.28|P-value:1.09E-6 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-4.48|P-value:3.53E-7 ID:SGTC_2395|Compound:5646831|FD-Score:4.87|P-value:2.35E-8 ID:SGTC_2464|Compound:5717415|FD-Score:4.02|P-value:3.14E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.21|P-value:1.52E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.12|P-value:2.29E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.33|P-value:1.19E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.12|P-value:2.24E-4 ID:SGTC_2821|Compound:7996764|FD-Score:5.60|P-value:1.84E-10 ID:SGTC_2823|Compound:7987624|FD-Score:4.40|P-value:3.98E-7 ID:SGTC_2876|Compound:9059903|FD-Score:2.76|P-value:9.50E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.22|P-value:1.47E-4 ID:SGTC_2878|Compound:9043973|FD-Score:4.37|P-value:4.83E-7 ID:SGTC_2975|Compound:9084847|FD-Score:-4.08|P-value:3.13E-6 ID:SGTC_2988|Compound:9073640|FD-Score:3.89|P-value:6.18E-6 ID:SGTC_3136|Compound:9095672|FD-Score:4.46|P-value:2.91E-7 ID:SGTC_3160|Compound:9100216|FD-Score:3.85|P-value:7.53E-6 ID:SGTC_3233|Compound:9132340|FD-Score:-2.90|P-value:7.02E-4 ID:SGTC_3323|Compound:9138564|FD-Score:4.98|P-value:1.17E-8 ID:SGTC_61|Compound:0978-8327|FD-Score:-2.99|P-value:4.78E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.37|P-value:7.67E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:2.95|P-value:4.52E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-2.89|P-value:7.20E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.06|P-value:3.65E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.78|P-value:1.09E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:3.03|P-value:3.33E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.48|P-value:5.91E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.14|P-value:2.64E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:2.82|P-value:7.58E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.46|P-value:6.75E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.22|P-value:1.93E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.19|P-value:1.69E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:4.47|P-value:2.61E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.49|P-value:5.70E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:4.44|P-value:3.14E-7 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.23|P-value:1.41E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:-4.20|P-value:1.67E-6 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.14|P-value:2.09E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:2.98|P-value:3.96E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.01|P-value:3.55E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.04|P-value:3.96E-4 ID:SGTC_1523|Compound:st012844|FD-Score:5.68|P-value:1.02E-10 ID:SGTC_1779|Compound:st039427|FD-Score:4.04|P-value:2.86E-6 ID:SGTC_1850|Compound:st056238|FD-Score:-3.00|P-value:4.62E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.14|P-value:2.09E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.14|P-value:2.04E-4 ID:SGTC_2060|Compound:5238662|FD-Score:6.37|P-value:5.11E-13 ID:SGTC_2242|Compound:6630449|FD-Score:2.87|P-value:6.23E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:2.82|P-value:7.60E-4 ID:SGTC_2278|Compound:7948257|FD-Score:4.25|P-value:9.41E-7 ID:SGTC_2370|Compound:9071495|FD-Score:2.96|P-value:4.31E-4 ID:SGTC_2374|Compound:9071832|FD-Score:4.24|P-value:9.75E-7 ID:SGTC_2378|Compound:9074213|FD-Score:-3.40|P-value:8.84E-5 ID:SGTC_2385|Compound:9074692|FD-Score:-4.43|P-value:4.84E-7 ID:SGTC_2387|Compound:9077560|FD-Score:-3.24|P-value:1.71E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-4.28|P-value:1.09E-6 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-4.48|P-value:3.53E-7 ID:SGTC_2395|Compound:5646831|FD-Score:4.87|P-value:2.35E-8 ID:SGTC_2464|Compound:5717415|FD-Score:4.02|P-value:3.14E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.21|P-value:1.52E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.12|P-value:2.29E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.33|P-value:1.19E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.12|P-value:2.24E-4 ID:SGTC_2821|Compound:7996764|FD-Score:5.60|P-value:1.84E-10 ID:SGTC_2823|Compound:7987624|FD-Score:4.40|P-value:3.98E-7 ID:SGTC_2876|Compound:9059903|FD-Score:2.76|P-value:9.50E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.22|P-value:1.47E-4 ID:SGTC_2878|Compound:9043973|FD-Score:4.37|P-value:4.83E-7 ID:SGTC_2975|Compound:9084847|FD-Score:-4.08|P-value:3.13E-6 ID:SGTC_2988|Compound:9073640|FD-Score:3.89|P-value:6.18E-6 ID:SGTC_3136|Compound:9095672|FD-Score:4.46|P-value:2.91E-7 ID:SGTC_3160|Compound:9100216|FD-Score:3.85|P-value:7.53E-6 ID:SGTC_3233|Compound:9132340|FD-Score:-2.90|P-value:7.02E-4 ID:SGTC_3323|Compound:9138564|FD-Score:4.98|P-value:1.17E-8

Top fitness defect scores for YLL005C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2060 5238662 6.37 140.0 µM 5.11E-13 2 9.60E-11
2 SGTC_1523 st012844 5.68 44.7 µM 1.02E-10 60S ribosome export 3 6.85E-9
3 SGTC_2821 7996764 5.60 71.4 µM 1.84E-10 9 1.10E-8
4 SGTC_3323 9138564 4.98 53.9 µM 1.17E-8 6 3.13E-7
5 SGTC_2395 5646831 4.87 180.2 µM 2.35E-8 12 5.50E-7
6 SGTC_1059 3448-6867 4.47 171.0 µM 2.61E-7 5 3.83E-6
7 SGTC_3136 9095672 4.46 49.5 µM 2.91E-7 13 4.19E-6
8 SGTC_1146 3579-1023 4.44 7.0 µM 3.14E-7 7 4.45E-6
9 SGTC_2823 7987624 4.40 58.4 µM 3.98E-7 18 5.39E-6
10 SGTC_2878 9043973 4.37 26.0 µM 4.83E-7 10 6.30E-6
11 SGTC_2278 7948257 4.25 134.3 µM 9.41E-7 18 1.08E-5
12 SGTC_2374 9071832 4.24 200.0 µM 9.75E-7 endomembrane recycling 12 1.11E-5
13 SGTC_1779 st039427 4.04 55.0 µM 2.86E-6 26 2.65E-5
14 SGTC_2464 5717415 4.02 7.7 µM 3.14E-6 15 2.86E-5
15 SGTC_2988 9073640 3.89 71.4 µM 6.18E-6 22 4.94E-5
16 SGTC_3160 9100216 3.85 49.5 µM 7.53E-6 9 5.79E-5
17 SGTC_496 calpeptin 3.78 138.0 µM 1.09E-5 20 7.79E-5
18 SGTC_359 0081-0058 3.37 15.9 µM 7.67E-5 60S ribosome export 74 3.78E-4
19 SGTC_1148 3909-7663 3.23 27.7 µM 1.41E-4 38 6.18E-4
20 SGTC_2877 9040724 3.22 71.4 µM 1.47E-4 39 6.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.186 2.04E-27 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.143 7.92E-17 YLR141W RRN5 het Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p
0.120 3.63E-12 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.119 5.28E-12 YOR031W CRS5 hom Copper-binding metallothionein, required for wild-type copper resistance
0.113 6.36E-11 YLR254C NDL1 hom Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends
0.111 1.02E-10 YBR063C_p YBR063C_p hom Putative protein of unknown function; YBR063C is not an essential gene
0.107 4.21E-10 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.106 8.16E-10 YJL082W IML2 hom Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication
0.103 2.05E-9 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.101 5.00E-9 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.100 6.29E-9 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.100 6.53E-9 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.098 1.22E-8 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.096 2.37E-8 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.095 3.05E-8 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS