YLL006W / MMM1

ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL006W / MMM1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:6.83|P-value:4.06E-9 ID:SGTC_68|Compound:0986-0284|FD-Score:4.76|P-value:2.99E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.35|P-value:1.24E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.91|P-value:1.18E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:11.40|P-value:1.87E-22 ID:SGTC_386|Compound:1509-0011|FD-Score:4.47|P-value:8.31E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.87|P-value:1.76E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:3.92|P-value:4.76E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.66|P-value:9.14E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.43|P-value:9.24E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:5.46|P-value:2.04E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:5.19|P-value:6.08E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:4.99|P-value:1.28E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:-4.31|P-value:1.24E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.14|P-value:2.43E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:6.18|P-value:9.18E-8 ID:SGTC_1024|Compound:4507-0395|FD-Score:-4.24|P-value:1.57E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:-4.04|P-value:2.97E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.76|P-value:6.96E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.89|P-value:5.19E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:4.58|P-value:5.63E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.78|P-value:2.73E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.92|P-value:4.83E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:4.18|P-value:2.13E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-5.48|P-value:1.61E-6 ID:SGTC_1750|Compound:st081859|FD-Score:5.49|P-value:1.79E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.01|P-value:3.27E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.67|P-value:8.95E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-4.72|P-value:3.01E-5 ID:SGTC_1893|Compound:st059353|FD-Score:-4.05|P-value:2.83E-4 ID:SGTC_2229|Compound:7354935|FD-Score:-3.82|P-value:5.72E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.31|P-value:1.40E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.97|P-value:4.13E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.88|P-value:5.32E-4 ID:SGTC_2374|Compound:9071832|FD-Score:-4.45|P-value:7.85E-5 ID:SGTC_2389|Compound:9091542|FD-Score:-5.27|P-value:3.72E-6 ID:SGTC_2391|Compound:6285546|FD-Score:3.76|P-value:7.74E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.78|P-value:6.44E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.79|P-value:5.13E-7 ID:SGTC_2720|Compound:fluspirilene|FD-Score:-3.95|P-value:3.95E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-4.25|P-value:1.51E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-5.20|P-value:5.02E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.63|P-value:4.20E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-4.05|P-value:2.83E-4 ID:SGTC_2842|Compound:9000675|FD-Score:4.03|P-value:3.38E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.78|P-value:6.42E-4 ID:SGTC_2900|Compound:5328528|FD-Score:5.16|P-value:6.76E-6 ID:SGTC_2974|Compound:9094440|FD-Score:6.10|P-value:1.31E-7 ID:SGTC_3154|Compound:9100113|FD-Score:4.08|P-value:2.90E-4 ID:SGTC_3159|Compound:9100096|FD-Score:4.26|P-value:1.66E-4 ID:SGTC_3234|Compound:9132280|FD-Score:5.67|P-value:8.42E-7 ID:SGTC_3263|Compound:9137018|FD-Score:3.82|P-value:6.54E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-6.09|P-value:1.17E-7 ID:SGTC_3274|Compound:9138298|FD-Score:4.59|P-value:5.40E-5 ID:SGTC_3345|Compound:9148410|FD-Score:-4.27|P-value:1.40E-4 ID:SGTC_3348|Compound:9149464|FD-Score:4.89|P-value:1.84E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:6.83|P-value:4.06E-9 ID:SGTC_68|Compound:0986-0284|FD-Score:4.76|P-value:2.99E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.35|P-value:1.24E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.91|P-value:1.18E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:11.40|P-value:1.87E-22 ID:SGTC_386|Compound:1509-0011|FD-Score:4.47|P-value:8.31E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.87|P-value:1.76E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:3.92|P-value:4.76E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.66|P-value:9.14E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.43|P-value:9.24E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:5.46|P-value:2.04E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:5.19|P-value:6.08E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:4.99|P-value:1.28E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:-4.31|P-value:1.24E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.14|P-value:2.43E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:6.18|P-value:9.18E-8 ID:SGTC_1024|Compound:4507-0395|FD-Score:-4.24|P-value:1.57E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:-4.04|P-value:2.97E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.76|P-value:6.96E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.89|P-value:5.19E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:4.58|P-value:5.63E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.78|P-value:2.73E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.92|P-value:4.83E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:4.18|P-value:2.13E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-5.48|P-value:1.61E-6 ID:SGTC_1750|Compound:st081859|FD-Score:5.49|P-value:1.79E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.01|P-value:3.27E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.67|P-value:8.95E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-4.72|P-value:3.01E-5 ID:SGTC_1893|Compound:st059353|FD-Score:-4.05|P-value:2.83E-4 ID:SGTC_2229|Compound:7354935|FD-Score:-3.82|P-value:5.72E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.31|P-value:1.40E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.97|P-value:4.13E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.88|P-value:5.32E-4 ID:SGTC_2374|Compound:9071832|FD-Score:-4.45|P-value:7.85E-5 ID:SGTC_2389|Compound:9091542|FD-Score:-5.27|P-value:3.72E-6 ID:SGTC_2391|Compound:6285546|FD-Score:3.76|P-value:7.74E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.78|P-value:6.44E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.79|P-value:5.13E-7 ID:SGTC_2720|Compound:fluspirilene|FD-Score:-3.95|P-value:3.95E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-4.25|P-value:1.51E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-5.20|P-value:5.02E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.63|P-value:4.20E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-4.05|P-value:2.83E-4 ID:SGTC_2842|Compound:9000675|FD-Score:4.03|P-value:3.38E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.78|P-value:6.42E-4 ID:SGTC_2900|Compound:5328528|FD-Score:5.16|P-value:6.76E-6 ID:SGTC_2974|Compound:9094440|FD-Score:6.10|P-value:1.31E-7 ID:SGTC_3154|Compound:9100113|FD-Score:4.08|P-value:2.90E-4 ID:SGTC_3159|Compound:9100096|FD-Score:4.26|P-value:1.66E-4 ID:SGTC_3234|Compound:9132280|FD-Score:5.67|P-value:8.42E-7 ID:SGTC_3263|Compound:9137018|FD-Score:3.82|P-value:6.54E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-6.09|P-value:1.17E-7 ID:SGTC_3274|Compound:9138298|FD-Score:4.59|P-value:5.40E-5 ID:SGTC_3345|Compound:9148410|FD-Score:-4.27|P-value:1.40E-4 ID:SGTC_3348|Compound:9149464|FD-Score:4.89|P-value:1.84E-5

Top fitness defect scores for YLL006W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 11.40 5.3 µM 1.87E-22 159 1.18E-30
2 SGTC_173 1273-0061 7.91 2.7 µM 1.18E-11 mitochondrial stress 68 1.27E-15
3 SGTC_10 0279-0212 6.83 42.6 µM 4.06E-9 TRP & mitochondrial translation 16 4.27E-12
4 SGTC_1018 4259-0013 6.18 28.1 µM 9.18E-8 2 3.23E-10
5 SGTC_2974 9094440 6.10 9.7 µM 1.31E-7 ergosterol biosynthesis 12 5.26E-10
6 SGTC_2603 homopterocarpin 5.79 100.0 µM 5.13E-7 7 3.51E-9
7 SGTC_3234 9132280 5.67 49.5 µM 8.42E-7 3 6.96E-9
8 SGTC_1750 st081859 5.49 2.4 µM 1.79E-6 endomembrane recycling 121 1.98E-8
9 SGTC_761 k216-0224 5.46 480.0 µM 2.04E-6 5 2.37E-8
10 SGTC_766 1391-0721 5.19 126.0 µM 6.08E-6 2 1.07E-7
11 SGTC_2900 5328528 5.16 85.3 µM 6.76E-6 Golgi 13 1.24E-7
12 SGTC_778 3456-2434 4.99 196.0 µM 1.28E-5 mitochondrial response to ROS 45 3.02E-7
13 SGTC_3348 9149464 4.89 3.5 µM 1.84E-5 5 4.95E-7
14 SGTC_1318 1280-3875 4.78 124.0 µM 2.73E-5 12 8.56E-7
15 SGTC_68 0986-0284 4.76 82.8 µM 2.99E-5 40 9.71E-7
16 SGTC_3274 9138298 4.59 49.5 µM 5.40E-5 10 2.19E-6
17 SGTC_1315 1237-0019 4.58 3.7 µM 5.63E-5 6 2.32E-6
18 SGTC_386 1509-0011 4.47 3.1 µM 8.31E-5 123 3.98E-6
19 SGTC_686 1319-0111 4.43 510.0 µM 9.24E-5 60S ribosome export 19 4.60E-6
20 SGTC_118 0083-0097 4.35 135.3 µM 1.24E-4 translation 98 6.93E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.352 3.55E-98 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.344 2.76E-93 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.329 1.95E-85 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.319 4.23E-80 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.314 1.01E-77 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.309 5.57E-75 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.308 1.64E-74 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.304 1.58E-72 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.301 2.78E-71 YBR251W MRPS5 hom Mitochondrial ribosomal protein of the small subunit
0.300 5.96E-71 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.290 5.60E-66 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.289 1.25E-65 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.289 1.45E-65 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.289 2.50E-65 YMR064W AEP1 hom Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase
0.288 4.80E-65 YLR439W MRPL4 hom Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit