YLL006W-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL006W-A / YLL006W-A

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:2.77|P-value:7.82E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:2.89|P-value:4.77E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-2.76|P-value:7.07E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:2.90|P-value:4.58E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.16|P-value:1.49E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.37|P-value:5.83E-5 ID:SGTC_458|Compound:nppb|FD-Score:2.76|P-value:7.90E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:4.90|P-value:9.85E-9 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.99|P-value:2.10E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.81|P-value:5.74E-6 ID:SGTC_668|Compound:1682-0499|FD-Score:-3.09|P-value:1.82E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-2.82|P-value:5.60E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.49|P-value:3.23E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.92|P-value:3.59E-6 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.26|P-value:8.29E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.07|P-value:2.18E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.72|P-value:9.27E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.05|P-value:2.16E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.30|P-value:8.11E-5 ID:SGTC_1297|Compound:1068-0111|FD-Score:2.81|P-value:6.47E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.16|P-value:1.48E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:2.96|P-value:3.51E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.54|P-value:2.56E-5 ID:SGTC_1672|Compound:st016598|FD-Score:2.76|P-value:7.89E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.23|P-value:1.07E-4 ID:SGTC_1765|Compound:st044815|FD-Score:-3.81|P-value:5.72E-6 ID:SGTC_1909|Compound:st060837|FD-Score:-3.20|P-value:1.12E-4 ID:SGTC_2074|Compound:5212007|FD-Score:2.71|P-value:9.64E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.30|P-value:7.96E-5 ID:SGTC_2239|Compound:6685329|FD-Score:3.06|P-value:2.34E-4 ID:SGTC_2253|Compound:7938677|FD-Score:2.82|P-value:6.30E-4 ID:SGTC_2254|Compound:7938975|FD-Score:-3.26|P-value:8.52E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:2.83|P-value:6.14E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:2.90|P-value:4.61E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.44|P-value:4.15E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.12|P-value:1.00E-6 ID:SGTC_2683|Compound:piperine|FD-Score:3.09|P-value:2.06E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-2.90|P-value:4.01E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.14|P-value:1.62E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.40|P-value:4.90E-5 ID:SGTC_3080|Compound:9117754|FD-Score:4.80|P-value:1.87E-8 ID:SGTC_3086|Compound:9117350|FD-Score:3.01|P-value:2.82E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.20|P-value:1.10E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.34|P-value:3.32E-7 ID:SGTC_3253|Compound:9135987|FD-Score:3.39|P-value:5.14E-5 ID:SGTC_3264|Compound:9137442|FD-Score:2.76|P-value:8.02E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:2.77|P-value:7.82E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:2.89|P-value:4.77E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-2.76|P-value:7.07E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:2.90|P-value:4.58E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.16|P-value:1.49E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.37|P-value:5.83E-5 ID:SGTC_458|Compound:nppb|FD-Score:2.76|P-value:7.90E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:4.90|P-value:9.85E-9 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.99|P-value:2.10E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.81|P-value:5.74E-6 ID:SGTC_668|Compound:1682-0499|FD-Score:-3.09|P-value:1.82E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-2.82|P-value:5.60E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.49|P-value:3.23E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.92|P-value:3.59E-6 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.26|P-value:8.29E-5 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.07|P-value:2.18E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.72|P-value:9.27E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.05|P-value:2.16E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.30|P-value:8.11E-5 ID:SGTC_1297|Compound:1068-0111|FD-Score:2.81|P-value:6.47E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.16|P-value:1.48E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:2.96|P-value:3.51E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.54|P-value:2.56E-5 ID:SGTC_1672|Compound:st016598|FD-Score:2.76|P-value:7.89E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.23|P-value:1.07E-4 ID:SGTC_1765|Compound:st044815|FD-Score:-3.81|P-value:5.72E-6 ID:SGTC_1909|Compound:st060837|FD-Score:-3.20|P-value:1.12E-4 ID:SGTC_2074|Compound:5212007|FD-Score:2.71|P-value:9.64E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.30|P-value:7.96E-5 ID:SGTC_2239|Compound:6685329|FD-Score:3.06|P-value:2.34E-4 ID:SGTC_2253|Compound:7938677|FD-Score:2.82|P-value:6.30E-4 ID:SGTC_2254|Compound:7938975|FD-Score:-3.26|P-value:8.52E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:2.83|P-value:6.14E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:2.90|P-value:4.61E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.44|P-value:4.15E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.12|P-value:1.00E-6 ID:SGTC_2683|Compound:piperine|FD-Score:3.09|P-value:2.06E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-2.90|P-value:4.01E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.14|P-value:1.62E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.40|P-value:4.90E-5 ID:SGTC_3080|Compound:9117754|FD-Score:4.80|P-value:1.87E-8 ID:SGTC_3086|Compound:9117350|FD-Score:3.01|P-value:2.82E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.20|P-value:1.10E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.34|P-value:3.32E-7 ID:SGTC_3253|Compound:9135987|FD-Score:3.39|P-value:5.14E-5 ID:SGTC_3264|Compound:9137442|FD-Score:2.76|P-value:8.02E-4

Top fitness defect scores for YLL006W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_557 1315-0110 4.90 16.2 µM 9.85E-9 Golgi 5 4.80E-7
2 SGTC_3080 9117754 4.80 49.5 µM 1.87E-8 8 7.86E-7
3 SGTC_3210 9128157 4.34 49.5 µM 3.32E-7 37 7.12E-6
4 SGTC_1064 honokiol 3.92 6.8 µM 3.59E-6 26 4.43E-5
5 SGTC_1635 st007035 3.54 42.4 µM 2.56E-5 246 2.02E-4
6 SGTC_1061 3448-9325 3.49 110.0 µM 3.23E-5 36 2.41E-4
7 SGTC_2576 guaiol 3.44 23.1 µM 4.15E-5 42 2.93E-4
8 SGTC_2848 9016370 3.40 26.0 µM 4.90E-5 52 3.33E-4
9 SGTC_3253 9135987 3.39 49.5 µM 5.14E-5 60S ribosome export 24 3.45E-4
10 SGTC_236 1509-0011 3.37 5.3 µM 5.83E-5 431 3.80E-4
11 SGTC_2125 5246583 3.30 200.0 µM 7.96E-5 tubulin folding & SWR complex 75 4.84E-4
12 SGTC_1267 0828-0272 3.30 9.5 µM 8.11E-5 43 4.91E-4
13 SGTC_1760 st045453 3.23 10.4 µM 1.07E-4 NEO1-PIK1 179 6.10E-4
14 SGTC_1409 3909-8004 3.16 61.9 µM 1.48E-4 61 7.80E-4
15 SGTC_180 1486-1293 3.16 102.8 µM 1.49E-4 73 7.86E-4
16 SGTC_2839 9003951 3.14 26.0 µM 1.62E-4 39 8.37E-4
17 SGTC_2683 piperine 3.09 63.0 µM 2.06E-4 38 0.00101
18 SGTC_1146 3579-1023 3.07 7.0 µM 2.18E-4 47 0.00106
19 SGTC_2239 6685329 3.06 187.6 µM 2.34E-4 74 0.00111
20 SGTC_3086 9117350 3.01 49.5 µM 2.82E-4 15 0.00129

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.251 2.80E-49 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.225 1.13E-39 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.223 6.69E-39 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.220 5.46E-38 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.217 5.30E-37 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.217 6.14E-37 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.216 1.11E-36 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.213 1.20E-35 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.211 3.16E-35 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.209 1.52E-34 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.209 2.57E-34 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.207 1.15E-33 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.205 2.55E-33 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.205 4.76E-33 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.197 8.61E-31 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV