YLL008W / DRS1

Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLL008W / DRS1

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:-4.29|P-value:8.19E-6 ID:SGTC_4|Compound:0960-0234|FD-Score:3.13|P-value:8.42E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.36|P-value:3.71E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:5.29|P-value:5.47E-8 ID:SGTC_32|Compound:0928-0142|FD-Score:-3.36|P-value:3.70E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.13|P-value:8.40E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.57|P-value:1.72E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.69|P-value:1.07E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:5.28|P-value:5.70E-8 ID:SGTC_138|Compound:0850-0259|FD-Score:3.11|P-value:9.07E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.46|P-value:2.62E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.74|P-value:8.69E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.21|P-value:1.18E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.56|P-value:1.80E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:4.91|P-value:4.16E-7 ID:SGTC_596|Compound:1155-0152|FD-Score:3.77|P-value:7.70E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.32|P-value:4.39E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.24|P-value:5.73E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.32|P-value:7.47E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.70|P-value:1.22E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:3.16|P-value:7.51E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:4.66|P-value:1.48E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:3.15|P-value:8.00E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:6.31|P-value:1.21E-10 ID:SGTC_848|Compound:0368-0089|FD-Score:4.44|P-value:4.11E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:3.64|P-value:1.31E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.21|P-value:6.33E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.13|P-value:8.29E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:4.27|P-value:9.18E-6 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.32|P-value:4.26E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.17|P-value:1.41E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.19|P-value:6.88E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.37|P-value:3.61E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.59|P-value:1.58E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.76|P-value:8.23E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.15|P-value:7.92E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.62|P-value:1.79E-6 ID:SGTC_1633|Compound:st005664|FD-Score:-3.42|P-value:3.04E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.51|P-value:2.14E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.95|P-value:3.68E-5 ID:SGTC_1745|Compound:st081495|FD-Score:4.34|P-value:6.66E-6 ID:SGTC_1845|Compound:st056753|FD-Score:3.91|P-value:4.31E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:-4.64|P-value:1.62E-6 ID:SGTC_1887|Compound:st057648|FD-Score:-5.79|P-value:3.20E-9 ID:SGTC_1888|Compound:azatryptophan|FD-Score:4.17|P-value:1.45E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.28|P-value:4.95E-4 ID:SGTC_1903|Compound:st060211|FD-Score:-4.22|P-value:1.12E-5 ID:SGTC_1905|Compound:st060207|FD-Score:-4.88|P-value:4.76E-7 ID:SGTC_1940|Compound:st075990|FD-Score:-3.19|P-value:6.84E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-3.60|P-value:1.49E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-3.14|P-value:8.14E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.08|P-value:9.99E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.32|P-value:4.32E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.60|P-value:1.52E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.94|P-value:3.81E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.95|P-value:3.70E-5 ID:SGTC_2404|Compound:5161160|FD-Score:-3.74|P-value:8.70E-5 ID:SGTC_2472|Compound:5377652|FD-Score:3.08|P-value:0.00100 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.65|P-value:1.26E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.43|P-value:2.84E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.23|P-value:5.89E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.85|P-value:5.71E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.46|P-value:2.57E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.38|P-value:3.51E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.24|P-value:5.68E-4 ID:SGTC_3213|Compound:9129884|FD-Score:4.00|P-value:2.94E-5 ID:SGTC_3225|Compound:9130819|FD-Score:3.98|P-value:3.24E-5 ID:SGTC_3236|Compound:9132701|FD-Score:3.62|P-value:1.42E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:-4.29|P-value:8.19E-6 ID:SGTC_4|Compound:0960-0234|FD-Score:3.13|P-value:8.42E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.36|P-value:3.71E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:5.29|P-value:5.47E-8 ID:SGTC_32|Compound:0928-0142|FD-Score:-3.36|P-value:3.70E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.13|P-value:8.40E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.57|P-value:1.72E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.69|P-value:1.07E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:5.28|P-value:5.70E-8 ID:SGTC_138|Compound:0850-0259|FD-Score:3.11|P-value:9.07E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.46|P-value:2.62E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.74|P-value:8.69E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.21|P-value:1.18E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.56|P-value:1.80E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:4.91|P-value:4.16E-7 ID:SGTC_596|Compound:1155-0152|FD-Score:3.77|P-value:7.70E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.32|P-value:4.39E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.24|P-value:5.73E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.32|P-value:7.47E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.70|P-value:1.22E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:3.16|P-value:7.51E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:4.66|P-value:1.48E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:3.15|P-value:8.00E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:6.31|P-value:1.21E-10 ID:SGTC_848|Compound:0368-0089|FD-Score:4.44|P-value:4.11E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:3.64|P-value:1.31E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.21|P-value:6.33E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.13|P-value:8.29E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:4.27|P-value:9.18E-6 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.32|P-value:4.26E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.17|P-value:1.41E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.19|P-value:6.88E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.37|P-value:3.61E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.59|P-value:1.58E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.76|P-value:8.23E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.15|P-value:7.92E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.62|P-value:1.79E-6 ID:SGTC_1633|Compound:st005664|FD-Score:-3.42|P-value:3.04E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.51|P-value:2.14E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.95|P-value:3.68E-5 ID:SGTC_1745|Compound:st081495|FD-Score:4.34|P-value:6.66E-6 ID:SGTC_1845|Compound:st056753|FD-Score:3.91|P-value:4.31E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:-4.64|P-value:1.62E-6 ID:SGTC_1887|Compound:st057648|FD-Score:-5.79|P-value:3.20E-9 ID:SGTC_1888|Compound:azatryptophan|FD-Score:4.17|P-value:1.45E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.28|P-value:4.95E-4 ID:SGTC_1903|Compound:st060211|FD-Score:-4.22|P-value:1.12E-5 ID:SGTC_1905|Compound:st060207|FD-Score:-4.88|P-value:4.76E-7 ID:SGTC_1940|Compound:st075990|FD-Score:-3.19|P-value:6.84E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-3.60|P-value:1.49E-4 ID:SGTC_2038|Compound:4100038|FD-Score:-3.14|P-value:8.14E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.08|P-value:9.99E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.32|P-value:4.32E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.60|P-value:1.52E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.94|P-value:3.81E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.95|P-value:3.70E-5 ID:SGTC_2404|Compound:5161160|FD-Score:-3.74|P-value:8.70E-5 ID:SGTC_2472|Compound:5377652|FD-Score:3.08|P-value:0.00100 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.65|P-value:1.26E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.43|P-value:2.84E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.23|P-value:5.89E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.85|P-value:5.71E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.46|P-value:2.57E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.38|P-value:3.51E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.24|P-value:5.68E-4 ID:SGTC_3213|Compound:9129884|FD-Score:4.00|P-value:2.94E-5 ID:SGTC_3225|Compound:9130819|FD-Score:3.98|P-value:3.24E-5 ID:SGTC_3236|Compound:9132701|FD-Score:3.62|P-value:1.42E-4

Top fitness defect scores for YLL008W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_839 0122-0028 6.31 230.0 µM 1.21E-10 RSC complex & mRNA processing 10 1.39E-10 0.22
2 SGTC_22 0964-0034 5.29 14.5 µM 5.47E-8 unfolded protein response 21 6.03E-8 0.22
3 SGTC_69 0096-0274 5.28 206.7 µM 5.70E-8 mitochondrial processes 28 6.29E-8 0.50
4 SGTC_491 tetrandrine 4.91 80.3 µM 4.16E-7 1 4.52E-7 0.54
5 SGTC_682 0kpi-0099 4.70 17.0 µM 1.22E-6 22 1.32E-6 0.18
6 SGTC_817 1391-0715 4.66 46.0 µM 1.48E-6 3 1.60E-6 0.23
7 SGTC_1589 2',5'-dimethoxyflavone 4.62 47.2 µM 1.79E-6 2 1.93E-6 0.49
8 SGTC_848 0368-0089 4.44 85.6 µM 4.11E-6 iron homeostasis 7 4.41E-6 0.06
9 SGTC_1745 st081495 4.34 74.0 µM 6.66E-6 RNA processing & uracil transport 26 7.11E-6 0.01
10 SGTC_644 1498-1197 4.32 63.3 µM 7.47E-6 6 7.98E-6 0.34
11 SGTC_977 1348-1378 4.27 135.0 µM 9.18E-6 6 9.79E-6 0.03
12 SGTC_392 N-ethylmaleimide 4.21 8.3 µM 1.18E-5 RNA pol III & RNase P/MRP 12 1.26E-5 0.05
13 SGTC_1351 1496-0003 4.17 46.5 µM 1.41E-5 3 1.50E-5 0.34
14 SGTC_1888 azatryptophan 4.17 97.5 µM 1.45E-5 3 1.54E-5 0.69
15 SGTC_3213 9129884 4.00 49.5 µM 2.94E-5 3 3.12E-5 0.28
16 SGTC_3225 9130819 3.98 49.5 µM 3.24E-5 amide catabolism 8 3.43E-5 0.15
17 SGTC_1683 st010134 3.95 710.0 nM 3.68E-5 4 3.89E-5 0.26
18 SGTC_2396 5342950 3.95 42.8 µM 3.70E-5 RSC complex & mRNA processing 36 3.91E-5 0.04
19 SGTC_2393 9031399 3.94 185.9 µM 3.81E-5 RNA processing & uracil transport 10 4.02E-5 0.04
20 SGTC_1845 st056753 3.91 3.0 µM 4.31E-5 TSC3-RPN4 8 4.55E-5 0.14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 3.09E-25 YMR277W FCP1 het Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
0.128 1.15E-13 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.126 2.21E-13 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.124 5.42E-13 YLR424W SPP382 het Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation
0.123 9.53E-13 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.120 2.44E-12 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.118 7.29E-12 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.117 1.17E-11 YDR413C_d YDR413C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing
0.116 1.67E-11 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.114 4.02E-11 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.114 4.33E-11 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.110 1.52E-10 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.108 3.61E-10 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.107 4.33E-10 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.105 1.02E-9 YIL104C SHQ1 het Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones