YLL010C / PSR1

Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL010C / PSR1

Click on Significant Values for Screen Details ID:SGTC_137|Compound:0438-0332|FD-Score:3.64|P-value:1.60E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.58|P-value:1.47E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-5.26|P-value:5.83E-8 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.78|P-value:6.75E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.77|P-value:7.08E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:3.50|P-value:2.73E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.58|P-value:2.04E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.35|P-value:4.69E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.36|P-value:4.56E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.51|P-value:2.57E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.09|P-value:2.58E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:3.21|P-value:7.65E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:4.50|P-value:4.03E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:3.27|P-value:6.14E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.51|P-value:2.24E-8 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.97|P-value:4.24E-7 ID:SGTC_1144|Compound:3486-0183|FD-Score:6.40|P-value:1.03E-10 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.25|P-value:6.68E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:4.63|P-value:2.18E-6 ID:SGTC_1786|Compound:berberine|FD-Score:4.14|P-value:2.09E-5 ID:SGTC_1807|Compound:st050092|FD-Score:4.14|P-value:2.11E-5 ID:SGTC_1949|Compound:st076024|FD-Score:4.50|P-value:4.06E-6 ID:SGTC_2001|Compound:4023502|FD-Score:4.24|P-value:1.35E-5 ID:SGTC_2133|Compound:5320837|FD-Score:3.37|P-value:4.36E-4 ID:SGTC_2146|Compound:5545642|FD-Score:4.05|P-value:3.11E-5 ID:SGTC_2258|Compound:7960471|FD-Score:3.78|P-value:9.18E-5 ID:SGTC_2308|Compound:7584454|FD-Score:-3.56|P-value:1.59E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.94|P-value:4.77E-5 ID:SGTC_2315|Compound:7733312|FD-Score:-4.12|P-value:1.59E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.15|P-value:9.52E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.59|P-value:1.93E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.97|P-value:4.22E-5 ID:SGTC_2415|Compound:st077333|FD-Score:3.13|P-value:9.88E-4 ID:SGTC_2424|Compound:5537928|FD-Score:3.19|P-value:8.15E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.83|P-value:8.34E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.09|P-value:8.85E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.11|P-value:8.11E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.28|P-value:5.95E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.42|P-value:3.58E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.70|P-value:1.29E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-5.04|P-value:1.97E-7 ID:SGTC_2788|Compound:5282734|FD-Score:3.26|P-value:6.48E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.52|P-value:2.54E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.57|P-value:2.08E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.56|P-value:2.13E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.18|P-value:8.40E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.33|P-value:3.84E-4 ID:SGTC_2878|Compound:9043973|FD-Score:3.30|P-value:5.58E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.36|P-value:4.46E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-4.48|P-value:3.09E-6 ID:SGTC_3270|Compound:9137563|FD-Score:-4.94|P-value:3.33E-7 ID:SGTC_3274|Compound:9138298|FD-Score:3.60|P-value:1.84E-4 ID:SGTC_3280|Compound:9140961|FD-Score:6.78|P-value:8.22E-12 ID:SGTC_3281|Compound:9140613|FD-Score:-5.87|P-value:1.81E-9 ID:SGTC_137|Compound:0438-0332|FD-Score:3.64|P-value:1.60E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.58|P-value:1.47E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-5.26|P-value:5.83E-8 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.78|P-value:6.75E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.77|P-value:7.08E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:3.50|P-value:2.73E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.58|P-value:2.04E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.35|P-value:4.69E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.36|P-value:4.56E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.51|P-value:2.57E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.09|P-value:2.58E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:3.21|P-value:7.65E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:4.50|P-value:4.03E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:3.27|P-value:6.14E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.51|P-value:2.24E-8 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.97|P-value:4.24E-7 ID:SGTC_1144|Compound:3486-0183|FD-Score:6.40|P-value:1.03E-10 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.25|P-value:6.68E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:4.63|P-value:2.18E-6 ID:SGTC_1786|Compound:berberine|FD-Score:4.14|P-value:2.09E-5 ID:SGTC_1807|Compound:st050092|FD-Score:4.14|P-value:2.11E-5 ID:SGTC_1949|Compound:st076024|FD-Score:4.50|P-value:4.06E-6 ID:SGTC_2001|Compound:4023502|FD-Score:4.24|P-value:1.35E-5 ID:SGTC_2133|Compound:5320837|FD-Score:3.37|P-value:4.36E-4 ID:SGTC_2146|Compound:5545642|FD-Score:4.05|P-value:3.11E-5 ID:SGTC_2258|Compound:7960471|FD-Score:3.78|P-value:9.18E-5 ID:SGTC_2308|Compound:7584454|FD-Score:-3.56|P-value:1.59E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.94|P-value:4.77E-5 ID:SGTC_2315|Compound:7733312|FD-Score:-4.12|P-value:1.59E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.15|P-value:9.52E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.59|P-value:1.93E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.97|P-value:4.22E-5 ID:SGTC_2415|Compound:st077333|FD-Score:3.13|P-value:9.88E-4 ID:SGTC_2424|Compound:5537928|FD-Score:3.19|P-value:8.15E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.83|P-value:8.34E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.09|P-value:8.85E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.11|P-value:8.11E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.28|P-value:5.95E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.42|P-value:3.58E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.70|P-value:1.29E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-5.04|P-value:1.97E-7 ID:SGTC_2788|Compound:5282734|FD-Score:3.26|P-value:6.48E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.52|P-value:2.54E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.57|P-value:2.08E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.56|P-value:2.13E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.18|P-value:8.40E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.33|P-value:3.84E-4 ID:SGTC_2878|Compound:9043973|FD-Score:3.30|P-value:5.58E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.36|P-value:4.46E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-4.48|P-value:3.09E-6 ID:SGTC_3270|Compound:9137563|FD-Score:-4.94|P-value:3.33E-7 ID:SGTC_3274|Compound:9138298|FD-Score:3.60|P-value:1.84E-4 ID:SGTC_3280|Compound:9140961|FD-Score:6.78|P-value:8.22E-12 ID:SGTC_3281|Compound:9140613|FD-Score:-5.87|P-value:1.81E-9

Top fitness defect scores for YLL010C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3280 9140961 6.78 49.5 µM 8.22E-12 60S ribosome export 1 6.14E-12
2 SGTC_1144 3486-0183 6.40 12.5 µM 1.03E-10 4 7.85E-11
3 SGTC_1130 3454-2858 5.51 15.9 µM 2.24E-8 NEO1 50 1.77E-8
4 SGTC_1131 3454-3128 4.97 32.3 µM 4.24E-7 16 3.43E-7
5 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 4.83 92.6 µM 8.34E-7 14 6.79E-7
6 SGTC_1412 3909-8563 4.63 178.0 µM 2.18E-6 2 1.79E-6
7 SGTC_994 3910-0338 4.50 138.0 µM 4.03E-6 calcium & mitochondrial duress 32 3.33E-6
8 SGTC_1949 st076024 4.50 69.1 µM 4.06E-6 11 3.35E-6
9 SGTC_2001 4023502 4.24 57.7 µM 1.35E-5 mitochondrial processes 11 1.13E-5
10 SGTC_1786 berberine 4.14 21.6 µM 2.09E-5 60S ribosome export 25 1.75E-5
11 SGTC_1807 st050092 4.14 58.9 µM 2.11E-5 60S ribosome export 9 1.77E-5
12 SGTC_858 0438-0351 4.09 2.8 µM 2.58E-5 copper-dependent oxidative stress 19 2.16E-5
13 SGTC_2146 5545642 4.05 200.0 µM 3.11E-5 15 2.61E-5
14 SGTC_2408 sulbentine 3.97 18.4 µM 4.22E-5 50 3.56E-5
15 SGTC_2314 7727897 3.94 200.0 µM 4.77E-5 25 4.03E-5
16 SGTC_2258 7960471 3.78 200.0 µM 9.18E-5 15 7.81E-5
17 SGTC_2564 betulinic acid 3.70 100.0 µM 1.29E-4 40 1.10E-4
18 SGTC_137 0438-0332 3.64 85.4 µM 1.60E-4 ubiquinone biosynthesis & proteasome 144 1.37E-4
19 SGTC_3274 9138298 3.60 49.5 µM 1.84E-4 28 1.58E-4
20 SGTC_2406 ethylparaben 3.59 405.7 µM 1.93E-4 59 1.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.40E-14 YBR089W_d YBR089W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30
0.105 1.10E-9 YNR011C PRP2 het RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16
0.104 1.35E-9 YFL034C-A RPL22B hom Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication
0.102 3.56E-9 YDR214W AHA1 hom Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress
0.090 1.79E-7 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.086 6.04E-7 YDR184C ATC1 hom Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress
0.086 6.08E-7 YER174C GRX4 hom Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; transcription is regulated by Yap5
0.082 1.74E-6 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.081 2.58E-6 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.079 5.00E-6 YLR421C RPN13 hom Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.077 7.93E-6 YPR049C ATG11 hom Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)
0.076 1.08E-5 YPR025C CCL1 het Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
0.075 1.20E-5 YMR059W SEN15 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
0.074 1.88E-5 YBL097W BRN1 het Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission
0.073 2.16E-5 YBR252W DUT1 het deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate