HIPHOP chemogenomics database

YLL014W / EMC6

Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93

Zygosity: Homozygous strain

fixedexpanded
Profile for YLL014W / EMC6

Click on Significant Values for Screen Details

Top fitness defect scores for YLL014W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_562	3772-2733	12.50	112.0 µM	1.05E-32	ERG2	4	2.21E-36
2	SGTC_1750	st081859	8.56	2.4 µM	3.74E-16	endomembrane recycling	59	5.84E-18
3	SGTC_2021	4019055	7.30	173.0 µM	3.19E-12	endomembrane recycling	27	1.41E-13
4	SGTC_676	falcarinol	6.12	140.0 µM	4.43E-9		15	4.54E-10
5	SGTC_1374	2889-5571	5.93	141.0 µM	1.28E-8	RSC complex & mRNA processing	12	1.48E-9
6	SGTC_1869	3',7'-dimethoxyflavone	5.49	40.3 µM	1.35E-7		5	2.06E-8
7	SGTC_1226	3909-7979	5.19	35.4 µM	5.86E-7		20	1.06E-7
8	SGTC_1130	3454-2858	4.78	15.9 µM	3.85E-6	NEO1	60	8.73E-7
9	SGTC_137	0438-0332	4.76	85.4 µM	4.27E-6	ubiquinone biosynthesis & proteasome	83	9.80E-7
10	SGTC_2013	4024628	4.73	200.0 µM	4.85E-6		26	1.13E-6
11	SGTC_1441	4106-0040	4.67	13.0 µM	6.33E-6		3	1.52E-6
12	SGTC_114	0364-0001	4.53	490.3 µM	1.16E-5		30	2.99E-6
13	SGTC_1511	0906-3109	4.41	28.5 µM	1.87E-5	excess fatty acid	31	5.10E-6
14	SGTC_1251	0490-5699	4.39	265.0 µM	2.06E-5		20	5.70E-6
15	SGTC_2612	dictamnine	4.20	15.5 µM	4.42E-5	RNA pol III & RNase P/MRP	39	1.34E-5
16	SGTC_1629	st005085	4.17	44.9 µM	4.98E-5	RPP1 & pyrimidine depletion	29	1.53E-5
17	SGTC_948	3448-0295	4.09	75.3 µM	6.89E-5		24	2.20E-5
18	SGTC_1721	st082152	4.05	9.3 µM	7.89E-5	60S ribosome export	18	2.56E-5
19	SGTC_2923	7992654	4.01	58.1 µM	9.27E-5	Golgi	24	3.07E-5
20	SGTC_924	2046-0044	3.99	21.3 µM	9.76E-5		14	3.25E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.316	1.12E-78	YJR088C	EMC2	hom	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.295	2.24E-68	YJR087W_d	YJR087W_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2
0.276	1.68E-59	YKL207W	EMC3	hom	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111
0.248	4.40E-48	YMR007W_d	YMR007W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.219	1.27E-37	YMR126C_p	DLT1_p	hom	Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.205	3.14E-33	YCL045C	EMC1	hom	Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090
0.193	2.44E-29	YCL046W_d	YCL046W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.189	3.21E-28	YGL231C	EMC4	hom	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85
0.176	9.72E-25	YPR153W	YPR153W	hom	Putative protein of unknown function
0.160	1.43E-20	YML072C	TCB3	hom	Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.151	1.25E-18	YKL098W	MTC2	hom	Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.150	2.25E-18	YPR029C	APL4	hom	Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.137	1.39E-15	YMR099C	YMR099C	hom	Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.132	1.52E-14	YIL027C	EMC5	hom	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT
0.125	3.76E-13	YLR170C	APS1	hom	Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex