YLL014W / EMC6

Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL014W / EMC6

Click on Significant Values for Screen Details ID:SGTC_114|Compound:0364-0001|FD-Score:4.53|P-value:1.16E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:4.76|P-value:4.27E-6 ID:SGTC_152|Compound:4469-0003|FD-Score:3.58|P-value:4.30E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.93|P-value:1.25E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.74|P-value:2.46E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.81|P-value:1.90E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:-3.21|P-value:8.81E-4 ID:SGTC_252|Compound:miconazole|FD-Score:-4.12|P-value:3.38E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.91|P-value:7.49E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:12.50|P-value:1.05E-32 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.41|P-value:4.67E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:6.12|P-value:4.43E-9 ID:SGTC_688|Compound:0527-0193|FD-Score:3.61|P-value:3.86E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.99|P-value:9.76E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:4.09|P-value:6.89E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.78|P-value:3.85E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.51|P-value:5.42E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:5.19|P-value:5.86E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.39|P-value:2.06E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.93|P-value:1.28E-8 ID:SGTC_1441|Compound:4106-0040|FD-Score:4.67|P-value:6.33E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.41|P-value:1.87E-5 ID:SGTC_1629|Compound:st005085|FD-Score:4.17|P-value:4.98E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.42|P-value:7.50E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.71|P-value:2.77E-4 ID:SGTC_1721|Compound:st082152|FD-Score:4.05|P-value:7.89E-5 ID:SGTC_1750|Compound:st081859|FD-Score:8.56|P-value:3.74E-16 ID:SGTC_1863|Compound:st057641|FD-Score:3.97|P-value:1.07E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.37|P-value:8.61E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:5.49|P-value:1.35E-7 ID:SGTC_2013|Compound:4024628|FD-Score:4.73|P-value:4.85E-6 ID:SGTC_2021|Compound:4019055|FD-Score:7.30|P-value:3.19E-12 ID:SGTC_2178|Compound:5812956|FD-Score:3.44|P-value:6.80E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.90|P-value:1.41E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.47|P-value:6.21E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-3.61|P-value:2.27E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.60|P-value:2.37E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-4.59|P-value:4.58E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.20|P-value:4.42E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.30|P-value:1.60E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.65|P-value:1.99E-4 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.54|P-value:4.98E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.55|P-value:4.81E-4 ID:SGTC_2923|Compound:7992654|FD-Score:4.01|P-value:9.27E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-3.34|P-value:5.91E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.36|P-value:5.48E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.28|P-value:7.14E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.53|P-value:5.19E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.88|P-value:1.47E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.36|P-value:8.84E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-3.34|P-value:5.84E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.72|P-value:2.70E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.53|P-value:1.16E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:4.76|P-value:4.27E-6 ID:SGTC_152|Compound:4469-0003|FD-Score:3.58|P-value:4.30E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.93|P-value:1.25E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.74|P-value:2.46E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.81|P-value:1.90E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:-3.21|P-value:8.81E-4 ID:SGTC_252|Compound:miconazole|FD-Score:-4.12|P-value:3.38E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.91|P-value:7.49E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:12.50|P-value:1.05E-32 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.41|P-value:4.67E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:6.12|P-value:4.43E-9 ID:SGTC_688|Compound:0527-0193|FD-Score:3.61|P-value:3.86E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.99|P-value:9.76E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:4.09|P-value:6.89E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.78|P-value:3.85E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.51|P-value:5.42E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:5.19|P-value:5.86E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.39|P-value:2.06E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.93|P-value:1.28E-8 ID:SGTC_1441|Compound:4106-0040|FD-Score:4.67|P-value:6.33E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.41|P-value:1.87E-5 ID:SGTC_1629|Compound:st005085|FD-Score:4.17|P-value:4.98E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.42|P-value:7.50E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.71|P-value:2.77E-4 ID:SGTC_1721|Compound:st082152|FD-Score:4.05|P-value:7.89E-5 ID:SGTC_1750|Compound:st081859|FD-Score:8.56|P-value:3.74E-16 ID:SGTC_1863|Compound:st057641|FD-Score:3.97|P-value:1.07E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.37|P-value:8.61E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:5.49|P-value:1.35E-7 ID:SGTC_2013|Compound:4024628|FD-Score:4.73|P-value:4.85E-6 ID:SGTC_2021|Compound:4019055|FD-Score:7.30|P-value:3.19E-12 ID:SGTC_2178|Compound:5812956|FD-Score:3.44|P-value:6.80E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.90|P-value:1.41E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.47|P-value:6.21E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-3.61|P-value:2.27E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.60|P-value:2.37E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-4.59|P-value:4.58E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.20|P-value:4.42E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.30|P-value:1.60E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.65|P-value:1.99E-4 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.54|P-value:4.98E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.55|P-value:4.81E-4 ID:SGTC_2923|Compound:7992654|FD-Score:4.01|P-value:9.27E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-3.34|P-value:5.91E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.36|P-value:5.48E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.28|P-value:7.14E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.53|P-value:5.19E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.88|P-value:1.47E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.36|P-value:8.84E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-3.34|P-value:5.84E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.72|P-value:2.70E-4

Top fitness defect scores for YLL014W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_562 3772-2733 12.50 112.0 µM 1.05E-32 ERG2 4 2.21E-36
2 SGTC_1750 st081859 8.56 2.4 µM 3.74E-16 endomembrane recycling 59 5.84E-18
3 SGTC_2021 4019055 7.30 173.0 µM 3.19E-12 endomembrane recycling 27 1.41E-13
4 SGTC_676 falcarinol 6.12 140.0 µM 4.43E-9 15 4.54E-10
5 SGTC_1374 2889-5571 5.93 141.0 µM 1.28E-8 RSC complex & mRNA processing 12 1.48E-9
6 SGTC_1869 3',7'-dimethoxyflavone 5.49 40.3 µM 1.35E-7 5 2.06E-8
7 SGTC_1226 3909-7979 5.19 35.4 µM 5.86E-7 20 1.06E-7
8 SGTC_1130 3454-2858 4.78 15.9 µM 3.85E-6 NEO1 60 8.73E-7
9 SGTC_137 0438-0332 4.76 85.4 µM 4.27E-6 ubiquinone biosynthesis & proteasome 83 9.80E-7
10 SGTC_2013 4024628 4.73 200.0 µM 4.85E-6 26 1.13E-6
11 SGTC_1441 4106-0040 4.67 13.0 µM 6.33E-6 3 1.52E-6
12 SGTC_114 0364-0001 4.53 490.3 µM 1.16E-5 30 2.99E-6
13 SGTC_1511 0906-3109 4.41 28.5 µM 1.87E-5 excess fatty acid 31 5.10E-6
14 SGTC_1251 0490-5699 4.39 265.0 µM 2.06E-5 20 5.70E-6
15 SGTC_2612 dictamnine 4.20 15.5 µM 4.42E-5 RNA pol III & RNase P/MRP 39 1.34E-5
16 SGTC_1629 st005085 4.17 44.9 µM 4.98E-5 RPP1 & pyrimidine depletion 29 1.53E-5
17 SGTC_948 3448-0295 4.09 75.3 µM 6.89E-5 24 2.20E-5
18 SGTC_1721 st082152 4.05 9.3 µM 7.89E-5 60S ribosome export 18 2.56E-5
19 SGTC_2923 7992654 4.01 58.1 µM 9.27E-5 Golgi 24 3.07E-5
20 SGTC_924 2046-0044 3.99 21.3 µM 9.76E-5 14 3.25E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.316 1.12E-78 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.295 2.24E-68 YJR087W_d YJR087W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2
0.276 1.68E-59 YKL207W EMC3 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111
0.248 4.40E-48 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.219 1.27E-37 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.205 3.14E-33 YCL045C EMC1 hom Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090
0.193 2.44E-29 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.189 3.21E-28 YGL231C EMC4 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85
0.176 9.72E-25 YPR153W YPR153W hom Putative protein of unknown function
0.160 1.43E-20 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.151 1.25E-18 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.150 2.25E-18 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.137 1.39E-15 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.132 1.52E-14 YIL027C EMC5 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT
0.125 3.76E-13 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex