YLL016W / SDC25

Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL016W / SDC25

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:3.40|P-value:2.04E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:3.38|P-value:2.16E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.94|P-value:2.01E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:3.35|P-value:2.47E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.20|P-value:6.08E-6 ID:SGTC_775|Compound:4577-0580|FD-Score:3.18|P-value:4.66E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.10|P-value:6.29E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.52|P-value:1.26E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.71|P-value:1.26E-9 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.69|P-value:6.15E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.26|P-value:4.53E-6 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.80|P-value:3.85E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:-3.22|P-value:3.56E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.09|P-value:1.02E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.23|P-value:5.12E-6 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.18|P-value:6.59E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.18|P-value:4.72E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-3.51|P-value:1.10E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.04|P-value:6.77E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.55|P-value:1.11E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.31|P-value:2.85E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.39|P-value:2.08E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.22|P-value:3.96E-4 ID:SGTC_2138|Compound:5575593|FD-Score:-4.25|P-value:4.03E-6 ID:SGTC_2187|Compound:6125751|FD-Score:-3.43|P-value:1.54E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.58|P-value:9.59E-5 ID:SGTC_2206|Compound:7254556|FD-Score:4.10|P-value:9.61E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.39|P-value:1.79E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-4.13|P-value:6.92E-6 ID:SGTC_2927|Compound:9011802|FD-Score:-3.47|P-value:1.30E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.12|P-value:5.80E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.23|P-value:3.38E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.43|P-value:1.80E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.23|P-value:3.83E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-2.96|P-value:9.18E-4 ID:SGTC_3114|Compound:9122766|FD-Score:-2.96|P-value:9.24E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.46|P-value:1.37E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.72|P-value:4.50E-5 ID:SGTC_82|Compound:0054-0107|FD-Score:3.40|P-value:2.04E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:3.38|P-value:2.16E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.94|P-value:2.01E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:3.35|P-value:2.47E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.20|P-value:6.08E-6 ID:SGTC_775|Compound:4577-0580|FD-Score:3.18|P-value:4.66E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.10|P-value:6.29E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.52|P-value:1.26E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.71|P-value:1.26E-9 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.69|P-value:6.15E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.26|P-value:4.53E-6 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.80|P-value:3.85E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:-3.22|P-value:3.56E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.09|P-value:1.02E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.23|P-value:5.12E-6 ID:SGTC_1363|Compound:1636-0063|FD-Score:4.18|P-value:6.59E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.18|P-value:4.72E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-3.51|P-value:1.10E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.04|P-value:6.77E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.55|P-value:1.11E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.31|P-value:2.85E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.39|P-value:2.08E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.22|P-value:3.96E-4 ID:SGTC_2138|Compound:5575593|FD-Score:-4.25|P-value:4.03E-6 ID:SGTC_2187|Compound:6125751|FD-Score:-3.43|P-value:1.54E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.58|P-value:9.59E-5 ID:SGTC_2206|Compound:7254556|FD-Score:4.10|P-value:9.61E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.39|P-value:1.79E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-4.13|P-value:6.92E-6 ID:SGTC_2927|Compound:9011802|FD-Score:-3.47|P-value:1.30E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.12|P-value:5.80E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.23|P-value:3.38E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.43|P-value:1.80E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.23|P-value:3.83E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-2.96|P-value:9.18E-4 ID:SGTC_3114|Compound:9122766|FD-Score:-2.96|P-value:9.24E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.46|P-value:1.37E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.72|P-value:4.50E-5

Top fitness defect scores for YLL016W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1131 3454-3128 5.71 32.3 µM 1.26E-9 8 5.60E-9
2 SGTC_1244 0416-0015 4.26 52.5 µM 4.53E-6 ERG2 27 1.03E-5
3 SGTC_1359 1582-0056 4.23 520.0 nM 5.12E-6 13 1.15E-5
4 SGTC_644 1498-1197 4.20 63.3 µM 6.08E-6 14 1.35E-5
5 SGTC_1363 1636-0063 4.18 10.4 µM 6.59E-6 Golgi 23 1.46E-5
6 SGTC_2206 7254556 4.10 147.0 µM 9.61E-6 60S ribosome export 3 2.06E-5
7 SGTC_1347 1493-0251 4.09 600.0 nM 1.02E-5 mitochondrial response to ROS 17 2.18E-5
8 SGTC_544 k015-0020 3.94 52.4 µM 2.01E-5 11 4.06E-5
9 SGTC_1285 0929-0069 3.80 65.5 µM 3.85E-5 20 7.38E-5
10 SGTC_1225 1216-0074 3.69 20.6 µM 6.15E-5 30 1.14E-4
11 SGTC_2203 7227154 3.58 166.4 µM 9.59E-5 23 1.71E-4
12 SGTC_1976 st070609 3.55 63.5 µM 1.11E-4 18 1.96E-4
13 SGTC_936 3005-4620 3.52 401.0 µM 1.26E-4 39 2.20E-4
14 SGTC_2988 9073640 3.43 71.4 µM 1.80E-4 33 3.06E-4
15 SGTC_82 0054-0107 3.40 293.8 µM 2.04E-4 18 3.43E-4
16 SGTC_2058 5236698 3.39 133.0 µM 2.08E-4 43 3.49E-4
17 SGTC_110 0850-0284 3.38 111.6 µM 2.16E-4 21 3.61E-4
18 SGTC_619 1652-1634 3.35 108.0 µM 2.47E-4 PDR1 39 4.10E-4
19 SGTC_1998 st075797 3.31 76.8 µM 2.85E-4 mitochondrial response to ROS 36 4.67E-4
20 SGTC_3066 9117245 3.23 49.5 µM 3.83E-4 31 6.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.58E-11 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.108 4.15E-10 YIL042C PKP1 hom Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
0.100 6.44E-9 YML086C ALO1 hom D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress
0.091 1.47E-7 YJL191W RPS14B hom Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication
0.086 6.67E-7 YMR004W MVP1 hom Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress
0.085 8.83E-7 YDR415C_p YDR415C_p hom Putative aminopeptidase
0.082 1.72E-6 YLR421C RPN13 hom Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.080 4.03E-6 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.078 5.61E-6 YCL030C HIS4 hom Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis
0.078 6.62E-6 YFL034C-A RPL22B hom Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication
0.076 1.03E-5 YFR030W MET10 hom Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide
0.076 1.18E-5 YDR034C LYS14 hom Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
0.075 1.31E-5 YMR247W-A_p YMR247W-A_p hom Putative protein of unknown function
0.075 1.47E-5 YJR152W DAL5 hom Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
0.073 2.05E-5 YBL030C PET9 het Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication