YLL017W

Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL017W / YLL017W

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-2.85|P-value:6.35E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.79|P-value:8.44E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.08|P-value:2.43E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:2.84|P-value:4.86E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.68|P-value:1.00E-5 ID:SGTC_693|Compound:4161-2696|FD-Score:2.87|P-value:4.18E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.66|P-value:1.11E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:2.94|P-value:3.15E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.17|P-value:1.15E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:-4.15|P-value:1.17E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.57|P-value:2.51E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:2.83|P-value:5.06E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.70|P-value:1.35E-5 ID:SGTC_1682|Compound:st012968|FD-Score:3.07|P-value:1.82E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-2.99|P-value:3.54E-4 ID:SGTC_1751|Compound:st044839|FD-Score:2.70|P-value:8.26E-4 ID:SGTC_1939|Compound:st074455|FD-Score:2.67|P-value:9.33E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:2.93|P-value:3.34E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.06|P-value:1.28E-6 ID:SGTC_2106|Compound:5357045|FD-Score:3.29|P-value:6.59E-5 ID:SGTC_2149|Compound:5554786|FD-Score:-3.13|P-value:1.92E-4 ID:SGTC_2158|Compound:5657123|FD-Score:2.85|P-value:4.62E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.24|P-value:1.20E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.14|P-value:1.34E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.06|P-value:2.64E-4 ID:SGTC_2472|Compound:5377652|FD-Score:-3.14|P-value:1.82E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.57|P-value:6.24E-8 ID:SGTC_2537|Compound:larixol|FD-Score:-3.60|P-value:2.19E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:2.67|P-value:9.33E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.04|P-value:2.06E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-2.84|P-value:6.45E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.28|P-value:5.68E-7 ID:SGTC_2848|Compound:9016370|FD-Score:-3.60|P-value:2.14E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-4.43|P-value:2.28E-7 ID:SGTC_2858|Compound:9025781|FD-Score:4.16|P-value:7.29E-7 ID:SGTC_2955|Compound:9076254|FD-Score:3.00|P-value:2.49E-4 ID:SGTC_3049|Compound:9092223|FD-Score:2.86|P-value:4.48E-4 ID:SGTC_3066|Compound:9117245|FD-Score:2.74|P-value:7.15E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.69|P-value:1.39E-5 ID:SGTC_3145|Compound:9085516|FD-Score:6.58|P-value:1.53E-14 ID:SGTC_3205|Compound:9113483|FD-Score:-3.42|P-value:5.12E-5 ID:SGTC_3207|Compound:9114163|FD-Score:3.92|P-value:2.82E-6 ID:SGTC_3210|Compound:9128157|FD-Score:7.95|P-value:2.46E-20 ID:SGTC_3285|Compound:9112818|FD-Score:-2.86|P-value:5.98E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.23|P-value:8.65E-5 ID:SGTC_3304|Compound:9125678|FD-Score:2.95|P-value:3.02E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-3.91|P-value:4.35E-6 ID:SGTC_38|Compound:0929-0051|FD-Score:-2.85|P-value:6.35E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.79|P-value:8.44E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.08|P-value:2.43E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:2.84|P-value:4.86E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.68|P-value:1.00E-5 ID:SGTC_693|Compound:4161-2696|FD-Score:2.87|P-value:4.18E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.66|P-value:1.11E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:2.94|P-value:3.15E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.17|P-value:1.15E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:-4.15|P-value:1.17E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:-3.57|P-value:2.51E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:2.83|P-value:5.06E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.70|P-value:1.35E-5 ID:SGTC_1682|Compound:st012968|FD-Score:3.07|P-value:1.82E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-2.99|P-value:3.54E-4 ID:SGTC_1751|Compound:st044839|FD-Score:2.70|P-value:8.26E-4 ID:SGTC_1939|Compound:st074455|FD-Score:2.67|P-value:9.33E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:2.93|P-value:3.34E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.06|P-value:1.28E-6 ID:SGTC_2106|Compound:5357045|FD-Score:3.29|P-value:6.59E-5 ID:SGTC_2149|Compound:5554786|FD-Score:-3.13|P-value:1.92E-4 ID:SGTC_2158|Compound:5657123|FD-Score:2.85|P-value:4.62E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.24|P-value:1.20E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.14|P-value:1.34E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.06|P-value:2.64E-4 ID:SGTC_2472|Compound:5377652|FD-Score:-3.14|P-value:1.82E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.57|P-value:6.24E-8 ID:SGTC_2537|Compound:larixol|FD-Score:-3.60|P-value:2.19E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:2.67|P-value:9.33E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.04|P-value:2.06E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-2.84|P-value:6.45E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.28|P-value:5.68E-7 ID:SGTC_2848|Compound:9016370|FD-Score:-3.60|P-value:2.14E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-4.43|P-value:2.28E-7 ID:SGTC_2858|Compound:9025781|FD-Score:4.16|P-value:7.29E-7 ID:SGTC_2955|Compound:9076254|FD-Score:3.00|P-value:2.49E-4 ID:SGTC_3049|Compound:9092223|FD-Score:2.86|P-value:4.48E-4 ID:SGTC_3066|Compound:9117245|FD-Score:2.74|P-value:7.15E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.69|P-value:1.39E-5 ID:SGTC_3145|Compound:9085516|FD-Score:6.58|P-value:1.53E-14 ID:SGTC_3205|Compound:9113483|FD-Score:-3.42|P-value:5.12E-5 ID:SGTC_3207|Compound:9114163|FD-Score:3.92|P-value:2.82E-6 ID:SGTC_3210|Compound:9128157|FD-Score:7.95|P-value:2.46E-20 ID:SGTC_3285|Compound:9112818|FD-Score:-2.86|P-value:5.98E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.23|P-value:8.65E-5 ID:SGTC_3304|Compound:9125678|FD-Score:2.95|P-value:3.02E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-3.91|P-value:4.35E-6

Top fitness defect scores for YLL017W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3210 9128157 7.95 49.5 µM 2.46E-20 7 9.52E-16
2 SGTC_3145 9085516 6.58 49.5 µM 1.53E-14 fatty acid desaturase (OLE1) 4 2.36E-11
3 SGTC_2533 agelasine 4.57 13.7 µM 6.24E-8 ERG2 34 2.47E-6
4 SGTC_2858 9025781 4.16 9.0 µM 7.29E-7 sphingolipid biosynthesis & PDR1 92 1.60E-5
5 SGTC_2057 5236571 4.06 38.3 µM 1.28E-6 RPP1 & pyrimidine depletion 28 2.46E-5
6 SGTC_3207 9114163 3.92 49.5 µM 2.82E-6 31 4.48E-5
7 SGTC_663 1486-0733 3.68 13.9 µM 1.00E-5 cell wall signaling 63 1.18E-4
8 SGTC_696 1560-0013 3.66 611.0 µM 1.11E-5 30 1.27E-4
9 SGTC_2106 5357045 3.29 167.3 µM 6.59E-5 40 4.96E-4
10 SGTC_3295 9122362 3.23 53.6 µM 8.65E-5 35 6.11E-4
11 SGTC_990 3985-0011 3.17 41.3 µM 1.15E-4 amide catabolism 43 7.60E-4
12 SGTC_2308 7584454 3.14 197.6 µM 1.34E-4 66 8.54E-4
13 SGTC_1682 st012968 3.07 530.0 nM 1.82E-4 54 0.00108
14 SGTC_2706 st078239 3.04 82.5 µM 2.06E-4 49 0.00119
15 SGTC_2955 9076254 3.00 12.2 µM 2.49E-4 48 0.00137
16 SGTC_3304 9125678 2.95 46.1 µM 3.02E-4 104 0.00159
17 SGTC_915 methyl methanesulfonate (MMS) 2.94 110.0 mM 3.15E-4 DNA damage response 90 0.00164
18 SGTC_1951 sophoraflavanone G 2.93 9.2 µM 3.34E-4 RNA processing & uracil transport 84 0.00172
19 SGTC_693 4161-2696 2.87 114.0 µM 4.18E-4 38 0.00204
20 SGTC_3049 9092223 2.86 49.5 µM 4.48E-4 82 0.00215

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 4.87E-24 YCR014C POL4 hom DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta
0.169 9.13E-23 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.160 9.64E-21 YGL122C NAB2 het Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
0.158 4.24E-20 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.137 1.96E-15 YDL079C MRK1 hom Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
0.135 4.07E-15 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.132 1.36E-14 YJR010W MET3 hom ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
0.127 1.67E-13 YBR052C RFS1 hom Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication
0.126 2.60E-13 YDL154W MSH5 hom Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans
0.120 2.53E-12 YGR035W-A_p YGR035W-A_p hom Putative protein of unknown function
0.117 8.57E-12 YDR105C TMS1 hom Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
0.115 2.21E-11 YMR183C SSO2 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
0.115 2.27E-11 YLR210W CLB4 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
0.111 1.01E-10 YKL020C SPT23 hom ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
0.111 1.25E-10 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription