YLL018C / DPS1

Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLL018C / DPS1

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:-5.12|P-value:8.10E-7 ID:SGTC_62|Compound:0180-0423|FD-Score:4.27|P-value:6.06E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:5.63|P-value:1.67E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:3.80|P-value:3.23E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.81|P-value:1.68E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.56|P-value:6.98E-4 ID:SGTC_462|Compound:ag-879|FD-Score:4.61|P-value:1.57E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.55|P-value:1.05E-7 ID:SGTC_975|Compound:1335-0046|FD-Score:-4.08|P-value:6.13E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.56|P-value:7.11E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.68|P-value:2.64E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:-3.28|P-value:9.56E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.35|P-value:4.41E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.83|P-value:2.90E-4 ID:SGTC_1554|Compound:st069299|FD-Score:6.34|P-value:4.47E-9 ID:SGTC_1754|Compound:st042065|FD-Score:-3.97|P-value:9.28E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-4.06|P-value:6.81E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.67|P-value:6.01E-6 ID:SGTC_1889|Compound:st059080|FD-Score:3.86|P-value:2.61E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-4.39|P-value:1.88E-5 ID:SGTC_1933|Compound:st074711|FD-Score:4.20|P-value:7.80E-5 ID:SGTC_1963|Compound:st076565|FD-Score:3.65|P-value:5.24E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.74|P-value:3.83E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.64|P-value:5.41E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-5.49|P-value:1.43E-7 ID:SGTC_2211|Compound:7117706|FD-Score:-3.68|P-value:2.63E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.61|P-value:5.93E-4 ID:SGTC_2257|Compound:7960413|FD-Score:-3.41|P-value:6.35E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.66|P-value:1.32E-5 ID:SGTC_2348|Compound:9022543|FD-Score:3.57|P-value:6.88E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.81|P-value:1.69E-4 ID:SGTC_2365|Compound:9042475|FD-Score:4.73|P-value:9.60E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:3.82|P-value:2.99E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:-3.39|P-value:6.76E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.50|P-value:4.72E-4 ID:SGTC_2702|Compound:st077768|FD-Score:4.32|P-value:4.90E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.20|P-value:7.77E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.89|P-value:1.25E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.44|P-value:5.76E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-7.19|P-value:1.06E-11 ID:SGTC_3037|Compound:9091026|FD-Score:-4.42|P-value:1.68E-5 ID:SGTC_3089|Compound:9117425|FD-Score:3.62|P-value:5.71E-4 ID:SGTC_3149|Compound:9097855|FD-Score:5.14|P-value:1.65E-6 ID:SGTC_3151|Compound:9099821|FD-Score:4.27|P-value:5.86E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-4.11|P-value:5.65E-5 ID:SGTC_3181|Compound:9108277|FD-Score:4.09|P-value:1.13E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:-5.12|P-value:8.10E-7 ID:SGTC_62|Compound:0180-0423|FD-Score:4.27|P-value:6.06E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:5.63|P-value:1.67E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:3.80|P-value:3.23E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.81|P-value:1.68E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.56|P-value:6.98E-4 ID:SGTC_462|Compound:ag-879|FD-Score:4.61|P-value:1.57E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.55|P-value:1.05E-7 ID:SGTC_975|Compound:1335-0046|FD-Score:-4.08|P-value:6.13E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.56|P-value:7.11E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.68|P-value:2.64E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:-3.28|P-value:9.56E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.35|P-value:4.41E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.83|P-value:2.90E-4 ID:SGTC_1554|Compound:st069299|FD-Score:6.34|P-value:4.47E-9 ID:SGTC_1754|Compound:st042065|FD-Score:-3.97|P-value:9.28E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-4.06|P-value:6.81E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-4.67|P-value:6.01E-6 ID:SGTC_1889|Compound:st059080|FD-Score:3.86|P-value:2.61E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-4.39|P-value:1.88E-5 ID:SGTC_1933|Compound:st074711|FD-Score:4.20|P-value:7.80E-5 ID:SGTC_1963|Compound:st076565|FD-Score:3.65|P-value:5.24E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.74|P-value:3.83E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.64|P-value:5.41E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-5.49|P-value:1.43E-7 ID:SGTC_2211|Compound:7117706|FD-Score:-3.68|P-value:2.63E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.61|P-value:5.93E-4 ID:SGTC_2257|Compound:7960413|FD-Score:-3.41|P-value:6.35E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.66|P-value:1.32E-5 ID:SGTC_2348|Compound:9022543|FD-Score:3.57|P-value:6.88E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.81|P-value:1.69E-4 ID:SGTC_2365|Compound:9042475|FD-Score:4.73|P-value:9.60E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:3.82|P-value:2.99E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:-3.39|P-value:6.76E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.50|P-value:4.72E-4 ID:SGTC_2702|Compound:st077768|FD-Score:4.32|P-value:4.90E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.20|P-value:7.77E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.89|P-value:1.25E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.44|P-value:5.76E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-7.19|P-value:1.06E-11 ID:SGTC_3037|Compound:9091026|FD-Score:-4.42|P-value:1.68E-5 ID:SGTC_3089|Compound:9117425|FD-Score:3.62|P-value:5.71E-4 ID:SGTC_3149|Compound:9097855|FD-Score:5.14|P-value:1.65E-6 ID:SGTC_3151|Compound:9099821|FD-Score:4.27|P-value:5.86E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-4.11|P-value:5.65E-5 ID:SGTC_3181|Compound:9108277|FD-Score:4.09|P-value:1.13E-4

Top fitness defect scores for YLL018C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1554 st069299 6.34 38.7 µM 4.47E-9 1 1.18E-10 1.20
2 SGTC_68 0986-0284 5.63 82.8 µM 1.67E-7 4 8.82E-9 0.69
3 SGTC_3149 9097855 5.14 49.5 µM 1.65E-6 Golgi 4 1.35E-7 0.01
4 SGTC_2365 9042475 4.73 200.0 µM 9.60E-6 4 1.11E-6 0.58
5 SGTC_2344 7990960 4.66 77.0 µM 1.32E-5 29 1.62E-6 0.20
6 SGTC_462 ag-879 4.61 158.0 µM 1.57E-5 8 1.99E-6 0.11
7 SGTC_1390 3413-2614 4.35 145.0 µM 4.41E-5 fatty acid desaturase (OLE1) 7 6.83E-6 0.15
8 SGTC_2702 st077768 4.32 96.8 µM 4.90E-5 5 7.74E-6 0.21
9 SGTC_3151 9099821 4.27 49.5 µM 5.86E-5 2 9.58E-6 0.19
10 SGTC_62 0180-0423 4.27 3.2 µM 6.06E-5 60S ribosome export 7 9.97E-6 0.06
11 SGTC_2759 disulfiram 4.20 3.4 µM 7.77E-5 16 1.34E-5 0.21
12 SGTC_1933 st074711 4.20 15.9 µM 7.80E-5 7 1.35E-5 0.27
13 SGTC_3181 9108277 4.09 49.5 µM 1.13E-4 iron homeostasis 11 2.11E-5 0.04
14 SGTC_1889 st059080 3.86 5.2 µM 2.61E-4 5 5.71E-5 0.20
15 SGTC_1544 7-methoxy-4-methylcoumarin 3.83 105.0 µM 2.90E-4 6 6.48E-5 0.35
16 SGTC_2645 abamectin 3.82 100.0 µM 2.99E-4 heme requiring 12 6.71E-5 0.03
17 SGTC_70 0141-0289 3.80 43.3 µM 3.23E-4 mitochondrial stress 20 7.36E-5 0.06
18 SGTC_1981 st071826 3.74 47.0 µM 3.83E-4 7 9.03E-5 0.24
19 SGTC_1963 st076565 3.65 50.3 µM 5.24E-4 6 1.31E-4 0.15
20 SGTC_2124 5246320 3.64 200.0 µM 5.41E-4 heme biosynthesis & mitochondrial translocase 34 1.36E-4 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 8.67E-13 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.114 4.18E-11 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.112 8.46E-11 YBL105C PKC1 het Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
0.110 2.01E-10 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.106 8.54E-10 YIL038C NOT3 hom Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
0.105 9.31E-10 YDR238C SEC26 het Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
0.104 1.50E-9 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.104 1.63E-9 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.101 4.54E-9 YNL284C MRPL10 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
0.101 5.48E-9 YBL090W MRP21 hom Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
0.099 8.99E-9 YDL145C COP1 het Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
0.098 1.20E-8 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.097 1.86E-8 YNR037C RSM19 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein
0.093 6.73E-8 YHR091C MSR1 hom Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6
0.093 7.85E-8 YLR439W MRPL4 hom Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit