YLL018C-A / COX19

Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL018C-A / COX19

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.70|P-value:3.00E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:10.60|P-value:4.25E-23 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.74|P-value:2.57E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:17.00|P-value:3.23E-56 ID:SGTC_310|Compound:1273-0058|FD-Score:3.75|P-value:2.52E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.85|P-value:1.73E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.85|P-value:1.73E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:5.39|P-value:2.82E-7 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.38|P-value:8.64E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.43|P-value:7.27E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.61|P-value:4.02E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:8.74|P-value:2.50E-16 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.08|P-value:7.60E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.97|P-value:1.12E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.91|P-value:1.44E-4 ID:SGTC_1617|Compound:st002906|FD-Score:4.82|P-value:3.76E-6 ID:SGTC_1635|Compound:st007035|FD-Score:5.16|P-value:8.19E-7 ID:SGTC_2034|Compound:5197015|FD-Score:3.98|P-value:1.11E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.68|P-value:3.20E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.88|P-value:1.58E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.90|P-value:1.46E-4 ID:SGTC_2088|Compound:5278280|FD-Score:-3.86|P-value:1.72E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.43|P-value:7.26E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.94|P-value:1.28E-4 ID:SGTC_2265|Compound:7929201|FD-Score:4.02|P-value:9.35E-5 ID:SGTC_2274|Compound:7947094|FD-Score:3.42|P-value:7.43E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-3.42|P-value:7.46E-4 ID:SGTC_2364|Compound:9055074|FD-Score:4.10|P-value:7.04E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.76|P-value:2.41E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.05|P-value:1.37E-6 ID:SGTC_3006|Compound:9075424|FD-Score:3.51|P-value:5.52E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-5.21|P-value:6.54E-7 ID:SGTC_3125|Compound:9127534|FD-Score:-3.59|P-value:4.27E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-4.69|P-value:6.78E-6 ID:SGTC_3208|Compound:9114115|FD-Score:3.82|P-value:1.97E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.70|P-value:3.00E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:10.60|P-value:4.25E-23 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.74|P-value:2.57E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:17.00|P-value:3.23E-56 ID:SGTC_310|Compound:1273-0058|FD-Score:3.75|P-value:2.52E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.85|P-value:1.73E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.85|P-value:1.73E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:5.39|P-value:2.82E-7 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.38|P-value:8.64E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.43|P-value:7.27E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.61|P-value:4.02E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:8.74|P-value:2.50E-16 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.08|P-value:7.60E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.97|P-value:1.12E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.91|P-value:1.44E-4 ID:SGTC_1617|Compound:st002906|FD-Score:4.82|P-value:3.76E-6 ID:SGTC_1635|Compound:st007035|FD-Score:5.16|P-value:8.19E-7 ID:SGTC_2034|Compound:5197015|FD-Score:3.98|P-value:1.11E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.68|P-value:3.20E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.88|P-value:1.58E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.90|P-value:1.46E-4 ID:SGTC_2088|Compound:5278280|FD-Score:-3.86|P-value:1.72E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.43|P-value:7.26E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.94|P-value:1.28E-4 ID:SGTC_2265|Compound:7929201|FD-Score:4.02|P-value:9.35E-5 ID:SGTC_2274|Compound:7947094|FD-Score:3.42|P-value:7.43E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-3.42|P-value:7.46E-4 ID:SGTC_2364|Compound:9055074|FD-Score:4.10|P-value:7.04E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.76|P-value:2.41E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.05|P-value:1.37E-6 ID:SGTC_3006|Compound:9075424|FD-Score:3.51|P-value:5.52E-4 ID:SGTC_3071|Compound:9117417|FD-Score:-5.21|P-value:6.54E-7 ID:SGTC_3125|Compound:9127534|FD-Score:-3.59|P-value:4.27E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-4.69|P-value:6.78E-6 ID:SGTC_3208|Compound:9114115|FD-Score:3.82|P-value:1.97E-4

Top fitness defect scores for YLL018C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 17.00 5.3 µM 3.23E-56 77 6.84E-65
2 SGTC_134 0269-0018 10.60 6.9 µM 4.25E-23 37 1.71E-26
3 SGTC_1446 4239-0190 8.74 62.0 µM 2.50E-16 2 1.19E-18
4 SGTC_579 4491-1009 5.39 110.0 µM 2.82E-7 60S ribosome export 3 3.53E-8
5 SGTC_1635 st007035 5.16 42.4 µM 8.19E-7 162 1.21E-7
6 SGTC_1617 st002906 4.82 78.0 µM 3.76E-6 15 7.04E-7
7 SGTC_2364 9055074 4.10 200.0 µM 7.04E-5 18 2.06E-5
8 SGTC_1456 k015-0012 4.08 13.0 µM 7.60E-5 28 2.25E-5
9 SGTC_2265 7929201 4.02 200.0 µM 9.35E-5 19 2.85E-5
10 SGTC_2034 5197015 3.98 53.1 µM 1.11E-4 SWF1 & branched chain AA biosynthesis 23 3.49E-5
11 SGTC_2097 5376186 3.94 200.0 µM 1.28E-4 19 4.10E-5
12 SGTC_1500 4488-1866 3.91 171.0 µM 1.44E-4 RPP1 & pyrimidine depletion 21 4.70E-5
13 SGTC_2082 5219693 3.90 150.0 µM 1.46E-4 RNA processing & uracil transport 30 4.76E-5
14 SGTC_2071 5230951 3.88 39.9 µM 1.58E-4 TSC3-RPN4 21 5.23E-5
15 SGTC_386 1509-0011 3.85 3.1 µM 1.73E-4 150 5.82E-5
16 SGTC_3208 9114115 3.82 49.5 µM 1.97E-4 43 6.75E-5
17 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 3.76 15.3 µM 2.41E-4 39 8.48E-5
18 SGTC_310 1273-0058 3.75 1.1 µM 2.52E-4 mitochondrial stress 257 8.93E-5
19 SGTC_6 0844-0013 3.70 19.8 µM 3.00E-4 117 1.09E-4
20 SGTC_2062 5245942 3.68 200.0 µM 3.20E-4 28 1.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.525 1.96E-237 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.515 3.01E-227 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.502 1.04E-213 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.501 2.06E-212 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.496 8.66E-208 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.495 9.24E-207 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.478 1.68E-190 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.477 5.72E-190 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.475 2.15E-188 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.469 2.77E-183 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.467 1.96E-181 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.467 3.55E-181 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.467 6.44E-181 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.463 1.58E-177 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.461 1.10E-175 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex