YLL024C / SSA2

ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL024C / SSA2

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.02|P-value:5.96E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.27|P-value:2.26E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:7.14|P-value:9.28E-15 ID:SGTC_249|Compound:wiskostatin|FD-Score:2.90|P-value:9.34E-4 ID:SGTC_269|Compound:exalamide|FD-Score:4.10|P-value:5.39E-6 ID:SGTC_271|Compound:rotenone|FD-Score:2.91|P-value:9.11E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:-3.18|P-value:3.25E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-3.99|P-value:9.25E-6 ID:SGTC_491|Compound:tetrandrine|FD-Score:2.99|P-value:6.69E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.11|P-value:4.22E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.01|P-value:6.23E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:-4.45|P-value:8.96E-7 ID:SGTC_844|Compound:0330-0132|FD-Score:3.07|P-value:4.94E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.22|P-value:2.80E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.96|P-value:1.07E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:3.05|P-value:5.37E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:4.33|P-value:1.73E-6 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.23|P-value:2.90E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.77|P-value:2.56E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.46|P-value:8.52E-7 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.31|P-value:1.91E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.15|P-value:3.65E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.04|P-value:5.51E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.18|P-value:3.16E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-2.90|P-value:9.16E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.50|P-value:8.60E-5 ID:SGTC_1649|Compound:st011737|FD-Score:3.79|P-value:2.39E-5 ID:SGTC_1677|Compound:st019204|FD-Score:2.94|P-value:8.00E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-2.89|P-value:9.75E-4 ID:SGTC_1813|Compound:st051246|FD-Score:3.07|P-value:4.85E-4 ID:SGTC_1860|Compound:st056228|FD-Score:2.89|P-value:9.62E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.34|P-value:1.68E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-3.23|P-value:2.62E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.45|P-value:1.05E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.32|P-value:1.84E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.11|P-value:4.30E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-2.90|P-value:9.41E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.34|P-value:1.67E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-3.12|P-value:4.03E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:5.31|P-value:5.92E-9 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.90|P-value:7.41E-8 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.70|P-value:3.58E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-2.88|P-value:9.95E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.56|P-value:6.74E-5 ID:SGTC_2837|Compound:9008476|FD-Score:4.16|P-value:4.01E-6 ID:SGTC_2947|Compound:9072639|FD-Score:3.86|P-value:1.73E-5 ID:SGTC_2949|Compound:9072542|FD-Score:3.06|P-value:5.18E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.57|P-value:6.50E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-3.25|P-value:2.41E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:2.99|P-value:6.66E-4 ID:SGTC_3084|Compound:9116877|FD-Score:3.01|P-value:6.09E-4 ID:SGTC_3122|Compound:9126309|FD-Score:-4.30|P-value:1.97E-6 ID:SGTC_3137|Compound:9097352|FD-Score:2.90|P-value:9.17E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.28|P-value:2.16E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.39|P-value:1.37E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.98|P-value:9.91E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:3.02|P-value:5.96E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.27|P-value:2.26E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:7.14|P-value:9.28E-15 ID:SGTC_249|Compound:wiskostatin|FD-Score:2.90|P-value:9.34E-4 ID:SGTC_269|Compound:exalamide|FD-Score:4.10|P-value:5.39E-6 ID:SGTC_271|Compound:rotenone|FD-Score:2.91|P-value:9.11E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:-3.18|P-value:3.25E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-3.99|P-value:9.25E-6 ID:SGTC_491|Compound:tetrandrine|FD-Score:2.99|P-value:6.69E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.11|P-value:4.22E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.01|P-value:6.23E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:-4.45|P-value:8.96E-7 ID:SGTC_844|Compound:0330-0132|FD-Score:3.07|P-value:4.94E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.22|P-value:2.80E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.96|P-value:1.07E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:3.05|P-value:5.37E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:4.33|P-value:1.73E-6 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.23|P-value:2.90E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.77|P-value:2.56E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.46|P-value:8.52E-7 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.31|P-value:1.91E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.15|P-value:3.65E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.04|P-value:5.51E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.18|P-value:3.16E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-2.90|P-value:9.16E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.50|P-value:8.60E-5 ID:SGTC_1649|Compound:st011737|FD-Score:3.79|P-value:2.39E-5 ID:SGTC_1677|Compound:st019204|FD-Score:2.94|P-value:8.00E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-2.89|P-value:9.75E-4 ID:SGTC_1813|Compound:st051246|FD-Score:3.07|P-value:4.85E-4 ID:SGTC_1860|Compound:st056228|FD-Score:2.89|P-value:9.62E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.34|P-value:1.68E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-3.23|P-value:2.62E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.45|P-value:1.05E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.32|P-value:1.84E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.11|P-value:4.30E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-2.90|P-value:9.41E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.34|P-value:1.67E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-3.12|P-value:4.03E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:5.31|P-value:5.92E-9 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.90|P-value:7.41E-8 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.70|P-value:3.58E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-2.88|P-value:9.95E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.56|P-value:6.74E-5 ID:SGTC_2837|Compound:9008476|FD-Score:4.16|P-value:4.01E-6 ID:SGTC_2947|Compound:9072639|FD-Score:3.86|P-value:1.73E-5 ID:SGTC_2949|Compound:9072542|FD-Score:3.06|P-value:5.18E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.57|P-value:6.50E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-3.25|P-value:2.41E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:2.99|P-value:6.66E-4 ID:SGTC_3084|Compound:9116877|FD-Score:3.01|P-value:6.09E-4 ID:SGTC_3122|Compound:9126309|FD-Score:-4.30|P-value:1.97E-6 ID:SGTC_3137|Compound:9097352|FD-Score:2.90|P-value:9.17E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.28|P-value:2.16E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.39|P-value:1.37E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.98|P-value:9.91E-6

Top fitness defect scores for YLL024C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_151 3013-0144 7.14 2.3 µM 9.28E-15 iron homeostasis 6 4.68E-13
2 SGTC_2538 3',7'-epoxycaryophyllan-6-one 5.31 100.0 µM 5.92E-9 6 5.35E-8
3 SGTC_2539 epi(13)torulosol 4.90 80.0 µM 7.41E-8 10 4.85E-7
4 SGTC_1214 0358-0031 4.46 63.7 µM 8.52E-7 7 4.09E-6
5 SGTC_1009 4106-0057 4.33 9.9 µM 1.73E-6 8 7.61E-6
6 SGTC_1119 parthenolide 4.23 318.5 nM 2.90E-6 TSC3-RPN4 29 1.19E-5
7 SGTC_2837 9008476 4.16 45.5 µM 4.01E-6 30 1.58E-5
8 SGTC_269 exalamide 4.10 29.0 µM 5.39E-6 ergosterol biosynthesis 20 2.05E-5
9 SGTC_3340 9146634 3.98 11.1 µM 9.91E-6 13 3.49E-5
10 SGTC_2947 9072639 3.86 7.7 µM 1.73E-5 tubulin folding & SWR complex 49 5.67E-5
11 SGTC_1649 st011737 3.79 51.3 µM 2.39E-5 31 7.54E-5
12 SGTC_1205 4161-2785 3.77 76.0 µM 2.56E-5 36 8.01E-5
13 SGTC_2566 crystal violet carbinol 3.70 226.0 nM 3.58E-5 46 1.07E-4
14 SGTC_2953 9074162 3.57 66.5 µM 6.50E-5 38 1.81E-4
15 SGTC_2807 7945238 3.56 52.0 µM 6.74E-5 36 1.87E-4
16 SGTC_1568 digitonin 3.50 820.0 nM 8.60E-5 sphingolipid biosynthesis & PDR1 47 2.31E-4
17 SGTC_2024 5144227 3.45 134.0 µM 1.05E-4 56 2.77E-4
18 SGTC_3263 9137018 3.39 49.5 µM 1.37E-4 38 3.48E-4
19 SGTC_2373 9071805 3.34 200.0 µM 1.67E-4 28 4.14E-4
20 SGTC_2069 5228469 3.32 200.0 µM 1.84E-4 35 4.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 6.58E-10 YHR107C CDC12 het Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells
0.106 6.91E-10 YBR101C FES1 hom Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.106 7.90E-10 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.103 2.52E-9 YNL095C_p YNL095C_p hom Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication
0.098 1.30E-8 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.096 2.43E-8 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.096 2.58E-8 YNL102W POL1 het Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
0.092 9.09E-8 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.087 5.01E-7 YAR050W FLO1 hom Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
0.085 7.27E-7 YHR190W ERG9 het Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
0.084 1.09E-6 YBR217W ATG12 hom Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
0.083 1.58E-6 YNR001C CIT1 hom Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication
0.081 2.38E-6 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.081 2.49E-6 YDR030C RAD28 hom Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair
0.081 3.01E-6 YMR140W SIP5 hom Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress