YLL025W / PAU17

Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL025W / PAU17

Click on Significant Values for Screen Details ID:SGTC_139|Compound:0099-0334|FD-Score:-2.82|P-value:8.06E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:2.75|P-value:9.17E-4 ID:SGTC_441|Compound:propafenone|FD-Score:3.08|P-value:2.44E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.57|P-value:2.77E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:2.85|P-value:6.18E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:4.44|P-value:2.68E-7 ID:SGTC_531|Compound:3788-1495|FD-Score:-4.01|P-value:3.43E-6 ID:SGTC_533|Compound:1222-0222|FD-Score:-3.64|P-value:2.26E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:4.94|P-value:1.20E-8 ID:SGTC_538|Compound:2922-0838|FD-Score:3.76|P-value:1.07E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:3.61|P-value:2.26E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:3.06|P-value:2.65E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:2.93|P-value:4.57E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.10|P-value:2.25E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:2.79|P-value:7.86E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.57|P-value:2.77E-5 ID:SGTC_1155|Compound:4088-0394|FD-Score:-3.53|P-value:3.79E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:-2.86|P-value:6.89E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.56|P-value:2.91E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.68|P-value:6.32E-8 ID:SGTC_1647|Compound:st011722|FD-Score:5.08|P-value:4.98E-9 ID:SGTC_1733|Compound:st037357|FD-Score:-4.34|P-value:5.64E-7 ID:SGTC_1830|Compound:st055982|FD-Score:3.23|P-value:1.27E-4 ID:SGTC_1973|Compound:st070275|FD-Score:2.82|P-value:6.95E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-2.80|P-value:8.60E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.19|P-value:1.53E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.56|P-value:2.84E-5 ID:SGTC_2223|Compound:6903751|FD-Score:-3.20|P-value:1.71E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.91|P-value:5.67E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.20|P-value:1.48E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-4.11|P-value:1.99E-6 ID:SGTC_2709|Compound:st078560|FD-Score:4.67|P-value:6.49E-8 ID:SGTC_2712|Compound:st079126|FD-Score:-3.07|P-value:2.97E-4 ID:SGTC_2794|Compound:7785382|FD-Score:2.82|P-value:7.01E-4 ID:SGTC_3008|Compound:9078912|FD-Score:-3.10|P-value:2.56E-4 ID:SGTC_3018|Compound:9082602|FD-Score:2.95|P-value:4.15E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-2.90|P-value:5.88E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.67|P-value:1.67E-5 ID:SGTC_3312|Compound:9133330|FD-Score:-2.87|P-value:6.50E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-3.01|P-value:3.66E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-2.82|P-value:8.06E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:2.75|P-value:9.17E-4 ID:SGTC_441|Compound:propafenone|FD-Score:3.08|P-value:2.44E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.57|P-value:2.77E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:2.85|P-value:6.18E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:4.44|P-value:2.68E-7 ID:SGTC_531|Compound:3788-1495|FD-Score:-4.01|P-value:3.43E-6 ID:SGTC_533|Compound:1222-0222|FD-Score:-3.64|P-value:2.26E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:4.94|P-value:1.20E-8 ID:SGTC_538|Compound:2922-0838|FD-Score:3.76|P-value:1.07E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:3.61|P-value:2.26E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:3.06|P-value:2.65E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:2.93|P-value:4.57E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.10|P-value:2.25E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:2.79|P-value:7.86E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.57|P-value:2.77E-5 ID:SGTC_1155|Compound:4088-0394|FD-Score:-3.53|P-value:3.79E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:-2.86|P-value:6.89E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.56|P-value:2.91E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.68|P-value:6.32E-8 ID:SGTC_1647|Compound:st011722|FD-Score:5.08|P-value:4.98E-9 ID:SGTC_1733|Compound:st037357|FD-Score:-4.34|P-value:5.64E-7 ID:SGTC_1830|Compound:st055982|FD-Score:3.23|P-value:1.27E-4 ID:SGTC_1973|Compound:st070275|FD-Score:2.82|P-value:6.95E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-2.80|P-value:8.60E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.19|P-value:1.53E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.56|P-value:2.84E-5 ID:SGTC_2223|Compound:6903751|FD-Score:-3.20|P-value:1.71E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.91|P-value:5.67E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.20|P-value:1.48E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-4.11|P-value:1.99E-6 ID:SGTC_2709|Compound:st078560|FD-Score:4.67|P-value:6.49E-8 ID:SGTC_2712|Compound:st079126|FD-Score:-3.07|P-value:2.97E-4 ID:SGTC_2794|Compound:7785382|FD-Score:2.82|P-value:7.01E-4 ID:SGTC_3008|Compound:9078912|FD-Score:-3.10|P-value:2.56E-4 ID:SGTC_3018|Compound:9082602|FD-Score:2.95|P-value:4.15E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-2.90|P-value:5.88E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.67|P-value:1.67E-5 ID:SGTC_3312|Compound:9133330|FD-Score:-2.87|P-value:6.50E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-3.01|P-value:3.66E-4

Top fitness defect scores for YLL025W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1647 st011722 5.08 22.4 µM 4.98E-9 4 1.92E-7
2 SGTC_534 k292-0788 4.94 63.4 µM 1.20E-8 mitochondrial processes 8 3.87E-7
3 SGTC_1456 k015-0012 4.68 13.0 µM 6.32E-8 16 1.44E-6
4 SGTC_2709 st078560 4.67 56.0 µM 6.49E-8 3 1.47E-6
5 SGTC_525 k781-2675 4.44 26.7 µM 2.68E-7 redox potentiating 39 4.53E-6
6 SGTC_538 2922-0838 3.76 53.3 µM 1.07E-5 Golgi 32 8.50E-5
7 SGTC_3218 9131285 3.67 49.5 µM 1.67E-5 endomembrane recycling 61 1.21E-4
8 SGTC_634 1611-4317 3.61 11.2 µM 2.26E-5 ERG2 27 1.54E-4
9 SGTC_459 nigericin 3.57 15.3 µM 2.77E-5 77 1.81E-4
10 SGTC_996 3970-0799 3.57 1.8 µM 2.77E-5 108 1.81E-4
11 SGTC_2211 7117706 3.56 200.0 µM 2.84E-5 19 1.84E-4
12 SGTC_1451 4152-0210 3.56 104.0 µM 2.91E-5 39 1.88E-4
13 SGTC_1830 st055982 3.23 50.3 µM 1.27E-4 52 6.09E-4
14 SGTC_2519 cryptotanshinone 3.20 88.0 µM 1.48E-4 heme biosynthesis & mitochondrial translocase 37 6.87E-4
15 SGTC_2184 6075246 3.19 200.0 µM 1.53E-4 52 7.06E-4
16 SGTC_808 0711-0032 3.10 135.0 µM 2.25E-4 45 9.62E-4
17 SGTC_441 propafenone 3.08 146.0 µM 2.44E-4 17 0.00103
18 SGTC_638 3970-0837 3.06 4.1 µM 2.65E-4 84 0.00109
19 SGTC_3018 9082602 2.95 49.5 µM 4.15E-4 79 0.00157
20 SGTC_668 1682-0499 2.93 62.6 µM 4.57E-4 73 0.00169

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 3.09E-22 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.155 1.98E-19 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.134 6.40E-15 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.118 8.02E-12 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.117 1.13E-11 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.108 4.14E-10 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.106 6.80E-10 YGL130W CEG1 het Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.105 9.69E-10 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.105 9.90E-10 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.104 1.42E-9 YJL148W RPA34 hom RNA polymerase I subunit A34.5
0.102 3.82E-9 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.102 3.97E-9 YIL127C_p RRT14_p hom Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.095 3.43E-8 YBR177C EHT1 hom Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication
0.093 6.63E-8 YAR020C PAU7 hom Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
0.093 7.29E-8 YDR262W_p YDR262W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment