YLL030C_d / RRT7

Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL030C / RRT7

Click on Significant Values for Screen Details ID:SGTC_99|Compound:0109-0120|FD-Score:3.66|P-value:4.89E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.72|P-value:3.84E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.27|P-value:2.55E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:3.60|P-value:6.57E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:4.33|P-value:2.12E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.80|P-value:2.93E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:3.29|P-value:2.35E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:3.08|P-value:5.29E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.09|P-value:5.31E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.03|P-value:9.28E-6 ID:SGTC_828|Compound:2074-0507|FD-Score:3.48|P-value:1.08E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.95|P-value:9.14E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:6.72|P-value:4.86E-13 ID:SGTC_1284|Compound:0929-0043|FD-Score:2.93|P-value:9.03E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:-3.09|P-value:5.29E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.95|P-value:9.11E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.14|P-value:4.17E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.12|P-value:4.49E-4 ID:SGTC_1683|Compound:st010134|FD-Score:2.98|P-value:7.76E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.35|P-value:1.81E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-3.53|P-value:9.43E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.00|P-value:7.10E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.73|P-value:3.62E-5 ID:SGTC_1975|Compound:st070967|FD-Score:2.97|P-value:7.87E-4 ID:SGTC_1976|Compound:st070609|FD-Score:4.44|P-value:1.21E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-3.93|P-value:1.61E-5 ID:SGTC_2117|Compound:5521686|FD-Score:3.20|P-value:3.32E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.17|P-value:3.91E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.19|P-value:3.40E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-3.60|P-value:6.98E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.66|P-value:4.94E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.05|P-value:6.16E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.32|P-value:2.18E-4 ID:SGTC_2880|Compound:9042983|FD-Score:5.54|P-value:1.99E-9 ID:SGTC_2937|Compound:9044753|FD-Score:3.21|P-value:3.20E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.07|P-value:5.72E-4 ID:SGTC_3189|Compound:9110682|FD-Score:5.62|P-value:1.15E-9 ID:SGTC_3274|Compound:9138298|FD-Score:4.95|P-value:7.15E-8 ID:SGTC_3281|Compound:9140613|FD-Score:4.09|P-value:6.91E-6 ID:SGTC_99|Compound:0109-0120|FD-Score:3.66|P-value:4.89E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.72|P-value:3.84E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.27|P-value:2.55E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:3.60|P-value:6.57E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:4.33|P-value:2.12E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.80|P-value:2.93E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:3.29|P-value:2.35E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:3.08|P-value:5.29E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.09|P-value:5.31E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.03|P-value:9.28E-6 ID:SGTC_828|Compound:2074-0507|FD-Score:3.48|P-value:1.08E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.95|P-value:9.14E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:6.72|P-value:4.86E-13 ID:SGTC_1284|Compound:0929-0043|FD-Score:2.93|P-value:9.03E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:-3.09|P-value:5.29E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.95|P-value:9.11E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.14|P-value:4.17E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.12|P-value:4.49E-4 ID:SGTC_1683|Compound:st010134|FD-Score:2.98|P-value:7.76E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.35|P-value:1.81E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-3.53|P-value:9.43E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.00|P-value:7.10E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.73|P-value:3.62E-5 ID:SGTC_1975|Compound:st070967|FD-Score:2.97|P-value:7.87E-4 ID:SGTC_1976|Compound:st070609|FD-Score:4.44|P-value:1.21E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-3.93|P-value:1.61E-5 ID:SGTC_2117|Compound:5521686|FD-Score:3.20|P-value:3.32E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.17|P-value:3.91E-4 ID:SGTC_2443|Compound:5493264|FD-Score:3.19|P-value:3.40E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-3.60|P-value:6.98E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.66|P-value:4.94E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.05|P-value:6.16E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.32|P-value:2.18E-4 ID:SGTC_2880|Compound:9042983|FD-Score:5.54|P-value:1.99E-9 ID:SGTC_2937|Compound:9044753|FD-Score:3.21|P-value:3.20E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-3.07|P-value:5.72E-4 ID:SGTC_3189|Compound:9110682|FD-Score:5.62|P-value:1.15E-9 ID:SGTC_3274|Compound:9138298|FD-Score:4.95|P-value:7.15E-8 ID:SGTC_3281|Compound:9140613|FD-Score:4.09|P-value:6.91E-6

Top fitness defect scores for YLL030C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1254 0550-0035 6.72 264.0 µM 4.86E-13 2 9.26E-12
2 SGTC_3189 9110682 5.62 49.5 µM 1.15E-9 13 9.29E-9
3 SGTC_2880 9042983 5.54 58.4 µM 1.99E-9 fatty acid desaturase (OLE1) 8 1.52E-8
4 SGTC_3274 9138298 4.95 49.5 µM 7.15E-8 6 3.68E-7
5 SGTC_1976 st070609 4.44 63.5 µM 1.21E-6 3 4.57E-6
6 SGTC_506 n9-isopropylolomoucine 4.33 153.0 µM 2.12E-6 9 7.55E-6
7 SGTC_3281 9140613 4.09 49.5 µM 6.91E-6 RPP1 & pyrimidine depletion 17 2.16E-5
8 SGTC_827 3253-0474 4.03 693.0 µM 9.28E-6 18 2.81E-5
9 SGTC_1958 st076513 3.73 41.9 µM 3.62E-5 60S ribosome export 37 9.47E-5
10 SGTC_103 0844-0104 3.72 51.8 µM 3.84E-5 ERAD & cell cycle 155 9.98E-5
11 SGTC_99 0109-0120 3.66 622.8 µM 4.89E-5 21 1.24E-4
12 SGTC_2529 gangaleoidin 3.66 93.6 µM 4.94E-5 24 1.25E-4
13 SGTC_504 lovastatin 3.60 124.0 µM 6.57E-5 18 1.61E-4
14 SGTC_828 2074-0507 3.48 139.0 µM 1.08E-4 RPP1 & pyrimidine depletion 35 2.52E-4
15 SGTC_1739 st037196 3.35 92.5 µM 1.81E-4 42 3.98E-4
16 SGTC_687 k029-0044 3.29 34.9 µM 2.35E-4 PDR1 38 5.04E-4
17 SGTC_495 decylubiquinone 3.27 155.0 µM 2.55E-4 copper-dependent oxidative stress 57 5.41E-4
18 SGTC_2937 9044753 3.21 11.3 µM 3.20E-4 60S ribosome export 67 6.64E-4
19 SGTC_2117 5521686 3.20 200.0 µM 3.32E-4 37 6.85E-4
20 SGTC_2443 5493264 3.19 126.7 µM 3.40E-4 44 7.00E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.52E-11 YPL185W_d YPL185W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
0.116 1.72E-11 YFR014C CMK1 hom Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication
0.110 1.81E-10 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.109 3.10E-10 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.104 1.32E-9 YAL051W OAF1 hom Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication
0.103 2.39E-9 YGL238W CSE1 het Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
0.097 1.86E-8 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.095 3.49E-8 YBR041W FAT1 hom Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids
0.094 4.19E-8 YKR041W YKR041W hom Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking
0.090 1.76E-7 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.090 2.03E-7 YLL028W TPO1 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
0.089 2.50E-7 YKR098C UBP11 hom Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins
0.087 5.09E-7 YHR177W_p YHR177W_p hom Putative protein of unknown function; overexpression causes a cell cycle delay or arrest
0.084 1.27E-6 YER124C DSE1 hom Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.083 1.45E-6 YMR276W DSK2 hom Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress