YLL031C / GPI13

ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLL031C / GPI13

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.32|P-value:9.17E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.53|P-value:4.60E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.65|P-value:6.51E-6 ID:SGTC_75|Compound:0159-0059|FD-Score:-5.11|P-value:8.83E-7 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.90|P-value:1.35E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-7.70|P-value:2.95E-13 ID:SGTC_176|Compound:1486-1328|FD-Score:3.38|P-value:7.40E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.36|P-value:8.50E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.67|P-value:3.03E-4 ID:SGTC_456|Compound:gingerol|FD-Score:5.86|P-value:1.92E-8 ID:SGTC_459|Compound:nigericin|FD-Score:5.88|P-value:1.70E-8 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.67|P-value:2.84E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.57|P-value:3.99E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:-5.16|P-value:7.11E-7 ID:SGTC_695|Compound:3505-6186|FD-Score:3.47|P-value:5.55E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:7.91|P-value:6.03E-14 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.61|P-value:3.77E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.21|P-value:3.93E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:5.34|P-value:2.71E-7 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.55|P-value:4.57E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.81|P-value:1.74E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.05|P-value:7.13E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.18|P-value:4.33E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.52|P-value:4.77E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.59|P-value:3.77E-4 ID:SGTC_1836|Compound:st055642|FD-Score:4.26|P-value:3.13E-5 ID:SGTC_1838|Compound:st055369|FD-Score:3.80|P-value:1.78E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.52|P-value:4.71E-4 ID:SGTC_1891|Compound:st059073|FD-Score:4.30|P-value:2.70E-5 ID:SGTC_1923|Compound:st058458|FD-Score:4.40|P-value:1.79E-5 ID:SGTC_1944|Compound:st076371|FD-Score:4.00|P-value:8.73E-5 ID:SGTC_2127|Compound:5253358|FD-Score:3.30|P-value:9.55E-4 ID:SGTC_2241|Compound:6772625|FD-Score:12.70|P-value:5.69E-33 ID:SGTC_2297|Compound:7971671|FD-Score:-4.24|P-value:3.69E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.64|P-value:3.17E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.06|P-value:1.03E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.08|P-value:6.88E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-7.02|P-value:2.56E-11 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:5.84|P-value:2.11E-8 ID:SGTC_2610|Compound:ononetin|FD-Score:4.22|P-value:3.70E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.39|P-value:7.17E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.52|P-value:4.76E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.41|P-value:6.71E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.95|P-value:1.05E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.57|P-value:9.14E-6 ID:SGTC_2968|Compound:9090663|FD-Score:3.79|P-value:1.87E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.77|P-value:2.02E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.66|P-value:2.91E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.58|P-value:3.81E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.40|P-value:7.44E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.32|P-value:9.17E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.53|P-value:4.60E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.65|P-value:6.51E-6 ID:SGTC_75|Compound:0159-0059|FD-Score:-5.11|P-value:8.83E-7 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.90|P-value:1.35E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-7.70|P-value:2.95E-13 ID:SGTC_176|Compound:1486-1328|FD-Score:3.38|P-value:7.40E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.36|P-value:8.50E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.67|P-value:3.03E-4 ID:SGTC_456|Compound:gingerol|FD-Score:5.86|P-value:1.92E-8 ID:SGTC_459|Compound:nigericin|FD-Score:5.88|P-value:1.70E-8 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.67|P-value:2.84E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.57|P-value:3.99E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:-5.16|P-value:7.11E-7 ID:SGTC_695|Compound:3505-6186|FD-Score:3.47|P-value:5.55E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:7.91|P-value:6.03E-14 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.61|P-value:3.77E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.21|P-value:3.93E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:5.34|P-value:2.71E-7 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.55|P-value:4.57E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.81|P-value:1.74E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.05|P-value:7.13E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.18|P-value:4.33E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.52|P-value:4.77E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.59|P-value:3.77E-4 ID:SGTC_1836|Compound:st055642|FD-Score:4.26|P-value:3.13E-5 ID:SGTC_1838|Compound:st055369|FD-Score:3.80|P-value:1.78E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.52|P-value:4.71E-4 ID:SGTC_1891|Compound:st059073|FD-Score:4.30|P-value:2.70E-5 ID:SGTC_1923|Compound:st058458|FD-Score:4.40|P-value:1.79E-5 ID:SGTC_1944|Compound:st076371|FD-Score:4.00|P-value:8.73E-5 ID:SGTC_2127|Compound:5253358|FD-Score:3.30|P-value:9.55E-4 ID:SGTC_2241|Compound:6772625|FD-Score:12.70|P-value:5.69E-33 ID:SGTC_2297|Compound:7971671|FD-Score:-4.24|P-value:3.69E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.64|P-value:3.17E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.06|P-value:1.03E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.08|P-value:6.88E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-7.02|P-value:2.56E-11 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:5.84|P-value:2.11E-8 ID:SGTC_2610|Compound:ononetin|FD-Score:4.22|P-value:3.70E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.39|P-value:7.17E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.52|P-value:4.76E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.41|P-value:6.71E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.95|P-value:1.05E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.57|P-value:9.14E-6 ID:SGTC_2968|Compound:9090663|FD-Score:3.79|P-value:1.87E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.77|P-value:2.02E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.66|P-value:2.91E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.58|P-value:3.81E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-3.40|P-value:7.44E-4

Top fitness defect scores for YLL031C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2241 6772625 12.70 37.8 µM 5.69E-33 1 2.88E-37 4.86
2 SGTC_696 1560-0013 7.91 611.0 µM 6.03E-14 1 1.29E-15 1.71
3 SGTC_459 nigericin 5.88 15.3 µM 1.70E-8 2 2.00E-9 0.67
4 SGTC_456 gingerol 5.86 170.0 µM 1.92E-8 2 2.29E-9 1.35
5 SGTC_2538 3',7'-epoxycaryophyllan-6-one 5.84 100.0 µM 2.11E-8 2 2.56E-9 0.72
6 SGTC_796 1234-0020 5.34 70.7 µM 2.71E-7 SWF1 & branched chain AA biosynthesis 2 4.63E-8 0.63
7 SGTC_2418 pentamidine 5.06 31.7 µM 1.03E-6 mitochondrial processes 9 2.10E-7 0.04
8 SGTC_64 000l-0018 4.65 272.1 µM 6.51E-6 ubiquinone biosynthesis & proteasome 37 1.69E-6 0.03
9 SGTC_2934 9036370 4.57 36.9 µM 9.14E-6 2 2.49E-6 0.07
10 SGTC_1923 st058458 4.40 19.1 µM 1.79E-5 9 5.34E-6 0.13
11 SGTC_1891 st059073 4.30 26.2 µM 2.70E-5 TSC3-RPN4 3 8.46E-6 0.17
12 SGTC_1836 st055642 4.26 81.0 µM 3.13E-5 4 1.00E-5 0.38
13 SGTC_2610 ononetin 4.22 44.2 µM 3.70E-5 4 1.21E-5 0.01
14 SGTC_708 3448-5400 4.21 146.0 µM 3.93E-5 15 1.30E-5 0.08
15 SGTC_1510 1123-0200 4.18 71.5 µM 4.33E-5 14 1.45E-5 0.14
16 SGTC_1112 tnp00069 4.05 1.2 µM 7.13E-5 3 2.54E-5 0.21
17 SGTC_1944 st076371 4.00 56.9 µM 8.73E-5 2 3.20E-5 0.10
18 SGTC_2902 5787006 3.95 60.5 µM 1.05E-4 Golgi 4 3.93E-5 0.15
19 SGTC_1053 3366-3204 3.81 134.0 µM 1.74E-4 cell wall 10 6.98E-5 0.14
20 SGTC_1838 st055369 3.80 84.5 µM 1.78E-4 8 7.14E-5 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 5.22E-11 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.104 1.56E-9 YGR007W ECT1 hom Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases
0.102 3.13E-9 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.102 3.58E-9 YBR235W VHC1 hom Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family
0.097 1.98E-8 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.095 3.71E-8 YDR302W GPI11 het ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
0.092 8.29E-8 YLR374C_d YLR374C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W
0.092 1.06E-7 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.091 1.20E-7 YPL052W OAZ1 hom Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p
0.090 1.58E-7 YDR207C UME6 hom Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
0.089 2.30E-7 YNL163C RIA1 het Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
0.087 4.54E-7 YBR240C THI2 hom Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type
0.086 6.07E-7 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.083 1.62E-6 YIR011C STS1 het Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation
0.081 2.39E-6 YHR046C INM1 hom Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate