YLL032C

Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL032C / YLL032C

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.31|P-value:1.51E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.70|P-value:1.20E-21 ID:SGTC_138|Compound:0850-0259|FD-Score:6.37|P-value:1.96E-12 ID:SGTC_145|Compound:3737-0113|FD-Score:-2.95|P-value:6.58E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.44|P-value:6.40E-7 ID:SGTC_305|Compound:1682-2595|FD-Score:2.94|P-value:6.66E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.05|P-value:5.14E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:4.04|P-value:5.25E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:3.50|P-value:6.80E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:12.70|P-value:3.25E-44 ID:SGTC_545|Compound:4218-0007|FD-Score:4.36|P-value:1.01E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:7.29|P-value:9.50E-16 ID:SGTC_547|Compound:1120-0019|FD-Score:3.20|P-value:2.44E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:6.35|P-value:2.19E-12 ID:SGTC_558|Compound:k064-0027|FD-Score:4.98|P-value:2.78E-8 ID:SGTC_575|Compound:k072-0246|FD-Score:2.91|P-value:7.57E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:-3.06|P-value:4.34E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.28|P-value:1.73E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.60|P-value:4.26E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:2.88|P-value:8.30E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.19|P-value:2.46E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.42|P-value:9.84E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:2.87|P-value:8.82E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-3.00|P-value:5.50E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:2.91|P-value:7.49E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.69|P-value:1.56E-7 ID:SGTC_1578|Compound:josamycin|FD-Score:-2.99|P-value:5.66E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.01|P-value:5.16E-4 ID:SGTC_2154|Compound:5570129|FD-Score:-3.19|P-value:2.56E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.44|P-value:6.38E-7 ID:SGTC_2292|Compound:7671323|FD-Score:3.39|P-value:1.10E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.23|P-value:2.16E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.20|P-value:2.37E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.16|P-value:2.83E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.15|P-value:2.94E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:14.30|P-value:6.41E-55 ID:SGTC_2601|Compound:securinine|FD-Score:-3.98|P-value:7.28E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:5.75|P-value:1.76E-10 ID:SGTC_2858|Compound:9025781|FD-Score:3.43|P-value:9.12E-5 ID:SGTC_2956|Compound:9076196|FD-Score:-3.50|P-value:6.99E-5 ID:SGTC_2957|Compound:9076800|FD-Score:-3.06|P-value:4.31E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.38|P-value:1.14E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.09|P-value:3.80E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-3.00|P-value:5.37E-4 ID:SGTC_3311|Compound:9131146|FD-Score:9.43|P-value:4.40E-25 ID:SGTC_3321|Compound:9137793|FD-Score:5.22|P-value:6.44E-9 ID:SGTC_3322|Compound:9139058|FD-Score:4.25|P-value:1.79E-6 ID:SGTC_3350|Compound:9150499|FD-Score:3.66|P-value:3.30E-5 ID:SGTC_3351|Compound:9150312|FD-Score:2.98|P-value:5.87E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.31|P-value:1.51E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.70|P-value:1.20E-21 ID:SGTC_138|Compound:0850-0259|FD-Score:6.37|P-value:1.96E-12 ID:SGTC_145|Compound:3737-0113|FD-Score:-2.95|P-value:6.58E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.44|P-value:6.40E-7 ID:SGTC_305|Compound:1682-2595|FD-Score:2.94|P-value:6.66E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.05|P-value:5.14E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:4.04|P-value:5.25E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:3.50|P-value:6.80E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:12.70|P-value:3.25E-44 ID:SGTC_545|Compound:4218-0007|FD-Score:4.36|P-value:1.01E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:7.29|P-value:9.50E-16 ID:SGTC_547|Compound:1120-0019|FD-Score:3.20|P-value:2.44E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:6.35|P-value:2.19E-12 ID:SGTC_558|Compound:k064-0027|FD-Score:4.98|P-value:2.78E-8 ID:SGTC_575|Compound:k072-0246|FD-Score:2.91|P-value:7.57E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:-3.06|P-value:4.34E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.28|P-value:1.73E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.60|P-value:4.26E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:2.88|P-value:8.30E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.19|P-value:2.46E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.42|P-value:9.84E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:2.87|P-value:8.82E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-3.00|P-value:5.50E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:2.91|P-value:7.49E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.69|P-value:1.56E-7 ID:SGTC_1578|Compound:josamycin|FD-Score:-2.99|P-value:5.66E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.01|P-value:5.16E-4 ID:SGTC_2154|Compound:5570129|FD-Score:-3.19|P-value:2.56E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.44|P-value:6.38E-7 ID:SGTC_2292|Compound:7671323|FD-Score:3.39|P-value:1.10E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.23|P-value:2.16E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.20|P-value:2.37E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.16|P-value:2.83E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.15|P-value:2.94E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:14.30|P-value:6.41E-55 ID:SGTC_2601|Compound:securinine|FD-Score:-3.98|P-value:7.28E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:5.75|P-value:1.76E-10 ID:SGTC_2858|Compound:9025781|FD-Score:3.43|P-value:9.12E-5 ID:SGTC_2956|Compound:9076196|FD-Score:-3.50|P-value:6.99E-5 ID:SGTC_2957|Compound:9076800|FD-Score:-3.06|P-value:4.31E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.38|P-value:1.14E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.09|P-value:3.80E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-3.00|P-value:5.37E-4 ID:SGTC_3311|Compound:9131146|FD-Score:9.43|P-value:4.40E-25 ID:SGTC_3321|Compound:9137793|FD-Score:5.22|P-value:6.44E-9 ID:SGTC_3322|Compound:9139058|FD-Score:4.25|P-value:1.79E-6 ID:SGTC_3350|Compound:9150499|FD-Score:3.66|P-value:3.30E-5 ID:SGTC_3351|Compound:9150312|FD-Score:2.98|P-value:5.87E-4

Top fitness defect scores for YLL032C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2584 androsterone 14.30 48.7 µM 6.41E-55 cell wall 5 1.51E-46
2 SGTC_514 4466-0038 12.70 2.6 nM 3.25E-44 cell wall 14 1.57E-37
3 SGTC_3311 9131146 9.43 2.9 µM 4.40E-25 cell wall 20 2.08E-21
4 SGTC_58 0957-0393 8.70 9.0 µM 1.20E-21 cell wall 106 1.64E-18
5 SGTC_546 peri-Naphthalide 7.29 147.0 µM 9.50E-16 DNA damage response 3 1.55E-13
6 SGTC_138 0850-0259 6.37 40.9 µM 1.96E-12 cell wall 96 9.75E-11
7 SGTC_554 4483-2211 6.35 187.0 µM 2.19E-12 2 1.07E-10
8 SGTC_2619 obliquin 5.75 87.9 µM 1.76E-10 cell wall 84 4.35E-9
9 SGTC_3321 9137793 5.22 26.8 µM 6.44E-9 cell wall 39 9.13E-8
10 SGTC_558 k064-0027 4.98 21.3 µM 2.78E-8 DNA damage response 14 3.14E-7
11 SGTC_1350 1495-0454 4.69 146.0 µM 1.56E-7 9 1.36E-6
12 SGTC_2249 haloperidol 4.44 116.4 µM 6.38E-7 ergosterol depletion effects on membrane 84 4.46E-6
13 SGTC_304 1310-0298 4.44 97.0 µM 6.40E-7 cell wall 46 4.47E-6
14 SGTC_545 4218-0007 4.36 221.0 µM 1.01E-6 18 6.60E-6
15 SGTC_3322 9139058 4.25 2.1 µM 1.79E-6 cell wall 23 1.07E-5
16 SGTC_916 4466-0038 4.19 42.0 nM 2.46E-6 cell wall 59 1.40E-5
17 SGTC_351 caspofungin 4.05 25.0 nM 5.14E-6 cell wall 91 2.62E-5
18 SGTC_360 0957-0399 4.04 1.0 µM 5.25E-6 cell wall 42 2.66E-5
19 SGTC_3350 9150499 3.66 3.6 µM 3.30E-5 cell wall 68 1.27E-4
20 SGTC_777 1315-0167 3.60 517.0 µM 4.26E-5 Golgi 37 1.57E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.522 7.55E-234 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.522 2.27E-233 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.514 1.15E-225 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.488 1.30E-200 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.487 1.29E-199 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.456 5.61E-172 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.444 1.22E-161 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.437 1.17E-156 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.428 3.93E-149 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.426 2.96E-148 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.425 2.40E-147 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.418 1.23E-141 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.417 3.44E-141 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.411 5.63E-137 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.394 2.19E-124 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP