YLL034C / RIX7

Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLL034C / RIX7

Click on Significant Values for Screen Details ID:SGTC_366|Compound:0181-0206|FD-Score:4.39|P-value:3.09E-7 ID:SGTC_777|Compound:1315-0167|FD-Score:-2.78|P-value:7.91E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:-3.65|P-value:1.69E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:3.33|P-value:7.67E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.41|P-value:5.34E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:6.65|P-value:2.16E-14 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.46|P-value:4.36E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:2.77|P-value:8.17E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:4.31|P-value:4.84E-7 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.10|P-value:2.18E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:4.83|P-value:2.05E-8 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:2.98|P-value:3.56E-4 ID:SGTC_1607|Compound:st000305|FD-Score:2.75|P-value:8.88E-4 ID:SGTC_1829|Compound:berberine|FD-Score:4.78|P-value:2.87E-8 ID:SGTC_1831|Compound:st055328|FD-Score:3.48|P-value:3.96E-5 ID:SGTC_1907|Compound:st060210|FD-Score:2.90|P-value:4.88E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.00|P-value:3.34E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.76|P-value:8.66E-4 ID:SGTC_2017|Compound:5132927|FD-Score:2.84|P-value:6.31E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-3.31|P-value:8.57E-5 ID:SGTC_2147|Compound:5545932|FD-Score:3.10|P-value:2.20E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-3.20|P-value:1.37E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-4.15|P-value:1.20E-6 ID:SGTC_2403|Compound:6032726|FD-Score:-4.94|P-value:1.00E-8 ID:SGTC_2434|Compound:5670830|FD-Score:4.12|P-value:1.45E-6 ID:SGTC_2448|Compound:5185112|FD-Score:3.02|P-value:3.04E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-2.73|P-value:9.59E-4 ID:SGTC_2696|Compound:st077691|FD-Score:2.99|P-value:3.44E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-6.09|P-value:2.33E-12 ID:SGTC_2821|Compound:7996764|FD-Score:3.48|P-value:3.93E-5 ID:SGTC_2962|Compound:9082311|FD-Score:2.73|P-value:9.58E-4 ID:SGTC_3030|Compound:9087619|FD-Score:-3.12|P-value:1.97E-4 ID:SGTC_3085|Compound:9117376|FD-Score:4.85|P-value:1.89E-8 ID:SGTC_3126|Compound:9127922|FD-Score:2.78|P-value:8.13E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-2.74|P-value:9.15E-4 ID:SGTC_3248|Compound:9135562|FD-Score:2.98|P-value:3.62E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-2.77|P-value:8.27E-4 ID:SGTC_3298|Compound:9116858|FD-Score:-3.98|P-value:3.03E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:4.39|P-value:3.09E-7 ID:SGTC_777|Compound:1315-0167|FD-Score:-2.78|P-value:7.91E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:-3.65|P-value:1.69E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:3.33|P-value:7.67E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.41|P-value:5.34E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:6.65|P-value:2.16E-14 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.46|P-value:4.36E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:2.77|P-value:8.17E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:4.31|P-value:4.84E-7 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.10|P-value:2.18E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:4.83|P-value:2.05E-8 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:2.98|P-value:3.56E-4 ID:SGTC_1607|Compound:st000305|FD-Score:2.75|P-value:8.88E-4 ID:SGTC_1829|Compound:berberine|FD-Score:4.78|P-value:2.87E-8 ID:SGTC_1831|Compound:st055328|FD-Score:3.48|P-value:3.96E-5 ID:SGTC_1907|Compound:st060210|FD-Score:2.90|P-value:4.88E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.00|P-value:3.34E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.76|P-value:8.66E-4 ID:SGTC_2017|Compound:5132927|FD-Score:2.84|P-value:6.31E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-3.31|P-value:8.57E-5 ID:SGTC_2147|Compound:5545932|FD-Score:3.10|P-value:2.20E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-3.20|P-value:1.37E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-4.15|P-value:1.20E-6 ID:SGTC_2403|Compound:6032726|FD-Score:-4.94|P-value:1.00E-8 ID:SGTC_2434|Compound:5670830|FD-Score:4.12|P-value:1.45E-6 ID:SGTC_2448|Compound:5185112|FD-Score:3.02|P-value:3.04E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-2.73|P-value:9.59E-4 ID:SGTC_2696|Compound:st077691|FD-Score:2.99|P-value:3.44E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-6.09|P-value:2.33E-12 ID:SGTC_2821|Compound:7996764|FD-Score:3.48|P-value:3.93E-5 ID:SGTC_2962|Compound:9082311|FD-Score:2.73|P-value:9.58E-4 ID:SGTC_3030|Compound:9087619|FD-Score:-3.12|P-value:1.97E-4 ID:SGTC_3085|Compound:9117376|FD-Score:4.85|P-value:1.89E-8 ID:SGTC_3126|Compound:9127922|FD-Score:2.78|P-value:8.13E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-2.74|P-value:9.15E-4 ID:SGTC_3248|Compound:9135562|FD-Score:2.98|P-value:3.62E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-2.77|P-value:8.27E-4 ID:SGTC_3298|Compound:9116858|FD-Score:-3.98|P-value:3.03E-6

Top fitness defect scores for YLL034C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1097 itavastatin 6.65 7.2 µM 2.16E-14 azole & statin 2 1.46E-11 0.54
2 SGTC_3085 9117376 4.85 49.5 µM 1.89E-8 4 6.31E-7 0.65
3 SGTC_1560 lithocholic acid 4.83 53.1 µM 2.05E-8 1 6.75E-7 0.62
4 SGTC_1829 berberine 4.78 14.4 µM 2.87E-8 60S ribosome export 8 8.77E-7 0.29
5 SGTC_366 0181-0206 4.39 4.3 µM 3.09E-7 Golgi 7 5.63E-6 0.17
6 SGTC_1555 citronellol 4.31 128.0 µM 4.84E-7 1 8.00E-6 0.63
7 SGTC_2434 5670830 4.12 169.9 µM 1.45E-6 5 1.89E-5 0.05
8 SGTC_2821 7996764 3.48 71.4 µM 3.93E-5 14 2.52E-4 0.17
9 SGTC_1831 st055328 3.48 12.0 µM 3.96E-5 heme biosynthesis & mitochondrial translocase 17 2.54E-4 0.03
10 SGTC_1178 0988-0033 3.46 191.0 µM 4.36E-5 10 2.74E-4 0.09
11 SGTC_1094 duloxetine 3.41 25.4 µM 5.34E-5 RPP1 & pyrimidine depletion 8 3.21E-4 0.04
12 SGTC_986 1493-0483 3.33 84.0 µM 7.67E-5 8 4.27E-4 7.28E-4
13 SGTC_1556 plumbagin 3.10 1.5 µM 2.18E-4 superoxide 34 9.72E-4 0.10
14 SGTC_2147 5545932 3.10 89.7 µM 2.20E-4 ergosterol biosynthesis 23 9.80E-4 0.07
15 SGTC_2448 5185112 3.02 27.2 µM 3.04E-4 16 0.00126 0.05
16 SGTC_2013 4024628 3.00 200.0 µM 3.34E-4 18 0.00136 0.02
17 SGTC_2696 st077691 2.99 74.3 µM 3.44E-4 24 0.00139 0.03
18 SGTC_1561 5-methoxyflavone 2.98 52.9 µM 3.56E-4 6 0.00143 0.04
19 SGTC_3248 9135562 2.98 49.5 µM 3.62E-4 8 0.00145 0.02
20 SGTC_1907 st060210 2.90 83.7 µM 4.88E-4 20 0.00184 0.19

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 5.08E-13 YDR524C AGE1 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif
0.118 7.63E-12 YFL055W AGP3 hom Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
0.110 2.04E-10 YGL230C_p YGL230C_p hom Putative protein of unknown function; non-essential gene
0.099 7.82E-9 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.096 2.54E-8 YDR525W-A SNA2 hom Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.096 2.59E-8 YMR149W SWP1 het Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
0.096 2.81E-8 YKL088W CAB3 het Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC
0.088 3.23E-7 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.086 5.20E-7 YOR269W PAC1 hom Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly
0.086 5.57E-7 YAR027W UIP3 hom Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
0.085 7.85E-7 YMR226C YMR226C hom NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments
0.080 3.95E-6 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.078 5.52E-6 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.075 1.30E-5 YLR112W_d YLR112W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.075 1.55E-5 YBR073W RDH54 hom DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p