YLL036C / PRP19

Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLL036C / PRP19

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.08|P-value:6.69E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.60|P-value:8.95E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.09|P-value:5.74E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:5.43|P-value:7.57E-9 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.47|P-value:1.29E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.15|P-value:3.86E-8 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.15|P-value:5.34E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:8.91|P-value:7.01E-21 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.67|P-value:5.59E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:3.45|P-value:1.63E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.30|P-value:2.98E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.41|P-value:1.64E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-5.21|P-value:2.19E-8 ID:SGTC_521|Compound:r062-0005|FD-Score:-4.77|P-value:2.72E-7 ID:SGTC_523|Compound:1934-0222|FD-Score:4.23|P-value:5.18E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:-5.05|P-value:5.65E-8 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.14|P-value:5.38E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.06|P-value:7.41E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.09|P-value:6.58E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:5.40|P-value:8.86E-9 ID:SGTC_855|Compound:0428-0020|FD-Score:3.71|P-value:5.54E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:4.06|P-value:1.19E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:3.01|P-value:8.63E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:4.78|P-value:3.13E-7 ID:SGTC_974|Compound:1326-0144|FD-Score:3.51|P-value:1.32E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.77|P-value:4.40E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.55|P-value:1.10E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.84|P-value:3.17E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.16|P-value:5.06E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.35|P-value:2.88E-6 ID:SGTC_1520|Compound:flindersine|FD-Score:-2.96|P-value:9.03E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.35|P-value:2.13E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.40|P-value:1.70E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:-3.01|P-value:7.54E-4 ID:SGTC_1704|Compound:st028805|FD-Score:4.12|P-value:8.80E-6 ID:SGTC_1781|Compound:st038725|FD-Score:3.42|P-value:1.88E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.07|P-value:6.98E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.67|P-value:6.56E-5 ID:SGTC_1815|Compound:st051655|FD-Score:3.17|P-value:4.90E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.10|P-value:6.23E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-3.11|P-value:5.24E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.94|P-value:2.04E-5 ID:SGTC_2316|Compound:5844804|FD-Score:-5.20|P-value:2.41E-8 ID:SGTC_2327|Compound:6189656|FD-Score:5.99|P-value:2.06E-10 ID:SGTC_2328|Compound:6201408|FD-Score:6.33|P-value:2.05E-11 ID:SGTC_2378|Compound:9074213|FD-Score:-3.01|P-value:7.51E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.63|P-value:7.16E-7 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.27|P-value:3.33E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.53|P-value:1.19E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.36|P-value:2.32E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.25|P-value:3.67E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.67|P-value:6.74E-5 ID:SGTC_3031|Compound:9088762|FD-Score:-3.69|P-value:5.23E-5 ID:SGTC_3035|Compound:9091303|FD-Score:-3.18|P-value:4.00E-4 ID:SGTC_3037|Compound:9091026|FD-Score:12.40|P-value:1.98E-38 ID:SGTC_3137|Compound:9097352|FD-Score:3.47|P-value:1.53E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.23|P-value:5.35E-6 ID:SGTC_3153|Compound:9100258|FD-Score:3.01|P-value:8.85E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-5.33|P-value:1.10E-8 ID:SGTC_3219|Compound:9131112|FD-Score:3.08|P-value:6.74E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.08|P-value:6.69E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.60|P-value:8.95E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.09|P-value:5.74E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:5.43|P-value:7.57E-9 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.47|P-value:1.29E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.15|P-value:3.86E-8 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.15|P-value:5.34E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:8.91|P-value:7.01E-21 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.67|P-value:5.59E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:3.45|P-value:1.63E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.30|P-value:2.98E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.41|P-value:1.64E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-5.21|P-value:2.19E-8 ID:SGTC_521|Compound:r062-0005|FD-Score:-4.77|P-value:2.72E-7 ID:SGTC_523|Compound:1934-0222|FD-Score:4.23|P-value:5.18E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:-5.05|P-value:5.65E-8 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.14|P-value:5.38E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.06|P-value:7.41E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.09|P-value:6.58E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:5.40|P-value:8.86E-9 ID:SGTC_855|Compound:0428-0020|FD-Score:3.71|P-value:5.54E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:4.06|P-value:1.19E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:3.01|P-value:8.63E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:4.78|P-value:3.13E-7 ID:SGTC_974|Compound:1326-0144|FD-Score:3.51|P-value:1.32E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.77|P-value:4.40E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.55|P-value:1.10E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.84|P-value:3.17E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.16|P-value:5.06E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.35|P-value:2.88E-6 ID:SGTC_1520|Compound:flindersine|FD-Score:-2.96|P-value:9.03E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.35|P-value:2.13E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.40|P-value:1.70E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:-3.01|P-value:7.54E-4 ID:SGTC_1704|Compound:st028805|FD-Score:4.12|P-value:8.80E-6 ID:SGTC_1781|Compound:st038725|FD-Score:3.42|P-value:1.88E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.07|P-value:6.98E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.67|P-value:6.56E-5 ID:SGTC_1815|Compound:st051655|FD-Score:3.17|P-value:4.90E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.10|P-value:6.23E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-3.11|P-value:5.24E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.94|P-value:2.04E-5 ID:SGTC_2316|Compound:5844804|FD-Score:-5.20|P-value:2.41E-8 ID:SGTC_2327|Compound:6189656|FD-Score:5.99|P-value:2.06E-10 ID:SGTC_2328|Compound:6201408|FD-Score:6.33|P-value:2.05E-11 ID:SGTC_2378|Compound:9074213|FD-Score:-3.01|P-value:7.51E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.63|P-value:7.16E-7 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.27|P-value:3.33E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.53|P-value:1.19E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.36|P-value:2.32E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.25|P-value:3.67E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.67|P-value:6.74E-5 ID:SGTC_3031|Compound:9088762|FD-Score:-3.69|P-value:5.23E-5 ID:SGTC_3035|Compound:9091303|FD-Score:-3.18|P-value:4.00E-4 ID:SGTC_3037|Compound:9091026|FD-Score:12.40|P-value:1.98E-38 ID:SGTC_3137|Compound:9097352|FD-Score:3.47|P-value:1.53E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.23|P-value:5.35E-6 ID:SGTC_3153|Compound:9100258|FD-Score:3.01|P-value:8.85E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-5.33|P-value:1.10E-8 ID:SGTC_3219|Compound:9131112|FD-Score:3.08|P-value:6.74E-4

Top fitness defect scores for YLL036C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3037 9091026 12.40 49.5 µM 1.98E-38 NEO1-PIK1 3 2.26E-35 1.65
2 SGTC_341 1486-1430 8.91 230.0 µM 7.01E-21 3 2.63E-19 0.10
3 SGTC_2328 6201408 6.33 200.0 µM 2.05E-11 2 1.25E-10 0.60
4 SGTC_2327 6189656 5.99 200.0 µM 2.06E-10 2 1.04E-9 1.05
5 SGTC_202 3594-0513 5.43 34.8 µM 7.57E-9 PDR1 4 2.85E-8 1.60
6 SGTC_836 0330-0104 5.40 1.4 µM 8.86E-9 1 3.29E-8 0.75
7 SGTC_221 trifluoperazine 5.15 10.3 µM 3.86E-8 NEO1-PIK1 20 1.27E-7 0.20
8 SGTC_971 1315-0384 4.78 26.7 µM 3.13E-7 cell wall signaling 3 8.70E-7 0.18
9 SGTC_2567 aureobasidin a 4.63 60.0 nM 7.16E-7 33 1.86E-6 0.04
10 SGTC_1381 2324-0066 4.35 62.1 µM 2.88E-6 6 6.70E-6 0.04
11 SGTC_523 1934-0222 4.23 13.7 µM 5.18E-6 3 1.15E-5 0.23
12 SGTC_3152 9099253 4.23 49.5 µM 5.35E-6 NEO1-PIK1 24 1.19E-5 0.02
13 SGTC_1704 st028805 4.12 70.8 µM 8.80E-6 2 1.88E-5 0.26
14 SGTC_874 0599-0792 4.06 117.0 µM 1.19E-5 4 2.48E-5 0.24
15 SGTC_1844 rapamycin 3.94 4.0 nM 2.04E-5 52 4.06E-5 0.04
16 SGTC_1151 3909-8316 3.84 15.3 µM 3.17E-5 7 6.11E-5 0.34
17 SGTC_1084 voriconazole 3.77 435.0 nM 4.40E-5 azole & statin 12 8.27E-5 0.03
18 SGTC_855 0428-0020 3.71 25.0 µM 5.54E-5 Golgi 11 1.02E-4 0.11
19 SGTC_1800 st050079 3.67 29.1 µM 6.56E-5 NEO1-PIK1 32 1.19E-4 0.02
20 SGTC_2985 9022375 3.67 71.4 µM 6.74E-5 RPP1 & pyrimidine depletion 9 1.23E-4 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.224 1.42E-39 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.203 2.00E-32 YDR141C DOP1 het Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies
0.180 8.12E-26 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.174 3.03E-24 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.173 5.04E-24 YKL039W PTM1 hom Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication
0.160 9.28E-21 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.160 1.11E-20 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.160 1.49E-20 YOL159C-A YOL159C-A hom Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species
0.159 1.67E-20 YLR095C IOC2 hom Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif
0.159 2.02E-20 YKR095W MLP1 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
0.156 8.97E-20 YOR295W UAF30 hom Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication
0.155 1.67E-19 YEL048C TCA17 hom Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder
0.154 3.44E-19 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.150 2.24E-18 YPL202C AFT2 hom Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication
0.149 3.27E-18 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress