YLL037W_d

Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLL037W / YLL037W

Click on Significant Values for Screen Details ID:SGTC_167|Compound:3672-0051|FD-Score:3.31|P-value:1.81E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.33|P-value:1.78E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.47|P-value:7.55E-7 ID:SGTC_699|Compound:0375-0592|FD-Score:3.17|P-value:3.28E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.32|P-value:1.87E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.14|P-value:3.72E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:-3.07|P-value:4.88E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.05|P-value:5.18E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.05|P-value:5.03E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.60|P-value:5.67E-5 ID:SGTC_980|Compound:1473-0395|FD-Score:3.34|P-value:1.65E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.01|P-value:6.01E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:2.95|P-value:7.34E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.07|P-value:4.96E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.86|P-value:1.65E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.38|P-value:1.36E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:4.60|P-value:3.66E-7 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.09|P-value:4.37E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.51|P-value:7.89E-5 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.10|P-value:4.16E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.51|P-value:7.84E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.65|P-value:4.58E-5 ID:SGTC_1530|Compound:rhein|FD-Score:3.09|P-value:4.43E-4 ID:SGTC_1659|Compound:st012954|FD-Score:-2.96|P-value:7.43E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.41|P-value:1.23E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-3.13|P-value:3.96E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-2.90|P-value:9.18E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.10|P-value:4.42E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.67|P-value:2.56E-7 ID:SGTC_1904|Compound:st060225|FD-Score:3.03|P-value:5.48E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.10|P-value:4.25E-4 ID:SGTC_2153|Compound:5569715|FD-Score:2.91|P-value:8.52E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.49|P-value:8.49E-5 ID:SGTC_2396|Compound:5342950|FD-Score:-4.77|P-value:1.56E-7 ID:SGTC_2413|Compound:inermin|FD-Score:-3.45|P-value:1.08E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-2.99|P-value:6.73E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.32|P-value:1.78E-6 ID:SGTC_2456|Compound:5770359|FD-Score:-4.07|P-value:6.13E-6 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.59|P-value:5.97E-5 ID:SGTC_2505|Compound:galangin|FD-Score:4.07|P-value:5.96E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.15|P-value:3.53E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.28|P-value:2.07E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.96|P-value:4.84E-8 ID:SGTC_2727|Compound:riluzole|FD-Score:-2.91|P-value:8.99E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.27|P-value:2.16E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.55|P-value:6.69E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-3.26|P-value:2.38E-4 ID:SGTC_3010|Compound:9080089|FD-Score:2.99|P-value:6.46E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-3.27|P-value:2.23E-4 ID:SGTC_3041|Compound:9091929|FD-Score:4.40|P-value:1.10E-6 ID:SGTC_3043|Compound:9092303|FD-Score:3.62|P-value:4.83E-5 ID:SGTC_3055|Compound:9094636|FD-Score:3.47|P-value:9.32E-5 ID:SGTC_3108|Compound:9121785|FD-Score:3.88|P-value:1.51E-5 ID:SGTC_3149|Compound:9097855|FD-Score:2.93|P-value:8.12E-4 ID:SGTC_3166|Compound:9102297|FD-Score:2.94|P-value:7.71E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.54|P-value:6.83E-5 ID:SGTC_3209|Compound:9113616|FD-Score:-3.57|P-value:6.33E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-4.54|P-value:5.58E-7 ID:SGTC_3249|Compound:9135183|FD-Score:4.15|P-value:4.06E-6 ID:SGTC_3293|Compound:9120939|FD-Score:4.63|P-value:3.18E-7 ID:SGTC_167|Compound:3672-0051|FD-Score:3.31|P-value:1.81E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.33|P-value:1.78E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.47|P-value:7.55E-7 ID:SGTC_699|Compound:0375-0592|FD-Score:3.17|P-value:3.28E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.32|P-value:1.87E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.14|P-value:3.72E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:-3.07|P-value:4.88E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.05|P-value:5.18E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.05|P-value:5.03E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.60|P-value:5.67E-5 ID:SGTC_980|Compound:1473-0395|FD-Score:3.34|P-value:1.65E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.01|P-value:6.01E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:2.95|P-value:7.34E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.07|P-value:4.96E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.86|P-value:1.65E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.38|P-value:1.36E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:4.60|P-value:3.66E-7 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.09|P-value:4.37E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.51|P-value:7.89E-5 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.10|P-value:4.16E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.51|P-value:7.84E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.65|P-value:4.58E-5 ID:SGTC_1530|Compound:rhein|FD-Score:3.09|P-value:4.43E-4 ID:SGTC_1659|Compound:st012954|FD-Score:-2.96|P-value:7.43E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.41|P-value:1.23E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-3.13|P-value:3.96E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-2.90|P-value:9.18E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.10|P-value:4.42E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.67|P-value:2.56E-7 ID:SGTC_1904|Compound:st060225|FD-Score:3.03|P-value:5.48E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.10|P-value:4.25E-4 ID:SGTC_2153|Compound:5569715|FD-Score:2.91|P-value:8.52E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.49|P-value:8.49E-5 ID:SGTC_2396|Compound:5342950|FD-Score:-4.77|P-value:1.56E-7 ID:SGTC_2413|Compound:inermin|FD-Score:-3.45|P-value:1.08E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-2.99|P-value:6.73E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.32|P-value:1.78E-6 ID:SGTC_2456|Compound:5770359|FD-Score:-4.07|P-value:6.13E-6 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.59|P-value:5.97E-5 ID:SGTC_2505|Compound:galangin|FD-Score:4.07|P-value:5.96E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.15|P-value:3.53E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.28|P-value:2.07E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.96|P-value:4.84E-8 ID:SGTC_2727|Compound:riluzole|FD-Score:-2.91|P-value:8.99E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.27|P-value:2.16E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.55|P-value:6.69E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-3.26|P-value:2.38E-4 ID:SGTC_3010|Compound:9080089|FD-Score:2.99|P-value:6.46E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-3.27|P-value:2.23E-4 ID:SGTC_3041|Compound:9091929|FD-Score:4.40|P-value:1.10E-6 ID:SGTC_3043|Compound:9092303|FD-Score:3.62|P-value:4.83E-5 ID:SGTC_3055|Compound:9094636|FD-Score:3.47|P-value:9.32E-5 ID:SGTC_3108|Compound:9121785|FD-Score:3.88|P-value:1.51E-5 ID:SGTC_3149|Compound:9097855|FD-Score:2.93|P-value:8.12E-4 ID:SGTC_3166|Compound:9102297|FD-Score:2.94|P-value:7.71E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.54|P-value:6.83E-5 ID:SGTC_3209|Compound:9113616|FD-Score:-3.57|P-value:6.33E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-4.54|P-value:5.58E-7 ID:SGTC_3249|Compound:9135183|FD-Score:4.15|P-value:4.06E-6 ID:SGTC_3293|Compound:9120939|FD-Score:4.63|P-value:3.18E-7

Top fitness defect scores for YLL037W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2567 aureobasidin a 4.96 60.0 nM 4.84E-8 27 3.59E-7 0.04
2 SGTC_1875 nocodazole 4.67 6.0 µM 2.56E-7 tubulin folding & SWR complex 19 1.52E-6 0.08
3 SGTC_3293 9120939 4.63 62.0 µM 3.18E-7 5 1.84E-6 0.06
4 SGTC_1104 tacrolimus 4.60 29.8 µM 3.66E-7 6 2.08E-6 0.58
5 SGTC_658 3253-0951 4.47 102.0 µM 7.55E-7 calcium & mitochondrial duress 5 3.91E-6 0.66
6 SGTC_3041 9091929 4.40 49.5 µM 1.10E-6 redox potentiating 3 5.44E-6 0.39
7 SGTC_3249 9135183 4.15 49.5 µM 4.06E-6 60S ribosome export 5 1.69E-5 0.46
8 SGTC_2505 galangin 4.07 7.9 µM 5.96E-6 RPP1 & pyrimidine depletion 5 2.36E-5 0.04
9 SGTC_3108 9121785 3.88 49.5 µM 1.51E-5 13 5.31E-5 0.06
10 SGTC_1053 3366-3204 3.86 134.0 µM 1.65E-5 cell wall 8 5.72E-5 0.00
11 SGTC_3043 9092303 3.62 49.5 µM 4.83E-5 7 1.46E-4 0.07
12 SGTC_2817 7995342 3.55 71.4 µM 6.69E-5 11 1.94E-4 0.06
13 SGTC_3204 9114183 3.54 49.5 µM 6.83E-5 9 1.97E-4 0.02
14 SGTC_1503 4585-0012 3.51 61.3 µM 7.84E-5 10 2.23E-4 0.21
15 SGTC_1416 3966-0321 3.51 25.3 µM 7.89E-5 9 2.24E-4 0.02
16 SGTC_2263 7948595 3.49 193.3 µM 8.49E-5 8 2.39E-4 0.01
17 SGTC_3055 9094636 3.47 49.5 µM 9.32E-5 11 2.59E-4 0.10
18 SGTC_1778 st046819 3.41 58.9 µM 1.23E-4 10 3.30E-4 0.05
19 SGTC_1091 telmisartan 3.38 47.6 µM 1.36E-4 5 3.59E-4 0.35
20 SGTC_980 1473-0395 3.34 201.0 µM 1.65E-4 12 4.26E-4 0.15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.181 3.11E-26 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.150 2.40E-18 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.128 1.10E-13 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.123 7.64E-13 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.114 3.98E-11 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.106 6.78E-10 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.103 1.99E-9 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.100 6.20E-9 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.098 1.50E-8 YLR029C RPL15A het Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication
0.094 5.06E-8 YGR124W ASN2 hom Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication
0.092 8.57E-8 YER036C ARB1 het ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
0.091 1.19E-7 YCL009C ILV6 hom Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria
0.085 7.05E-7 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.083 1.64E-6 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.083 1.65E-6 YKL165C MCD4 het Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes