YLL040C / VPS13

Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL040C / VPS13

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.19|P-value:9.13E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:4.48|P-value:6.46E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:13.90|P-value:2.63E-41 ID:SGTC_70|Compound:0141-0289|FD-Score:14.50|P-value:6.95E-45 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.81|P-value:1.49E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:-4.68|P-value:4.14E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.12|P-value:4.47E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:18.00|P-value:5.18E-68 ID:SGTC_124|Compound:0136-0217|FD-Score:13.10|P-value:8.06E-37 ID:SGTC_131|Compound:0141-0277|FD-Score:6.68|P-value:4.44E-11 ID:SGTC_138|Compound:0850-0259|FD-Score:4.87|P-value:1.08E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:5.13|P-value:3.02E-7 ID:SGTC_149|Compound:3970-0822|FD-Score:4.54|P-value:4.94E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.96|P-value:3.62E-9 ID:SGTC_232|Compound:clozapine|FD-Score:4.54|P-value:4.93E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:3.87|P-value:8.12E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:4.34|P-value:1.20E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:3.53|P-value:2.84E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.83|P-value:9.13E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:4.68|P-value:2.66E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:8.92|P-value:2.93E-18 ID:SGTC_447|Compound:ml7|FD-Score:3.56|P-value:2.54E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.18|P-value:9.37E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.22|P-value:8.10E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.68|P-value:1.64E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.83|P-value:9.22E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:8.07|P-value:2.58E-15 ID:SGTC_528|Compound:3492-0019|FD-Score:16.10|P-value:4.27E-55 ID:SGTC_535|Compound:2293-4129|FD-Score:7.05|P-value:4.11E-12 ID:SGTC_651|Compound:3253-0966|FD-Score:-3.38|P-value:6.78E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.38|P-value:9.76E-6 ID:SGTC_819|Compound:1013-0258|FD-Score:3.37|P-value:4.89E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.74|P-value:1.97E-6 ID:SGTC_849|Compound:0386-0493|FD-Score:3.22|P-value:8.06E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:4.68|P-value:2.56E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:3.89|P-value:7.29E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:7.04|P-value:4.43E-12 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.43|P-value:3.96E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:10.90|P-value:3.54E-26 ID:SGTC_1687|Compound:st020778|FD-Score:4.17|P-value:2.40E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.66|P-value:2.87E-6 ID:SGTC_1727|Compound:st034309|FD-Score:-3.39|P-value:6.46E-4 ID:SGTC_1760|Compound:st045453|FD-Score:5.44|P-value:6.25E-8 ID:SGTC_1777|Compound:st045864|FD-Score:3.34|P-value:5.43E-4 ID:SGTC_1795|Compound:st049545|FD-Score:-3.29|P-value:9.09E-4 ID:SGTC_1800|Compound:st050079|FD-Score:8.17|P-value:1.27E-15 ID:SGTC_1803|Compound:st050068|FD-Score:10.50|P-value:1.79E-24 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.56|P-value:9.84E-11 ID:SGTC_2057|Compound:5236571|FD-Score:3.66|P-value:1.77E-4 ID:SGTC_2059|Compound:5238311|FD-Score:4.03|P-value:4.33E-5 ID:SGTC_2064|Compound:5220758|FD-Score:-3.48|P-value:4.91E-4 ID:SGTC_2415|Compound:st077333|FD-Score:4.43|P-value:8.06E-6 ID:SGTC_2416|Compound:tofa|FD-Score:-4.27|P-value:2.47E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.69|P-value:2.31E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:5.09|P-value:3.74E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:4.35|P-value:1.11E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.86|P-value:8.15E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.82|P-value:1.37E-6 ID:SGTC_2699|Compound:st077704|FD-Score:3.84|P-value:9.01E-5 ID:SGTC_2706|Compound:st078239|FD-Score:3.96|P-value:5.69E-5 ID:SGTC_2809|Compound:7964133|FD-Score:5.68|P-value:1.75E-8 ID:SGTC_2829|Compound:7992743|FD-Score:-4.88|P-value:1.66E-6 ID:SGTC_2945|Compound:9067681|FD-Score:6.95|P-value:7.95E-12 ID:SGTC_2946|Compound:9065502|FD-Score:-3.34|P-value:7.83E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.75|P-value:1.85E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.80|P-value:1.06E-4 ID:SGTC_3105|Compound:9121040|FD-Score:-3.85|P-value:1.30E-4 ID:SGTC_3118|Compound:9124250|FD-Score:-6.02|P-value:4.54E-9 ID:SGTC_3120|Compound:9124077|FD-Score:4.91|P-value:9.00E-7 ID:SGTC_3219|Compound:9131112|FD-Score:-3.33|P-value:8.05E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.20|P-value:8.75E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.47|P-value:3.45E-4 ID:SGTC_3321|Compound:9137793|FD-Score:4.57|P-value:4.35E-6 ID:SGTC_3356|Compound:9151811|FD-Score:3.25|P-value:7.49E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.19|P-value:9.13E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:4.48|P-value:6.46E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:13.90|P-value:2.63E-41 ID:SGTC_70|Compound:0141-0289|FD-Score:14.50|P-value:6.95E-45 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.81|P-value:1.49E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:-4.68|P-value:4.14E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.12|P-value:4.47E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:18.00|P-value:5.18E-68 ID:SGTC_124|Compound:0136-0217|FD-Score:13.10|P-value:8.06E-37 ID:SGTC_131|Compound:0141-0277|FD-Score:6.68|P-value:4.44E-11 ID:SGTC_138|Compound:0850-0259|FD-Score:4.87|P-value:1.08E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:5.13|P-value:3.02E-7 ID:SGTC_149|Compound:3970-0822|FD-Score:4.54|P-value:4.94E-6 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.96|P-value:3.62E-9 ID:SGTC_232|Compound:clozapine|FD-Score:4.54|P-value:4.93E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:3.87|P-value:8.12E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:4.34|P-value:1.20E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:3.53|P-value:2.84E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.83|P-value:9.13E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:4.68|P-value:2.66E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:8.92|P-value:2.93E-18 ID:SGTC_447|Compound:ml7|FD-Score:3.56|P-value:2.54E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.18|P-value:9.37E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.22|P-value:8.10E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.68|P-value:1.64E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.83|P-value:9.22E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:8.07|P-value:2.58E-15 ID:SGTC_528|Compound:3492-0019|FD-Score:16.10|P-value:4.27E-55 ID:SGTC_535|Compound:2293-4129|FD-Score:7.05|P-value:4.11E-12 ID:SGTC_651|Compound:3253-0966|FD-Score:-3.38|P-value:6.78E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.38|P-value:9.76E-6 ID:SGTC_819|Compound:1013-0258|FD-Score:3.37|P-value:4.89E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.74|P-value:1.97E-6 ID:SGTC_849|Compound:0386-0493|FD-Score:3.22|P-value:8.06E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:4.68|P-value:2.56E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:3.89|P-value:7.29E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:7.04|P-value:4.43E-12 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.43|P-value:3.96E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:10.90|P-value:3.54E-26 ID:SGTC_1687|Compound:st020778|FD-Score:4.17|P-value:2.40E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.66|P-value:2.87E-6 ID:SGTC_1727|Compound:st034309|FD-Score:-3.39|P-value:6.46E-4 ID:SGTC_1760|Compound:st045453|FD-Score:5.44|P-value:6.25E-8 ID:SGTC_1777|Compound:st045864|FD-Score:3.34|P-value:5.43E-4 ID:SGTC_1795|Compound:st049545|FD-Score:-3.29|P-value:9.09E-4 ID:SGTC_1800|Compound:st050079|FD-Score:8.17|P-value:1.27E-15 ID:SGTC_1803|Compound:st050068|FD-Score:10.50|P-value:1.79E-24 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.56|P-value:9.84E-11 ID:SGTC_2057|Compound:5236571|FD-Score:3.66|P-value:1.77E-4 ID:SGTC_2059|Compound:5238311|FD-Score:4.03|P-value:4.33E-5 ID:SGTC_2064|Compound:5220758|FD-Score:-3.48|P-value:4.91E-4 ID:SGTC_2415|Compound:st077333|FD-Score:4.43|P-value:8.06E-6 ID:SGTC_2416|Compound:tofa|FD-Score:-4.27|P-value:2.47E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.69|P-value:2.31E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:5.09|P-value:3.74E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:4.35|P-value:1.11E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.86|P-value:8.15E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.82|P-value:1.37E-6 ID:SGTC_2699|Compound:st077704|FD-Score:3.84|P-value:9.01E-5 ID:SGTC_2706|Compound:st078239|FD-Score:3.96|P-value:5.69E-5 ID:SGTC_2809|Compound:7964133|FD-Score:5.68|P-value:1.75E-8 ID:SGTC_2829|Compound:7992743|FD-Score:-4.88|P-value:1.66E-6 ID:SGTC_2945|Compound:9067681|FD-Score:6.95|P-value:7.95E-12 ID:SGTC_2946|Compound:9065502|FD-Score:-3.34|P-value:7.83E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.75|P-value:1.85E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.80|P-value:1.06E-4 ID:SGTC_3105|Compound:9121040|FD-Score:-3.85|P-value:1.30E-4 ID:SGTC_3118|Compound:9124250|FD-Score:-6.02|P-value:4.54E-9 ID:SGTC_3120|Compound:9124077|FD-Score:4.91|P-value:9.00E-7 ID:SGTC_3219|Compound:9131112|FD-Score:-3.33|P-value:8.05E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.20|P-value:8.75E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.47|P-value:3.45E-4 ID:SGTC_3321|Compound:9137793|FD-Score:4.57|P-value:4.35E-6 ID:SGTC_3356|Compound:9151811|FD-Score:3.25|P-value:7.49E-4

Top fitness defect scores for YLL040C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_119 0121-0043 18.00 24.8 µM 5.18E-68 mitochondrial stress 2 8.27E-73
2 SGTC_528 3492-0019 16.10 172.0 µM 4.27E-55 calcium & mitochondrial duress 9 6.43E-59
3 SGTC_70 0141-0289 14.50 43.3 µM 6.95E-45 mitochondrial stress 10 6.12E-48
4 SGTC_58 0957-0393 13.90 9.0 µM 2.63E-41 cell wall 34 4.29E-44
5 SGTC_124 0136-0217 13.10 7.1 µM 8.06E-37 mitochondrial stress 4 2.84E-39
6 SGTC_1495 4469-0029 10.90 237.0 µM 3.54E-26 12 7.63E-28
7 SGTC_1803 st050068 10.50 52.4 µM 1.79E-24 NEO1-PIK1 23 5.14E-26
8 SGTC_445 e6 berbamine 8.92 66.0 µM 2.93E-18 NEO1-PIK1 8 2.38E-19
9 SGTC_1800 st050079 8.17 29.1 µM 1.27E-15 NEO1-PIK1 10 1.59E-16
10 SGTC_514 4466-0038 8.07 2.6 nM 2.58E-15 cell wall 38 3.40E-16
11 SGTC_535 2293-4129 7.05 48.2 µM 4.11E-12 NEO1 20 9.10E-13
12 SGTC_951 1171-0579 7.04 82.7 µM 4.43E-12 cell wall 22 9.87E-13
13 SGTC_2945 9067681 6.95 61.8 µM 7.95E-12 2 1.84E-12
14 SGTC_131 0141-0277 6.68 33.9 µM 4.44E-11 4 1.16E-11
15 SGTC_1844 rapamycin 6.56 4.0 nM 9.84E-11 79 2.72E-11
16 SGTC_221 trifluoperazine 5.96 10.3 µM 3.62E-9 NEO1-PIK1 122 1.28E-9
17 SGTC_2809 7964133 5.68 13.0 µM 1.75E-8 60S ribosome export 7 6.91E-9
18 SGTC_1760 st045453 5.44 10.4 µM 6.25E-8 NEO1-PIK1 97 2.68E-8
19 SGTC_146 3448-8650 5.13 53.1 µM 3.02E-7 NEO1-PIK1 81 1.44E-7
20 SGTC_2498 4'-Methoxychalcone 5.09 54.6 µM 3.74E-7 RPP1 & pyrimidine depletion 12 1.81E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.328 3.88E-85 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.323 2.50E-82 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.314 1.98E-77 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.299 1.92E-70 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.298 7.99E-70 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.291 1.00E-66 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.290 4.60E-66 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.272 7.67E-58 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.272 8.86E-58 YML094C-A_d YML094C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
0.270 3.06E-57 YDL023C_d YDL023C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
0.260 5.80E-53 YPR050C_d YPR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W
0.260 6.10E-53 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.253 5.49E-50 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.250 4.97E-49 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.248 4.52E-48 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress