YLL041C / SDH2

Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL041C / SDH2

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:6.26|P-value:5.18E-10 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.74|P-value:1.63E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.65|P-value:2.26E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.06|P-value:3.58E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.49|P-value:3.12E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.74|P-value:1.29E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.40|P-value:4.29E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:6.95|P-value:6.28E-12 ID:SGTC_1647|Compound:st011722|FD-Score:3.19|P-value:9.00E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.31|P-value:1.68E-5 ID:SGTC_2005|Compound:4024620|FD-Score:3.32|P-value:5.69E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.04|P-value:3.93E-5 ID:SGTC_2011|Compound:4012611|FD-Score:-4.17|P-value:2.97E-5 ID:SGTC_2144|Compound:5628481|FD-Score:-4.05|P-value:4.88E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.62|P-value:4.34E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-4.34|P-value:1.47E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.88|P-value:7.54E-5 ID:SGTC_2878|Compound:9043973|FD-Score:3.82|P-value:9.38E-5 ID:SGTC_3146|Compound:9095609|FD-Score:3.17|P-value:9.49E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.97|P-value:5.17E-5 ID:SGTC_3219|Compound:9131112|FD-Score:3.20|P-value:8.66E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.38|P-value:4.69E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.53|P-value:2.71E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:6.26|P-value:5.18E-10 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.74|P-value:1.63E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.65|P-value:2.26E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.06|P-value:3.58E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:3.49|P-value:3.12E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.74|P-value:1.29E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.40|P-value:4.29E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:6.95|P-value:6.28E-12 ID:SGTC_1647|Compound:st011722|FD-Score:3.19|P-value:9.00E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.31|P-value:1.68E-5 ID:SGTC_2005|Compound:4024620|FD-Score:3.32|P-value:5.69E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.04|P-value:3.93E-5 ID:SGTC_2011|Compound:4012611|FD-Score:-4.17|P-value:2.97E-5 ID:SGTC_2144|Compound:5628481|FD-Score:-4.05|P-value:4.88E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.62|P-value:4.34E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-4.34|P-value:1.47E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.88|P-value:7.54E-5 ID:SGTC_2878|Compound:9043973|FD-Score:3.82|P-value:9.38E-5 ID:SGTC_3146|Compound:9095609|FD-Score:3.17|P-value:9.49E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.97|P-value:5.17E-5 ID:SGTC_3219|Compound:9131112|FD-Score:3.20|P-value:8.66E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.38|P-value:4.69E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.53|P-value:2.71E-4

Top fitness defect scores for YLL041C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1435 4092-0789 6.95 56.7 µM 6.28E-12 plasma membrane duress 4 1.80E-12
2 SGTC_64 000l-0018 6.26 272.1 µM 5.18E-10 ubiquinone biosynthesis & proteasome 74 1.91E-10
3 SGTC_769 0302-0231 4.06 76.0 µM 3.58E-5 35 2.43E-5
4 SGTC_2007 4011539 4.04 71.8 µM 3.93E-5 cell wall signaling 57 2.68E-5
5 SGTC_3174 9107204 3.97 49.5 µM 5.17E-5 ERG2 31 3.58E-5
6 SGTC_2621 lithochol-11-enic acid 3.88 100.0 µM 7.54E-5 25 5.33E-5
7 SGTC_2878 9043973 3.82 26.0 µM 9.38E-5 22 6.71E-5
8 SGTC_1255 0566-0045 3.74 221.0 µM 1.29E-4 excess fatty acid 37 9.35E-5
9 SGTC_3329 9141233 3.53 27.6 µM 2.71E-4 22 2.04E-4
10 SGTC_1136 pergolide 3.49 1.1 µM 3.12E-4 59 2.37E-4
11 SGTC_1344 1488-0097 3.40 29.1 µM 4.29E-4 31 3.31E-4
12 SGTC_3233 9132340 3.38 49.5 µM 4.69E-4 41 3.64E-4
13 SGTC_2005 4024620 3.32 188.0 µM 5.69E-4 45 4.46E-4
14 SGTC_3219 9131112 3.20 49.5 µM 8.66E-4 Golgi 59 6.93E-4
15 SGTC_1647 st011722 3.19 22.4 µM 9.00E-4 28 7.22E-4
16 SGTC_3146 9095609 3.17 49.5 µM 9.49E-4 47 7.63E-4
17 SGTC_1247 0448-0043 3.14 5.8 µM 0.00105 ERG2 98 8.46E-4
18 SGTC_634 1611-4317 3.10 11.2 µM 0.00119 ERG2 46 9.71E-4
19 SGTC_628 1636-0253 3.10 16.0 µM 0.00121 sphingolipid biosynthesis & PDR1 71 9.82E-4
20 SGTC_3177 9107506 3.09 49.5 µM 0.00122 ERG2 21 9.90E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.72E-18 YPL144W POC4 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.149 4.03E-18 YLR127C APC2 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p
0.138 1.18E-15 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.134 6.47E-15 YLR324W PEX30 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.134 9.30E-15 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.129 6.85E-14 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.129 7.95E-14 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.128 1.04E-13 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.125 4.25E-13 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.120 3.03E-12 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.120 3.77E-12 YPR133W-A TOM5 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore
0.119 4.59E-12 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.115 2.09E-11 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.113 5.41E-11 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.107 5.46E-10 YOR252W TMA16 hom Protein of unknown function that associates with ribosomes