YLL042C / ATG10

Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL042C / ATG10

Click on Significant Values for Screen Details ID:SGTC_79|Compound:0052-0007|FD-Score:3.18|P-value:2.04E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:3.88|P-value:7.95E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:-2.84|P-value:8.09E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:-2.92|P-value:5.89E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.27|P-value:1.41E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.78|P-value:1.36E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-2.91|P-value:6.18E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:4.01|P-value:4.15E-6 ID:SGTC_559|Compound:1550-0661|FD-Score:3.06|P-value:3.38E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:-2.80|P-value:9.25E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.98|P-value:4.79E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:3.91|P-value:7.00E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:-2.90|P-value:6.46E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-4.33|P-value:7.28E-7 ID:SGTC_793|Compound:0488-0545|FD-Score:3.10|P-value:2.81E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-3.08|P-value:3.08E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.91|P-value:6.74E-6 ID:SGTC_957|Compound:1187-1561|FD-Score:-2.97|P-value:4.74E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.02|P-value:3.96E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:2.89|P-value:6.45E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:2.90|P-value:6.27E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.06|P-value:3.33E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.05|P-value:3.50E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:-3.39|P-value:8.21E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.08|P-value:3.14E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-2.83|P-value:8.22E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-2.86|P-value:7.38E-4 ID:SGTC_2001|Compound:4023502|FD-Score:2.94|P-value:5.49E-4 ID:SGTC_2262|Compound:9014885|FD-Score:-2.79|P-value:9.65E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.71|P-value:1.87E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.24|P-value:1.57E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.78|P-value:1.34E-5 ID:SGTC_2399|Compound:5884133|FD-Score:3.43|P-value:6.94E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.76|P-value:1.45E-5 ID:SGTC_2485|Compound:5633444|FD-Score:3.32|P-value:1.13E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:4.46|P-value:3.57E-7 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.47|P-value:5.68E-5 ID:SGTC_2695|Compound:st077686|FD-Score:3.78|P-value:1.31E-5 ID:SGTC_2793|Compound:7325131|FD-Score:4.26|P-value:1.08E-6 ID:SGTC_2982|Compound:9019404|FD-Score:-3.60|P-value:3.21E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-3.23|P-value:1.69E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.51|P-value:4.75E-5 ID:SGTC_3158|Compound:9100007|FD-Score:3.37|P-value:9.01E-5 ID:SGTC_79|Compound:0052-0007|FD-Score:3.18|P-value:2.04E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:3.88|P-value:7.95E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:-2.84|P-value:8.09E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:-2.92|P-value:5.89E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.27|P-value:1.41E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.78|P-value:1.36E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-2.91|P-value:6.18E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:4.01|P-value:4.15E-6 ID:SGTC_559|Compound:1550-0661|FD-Score:3.06|P-value:3.38E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:-2.80|P-value:9.25E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.98|P-value:4.79E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:3.91|P-value:7.00E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:-2.90|P-value:6.46E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-4.33|P-value:7.28E-7 ID:SGTC_793|Compound:0488-0545|FD-Score:3.10|P-value:2.81E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:-3.08|P-value:3.08E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.91|P-value:6.74E-6 ID:SGTC_957|Compound:1187-1561|FD-Score:-2.97|P-value:4.74E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.02|P-value:3.96E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:2.89|P-value:6.45E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:2.90|P-value:6.27E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.06|P-value:3.33E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.05|P-value:3.50E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:-3.39|P-value:8.21E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.08|P-value:3.14E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-2.83|P-value:8.22E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-2.86|P-value:7.38E-4 ID:SGTC_2001|Compound:4023502|FD-Score:2.94|P-value:5.49E-4 ID:SGTC_2262|Compound:9014885|FD-Score:-2.79|P-value:9.65E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.71|P-value:1.87E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.24|P-value:1.57E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.78|P-value:1.34E-5 ID:SGTC_2399|Compound:5884133|FD-Score:3.43|P-value:6.94E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.76|P-value:1.45E-5 ID:SGTC_2485|Compound:5633444|FD-Score:3.32|P-value:1.13E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:4.46|P-value:3.57E-7 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.47|P-value:5.68E-5 ID:SGTC_2695|Compound:st077686|FD-Score:3.78|P-value:1.31E-5 ID:SGTC_2793|Compound:7325131|FD-Score:4.26|P-value:1.08E-6 ID:SGTC_2982|Compound:9019404|FD-Score:-3.60|P-value:3.21E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-3.23|P-value:1.69E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.51|P-value:4.75E-5 ID:SGTC_3158|Compound:9100007|FD-Score:3.37|P-value:9.01E-5

Top fitness defect scores for YLL042C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2559 tetrahydrosappanone a trimethyl ether 4.46 100.0 µM 3.57E-7 5 4.12E-6
2 SGTC_2793 7325131 4.26 81.8 µM 1.08E-6 12 1.02E-5
3 SGTC_551 k048-0028 4.01 34.9 µM 4.15E-6 14 3.05E-5
4 SGTC_652 0437-0092 3.98 114.0 µM 4.79E-6 17 3.43E-5
5 SGTC_940 3232-1287 3.91 54.8 µM 6.74E-6 NEO1 39 4.53E-5
6 SGTC_697 0508-1955 3.91 564.0 µM 7.00E-6 34 4.68E-5
7 SGTC_83 0170-0301 3.88 39.0 µM 7.95E-6 endomembrane recycling 7 5.19E-5
8 SGTC_2695 st077686 3.78 52.0 µM 1.31E-5 43 7.81E-5
9 SGTC_2317 5986382 3.78 200.0 µM 1.34E-5 16 7.94E-5
10 SGTC_2409 alverine citrate 3.76 64.0 µM 1.45E-5 58 8.49E-5
11 SGTC_2308 7584454 3.71 197.6 µM 1.87E-5 27 1.04E-4
12 SGTC_2998 9066762 3.51 71.4 µM 4.75E-5 RPP1 & pyrimidine depletion 35 2.24E-4
13 SGTC_2562 3',7'-dimethoxyflavone 3.47 64.9 µM 5.68E-5 52 2.59E-4
14 SGTC_2399 5884133 3.43 200.0 µM 6.94E-5 cell wall signaling 99 3.05E-4
15 SGTC_3158 9100007 3.37 49.5 µM 9.01E-5 36 3.78E-4
16 SGTC_2485 5633444 3.32 17.8 µM 1.13E-4 redox potentiating 70 4.56E-4
17 SGTC_379 3970-0972 3.27 5.9 µM 1.41E-4 tubulin folding & SWR complex 65 5.45E-4
18 SGTC_2309 7664088 3.24 163.9 µM 1.57E-4 81 5.97E-4
19 SGTC_79 0052-0007 3.18 94.1 µM 2.04E-4 67 7.38E-4
20 SGTC_793 0488-0545 3.10 106.0 µM 2.81E-4 42 9.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 6.28E-14 YER121W_p YER121W_p hom Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
0.124 5.15E-13 YCR005C CIT2 hom Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication
0.124 5.73E-13 YJR053W BFA1 hom Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis
0.115 2.79E-11 YNL013C_d YNL013C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W
0.105 1.03E-9 YNL154C YCK2 hom Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication
0.103 2.35E-9 YJL196C ELO1 hom Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication
0.098 1.37E-8 YPR043W RPL43A hom Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication
0.093 6.48E-8 YHL022C SPO11 hom Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation
0.087 4.65E-7 YDR195W REF2 hom RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes
0.083 1.29E-6 YEL071W DLD3 hom D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm
0.083 1.30E-6 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.082 2.26E-6 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.081 2.80E-6 YIL159W BNR1 hom Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1
0.081 2.97E-6 YGL154C LYS5 hom Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine
0.079 4.98E-6 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization