YLL043W / FPS1

Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL043W / FPS1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:12.80|P-value:6.35E-37 ID:SGTC_138|Compound:0850-0259|FD-Score:24.00|P-value:2.55E-123 ID:SGTC_157|Compound:1348-1695|FD-Score:6.66|P-value:2.56E-11 ID:SGTC_195|Compound:4234-0266|FD-Score:4.55|P-value:3.42E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:5.91|P-value:2.68E-9 ID:SGTC_351|Compound:caspofungin|FD-Score:4.71|P-value:1.63E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:8.81|P-value:1.88E-18 ID:SGTC_360|Compound:0957-0399|FD-Score:16.50|P-value:7.98E-60 ID:SGTC_393|Compound:acivicin|FD-Score:4.21|P-value:1.61E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:4.01|P-value:3.64E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:3.62|P-value:1.72E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:11.40|P-value:2.36E-29 ID:SGTC_663|Compound:1486-0733|FD-Score:4.62|P-value:2.52E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:4.83|P-value:9.33E-7 ID:SGTC_744|Compound:1594-0068|FD-Score:3.51|P-value:2.60E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.32|P-value:5.04E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.20|P-value:4.86E-10 ID:SGTC_830|Compound:4076-0286|FD-Score:3.19|P-value:7.93E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:7.46|P-value:9.73E-14 ID:SGTC_853|Compound:0419-0306|FD-Score:3.23|P-value:6.79E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.79|P-value:1.09E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:6.47|P-value:8.74E-11 ID:SGTC_964|Compound:1287-0107|FD-Score:3.57|P-value:2.08E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:4.14|P-value:2.11E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.23|P-value:8.13E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.56|P-value:2.15E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.88|P-value:6.26E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.48|P-value:2.84E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.68|P-value:1.34E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.34|P-value:8.92E-6 ID:SGTC_1583|Compound:clindamycin|FD-Score:4.12|P-value:2.27E-5 ID:SGTC_1652|Compound:st011932|FD-Score:3.15|P-value:9.01E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.40|P-value:3.82E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.22|P-value:7.03E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.36|P-value:4.46E-4 ID:SGTC_1760|Compound:st045453|FD-Score:4.41|P-value:6.44E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.19|P-value:9.48E-4 ID:SGTC_1800|Compound:st050079|FD-Score:6.75|P-value:1.39E-11 ID:SGTC_1801|Compound:st050089|FD-Score:6.62|P-value:3.31E-11 ID:SGTC_1803|Compound:st050068|FD-Score:8.54|P-value:1.94E-17 ID:SGTC_1830|Compound:st055982|FD-Score:-3.44|P-value:3.98E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:17.80|P-value:9.70E-69 ID:SGTC_1862|Compound:st057513|FD-Score:3.30|P-value:5.48E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.50|P-value:2.62E-4 ID:SGTC_1959|Compound:st077091|FD-Score:5.11|P-value:2.21E-7 ID:SGTC_2007|Compound:4011539|FD-Score:4.11|P-value:2.38E-5 ID:SGTC_2016|Compound:5121758|FD-Score:7.64|P-value:2.49E-14 ID:SGTC_2021|Compound:4019055|FD-Score:-3.80|P-value:1.03E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:6.86|P-value:6.51E-12 ID:SGTC_2177|Compound:5811945|FD-Score:4.42|P-value:6.27E-6 ID:SGTC_2257|Compound:7960413|FD-Score:3.46|P-value:3.11E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.22|P-value:1.54E-5 ID:SGTC_2289|Compound:7946404|FD-Score:5.56|P-value:1.99E-8 ID:SGTC_2323|Compound:6148992|FD-Score:6.91|P-value:4.80E-12 ID:SGTC_2334|Compound:9017922|FD-Score:3.13|P-value:9.73E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.37|P-value:4.27E-4 ID:SGTC_2361|Compound:9034121|FD-Score:5.52|P-value:2.56E-8 ID:SGTC_2396|Compound:5342950|FD-Score:4.01|P-value:3.64E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.63|P-value:2.39E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.49|P-value:5.75E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.33|P-value:4.84E-4 ID:SGTC_2601|Compound:securinine|FD-Score:-9.73|P-value:6.94E-22 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.04|P-value:3.23E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:6.89|P-value:5.45E-12 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.81|P-value:8.07E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:10.70|P-value:2.67E-26 ID:SGTC_2696|Compound:st077691|FD-Score:6.33|P-value:2.15E-10 ID:SGTC_2810|Compound:7959871|FD-Score:5.97|P-value:1.87E-9 ID:SGTC_2812|Compound:7970281|FD-Score:4.33|P-value:9.17E-6 ID:SGTC_2864|Compound:9034755|FD-Score:3.33|P-value:4.84E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.24|P-value:7.82E-4 ID:SGTC_2912|Compound:7964298|FD-Score:19.80|P-value:7.44E-85 ID:SGTC_2931|Compound:9014674|FD-Score:5.37|P-value:5.60E-8 ID:SGTC_3094|Compound:9117742|FD-Score:3.43|P-value:3.37E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.65|P-value:1.24E-8 ID:SGTC_3324|Compound:9138759|FD-Score:3.82|P-value:7.76E-5 ID:SGTC_3331|Compound:9141060|FD-Score:6.88|P-value:5.88E-12 ID:SGTC_58|Compound:0957-0393|FD-Score:12.80|P-value:6.35E-37 ID:SGTC_138|Compound:0850-0259|FD-Score:24.00|P-value:2.55E-123 ID:SGTC_157|Compound:1348-1695|FD-Score:6.66|P-value:2.56E-11 ID:SGTC_195|Compound:4234-0266|FD-Score:4.55|P-value:3.42E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:5.91|P-value:2.68E-9 ID:SGTC_351|Compound:caspofungin|FD-Score:4.71|P-value:1.63E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:8.81|P-value:1.88E-18 ID:SGTC_360|Compound:0957-0399|FD-Score:16.50|P-value:7.98E-60 ID:SGTC_393|Compound:acivicin|FD-Score:4.21|P-value:1.61E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:4.01|P-value:3.64E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:3.62|P-value:1.72E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:11.40|P-value:2.36E-29 ID:SGTC_663|Compound:1486-0733|FD-Score:4.62|P-value:2.52E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:4.83|P-value:9.33E-7 ID:SGTC_744|Compound:1594-0068|FD-Score:3.51|P-value:2.60E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.32|P-value:5.04E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.20|P-value:4.86E-10 ID:SGTC_830|Compound:4076-0286|FD-Score:3.19|P-value:7.93E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:7.46|P-value:9.73E-14 ID:SGTC_853|Compound:0419-0306|FD-Score:3.23|P-value:6.79E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.79|P-value:1.09E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:6.47|P-value:8.74E-11 ID:SGTC_964|Compound:1287-0107|FD-Score:3.57|P-value:2.08E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:4.14|P-value:2.11E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.23|P-value:8.13E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.56|P-value:2.15E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.88|P-value:6.26E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.48|P-value:2.84E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.68|P-value:1.34E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.34|P-value:8.92E-6 ID:SGTC_1583|Compound:clindamycin|FD-Score:4.12|P-value:2.27E-5 ID:SGTC_1652|Compound:st011932|FD-Score:3.15|P-value:9.01E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.40|P-value:3.82E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.22|P-value:7.03E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.36|P-value:4.46E-4 ID:SGTC_1760|Compound:st045453|FD-Score:4.41|P-value:6.44E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.19|P-value:9.48E-4 ID:SGTC_1800|Compound:st050079|FD-Score:6.75|P-value:1.39E-11 ID:SGTC_1801|Compound:st050089|FD-Score:6.62|P-value:3.31E-11 ID:SGTC_1803|Compound:st050068|FD-Score:8.54|P-value:1.94E-17 ID:SGTC_1830|Compound:st055982|FD-Score:-3.44|P-value:3.98E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:17.80|P-value:9.70E-69 ID:SGTC_1862|Compound:st057513|FD-Score:3.30|P-value:5.48E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.50|P-value:2.62E-4 ID:SGTC_1959|Compound:st077091|FD-Score:5.11|P-value:2.21E-7 ID:SGTC_2007|Compound:4011539|FD-Score:4.11|P-value:2.38E-5 ID:SGTC_2016|Compound:5121758|FD-Score:7.64|P-value:2.49E-14 ID:SGTC_2021|Compound:4019055|FD-Score:-3.80|P-value:1.03E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:6.86|P-value:6.51E-12 ID:SGTC_2177|Compound:5811945|FD-Score:4.42|P-value:6.27E-6 ID:SGTC_2257|Compound:7960413|FD-Score:3.46|P-value:3.11E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.22|P-value:1.54E-5 ID:SGTC_2289|Compound:7946404|FD-Score:5.56|P-value:1.99E-8 ID:SGTC_2323|Compound:6148992|FD-Score:6.91|P-value:4.80E-12 ID:SGTC_2334|Compound:9017922|FD-Score:3.13|P-value:9.73E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.37|P-value:4.27E-4 ID:SGTC_2361|Compound:9034121|FD-Score:5.52|P-value:2.56E-8 ID:SGTC_2396|Compound:5342950|FD-Score:4.01|P-value:3.64E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.63|P-value:2.39E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.49|P-value:5.75E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.33|P-value:4.84E-4 ID:SGTC_2601|Compound:securinine|FD-Score:-9.73|P-value:6.94E-22 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.04|P-value:3.23E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:6.89|P-value:5.45E-12 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.81|P-value:8.07E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:10.70|P-value:2.67E-26 ID:SGTC_2696|Compound:st077691|FD-Score:6.33|P-value:2.15E-10 ID:SGTC_2810|Compound:7959871|FD-Score:5.97|P-value:1.87E-9 ID:SGTC_2812|Compound:7970281|FD-Score:4.33|P-value:9.17E-6 ID:SGTC_2864|Compound:9034755|FD-Score:3.33|P-value:4.84E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.24|P-value:7.82E-4 ID:SGTC_2912|Compound:7964298|FD-Score:19.80|P-value:7.44E-85 ID:SGTC_2931|Compound:9014674|FD-Score:5.37|P-value:5.60E-8 ID:SGTC_3094|Compound:9117742|FD-Score:3.43|P-value:3.37E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.65|P-value:1.24E-8 ID:SGTC_3324|Compound:9138759|FD-Score:3.82|P-value:7.76E-5 ID:SGTC_3331|Compound:9141060|FD-Score:6.88|P-value:5.88E-12

Top fitness defect scores for YLL043W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 24.00 40.9 µM 2.55E-123 cell wall 3 2.45E-127
2 SGTC_2912 7964298 19.80 10.9 µM 7.44E-85 cell wall 5 1.46E-87
3 SGTC_1844 rapamycin 17.80 4.0 nM 9.70E-69 9 6.70E-71
4 SGTC_360 0957-0399 16.50 1.0 µM 7.98E-60 cell wall 3 1.10E-61
5 SGTC_58 0957-0393 12.80 9.0 µM 6.35E-37 cell wall 41 5.11E-38
6 SGTC_586 0957-0265 11.40 8.2 µM 2.36E-29 cell wall 4 3.37E-30
7 SGTC_2679 rapamycin 10.70 1.0 nM 2.67E-26 20 4.81E-27
8 SGTC_354 2783-3500 8.81 4.9 µM 1.88E-18 cell wall 6 6.08E-19
9 SGTC_1803 st050068 8.54 52.4 µM 1.94E-17 NEO1-PIK1 32 6.77E-18
10 SGTC_2016 5121758 7.64 140.0 µM 2.49E-14 redox potentiating 6 1.09E-14
11 SGTC_839 0122-0028 7.46 230.0 µM 9.73E-14 RSC complex & mRNA processing 2 4.44E-14
12 SGTC_2323 6148992 6.91 148.3 µM 4.80E-12 5 2.48E-12
13 SGTC_2619 obliquin 6.89 87.9 µM 5.45E-12 cell wall 61 2.82E-12
14 SGTC_3331 9141060 6.88 2.0 µM 5.88E-12 cell wall 7 3.05E-12
15 SGTC_2129 girgensonine 6.86 121.0 µM 6.51E-12 heme biosynthesis & mitochondrial translocase 8 3.39E-12
16 SGTC_1800 st050079 6.75 29.1 µM 1.39E-11 NEO1-PIK1 29 7.41E-12
17 SGTC_157 1348-1695 6.66 65.8 µM 2.56E-11 iron homeostasis 18 1.39E-11
18 SGTC_1801 st050089 6.62 28.4 µM 3.31E-11 NEO1-PIK1 42 1.81E-11
19 SGTC_951 1171-0579 6.47 82.7 µM 8.74E-11 cell wall 27 4.93E-11
20 SGTC_2696 st077691 6.33 74.3 µM 2.15E-10 4 1.25E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.503 4.82E-215 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.435 7.67E-155 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.427 4.98E-149 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.422 2.28E-145 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.409 9.98E-136 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.403 6.41E-131 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.373 1.35E-111 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.370 1.17E-109 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.367 8.78E-108 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
0.351 9.82E-98 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.351 9.17E-98 YNL233W BNI4 hom Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
0.350 1.47E-97 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.347 2.01E-95 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.346 3.28E-95 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.341 4.99E-92 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB