YLL044W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL044W / YLL044W

Click on Significant Values for Screen Details ID:SGTC_106|Compound:0092-0003|FD-Score:-3.76|P-value:2.21E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:-3.74|P-value:2.35E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:-4.76|P-value:3.86E-6 ID:SGTC_114|Compound:0364-0001|FD-Score:4.31|P-value:1.30E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:5.39|P-value:8.13E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:10.10|P-value:6.79E-23 ID:SGTC_123|Compound:0083-0120|FD-Score:5.70|P-value:1.56E-8 ID:SGTC_130|Compound:0136-0219|FD-Score:4.05|P-value:3.86E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:6.37|P-value:3.24E-10 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.69|P-value:2.78E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.18|P-value:8.82E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.37|P-value:1.03E-5 ID:SGTC_480|Compound:am 92016|FD-Score:-3.45|P-value:6.33E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.70|P-value:1.45E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.20|P-value:8.48E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:4.91|P-value:8.59E-7 ID:SGTC_655|Compound:k060-0012|FD-Score:3.31|P-value:5.75E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-7.39|P-value:1.34E-12 ID:SGTC_753|Compound:1322-0200|FD-Score:3.24|P-value:7.43E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.11|P-value:7.61E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:3.66|P-value:1.70E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:4.46|P-value:6.77E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:-7.67|P-value:1.97E-13 ID:SGTC_1044|Compound:1222-0021|FD-Score:-5.05|P-value:9.86E-7 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.36|P-value:4.89E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-4.14|P-value:5.12E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.40|P-value:4.25E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.01|P-value:8.51E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.16|P-value:2.45E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:-4.29|P-value:2.90E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-7.02|P-value:1.57E-11 ID:SGTC_1626|Compound:st003712|FD-Score:-3.46|P-value:6.25E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.84|P-value:8.74E-5 ID:SGTC_1724|Compound:st037281|FD-Score:3.84|P-value:8.50E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.21|P-value:8.06E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.22|P-value:7.80E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.19|P-value:8.71E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.29|P-value:6.30E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.61|P-value:2.04E-4 ID:SGTC_1849|Compound:st056239|FD-Score:4.26|P-value:1.59E-5 ID:SGTC_1852|Compound:st056254|FD-Score:-6.25|P-value:1.78E-9 ID:SGTC_1889|Compound:st059080|FD-Score:3.54|P-value:2.64E-4 ID:SGTC_1960|Compound:st011366|FD-Score:4.21|P-value:1.96E-5 ID:SGTC_2133|Compound:5320837|FD-Score:3.35|P-value:5.03E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.38|P-value:9.48E-6 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-4.82|P-value:2.87E-6 ID:SGTC_2261|Compound:9010538|FD-Score:-4.26|P-value:3.18E-5 ID:SGTC_2333|Compound:9017922|FD-Score:3.82|P-value:9.36E-5 ID:SGTC_2335|Compound:9018011|FD-Score:4.73|P-value:2.04E-6 ID:SGTC_2404|Compound:5161160|FD-Score:-4.14|P-value:5.23E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:10.10|P-value:6.38E-23 ID:SGTC_2482|Compound:5981709|FD-Score:-3.83|P-value:1.68E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.61|P-value:2.07E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.17|P-value:4.70E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.88|P-value:7.47E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.71|P-value:1.42E-4 ID:SGTC_2826|Compound:7992541|FD-Score:4.41|P-value:8.48E-6 ID:SGTC_2850|Compound:9015429|FD-Score:-7.23|P-value:3.92E-12 ID:SGTC_2853|Compound:9015042|FD-Score:6.66|P-value:5.54E-11 ID:SGTC_2855|Compound:9016525|FD-Score:12.00|P-value:2.48E-31 ID:SGTC_2887|Compound:9044784|FD-Score:3.30|P-value:5.92E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.40|P-value:4.30E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.35|P-value:8.89E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.48|P-value:6.31E-6 ID:SGTC_3216|Compound:9129716|FD-Score:3.83|P-value:9.06E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-5.82|P-value:2.04E-8 ID:SGTC_3224|Compound:9130643|FD-Score:8.67|P-value:2.67E-17 ID:SGTC_3240|Compound:9133527|FD-Score:4.21|P-value:2.01E-5 ID:SGTC_3305|Compound:9127027|FD-Score:3.27|P-value:6.67E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.27|P-value:6.65E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.61|P-value:2.03E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.53|P-value:4.85E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.74|P-value:1.25E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:-3.76|P-value:2.21E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:-3.74|P-value:2.35E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:-4.76|P-value:3.86E-6 ID:SGTC_114|Compound:0364-0001|FD-Score:4.31|P-value:1.30E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:5.39|P-value:8.13E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:10.10|P-value:6.79E-23 ID:SGTC_123|Compound:0083-0120|FD-Score:5.70|P-value:1.56E-8 ID:SGTC_130|Compound:0136-0219|FD-Score:4.05|P-value:3.86E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:6.37|P-value:3.24E-10 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.69|P-value:2.78E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.18|P-value:8.82E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.37|P-value:1.03E-5 ID:SGTC_480|Compound:am 92016|FD-Score:-3.45|P-value:6.33E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.70|P-value:1.45E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.20|P-value:8.48E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:4.91|P-value:8.59E-7 ID:SGTC_655|Compound:k060-0012|FD-Score:3.31|P-value:5.75E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-7.39|P-value:1.34E-12 ID:SGTC_753|Compound:1322-0200|FD-Score:3.24|P-value:7.43E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.11|P-value:7.61E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:3.66|P-value:1.70E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:4.46|P-value:6.77E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:-7.67|P-value:1.97E-13 ID:SGTC_1044|Compound:1222-0021|FD-Score:-5.05|P-value:9.86E-7 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.36|P-value:4.89E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-4.14|P-value:5.12E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.40|P-value:4.25E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.01|P-value:8.51E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.16|P-value:2.45E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:-4.29|P-value:2.90E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-7.02|P-value:1.57E-11 ID:SGTC_1626|Compound:st003712|FD-Score:-3.46|P-value:6.25E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.84|P-value:8.74E-5 ID:SGTC_1724|Compound:st037281|FD-Score:3.84|P-value:8.50E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.21|P-value:8.06E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.22|P-value:7.80E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.19|P-value:8.71E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.29|P-value:6.30E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.61|P-value:2.04E-4 ID:SGTC_1849|Compound:st056239|FD-Score:4.26|P-value:1.59E-5 ID:SGTC_1852|Compound:st056254|FD-Score:-6.25|P-value:1.78E-9 ID:SGTC_1889|Compound:st059080|FD-Score:3.54|P-value:2.64E-4 ID:SGTC_1960|Compound:st011366|FD-Score:4.21|P-value:1.96E-5 ID:SGTC_2133|Compound:5320837|FD-Score:3.35|P-value:5.03E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.38|P-value:9.48E-6 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-4.82|P-value:2.87E-6 ID:SGTC_2261|Compound:9010538|FD-Score:-4.26|P-value:3.18E-5 ID:SGTC_2333|Compound:9017922|FD-Score:3.82|P-value:9.36E-5 ID:SGTC_2335|Compound:9018011|FD-Score:4.73|P-value:2.04E-6 ID:SGTC_2404|Compound:5161160|FD-Score:-4.14|P-value:5.23E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:10.10|P-value:6.38E-23 ID:SGTC_2482|Compound:5981709|FD-Score:-3.83|P-value:1.68E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.61|P-value:2.07E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.17|P-value:4.70E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.88|P-value:7.47E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.71|P-value:1.42E-4 ID:SGTC_2826|Compound:7992541|FD-Score:4.41|P-value:8.48E-6 ID:SGTC_2850|Compound:9015429|FD-Score:-7.23|P-value:3.92E-12 ID:SGTC_2853|Compound:9015042|FD-Score:6.66|P-value:5.54E-11 ID:SGTC_2855|Compound:9016525|FD-Score:12.00|P-value:2.48E-31 ID:SGTC_2887|Compound:9044784|FD-Score:3.30|P-value:5.92E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.40|P-value:4.30E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.35|P-value:8.89E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.48|P-value:6.31E-6 ID:SGTC_3216|Compound:9129716|FD-Score:3.83|P-value:9.06E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-5.82|P-value:2.04E-8 ID:SGTC_3224|Compound:9130643|FD-Score:8.67|P-value:2.67E-17 ID:SGTC_3240|Compound:9133527|FD-Score:4.21|P-value:2.01E-5 ID:SGTC_3305|Compound:9127027|FD-Score:3.27|P-value:6.67E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.27|P-value:6.65E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.61|P-value:2.03E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.53|P-value:4.85E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.74|P-value:1.25E-4

Top fitness defect scores for YLL044W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2855 9016525 12.00 58.4 µM 2.48E-31 1 1.37E-33
2 SGTC_2407 paclitaxel 10.10 400.0 µM 6.38E-23 2 1.77E-24
3 SGTC_118 0083-0097 10.10 135.3 µM 6.79E-23 translation 1 1.89E-24
4 SGTC_3224 9130643 8.67 49.5 µM 2.67E-17 RPP1 & pyrimidine depletion 2 2.13E-18
5 SGTC_2853 9015042 6.66 58.4 µM 5.54E-11 3 1.39E-11
6 SGTC_140 0062-0056 6.37 502.5 µM 3.24E-10 2 9.32E-11
7 SGTC_123 0083-0120 5.70 66.7 µM 1.56E-8 22 6.03E-9
8 SGTC_117 lucigenin 5.39 22.1 µM 8.13E-8 redox potentiating 49 3.54E-8
9 SGTC_541 4513-1321 4.91 94.0 µM 8.59E-7 9 4.44E-7
10 SGTC_2335 9018011 4.73 154.2 µM 2.04E-6 17 1.12E-6
11 SGTC_3214 9129694 4.48 49.5 µM 6.31E-6 13 3.75E-6
12 SGTC_853 0419-0306 4.46 21.0 µM 6.77E-6 7 4.05E-6
13 SGTC_2826 7992541 4.41 19.5 µM 8.48E-6 11 5.15E-6
14 SGTC_2183 6420625 4.38 130.5 µM 9.48E-6 mitochondrial processes 39 5.80E-6
15 SGTC_439 amiodarone 4.37 34.4 µM 1.03E-5 NEO1-PIK1 81 6.31E-6
16 SGTC_114 0364-0001 4.31 490.3 µM 1.30E-5 37 8.15E-6
17 SGTC_1849 st056239 4.26 19.2 µM 1.59E-5 RPP1 & pyrimidine depletion 19 1.01E-5
18 SGTC_1960 st011366 4.21 51.8 µM 1.96E-5 6 1.26E-5
19 SGTC_3240 9133527 4.21 49.5 µM 2.01E-5 9 1.30E-5
20 SGTC_1357 1503-1303 4.16 39.5 µM 2.45E-5 24 1.60E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.04E-18 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.134 6.58E-15 YLR402W_d YLR402W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.120 2.64E-12 YMR097C MTG1 hom Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
0.117 9.63E-12 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.116 1.41E-11 YMR158W MRPS8 hom Mitochondrial ribosomal protein of the small subunit
0.115 2.01E-11 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.113 5.09E-11 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.111 1.01E-10 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.107 4.64E-10 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.106 7.67E-10 YDR241W_d BUD26_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.103 2.45E-9 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.100 5.49E-9 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.099 8.54E-9 YER131W RPS26B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication
0.097 1.78E-8 YKR092C SRP40 hom Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
0.097 1.80E-8 YCR015C_p YCR015C_p hom Putative protein of unknown function; YCR015C is not an essential gene