YLL048C / YBT1

Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL048C / YBT1

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.28|P-value:3.05E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:25.80|P-value:4.63E-163 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.32|P-value:2.59E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.21|P-value:3.88E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.32|P-value:2.59E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.24|P-value:4.51E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:3.41|P-value:1.79E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.40|P-value:1.90E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.87|P-value:2.59E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:3.62|P-value:7.53E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:3.34|P-value:2.40E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.15|P-value:4.16E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:8.43|P-value:4.28E-19 ID:SGTC_966|Compound:1300-0360|FD-Score:3.02|P-value:7.93E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.99|P-value:1.44E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.49|P-value:1.28E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.41|P-value:1.47E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.61|P-value:7.94E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.41|P-value:1.47E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.35|P-value:1.93E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.51|P-value:1.13E-6 ID:SGTC_1271|Compound:0832-2808|FD-Score:4.35|P-value:2.52E-6 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.40|P-value:1.90E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.14|P-value:5.10E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.91|P-value:2.13E-5 ID:SGTC_1748|Compound:st037455|FD-Score:3.35|P-value:2.31E-4 ID:SGTC_1770|Compound:st043884|FD-Score:-3.20|P-value:3.42E-4 ID:SGTC_1772|Compound:st048439|FD-Score:-3.12|P-value:4.62E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-3.20|P-value:3.42E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.56|P-value:9.64E-5 ID:SGTC_1796|Compound:st049173|FD-Score:3.08|P-value:6.38E-4 ID:SGTC_1816|Compound:st051957|FD-Score:3.31|P-value:2.72E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.18|P-value:6.10E-6 ID:SGTC_1908|Compound:st060353|FD-Score:3.07|P-value:6.69E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.17|P-value:3.89E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-5.87|P-value:2.72E-10 ID:SGTC_2168|Compound:5727979|FD-Score:-3.31|P-value:2.21E-4 ID:SGTC_2185|Compound:6113692|FD-Score:5.19|P-value:2.57E-8 ID:SGTC_2343|Compound:7990716|FD-Score:-3.57|P-value:7.62E-5 ID:SGTC_2381|Compound:9035592|FD-Score:-2.98|P-value:7.74E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-3.78|P-value:3.10E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.35|P-value:2.27E-4 ID:SGTC_2570|Compound:licareol|FD-Score:4.40|P-value:1.97E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.53|P-value:1.10E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.22|P-value:3.83E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.04|P-value:7.33E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:5.68|P-value:1.26E-9 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-4.14|P-value:5.72E-6 ID:SGTC_2779|Compound:methotrexate|FD-Score:27.20|P-value:1.69E-180 ID:SGTC_2922|Compound:7999257|FD-Score:4.21|P-value:5.21E-6 ID:SGTC_3020|Compound:9089140|FD-Score:3.57|P-value:9.33E-5 ID:SGTC_3031|Compound:9088762|FD-Score:3.76|P-value:4.19E-5 ID:SGTC_3035|Compound:9091303|FD-Score:3.10|P-value:6.01E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.90|P-value:2.18E-5 ID:SGTC_3086|Compound:9117350|FD-Score:3.62|P-value:7.57E-5 ID:SGTC_3133|Compound:9127736|FD-Score:3.56|P-value:9.60E-5 ID:SGTC_3136|Compound:9095672|FD-Score:3.70|P-value:5.45E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-2.93|P-value:9.20E-4 ID:SGTC_3195|Compound:9113082|FD-Score:4.41|P-value:1.95E-6 ID:SGTC_3199|Compound:9111318|FD-Score:3.95|P-value:1.79E-5 ID:SGTC_3218|Compound:9131285|FD-Score:3.83|P-value:2.99E-5 ID:SGTC_3271|Compound:9137798|FD-Score:3.09|P-value:6.07E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.34|P-value:1.96E-4 ID:SGTC_3340|Compound:9146634|FD-Score:2.99|P-value:8.75E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:3.28|P-value:3.05E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:25.80|P-value:4.63E-163 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.32|P-value:2.59E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.21|P-value:3.88E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.32|P-value:2.59E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.24|P-value:4.51E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:3.41|P-value:1.79E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.40|P-value:1.90E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.87|P-value:2.59E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:3.62|P-value:7.53E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:3.34|P-value:2.40E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.15|P-value:4.16E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:8.43|P-value:4.28E-19 ID:SGTC_966|Compound:1300-0360|FD-Score:3.02|P-value:7.93E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.99|P-value:1.44E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.49|P-value:1.28E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.41|P-value:1.47E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.61|P-value:7.94E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.41|P-value:1.47E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.35|P-value:1.93E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.51|P-value:1.13E-6 ID:SGTC_1271|Compound:0832-2808|FD-Score:4.35|P-value:2.52E-6 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.40|P-value:1.90E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.14|P-value:5.10E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.91|P-value:2.13E-5 ID:SGTC_1748|Compound:st037455|FD-Score:3.35|P-value:2.31E-4 ID:SGTC_1770|Compound:st043884|FD-Score:-3.20|P-value:3.42E-4 ID:SGTC_1772|Compound:st048439|FD-Score:-3.12|P-value:4.62E-4 ID:SGTC_1777|Compound:st045864|FD-Score:-3.20|P-value:3.42E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.56|P-value:9.64E-5 ID:SGTC_1796|Compound:st049173|FD-Score:3.08|P-value:6.38E-4 ID:SGTC_1816|Compound:st051957|FD-Score:3.31|P-value:2.72E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:4.18|P-value:6.10E-6 ID:SGTC_1908|Compound:st060353|FD-Score:3.07|P-value:6.69E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.17|P-value:3.89E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-5.87|P-value:2.72E-10 ID:SGTC_2168|Compound:5727979|FD-Score:-3.31|P-value:2.21E-4 ID:SGTC_2185|Compound:6113692|FD-Score:5.19|P-value:2.57E-8 ID:SGTC_2343|Compound:7990716|FD-Score:-3.57|P-value:7.62E-5 ID:SGTC_2381|Compound:9035592|FD-Score:-2.98|P-value:7.74E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-3.78|P-value:3.10E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.35|P-value:2.27E-4 ID:SGTC_2570|Compound:licareol|FD-Score:4.40|P-value:1.97E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.53|P-value:1.10E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.22|P-value:3.83E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.04|P-value:7.33E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:5.68|P-value:1.26E-9 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-4.14|P-value:5.72E-6 ID:SGTC_2779|Compound:methotrexate|FD-Score:27.20|P-value:1.69E-180 ID:SGTC_2922|Compound:7999257|FD-Score:4.21|P-value:5.21E-6 ID:SGTC_3020|Compound:9089140|FD-Score:3.57|P-value:9.33E-5 ID:SGTC_3031|Compound:9088762|FD-Score:3.76|P-value:4.19E-5 ID:SGTC_3035|Compound:9091303|FD-Score:3.10|P-value:6.01E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.90|P-value:2.18E-5 ID:SGTC_3086|Compound:9117350|FD-Score:3.62|P-value:7.57E-5 ID:SGTC_3133|Compound:9127736|FD-Score:3.56|P-value:9.60E-5 ID:SGTC_3136|Compound:9095672|FD-Score:3.70|P-value:5.45E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-2.93|P-value:9.20E-4 ID:SGTC_3195|Compound:9113082|FD-Score:4.41|P-value:1.95E-6 ID:SGTC_3199|Compound:9111318|FD-Score:3.95|P-value:1.79E-5 ID:SGTC_3218|Compound:9131285|FD-Score:3.83|P-value:2.99E-5 ID:SGTC_3271|Compound:9137798|FD-Score:3.09|P-value:6.07E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.34|P-value:1.96E-4 ID:SGTC_3340|Compound:9146634|FD-Score:2.99|P-value:8.75E-4

Top fitness defect scores for YLL048C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2779 methotrexate 27.20 400.0 µM 1.69E-180 1 3.98E-163
2 SGTC_245 methotrexate 25.80 289.6 µM 4.63E-163 1 2.12E-147
3 SGTC_962 1254-0300 8.43 21.5 µM 4.28E-19 2 1.78E-17
4 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 5.68 100.0 µM 1.26E-9 5 6.70E-9
5 SGTC_2185 6113692 5.19 200.0 µM 2.57E-8 ergosterol biosynthesis 2 1.03E-7
6 SGTC_1205 4161-2785 4.51 76.0 µM 1.13E-6 16 3.22E-6
7 SGTC_3195 9113082 4.41 49.5 µM 1.95E-6 9 5.27E-6
8 SGTC_2570 licareol 4.40 100.0 µM 1.97E-6 19 5.33E-6
9 SGTC_1271 0832-2808 4.35 169.0 µM 2.52E-6 5 6.66E-6
10 SGTC_670 4204-0025 4.24 119.0 µM 4.51E-6 copper-dependent oxidative stress 25 1.13E-5
11 SGTC_2922 7999257 4.21 32.5 µM 5.21E-6 9 1.29E-5
12 SGTC_1823 3-hydroxy-2-naphthoic acid 4.18 106.0 µM 6.10E-6 11 1.49E-5
13 SGTC_1015 4130-4525 3.99 82.0 µM 1.44E-5 60S ribosome export 19 3.24E-5
14 SGTC_3199 9111318 3.95 49.5 µM 1.79E-5 20 3.96E-5
15 SGTC_1727 st034309 3.91 9.9 µM 2.13E-5 41 4.63E-5
16 SGTC_3045 9092950 3.90 49.5 µM 2.18E-5 16 4.73E-5
17 SGTC_753 1322-0200 3.87 289.0 µM 2.59E-5 25 5.54E-5
18 SGTC_3218 9131285 3.83 49.5 µM 2.99E-5 endomembrane recycling 51 6.32E-5
19 SGTC_3031 9088762 3.76 49.5 µM 4.19E-5 27 8.59E-5
20 SGTC_3136 9095672 3.70 49.5 µM 5.45E-5 31 1.09E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.509 6.94E-221 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.506 5.47E-218 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.307 3.37E-74 YER056C FCY2 hom Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress
0.272 7.36E-58 YNL256W FOL1 het Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
0.256 1.87E-51 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.245 3.58E-47 YPL195W APL5 hom Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function
0.228 1.13E-40 YBR252W DUT1 het deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate
0.219 1.01E-37 YDR399W HPT1 hom Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
0.191 5.25E-29 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.186 1.25E-27 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.182 1.76E-26 YLL047W_d YLL047W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1
0.180 9.85E-26 YER091C MET6 hom Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
0.178 2.82E-25 YDL145C COP1 het Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
0.175 2.15E-24 YER123W YCK3 hom Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway
0.173 6.28E-24 YIR039C YPS6 hom Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance