Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLL049W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.169 | 4.93E-23 | YKR031C | SPO14 | hom | Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions |
0.152 | 7.24E-19 | YBR285W_p | YBR285W_p | hom | Putative protein of unknown function; YBR285W is not an essential gene |
0.105 | 9.32E-10 | YDL068W_d | YDL068W_d | hom | Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data |
0.102 | 3.59E-9 | YMR079W | SEC14 | het | Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs |
0.101 | 4.34E-9 | YLR057W | MNL2 | hom | Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene |
0.100 | 7.11E-9 | YHR209W | CRG1 | hom | S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin |
0.096 | 2.18E-8 | YJR118C | ILM1 | hom | Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth |
0.096 | 2.22E-8 | YDR393W | SHE9 | hom | Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex |
0.090 | 2.02E-7 | YDR524C | AGE1 | hom | ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif |
0.089 | 2.68E-7 | YGL045W | RIM8 | hom | Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family |
0.087 | 3.97E-7 | YPR040W | TIP41 | hom | Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress |
0.087 | 4.25E-7 | YCL054W | SPB1 | het | AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants |
0.087 | 4.90E-7 | YKL183W | LOT5 | hom | Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress |
0.086 | 5.90E-7 | YLR350W | ORM2 | hom | Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress |
0.085 | 7.87E-7 | YOR245C | DGA1 | hom | Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles |