YLL052C / AQY2

Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL052C / AQY2

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.47|P-value:5.30E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.60|P-value:3.46E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-4.59|P-value:9.73E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.96|P-value:1.16E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.44|P-value:7.04E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.10|P-value:7.00E-5 ID:SGTC_622|Compound:1348-1566|FD-Score:-3.83|P-value:1.84E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.51|P-value:4.62E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.63|P-value:3.08E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.61|P-value:3.29E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.32|P-value:8.58E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.49|P-value:4.91E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:4.92|P-value:1.78E-6 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.82|P-value:1.92E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.20|P-value:3.80E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:-4.06|P-value:8.01E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:-4.83|P-value:3.55E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.33|P-value:2.87E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.03|P-value:9.02E-5 ID:SGTC_1486|Compound:3970-0793|FD-Score:5.52|P-value:1.06E-7 ID:SGTC_1487|Compound:3970-0795|FD-Score:-3.57|P-value:4.50E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-4.01|P-value:9.59E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.98|P-value:1.07E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-4.54|P-value:1.22E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.30|P-value:9.31E-4 ID:SGTC_1990|Compound:st072050|FD-Score:4.98|P-value:1.37E-6 ID:SGTC_1992|Compound:st073643|FD-Score:3.43|P-value:6.10E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.74|P-value:2.55E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.45|P-value:5.67E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.28|P-value:9.71E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-3.64|P-value:3.58E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-4.52|P-value:1.32E-5 ID:SGTC_2477|Compound:5967686|FD-Score:-3.39|P-value:8.17E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.21|P-value:4.54E-5 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.69|P-value:2.49E-4 ID:SGTC_2695|Compound:st077686|FD-Score:4.69|P-value:5.06E-6 ID:SGTC_2956|Compound:9076196|FD-Score:3.29|P-value:9.52E-4 ID:SGTC_2967|Compound:9089538|FD-Score:-4.70|P-value:6.24E-6 ID:SGTC_2973|Compound:9094665|FD-Score:-3.89|P-value:1.48E-4 ID:SGTC_2979|Compound:9012552|FD-Score:3.81|P-value:1.65E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.40|P-value:6.64E-4 ID:SGTC_3053|Compound:9095903|FD-Score:3.37|P-value:7.24E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.67|P-value:2.71E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.42|P-value:6.17E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.47|P-value:5.30E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.60|P-value:3.46E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-4.59|P-value:9.73E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.96|P-value:1.16E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.44|P-value:7.04E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.10|P-value:7.00E-5 ID:SGTC_622|Compound:1348-1566|FD-Score:-3.83|P-value:1.84E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.51|P-value:4.62E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.63|P-value:3.08E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.61|P-value:3.29E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.32|P-value:8.58E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.49|P-value:4.91E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:4.92|P-value:1.78E-6 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.82|P-value:1.92E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.20|P-value:3.80E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:-4.06|P-value:8.01E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:-4.83|P-value:3.55E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.33|P-value:2.87E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.03|P-value:9.02E-5 ID:SGTC_1486|Compound:3970-0793|FD-Score:5.52|P-value:1.06E-7 ID:SGTC_1487|Compound:3970-0795|FD-Score:-3.57|P-value:4.50E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-4.01|P-value:9.59E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.98|P-value:1.07E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-4.54|P-value:1.22E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.30|P-value:9.31E-4 ID:SGTC_1990|Compound:st072050|FD-Score:4.98|P-value:1.37E-6 ID:SGTC_1992|Compound:st073643|FD-Score:3.43|P-value:6.10E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.74|P-value:2.55E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.45|P-value:5.67E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.28|P-value:9.71E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-3.64|P-value:3.58E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-4.52|P-value:1.32E-5 ID:SGTC_2477|Compound:5967686|FD-Score:-3.39|P-value:8.17E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.21|P-value:4.54E-5 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.69|P-value:2.49E-4 ID:SGTC_2695|Compound:st077686|FD-Score:4.69|P-value:5.06E-6 ID:SGTC_2956|Compound:9076196|FD-Score:3.29|P-value:9.52E-4 ID:SGTC_2967|Compound:9089538|FD-Score:-4.70|P-value:6.24E-6 ID:SGTC_2973|Compound:9094665|FD-Score:-3.89|P-value:1.48E-4 ID:SGTC_2979|Compound:9012552|FD-Score:3.81|P-value:1.65E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.40|P-value:6.64E-4 ID:SGTC_3053|Compound:9095903|FD-Score:3.37|P-value:7.24E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.67|P-value:2.71E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.42|P-value:6.17E-4

Top fitness defect scores for YLL052C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1486 3970-0793 5.52 4.5 µM 1.06E-7 3 1.73E-8
2 SGTC_1990 st072050 4.98 59.8 µM 1.37E-6 3 3.15E-7
3 SGTC_966 1300-0360 4.92 30.2 µM 1.78E-6 heme requiring 9 4.24E-7
4 SGTC_2695 st077686 4.69 52.0 µM 5.06E-6 18 1.38E-6
5 SGTC_1149 3909-7961 4.20 23.3 µM 3.80E-5 13 1.34E-5
6 SGTC_2979 9012552 3.81 45.5 µM 1.65E-4 10 7.00E-5
7 SGTC_2587 piperic acid 3.69 92.2 µM 2.49E-4 28 1.11E-4
8 SGTC_3057 9095946 3.67 49.5 µM 2.71E-4 Golgi 20 1.22E-4
9 SGTC_640 3381-0960 3.63 37.1 µM 3.08E-4 21 1.41E-4
10 SGTC_811 0416-0114 3.61 265.0 µM 3.29E-4 36 1.52E-4
11 SGTC_94 0334-0113 3.60 514.8 µM 3.46E-4 31 1.61E-4
12 SGTC_633 0437-0093 3.51 97.7 µM 4.62E-4 DNA intercalators 23 2.23E-4
13 SGTC_963 1269-2853 3.49 151.0 µM 4.91E-4 39 2.39E-4
14 SGTC_6 0844-0013 3.47 19.8 µM 5.30E-4 142 2.60E-4
15 SGTC_2018 5133068 3.45 143.0 µM 5.67E-4 37 2.81E-4
16 SGTC_1992 st073643 3.43 23.3 µM 6.10E-4 mitochondrial processes 18 3.05E-4
17 SGTC_3134 9127454 3.42 49.5 µM 6.17E-4 22 3.09E-4
18 SGTC_2984 9022109 3.40 39.0 µM 6.64E-4 18 3.35E-4
19 SGTC_3053 9095903 3.37 49.5 µM 7.24E-4 Golgi 10 3.70E-4
20 SGTC_961 1252-1571 3.32 372.0 µM 8.58E-4 51 4.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 8.61E-23 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.158 2.90E-20 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.156 9.66E-20 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.142 1.41E-16 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.139 5.58E-16 YLR054C OSW2 hom Protein of unknown function proposed to be involved in the assembly of the spore wall
0.137 2.22E-15 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.136 2.72E-15 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.136 2.96E-15 YMR137C PSO2 hom Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress
0.135 4.52E-15 YKL128C PMU1 hom Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
0.133 1.21E-14 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.131 2.26E-14 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.130 4.38E-14 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.125 5.13E-13 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.124 6.31E-13 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.123 8.40E-13 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p