YLL053C_p

Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL053C / YLL053C

Click on Significant Values for Screen Details ID:SGTC_300|Compound:r073-0011|FD-Score:3.52|P-value:7.27E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:4.25|P-value:2.29E-6 ID:SGTC_307|Compound:1501-1223|FD-Score:3.28|P-value:2.06E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.03|P-value:5.79E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:4.79|P-value:1.25E-7 ID:SGTC_455|Compound:paf C-16|FD-Score:3.22|P-value:2.63E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.32|P-value:1.73E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.56|P-value:6.08E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:3.76|P-value:2.55E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:4.02|P-value:7.39E-6 ID:SGTC_651|Compound:3253-0966|FD-Score:3.02|P-value:5.61E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:2.89|P-value:9.10E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-2.97|P-value:7.14E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:3.02|P-value:5.52E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.07|P-value:4.62E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:6.63|P-value:4.56E-13 ID:SGTC_895|Compound:0964-0006|FD-Score:3.22|P-value:2.58E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.51|P-value:7.87E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:5.61|P-value:7.64E-10 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.06|P-value:4.77E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.30|P-value:1.83E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.87|P-value:1.53E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:2.99|P-value:6.32E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.27|P-value:2.09E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:2.97|P-value:6.69E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.50|P-value:8.79E-5 ID:SGTC_1605|Compound:st000082|FD-Score:4.49|P-value:6.39E-7 ID:SGTC_1999|Compound:st074831|FD-Score:3.66|P-value:3.96E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-3.82|P-value:2.08E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.18|P-value:2.98E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.53|P-value:7.17E-5 ID:SGTC_2166|Compound:5933061|FD-Score:4.17|P-value:3.42E-6 ID:SGTC_2243|Compound:6634756|FD-Score:4.35|P-value:1.41E-6 ID:SGTC_2273|Compound:7815444|FD-Score:3.34|P-value:1.55E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.02|P-value:5.53E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-3.85|P-value:1.84E-5 ID:SGTC_2371|Compound:9071574|FD-Score:3.57|P-value:5.92E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.04|P-value:6.74E-6 ID:SGTC_2455|Compound:5377712|FD-Score:3.01|P-value:5.90E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.90|P-value:1.44E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.90|P-value:6.49E-8 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.68|P-value:2.51E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.97|P-value:9.40E-6 ID:SGTC_2953|Compound:9074162|FD-Score:3.33|P-value:1.64E-4 ID:SGTC_2988|Compound:9073640|FD-Score:2.93|P-value:7.87E-4 ID:SGTC_3007|Compound:9078383|FD-Score:4.06|P-value:6.09E-6 ID:SGTC_3044|Compound:9093193|FD-Score:2.95|P-value:7.20E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.07|P-value:4.64E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.10|P-value:4.20E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.38|P-value:1.42E-4 ID:SGTC_3286|Compound:9117135|FD-Score:2.87|P-value:9.90E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.02|P-value:5.97E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.52|P-value:7.27E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:4.25|P-value:2.29E-6 ID:SGTC_307|Compound:1501-1223|FD-Score:3.28|P-value:2.06E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.03|P-value:5.79E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:4.79|P-value:1.25E-7 ID:SGTC_455|Compound:paf C-16|FD-Score:3.22|P-value:2.63E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.32|P-value:1.73E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.56|P-value:6.08E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:3.76|P-value:2.55E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:4.02|P-value:7.39E-6 ID:SGTC_651|Compound:3253-0966|FD-Score:3.02|P-value:5.61E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:2.89|P-value:9.10E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-2.97|P-value:7.14E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:3.02|P-value:5.52E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.07|P-value:4.62E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:6.63|P-value:4.56E-13 ID:SGTC_895|Compound:0964-0006|FD-Score:3.22|P-value:2.58E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.51|P-value:7.87E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:5.61|P-value:7.64E-10 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.06|P-value:4.77E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.30|P-value:1.83E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.87|P-value:1.53E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:2.99|P-value:6.32E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.27|P-value:2.09E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:2.97|P-value:6.69E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.50|P-value:8.79E-5 ID:SGTC_1605|Compound:st000082|FD-Score:4.49|P-value:6.39E-7 ID:SGTC_1999|Compound:st074831|FD-Score:3.66|P-value:3.96E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-3.82|P-value:2.08E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.18|P-value:2.98E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.53|P-value:7.17E-5 ID:SGTC_2166|Compound:5933061|FD-Score:4.17|P-value:3.42E-6 ID:SGTC_2243|Compound:6634756|FD-Score:4.35|P-value:1.41E-6 ID:SGTC_2273|Compound:7815444|FD-Score:3.34|P-value:1.55E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.02|P-value:5.53E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-3.85|P-value:1.84E-5 ID:SGTC_2371|Compound:9071574|FD-Score:3.57|P-value:5.92E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.04|P-value:6.74E-6 ID:SGTC_2455|Compound:5377712|FD-Score:3.01|P-value:5.90E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.90|P-value:1.44E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.90|P-value:6.49E-8 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.68|P-value:2.51E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.97|P-value:9.40E-6 ID:SGTC_2953|Compound:9074162|FD-Score:3.33|P-value:1.64E-4 ID:SGTC_2988|Compound:9073640|FD-Score:2.93|P-value:7.87E-4 ID:SGTC_3007|Compound:9078383|FD-Score:4.06|P-value:6.09E-6 ID:SGTC_3044|Compound:9093193|FD-Score:2.95|P-value:7.20E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.07|P-value:4.64E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.10|P-value:4.20E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.38|P-value:1.42E-4 ID:SGTC_3286|Compound:9117135|FD-Score:2.87|P-value:9.90E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.02|P-value:5.97E-4

Top fitness defect scores for YLL053C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_833 3852-0053 6.63 558.0 µM 4.56E-13 1 1.64E-11
2 SGTC_1118 chelidonine 5.61 707.5 nM 7.64E-10 3 1.02E-8
3 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 4.90 92.6 µM 6.49E-8 12 4.79E-7
4 SGTC_375 3970-0961 4.79 9.3 µM 1.25E-7 tubulin folding & SWR complex 9 8.49E-7
5 SGTC_1605 st000082 4.49 49.1 µM 6.39E-7 60S ribosome export 7 3.49E-6
6 SGTC_2243 6634756 4.35 200.0 µM 1.41E-6 16 6.93E-6
7 SGTC_303 1348-1668 4.25 34.2 µM 2.29E-6 6 1.06E-5
8 SGTC_2166 5933061 4.17 31.5 µM 3.42E-6 tubulin folding & SWR complex 35 1.49E-5
9 SGTC_3007 9078383 4.06 71.4 µM 6.09E-6 13 2.47E-5
10 SGTC_2420 aureobasidin a 4.04 50.0 nM 6.74E-6 40 2.69E-5
11 SGTC_551 k048-0028 4.02 34.9 µM 7.39E-6 13 2.92E-5
12 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.97 70.0 µM 9.40E-6 redox potentiating 72 3.60E-5
13 SGTC_1388 3346-4487 3.87 254.0 µM 1.53E-5 30 5.51E-5
14 SGTC_534 k292-0788 3.76 63.4 µM 2.55E-5 mitochondrial processes 33 8.57E-5
15 SGTC_1999 st074831 3.66 12.5 µM 3.96E-5 plasma membrane duress 41 1.25E-4
16 SGTC_2371 9071574 3.57 200.0 µM 5.92E-5 17 1.78E-4
17 SGTC_531 3788-1495 3.56 174.0 µM 6.08E-5 unfolded protein response 27 1.82E-4
18 SGTC_2102 5377816 3.53 72.8 µM 7.17E-5 34 2.10E-4
19 SGTC_300 r073-0011 3.52 5.0 µM 7.27E-5 33 2.13E-4
20 SGTC_980 1473-0395 3.51 201.0 µM 7.87E-5 19 2.28E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 6.93E-11 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.105 9.21E-10 YIR020C_p YIR020C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.096 2.29E-8 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.095 3.69E-8 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.089 2.54E-7 YJL091C GWT1 het Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors
0.088 2.97E-7 YOR313C SPS4 hom Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
0.083 1.37E-6 YML090W_d YML090W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
0.081 2.72E-6 YMR252C_p YMR252C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene
0.079 4.87E-6 YCR008W SAT4 hom Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
0.078 5.88E-6 YPR035W GLN1 het Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.077 6.99E-6 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.073 2.10E-5 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.073 2.16E-5 YOL111C MDY2 hom Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes
0.072 2.73E-5 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.072 3.17E-5 YMR310C_p YMR310C_p hom Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene