YLL057C / JLP1

Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL057C / JLP1

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:3.20|P-value:1.36E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.02|P-value:3.10E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:-2.77|P-value:8.35E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-4.43|P-value:2.52E-7 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.00|P-value:3.37E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.19|P-value:1.42E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:-3.53|P-value:3.11E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:3.73|P-value:1.09E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:3.52|P-value:3.21E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:2.74|P-value:9.04E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-4.08|P-value:1.84E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.87|P-value:5.72E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.81|P-value:7.48E-6 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.19|P-value:1.43E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.75|P-value:8.73E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.14|P-value:1.28E-6 ID:SGTC_1338|Compound:1486-1223|FD-Score:2.92|P-value:4.41E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:5.36|P-value:5.68E-10 ID:SGTC_1387|Compound:3342-1166|FD-Score:-5.04|P-value:5.33E-9 ID:SGTC_1705|Compound:st027868|FD-Score:2.85|P-value:5.85E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-4.75|P-value:3.56E-8 ID:SGTC_1986|Compound:st071812|FD-Score:-3.00|P-value:3.33E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.50|P-value:3.51E-5 ID:SGTC_2100|Compound:5377183|FD-Score:-3.45|P-value:4.56E-5 ID:SGTC_2312|Compound:7706453|FD-Score:-2.88|P-value:5.32E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.53|P-value:2.99E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-3.15|P-value:1.78E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:2.75|P-value:8.65E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-4.02|P-value:2.51E-6 ID:SGTC_2693|Compound:st077581|FD-Score:3.69|P-value:1.38E-5 ID:SGTC_2708|Compound:st078559|FD-Score:2.80|P-value:7.39E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.18|P-value:1.50E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.16|P-value:1.65E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.03|P-value:2.86E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.85|P-value:6.00E-6 ID:SGTC_3328|Compound:9140624|FD-Score:2.93|P-value:4.31E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.20|P-value:1.36E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.02|P-value:3.10E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:-2.77|P-value:8.35E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-4.43|P-value:2.52E-7 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.00|P-value:3.37E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.19|P-value:1.42E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:-3.53|P-value:3.11E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:3.73|P-value:1.09E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:3.52|P-value:3.21E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:2.74|P-value:9.04E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-4.08|P-value:1.84E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.87|P-value:5.72E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.81|P-value:7.48E-6 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.19|P-value:1.43E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.75|P-value:8.73E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.14|P-value:1.28E-6 ID:SGTC_1338|Compound:1486-1223|FD-Score:2.92|P-value:4.41E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:5.36|P-value:5.68E-10 ID:SGTC_1387|Compound:3342-1166|FD-Score:-5.04|P-value:5.33E-9 ID:SGTC_1705|Compound:st027868|FD-Score:2.85|P-value:5.85E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-4.75|P-value:3.56E-8 ID:SGTC_1986|Compound:st071812|FD-Score:-3.00|P-value:3.33E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.50|P-value:3.51E-5 ID:SGTC_2100|Compound:5377183|FD-Score:-3.45|P-value:4.56E-5 ID:SGTC_2312|Compound:7706453|FD-Score:-2.88|P-value:5.32E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.53|P-value:2.99E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-3.15|P-value:1.78E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:2.75|P-value:8.65E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-4.02|P-value:2.51E-6 ID:SGTC_2693|Compound:st077581|FD-Score:3.69|P-value:1.38E-5 ID:SGTC_2708|Compound:st078559|FD-Score:2.80|P-value:7.39E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.18|P-value:1.50E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.16|P-value:1.65E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.03|P-value:2.86E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.85|P-value:6.00E-6 ID:SGTC_3328|Compound:9140624|FD-Score:2.93|P-value:4.31E-4

Top fitness defect scores for YLL057C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1383 3049-0032 5.36 20.7 µM 5.68E-10 60S ribosome export 5 4.24E-8
2 SGTC_1332 1480-0653 4.14 17.5 µM 1.28E-6 TSC3-RPN4 14 1.75E-5
3 SGTC_2829 7992743 3.85 58.4 µM 6.00E-6 43 5.90E-5
4 SGTC_1169 aniline yellow 3.81 25.8 µM 7.48E-6 12 7.01E-5
5 SGTC_716 1683-5115 3.73 658.0 µM 1.09E-5 27 9.41E-5
6 SGTC_2693 st077581 3.69 40.7 µM 1.38E-5 46 1.13E-4
7 SGTC_2479 5617353 3.53 43.9 µM 2.99E-5 58 2.08E-4
8 SGTC_751 0833-0568 3.52 350.0 µM 3.21E-5 36 2.20E-4
9 SGTC_2093 5331342 3.50 194.4 µM 3.51E-5 33 2.36E-4
10 SGTC_57 miconazole 3.20 162.5 nM 1.36E-4 ergosterol depletion effects on membrane 47 6.84E-4
11 SGTC_687 k029-0044 3.19 34.9 µM 1.42E-4 PDR1 46 7.06E-4
12 SGTC_1177 0983-0204 3.19 23.6 µM 1.43E-4 35 7.12E-4
13 SGTC_2711 st079103 3.18 59.1 µM 1.50E-4 21 7.38E-4
14 SGTC_2716 st080858 3.16 38.6 µM 1.65E-4 60S ribosome export 43 7.96E-4
15 SGTC_2794 7785382 3.03 27.3 µM 2.86E-4 91 0.00123
16 SGTC_3328 9140624 2.93 29.0 µM 4.31E-4 58 0.00170
17 SGTC_1338 1486-1223 2.92 76.0 µM 4.41E-4 65 0.00172
18 SGTC_1705 st027868 2.85 56.3 µM 5.85E-4 53 0.00215
19 SGTC_2708 st078559 2.80 56.0 µM 7.39E-4 38 0.00259
20 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 2.75 100.0 µM 8.65E-4 60S ribosome export 83 0.00294

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.38E-16 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.122 1.20E-12 YIR003W AIM21 hom Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton
0.122 1.48E-12 YML107C PML39 hom Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes
0.120 3.37E-12 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.114 3.29E-11 YOR142W LSC1 hom Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated
0.109 2.41E-10 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.109 2.48E-10 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.101 5.25E-9 YFL010C WWM1 hom WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1
0.100 5.82E-9 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.093 6.45E-8 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.091 1.34E-7 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.089 2.63E-7 YHR018C ARG4 hom Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
0.085 7.06E-7 YLR080W EMP46 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.085 7.66E-7 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.085 7.89E-7 YJL118W YJL118W hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein