YLL059C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL059C / YLL059C

Click on Significant Values for Screen Details ID:SGTC_91|Compound:0417-1751|FD-Score:4.25|P-value:5.89E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.52|P-value:7.10E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.71|P-value:3.96E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.64|P-value:4.88E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.59|P-value:5.80E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.52|P-value:7.10E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:4.82|P-value:6.48E-6 ID:SGTC_888|Compound:0916-0002|FD-Score:6.26|P-value:7.13E-9 ID:SGTC_890|Compound:0929-0006|FD-Score:3.69|P-value:4.20E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.71|P-value:3.96E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.55|P-value:6.51E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.15|P-value:8.59E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:3.45|P-value:8.84E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:6.10|P-value:1.62E-8 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.10|P-value:1.04E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.50|P-value:7.60E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.43|P-value:9.39E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.16|P-value:8.22E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.24|P-value:6.14E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.59|P-value:5.84E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.25|P-value:5.86E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.20|P-value:7.23E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.90|P-value:2.04E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.38|P-value:3.72E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:7.83|P-value:6.76E-13 ID:SGTC_2213|Compound:7173844|FD-Score:4.34|P-value:4.28E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.65|P-value:1.27E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-6.80|P-value:3.79E-10 ID:SGTC_2337|Compound:9009472|FD-Score:-6.88|P-value:2.29E-10 ID:SGTC_2367|Compound:9070478|FD-Score:3.95|P-value:1.71E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.44|P-value:9.15E-4 ID:SGTC_2461|Compound:5755302|FD-Score:-3.51|P-value:7.36E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-4.60|P-value:1.53E-5 ID:SGTC_2994|Compound:9053520|FD-Score:4.88|P-value:4.96E-6 ID:SGTC_2995|Compound:9067767|FD-Score:5.14|P-value:1.61E-6 ID:SGTC_2996|Compound:9066192|FD-Score:3.81|P-value:2.78E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.98|P-value:1.57E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.84|P-value:2.56E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.51|P-value:7.44E-4 ID:SGTC_3183|Compound:9108214|FD-Score:3.82|P-value:2.67E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:4.25|P-value:5.89E-5 ID:SGTC_263|Compound:alizarin|FD-Score:3.52|P-value:7.10E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.71|P-value:3.96E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.64|P-value:4.88E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.59|P-value:5.80E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.52|P-value:7.10E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:4.82|P-value:6.48E-6 ID:SGTC_888|Compound:0916-0002|FD-Score:6.26|P-value:7.13E-9 ID:SGTC_890|Compound:0929-0006|FD-Score:3.69|P-value:4.20E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.71|P-value:3.96E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.55|P-value:6.51E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.15|P-value:8.59E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:3.45|P-value:8.84E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:6.10|P-value:1.62E-8 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.10|P-value:1.04E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.50|P-value:7.60E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.43|P-value:9.39E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.16|P-value:8.22E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.24|P-value:6.14E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.59|P-value:5.84E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.25|P-value:5.86E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.20|P-value:7.23E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.90|P-value:2.04E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.38|P-value:3.72E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:7.83|P-value:6.76E-13 ID:SGTC_2213|Compound:7173844|FD-Score:4.34|P-value:4.28E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.65|P-value:1.27E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-6.80|P-value:3.79E-10 ID:SGTC_2337|Compound:9009472|FD-Score:-6.88|P-value:2.29E-10 ID:SGTC_2367|Compound:9070478|FD-Score:3.95|P-value:1.71E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.44|P-value:9.15E-4 ID:SGTC_2461|Compound:5755302|FD-Score:-3.51|P-value:7.36E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-4.60|P-value:1.53E-5 ID:SGTC_2994|Compound:9053520|FD-Score:4.88|P-value:4.96E-6 ID:SGTC_2995|Compound:9067767|FD-Score:5.14|P-value:1.61E-6 ID:SGTC_2996|Compound:9066192|FD-Score:3.81|P-value:2.78E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.98|P-value:1.57E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.84|P-value:2.56E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.51|P-value:7.44E-4 ID:SGTC_3183|Compound:9108214|FD-Score:3.82|P-value:2.67E-4

Top fitness defect scores for YLL059C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1787 fluconazole 7.83 80.0 µM 6.76E-13 iron homeostasis 1 2.46E-15
2 SGTC_888 0916-0002 6.26 7.0 µM 7.13E-9 NEO1 23 1.90E-10
3 SGTC_951 1171-0579 6.10 82.7 µM 1.62E-8 cell wall 32 5.15E-10
4 SGTC_2995 9067767 5.14 71.4 µM 1.61E-6 8 1.36E-7
5 SGTC_2994 9053520 4.88 71.4 µM 4.96E-6 RPP1 & pyrimidine depletion 12 5.30E-7
6 SGTC_816 0325-0417 4.82 81.3 µM 6.48E-6 5 7.32E-7
7 SGTC_2247 cerulenin 4.65 830.0 nM 1.27E-5 7 1.65E-6
8 SGTC_1658 st012944 4.38 20.0 µM 3.72E-5 iron homeostasis 66 6.07E-6
9 SGTC_2213 7173844 4.34 200.0 µM 4.28E-5 9 7.18E-6
10 SGTC_1265 0819-1001 4.25 68.8 µM 5.86E-5 18 1.05E-5
11 SGTC_91 0417-1751 4.25 58.4 µM 5.89E-5 Golgi 43 1.06E-5
12 SGTC_1180 1193-0155 4.24 285.0 µM 6.14E-5 11 1.11E-5
13 SGTC_1385 3091-4834 4.20 14.1 µM 7.23E-5 RPP1 & pyrimidine depletion 16 1.35E-5
14 SGTC_1126 isoteolin 4.16 1.0 µM 8.22E-5 23 1.58E-5
15 SGTC_922 1866-0035 4.15 480.0 µM 8.59E-5 excess fatty acid 49 1.67E-5
16 SGTC_1045 1348-1485 4.10 165.0 µM 1.04E-4 24 2.10E-5
17 SGTC_2998 9066762 3.98 71.4 µM 1.57E-4 RPP1 & pyrimidine depletion 25 3.46E-5
18 SGTC_2367 9070478 3.95 135.4 µM 1.71E-4 cell wall 33 3.84E-5
19 SGTC_1505 k297-0037 3.90 20.6 µM 2.04E-4 19 4.75E-5
20 SGTC_3045 9092950 3.84 49.5 µM 2.56E-4 18 6.22E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 2.97E-10 YDL229W SSB1 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication
0.099 9.75E-9 YER168C CCA1 het ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
0.084 1.26E-6 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.080 3.08E-6 YPR174C YPR174C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication
0.080 3.14E-6 YJR017C ESS1 het Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3
0.077 7.81E-6 YML009C MRPL39 hom Mitochondrial ribosomal protein of the large subunit
0.076 9.34E-6 YOL090W MSH2 hom Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP
0.072 2.66E-5 YGL038C OCH1 hom Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins
0.072 2.74E-5 YGR278W CWC22 het Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein
0.072 3.28E-5 YMR065W KAR5 hom Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone
0.071 3.55E-5 YNL328C MDJ2 hom Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain
0.071 4.12E-5 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.070 4.96E-5 YJR012C_p YJR012C_p het Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W
0.069 5.86E-5 YPL030W TRM44 hom tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene
0.069 6.65E-5 YCR031C RPS14A hom Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication