YLL060C / GTT2

Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL060C / GTT2

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:4.38|P-value:5.78E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.31|P-value:4.55E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:-3.28|P-value:6.14E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.97|P-value:4.50E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.09|P-value:2.63E-5 ID:SGTC_326|Compound:k292-0812|FD-Score:4.10|P-value:1.98E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:4.63|P-value:1.76E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:-8.36|P-value:5.74E-17 ID:SGTC_366|Compound:0181-0206|FD-Score:10.10|P-value:2.58E-24 ID:SGTC_367|Compound:0335-0881|FD-Score:3.71|P-value:1.01E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.55|P-value:3.47E-6 ID:SGTC_382|Compound:3229-0966|FD-Score:4.44|P-value:4.51E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:3.31|P-value:4.43E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.33|P-value:5.19E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-5.57|P-value:1.74E-8 ID:SGTC_426|Compound:0988-0037|FD-Score:4.24|P-value:1.08E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.89|P-value:4.83E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.34|P-value:4.03E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.28|P-value:5.04E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.60|P-value:1.52E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.10|P-value:9.20E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.39|P-value:3.37E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-4.82|P-value:9.66E-7 ID:SGTC_740|Compound:k014-0057|FD-Score:-5.18|P-value:1.53E-7 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.70|P-value:8.71E-9 ID:SGTC_753|Compound:1322-0200|FD-Score:3.91|P-value:4.52E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:3.66|P-value:1.20E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.67|P-value:1.47E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.59|P-value:1.61E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.33|P-value:5.14E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-4.24|P-value:1.43E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.26|P-value:5.35E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.09|P-value:9.76E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.54|P-value:2.42E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.38|P-value:3.54E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.39|P-value:3.40E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.22|P-value:6.27E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.29|P-value:4.75E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.25|P-value:6.82E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:-5.43|P-value:3.95E-8 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.45|P-value:3.30E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.58|P-value:2.10E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.23|P-value:5.99E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-4.21|P-value:1.63E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.17|P-value:7.36E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.38|P-value:3.53E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.14|P-value:8.24E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.48|P-value:2.45E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.55|P-value:1.86E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.73|P-value:9.22E-5 ID:SGTC_2058|Compound:5236698|FD-Score:-4.45|P-value:5.37E-6 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.23|P-value:7.34E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.33|P-value:7.38E-6 ID:SGTC_2136|Compound:5328288|FD-Score:3.13|P-value:8.34E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.40|P-value:3.28E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.89|P-value:4.83E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.32|P-value:4.40E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.19|P-value:6.86E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.37|P-value:3.65E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.34|P-value:4.03E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.21|P-value:6.46E-4 ID:SGTC_2916|Compound:7875993|FD-Score:5.38|P-value:3.79E-8 ID:SGTC_2972|Compound:9093619|FD-Score:-3.38|P-value:4.22E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.36|P-value:6.50E-6 ID:SGTC_3147|Compound:9097027|FD-Score:3.37|P-value:3.68E-4 ID:SGTC_3168|Compound:9103419|FD-Score:3.56|P-value:1.78E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.02|P-value:2.83E-5 ID:SGTC_57|Compound:miconazole|FD-Score:4.38|P-value:5.78E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:3.31|P-value:4.55E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:-3.28|P-value:6.14E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.97|P-value:4.50E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.09|P-value:2.63E-5 ID:SGTC_326|Compound:k292-0812|FD-Score:4.10|P-value:1.98E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:4.63|P-value:1.76E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:-8.36|P-value:5.74E-17 ID:SGTC_366|Compound:0181-0206|FD-Score:10.10|P-value:2.58E-24 ID:SGTC_367|Compound:0335-0881|FD-Score:3.71|P-value:1.01E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.55|P-value:3.47E-6 ID:SGTC_382|Compound:3229-0966|FD-Score:4.44|P-value:4.51E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:3.31|P-value:4.43E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.33|P-value:5.19E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-5.57|P-value:1.74E-8 ID:SGTC_426|Compound:0988-0037|FD-Score:4.24|P-value:1.08E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.89|P-value:4.83E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.34|P-value:4.03E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.28|P-value:5.04E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.60|P-value:1.52E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.10|P-value:9.20E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.39|P-value:3.37E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-4.82|P-value:9.66E-7 ID:SGTC_740|Compound:k014-0057|FD-Score:-5.18|P-value:1.53E-7 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.70|P-value:8.71E-9 ID:SGTC_753|Compound:1322-0200|FD-Score:3.91|P-value:4.52E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:3.66|P-value:1.20E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.67|P-value:1.47E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.59|P-value:1.61E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.33|P-value:5.14E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-4.24|P-value:1.43E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.26|P-value:5.35E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.09|P-value:9.76E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.54|P-value:2.42E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.38|P-value:3.54E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.39|P-value:3.40E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.22|P-value:6.27E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.29|P-value:4.75E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.25|P-value:6.82E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:-5.43|P-value:3.95E-8 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.45|P-value:3.30E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.58|P-value:2.10E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.23|P-value:5.99E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-4.21|P-value:1.63E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.17|P-value:7.36E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.38|P-value:3.53E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.14|P-value:8.24E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.48|P-value:2.45E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.55|P-value:1.86E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.73|P-value:9.22E-5 ID:SGTC_2058|Compound:5236698|FD-Score:-4.45|P-value:5.37E-6 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.23|P-value:7.34E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.33|P-value:7.38E-6 ID:SGTC_2136|Compound:5328288|FD-Score:3.13|P-value:8.34E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.40|P-value:3.28E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.89|P-value:4.83E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.32|P-value:4.40E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.19|P-value:6.86E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.37|P-value:3.65E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.34|P-value:4.03E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.21|P-value:6.46E-4 ID:SGTC_2916|Compound:7875993|FD-Score:5.38|P-value:3.79E-8 ID:SGTC_2972|Compound:9093619|FD-Score:-3.38|P-value:4.22E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.36|P-value:6.50E-6 ID:SGTC_3147|Compound:9097027|FD-Score:3.37|P-value:3.68E-4 ID:SGTC_3168|Compound:9103419|FD-Score:3.56|P-value:1.78E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.02|P-value:2.83E-5

Top fitness defect scores for YLL060C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_366 0181-0206 10.10 4.3 µM 2.58E-24 Golgi 2 1.96E-24
2 SGTC_2916 7875993 5.38 68.8 µM 3.79E-8 6 3.77E-8
3 SGTC_360 0957-0399 4.63 1.0 µM 1.76E-6 cell wall 27 1.79E-6
4 SGTC_382 3229-0966 4.44 23.2 µM 4.51E-6 11 4.60E-6
5 SGTC_57 miconazole 4.38 162.5 nM 5.78E-6 ergosterol depletion effects on membrane 22 5.90E-6
6 SGTC_3136 9095672 4.36 49.5 µM 6.50E-6 16 6.64E-6
7 SGTC_2131 toluylene red 4.33 5.3 µM 7.38E-6 60S ribosome export 16 7.54E-6
8 SGTC_426 0988-0037 4.24 14.6 µM 1.08E-5 ERAD & cell cycle 26 1.10E-5
9 SGTC_326 k292-0812 4.10 17.5 µM 1.98E-5 6 2.03E-5
10 SGTC_3293 9120939 4.02 62.0 µM 2.83E-5 20 2.90E-5
11 SGTC_753 1322-0200 3.91 289.0 µM 4.52E-5 20 4.66E-5
12 SGTC_2299 7976368 3.89 114.9 µM 4.83E-5 32 4.97E-5
13 SGTC_435 c-PAF 3.89 6.7 µM 4.83E-5 47 4.98E-5
14 SGTC_2048 5246248 3.73 200.0 µM 9.22E-5 8 9.52E-5
15 SGTC_367 0335-0881 3.71 7.1 µM 1.01E-4 ubiquinone biosynthesis & proteasome 90 1.04E-4
16 SGTC_960 1222-0186 3.66 7.7 µM 1.20E-4 40 1.24E-4
17 SGTC_507 nimesulide 3.60 162.0 µM 1.52E-4 24 1.58E-4
18 SGTC_1022 4477-0945 3.59 21.3 µM 1.61E-4 37 1.67E-4
19 SGTC_3168 9103419 3.56 49.5 µM 1.78E-4 60S ribosome export 8 1.84E-4
20 SGTC_2042 p-Dimethylaminoacetophenone 3.55 200.0 µM 1.86E-4 31 1.93E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 8.42E-20 YML116W-A_d YML116W-A_d hom Putative protein of unknown function
0.131 2.62E-14 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.117 1.21E-11 YGL243W TAD1 hom tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala
0.113 6.24E-11 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.112 8.78E-11 YJR056C YJR056C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress
0.108 3.62E-10 YGL074C_d YGL074C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
0.105 1.16E-9 YHR006W STP2 hom Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication
0.098 1.32E-8 YFL040W_p YFL040W_p hom Putative transporter, member of the sugar porter family; YFL040W is not an essential gene
0.098 1.49E-8 YBR180W DTR1 hom Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation
0.096 2.30E-8 YGL157W ARI1 hom NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily
0.096 2.47E-8 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.096 2.71E-8 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.093 7.24E-8 YPL121C MEI5 hom Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p
0.090 1.86E-7 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.088 3.53E-7 YBR172C SMY2 hom Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication