HIPHOP chemogenomics database
YLR002C / NOC3 
Component of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YLR002C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.158 | 3.21E-20 | YLR154C | RNH203 | hom | Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome |
| 0.102 | 2.72E-9 | YKR079C | TRZ1 | het | tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2 |
| 0.101 | 4.05E-9 | YGL231C | EMC4 | hom | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85 |
| 0.099 | 1.02E-8 | YDR042C_p | YDR042C_p | hom | Putative protein of unknown function; expression is increased in ssu72-ts69 mutant |
| 0.097 | 1.87E-8 | YOL014W_p | YOL014W_p | hom | Putative protein of unknown function |
| 0.094 | 4.42E-8 | YKL167C | MRP49 | hom | Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation |
| 0.093 | 5.82E-8 | YOR266W | PNT1 | hom | Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine |
| 0.089 | 2.37E-7 | YJR079W_p | YJR079W_p | hom | Putative protein of unknown function; mutation results in impaired mitochondrial respiration |
| 0.085 | 7.29E-7 | YDR109C_p | YDR109C_p | hom | Putative kinase |
| 0.084 | 1.09E-6 | YDL217C | TIM22 | het | Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported |
| 0.083 | 1.40E-6 | YBL056W | PTC3 | hom | Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication |
| 0.079 | 5.27E-6 | YOR269W | PAC1 | hom | Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly |
| 0.078 | 6.09E-6 | YLR326W_p | YLR326W_p | hom | Putative protein of unknown function, predicted to be palmitoylated |
| 0.077 | 7.09E-6 | YPR018W | RLF2 | hom | Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription |
| 0.077 | 8.89E-6 | YBR184W_p | YBR184W_p | hom | Putative protein of unknown function; YBR184W is not an essential gene |