YLR004C / THI73

Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR004C / THI73

Click on Significant Values for Screen Details ID:SGTC_134|Compound:0269-0018|FD-Score:-3.12|P-value:4.91E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.90|P-value:1.90E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.38|P-value:1.77E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-6.16|P-value:3.42E-11 ID:SGTC_351|Compound:caspofungin|FD-Score:-4.51|P-value:9.26E-7 ID:SGTC_435|Compound:c-PAF|FD-Score:2.96|P-value:7.54E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.10|P-value:4.40E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:2.91|P-value:8.99E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:2.99|P-value:6.60E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:2.99|P-value:6.67E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-5.05|P-value:4.58E-8 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.17|P-value:3.39E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:-3.13|P-value:4.83E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-2.97|P-value:8.70E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-4.08|P-value:8.04E-6 ID:SGTC_1686|Compound:st019653|FD-Score:3.39|P-value:1.39E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.18|P-value:3.19E-4 ID:SGTC_2120|Compound:5538279|FD-Score:-2.97|P-value:8.75E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.02|P-value:5.94E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.06|P-value:6.09E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.30|P-value:1.96E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.25|P-value:3.04E-4 ID:SGTC_2783|Compound:7738165|FD-Score:2.95|P-value:7.73E-4 ID:SGTC_2784|Compound:7567673|FD-Score:5.80|P-value:2.78E-10 ID:SGTC_2789|Compound:5281112|FD-Score:3.07|P-value:4.94E-4 ID:SGTC_2879|Compound:9041815|FD-Score:3.14|P-value:3.78E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-2.98|P-value:8.22E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.20|P-value:3.00E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-7.36|P-value:2.92E-15 ID:SGTC_3212|Compound:9128307|FD-Score:-3.41|P-value:1.61E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.12|P-value:4.91E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.90|P-value:1.90E-5 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.38|P-value:1.77E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-6.16|P-value:3.42E-11 ID:SGTC_351|Compound:caspofungin|FD-Score:-4.51|P-value:9.26E-7 ID:SGTC_435|Compound:c-PAF|FD-Score:2.96|P-value:7.54E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.10|P-value:4.40E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:2.91|P-value:8.99E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:2.99|P-value:6.60E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:2.99|P-value:6.67E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-5.05|P-value:4.58E-8 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.17|P-value:3.39E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:-3.13|P-value:4.83E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-2.97|P-value:8.70E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-4.08|P-value:8.04E-6 ID:SGTC_1686|Compound:st019653|FD-Score:3.39|P-value:1.39E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.18|P-value:3.19E-4 ID:SGTC_2120|Compound:5538279|FD-Score:-2.97|P-value:8.75E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.02|P-value:5.94E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.06|P-value:6.09E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.30|P-value:1.96E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.25|P-value:3.04E-4 ID:SGTC_2783|Compound:7738165|FD-Score:2.95|P-value:7.73E-4 ID:SGTC_2784|Compound:7567673|FD-Score:5.80|P-value:2.78E-10 ID:SGTC_2789|Compound:5281112|FD-Score:3.07|P-value:4.94E-4 ID:SGTC_2879|Compound:9041815|FD-Score:3.14|P-value:3.78E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-2.98|P-value:8.22E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.20|P-value:3.00E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-7.36|P-value:2.92E-15 ID:SGTC_3212|Compound:9128307|FD-Score:-3.41|P-value:1.61E-4

Top fitness defect scores for YLR004C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2784 7567673 5.80 72.7 µM 2.78E-10 iron homeostasis 7 3.29E-9
2 SGTC_1686 st019653 3.39 115.5 µM 1.39E-4 mitochondrial processes 22 3.51E-4
3 SGTC_2595 hexamethylquercetagetin 3.30 100.0 µM 1.96E-4 52 4.75E-4
4 SGTC_3202 9113761 3.20 49.5 µM 3.00E-4 84 6.92E-4
5 SGTC_1874 staurosporine 3.18 7.6 µM 3.19E-4 cell wall signaling 56 7.30E-4
6 SGTC_1246 0422-0085 3.17 105.0 µM 3.39E-4 70 7.70E-4
7 SGTC_2879 9041815 3.14 71.4 µM 3.78E-4 8 8.48E-4
8 SGTC_643 k048-0106 3.10 28.4 µM 4.40E-4 RSC & ERG11 31 9.70E-4
9 SGTC_2789 5281112 3.07 71.4 µM 4.94E-4 85 0.00107
10 SGTC_2488 5268135 3.02 45.7 µM 5.94E-4 100 0.00127
11 SGTC_807 1315-0151 2.99 48.0 µM 6.60E-4 70 0.00139
12 SGTC_862 0452-0056 2.99 10.2 µM 6.67E-4 azole & statin 69 0.00140
13 SGTC_435 c-PAF 2.96 6.7 µM 7.54E-4 100 0.00156
14 SGTC_2783 7738165 2.95 71.4 µM 7.73E-4 72 0.00160
15 SGTC_770 0389-1121 2.91 67.2 µM 8.99E-4 RPP1 & pyrimidine depletion 72 0.00182
16 SGTC_622 1348-1566 2.82 26.3 µM 0.00122 75 0.00239
17 SGTC_1705 st027868 2.76 56.3 µM 0.00150 64 0.00287
18 SGTC_3001 9076041 2.75 71.4 µM 0.00154 68 0.00294
19 SGTC_3017 9080681 2.75 49.5 µM 0.00155 78 0.00295
20 SGTC_1524 corynanthine 2.74 62.1 µM 0.00161 90 0.00305

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 4.28E-19 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.131 3.25E-14 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.130 4.02E-14 YMR215W GAS3 hom Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation
0.119 5.61E-12 YGR003W CUL3 hom Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3
0.113 5.74E-11 YML080W DUS1 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17
0.112 7.34E-11 YGR134W CAF130 hom Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
0.112 8.38E-11 YKR002W PAP1 het Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
0.110 2.04E-10 YGR138C TPO2 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication
0.104 1.56E-9 YNL009W IDP3 hom Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication
0.101 4.45E-9 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.098 1.46E-8 YDL108W KIN28 het Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
0.096 2.47E-8 YOL164W BDS1 hom Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources
0.096 2.69E-8 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.095 3.39E-8 YOL013W-B_d YOL013W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element
0.094 5.61E-8 YKL096W CWP1 hom Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance