YLR006C / SSK1

Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR006C / SSK1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.19|P-value:7.12E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:6.13|P-value:6.14E-10 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.68|P-value:2.05E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.13|P-value:1.93E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.96|P-value:7.03E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.12|P-value:9.01E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:-4.10|P-value:3.93E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:3.13|P-value:8.74E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:-4.40|P-value:1.09E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:3.20|P-value:6.72E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.13|P-value:8.52E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.30|P-value:7.84E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.80|P-value:7.62E-5 ID:SGTC_298|Compound:1391-0729|FD-Score:-4.13|P-value:3.49E-5 ID:SGTC_306|Compound:1672-3436|FD-Score:-4.22|P-value:2.42E-5 ID:SGTC_317|Compound:4495-0002|FD-Score:-3.57|P-value:3.04E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.72|P-value:1.74E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.51|P-value:2.24E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.55|P-value:1.98E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:-5.61|P-value:2.84E-8 ID:SGTC_765|Compound:1319-0117|FD-Score:3.18|P-value:7.34E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.72|P-value:1.72E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:-3.30|P-value:7.66E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.24|P-value:5.98E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-4.51|P-value:6.76E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:-3.61|P-value:2.59E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:4.12|P-value:2.07E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.57|P-value:1.83E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:8.00|P-value:1.34E-15 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.97|P-value:3.88E-5 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.24|P-value:5.92E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.59|P-value:1.67E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:-3.25|P-value:9.08E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:-3.68|P-value:2.06E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.91|P-value:8.42E-5 ID:SGTC_1567|Compound:st069303|FD-Score:4.26|P-value:1.10E-5 ID:SGTC_1610|Compound:st001799|FD-Score:3.35|P-value:4.05E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.65|P-value:2.30E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.32|P-value:4.56E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-4.07|P-value:4.50E-5 ID:SGTC_1966|Compound:st070145|FD-Score:-3.34|P-value:6.90E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.21|P-value:6.59E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.67|P-value:1.24E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.09|P-value:9.82E-4 ID:SGTC_2275|Compound:7947463|FD-Score:-4.18|P-value:2.88E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-4.86|P-value:1.35E-6 ID:SGTC_2370|Compound:9071495|FD-Score:6.55|P-value:4.52E-11 ID:SGTC_2379|Compound:9035213|FD-Score:-4.32|P-value:1.56E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.74|P-value:9.58E-5 ID:SGTC_2443|Compound:5493264|FD-Score:4.70|P-value:1.53E-6 ID:SGTC_2450|Compound:5739737|FD-Score:-4.31|P-value:1.65E-5 ID:SGTC_2459|Compound:5811157|FD-Score:4.26|P-value:1.09E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.41|P-value:5.26E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-3.47|P-value:4.39E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.10|P-value:9.42E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.58|P-value:2.87E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.39|P-value:3.47E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.99|P-value:6.27E-5 ID:SGTC_2831|Compound:7999036|FD-Score:5.77|P-value:5.34E-9 ID:SGTC_2833|Compound:9001315|FD-Score:-4.58|P-value:4.91E-6 ID:SGTC_2949|Compound:9072542|FD-Score:-4.56|P-value:5.43E-6 ID:SGTC_3044|Compound:9093193|FD-Score:-3.35|P-value:6.60E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.49|P-value:4.04E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:3.19|P-value:7.12E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:6.13|P-value:6.14E-10 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.68|P-value:2.05E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.13|P-value:1.93E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.96|P-value:7.03E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.12|P-value:9.01E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:-4.10|P-value:3.93E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:3.13|P-value:8.74E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:-4.40|P-value:1.09E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:3.20|P-value:6.72E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.13|P-value:8.52E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.30|P-value:7.84E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.80|P-value:7.62E-5 ID:SGTC_298|Compound:1391-0729|FD-Score:-4.13|P-value:3.49E-5 ID:SGTC_306|Compound:1672-3436|FD-Score:-4.22|P-value:2.42E-5 ID:SGTC_317|Compound:4495-0002|FD-Score:-3.57|P-value:3.04E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.72|P-value:1.74E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.51|P-value:2.24E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.55|P-value:1.98E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:-5.61|P-value:2.84E-8 ID:SGTC_765|Compound:1319-0117|FD-Score:3.18|P-value:7.34E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.72|P-value:1.72E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:-3.30|P-value:7.66E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.24|P-value:5.98E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:-4.51|P-value:6.76E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:-3.61|P-value:2.59E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:4.12|P-value:2.07E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.57|P-value:1.83E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:8.00|P-value:1.34E-15 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.97|P-value:3.88E-5 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.24|P-value:5.92E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.59|P-value:1.67E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:-3.25|P-value:9.08E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:-3.68|P-value:2.06E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.91|P-value:8.42E-5 ID:SGTC_1567|Compound:st069303|FD-Score:4.26|P-value:1.10E-5 ID:SGTC_1610|Compound:st001799|FD-Score:3.35|P-value:4.05E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.65|P-value:2.30E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.32|P-value:4.56E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-4.07|P-value:4.50E-5 ID:SGTC_1966|Compound:st070145|FD-Score:-3.34|P-value:6.90E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.21|P-value:6.59E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.67|P-value:1.24E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.09|P-value:9.82E-4 ID:SGTC_2275|Compound:7947463|FD-Score:-4.18|P-value:2.88E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-4.86|P-value:1.35E-6 ID:SGTC_2370|Compound:9071495|FD-Score:6.55|P-value:4.52E-11 ID:SGTC_2379|Compound:9035213|FD-Score:-4.32|P-value:1.56E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.74|P-value:9.58E-5 ID:SGTC_2443|Compound:5493264|FD-Score:4.70|P-value:1.53E-6 ID:SGTC_2450|Compound:5739737|FD-Score:-4.31|P-value:1.65E-5 ID:SGTC_2459|Compound:5811157|FD-Score:4.26|P-value:1.09E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.41|P-value:5.26E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-3.47|P-value:4.39E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.10|P-value:9.42E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.58|P-value:2.87E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.39|P-value:3.47E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.99|P-value:6.27E-5 ID:SGTC_2831|Compound:7999036|FD-Score:5.77|P-value:5.34E-9 ID:SGTC_2833|Compound:9001315|FD-Score:-4.58|P-value:4.91E-6 ID:SGTC_2949|Compound:9072542|FD-Score:-4.56|P-value:5.43E-6 ID:SGTC_3044|Compound:9093193|FD-Score:-3.35|P-value:6.60E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.49|P-value:4.04E-6

Top fitness defect scores for YLR006C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_946 3434-1334 8.00 87.4 µM 1.34E-15 1 6.11E-16
2 SGTC_2370 9071495 6.55 200.0 µM 4.52E-11 mitochondrial processes 4 2.89E-11
3 SGTC_69 0096-0274 6.13 206.7 µM 6.14E-10 mitochondrial processes 9 4.26E-10
4 SGTC_2831 7999036 5.77 19.5 µM 5.34E-9 7 3.95E-9
5 SGTC_2443 5493264 4.70 126.7 µM 1.53E-6 11 1.33E-6
6 SGTC_3059 1327-0034 4.49 3.0 µM 4.04E-6 42 3.60E-6
7 SGTC_2459 5811157 4.26 9.2 µM 1.09E-5 mitochondrial processes 8 1.00E-5
8 SGTC_1567 st069303 4.26 68.4 µM 1.10E-5 mitochondrial processes 13 1.01E-5
9 SGTC_73 0327-0325 4.13 16.2 µM 1.93E-5 DNA damage response 44 1.79E-5
10 SGTC_864 0469-0573 4.12 172.0 µM 2.07E-5 13 1.93E-5
11 SGTC_1027 k015-0025 3.97 8.7 µM 3.88E-5 25 3.66E-5
12 SGTC_291 4130-1278 3.80 35.5 µM 7.62E-5 Golgi 19 7.32E-5
13 SGTC_2425 5628681 3.74 7.8 µM 9.58E-5 33 9.24E-5
14 SGTC_2249 haloperidol 3.67 116.4 µM 1.24E-4 ergosterol depletion effects on membrane 132 1.20E-4
15 SGTC_1164 k060-0068 3.59 93.7 µM 1.67E-4 42 1.63E-4
16 SGTC_919 tnp00227 3.57 403.6 nM 1.83E-4 RNA pol III & RNase P/MRP 55 1.79E-4
17 SGTC_718 1130-0073 3.55 349.0 µM 1.98E-4 29 1.94E-4
18 SGTC_690 glyoxal 3.51 20.3 µM 2.24E-4 103 2.20E-4
19 SGTC_2629 bisabolol 3.39 100.0 µM 3.47E-4 41 3.44E-4
20 SGTC_1610 st001799 3.35 48.1 µM 4.05E-4 28 4.04E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 9.52E-14 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.122 1.64E-12 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.117 1.21E-11 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.107 5.35E-10 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.106 8.78E-10 YNL044W YIP3 hom Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
0.104 1.68E-9 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.101 4.70E-9 YBR089C-A NHP6B hom High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication
0.098 1.09E-8 YML009C MRPL39 hom Mitochondrial ribosomal protein of the large subunit
0.097 1.99E-8 YJR105W ADO1 hom Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
0.094 5.82E-8 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.089 2.56E-7 YCL032W STE50 hom Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction
0.088 3.36E-7 YBL030C PET9 het Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication
0.086 6.26E-7 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.086 6.49E-7 YIL097W FYV10 hom Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin
0.086 6.41E-7 YLR420W URA4 hom Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate