HIPHOP chemogenomics database

YLR006C / SSK1

Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR006C / SSK1

Click on Significant Values for Screen Details

Top fitness defect scores for YLR006C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_946	3434-1334	8.00	87.4 µM	1.34E-15		1	6.11E-16
2	SGTC_2370	9071495	6.55	200.0 µM	4.52E-11	mitochondrial processes	4	2.89E-11
3	SGTC_69	0096-0274	6.13	206.7 µM	6.14E-10	mitochondrial processes	9	4.26E-10
4	SGTC_2831	7999036	5.77	19.5 µM	5.34E-9		7	3.95E-9
5	SGTC_2443	5493264	4.70	126.7 µM	1.53E-6		11	1.33E-6
6	SGTC_3059	1327-0034	4.49	3.0 µM	4.04E-6		42	3.60E-6
7	SGTC_2459	5811157	4.26	9.2 µM	1.09E-5	mitochondrial processes	8	1.00E-5
8	SGTC_1567	st069303	4.26	68.4 µM	1.10E-5	mitochondrial processes	13	1.01E-5
9	SGTC_73	0327-0325	4.13	16.2 µM	1.93E-5	DNA damage response	44	1.79E-5
10	SGTC_864	0469-0573	4.12	172.0 µM	2.07E-5		13	1.93E-5
11	SGTC_1027	k015-0025	3.97	8.7 µM	3.88E-5		25	3.66E-5
12	SGTC_291	4130-1278	3.80	35.5 µM	7.62E-5	Golgi	19	7.32E-5
13	SGTC_2425	5628681	3.74	7.8 µM	9.58E-5		33	9.24E-5
14	SGTC_2249	haloperidol	3.67	116.4 µM	1.24E-4	ergosterol depletion effects on membrane	132	1.20E-4
15	SGTC_1164	k060-0068	3.59	93.7 µM	1.67E-4		42	1.63E-4
16	SGTC_919	tnp00227	3.57	403.6 nM	1.83E-4	RNA pol III & RNase P/MRP	55	1.79E-4
17	SGTC_718	1130-0073	3.55	349.0 µM	1.98E-4		29	1.94E-4
18	SGTC_690	glyoxal	3.51	20.3 µM	2.24E-4		103	2.20E-4
19	SGTC_2629	bisabolol	3.39	100.0 µM	3.47E-4		41	3.44E-4
20	SGTC_1610	st001799	3.35	48.1 µM	4.05E-4		28	4.04E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.128	9.52E-14	YER041W	YEN1	hom	Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.122	1.64E-12	YFR007W	YFH7	hom	Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.117	1.21E-11	YMR182W-A_p	YMR182W-A_p	hom	Putative protein of unknown function
0.107	5.35E-10	YBR243C	ALG7	het	UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.106	8.78E-10	YNL044W	YIP3	hom	Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
0.104	1.68E-9	YPR146C_d	YPR146C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.101	4.70E-9	YBR089C-A	NHP6B	hom	High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication
0.098	1.09E-8	YML009C	MRPL39	hom	Mitochondrial ribosomal protein of the large subunit
0.097	1.99E-8	YJR105W	ADO1	hom	Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
0.094	5.82E-8	YKL104C	GFA1	het	Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.089	2.56E-7	YCL032W	STE50	hom	Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction
0.088	3.36E-7	YBL030C	PET9	het	Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication
0.086	6.26E-7	YKL124W	SSH4	hom	Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.086	6.49E-7	YIL097W	FYV10	hom	Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin
0.086	6.41E-7	YLR420W	URA4	hom	Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate