YLR007W / NSE1

Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR007W / NSE1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.95|P-value:7.05E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:6.16|P-value:6.61E-12 ID:SGTC_88|Compound:0180-0332|FD-Score:-2.83|P-value:9.97E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:-3.00|P-value:5.06E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:3.01|P-value:4.65E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:3.60|P-value:3.83E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.58|P-value:4.18E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.31|P-value:1.35E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:2.96|P-value:5.73E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.70|P-value:1.21E-7 ID:SGTC_206|Compound:4546-0025|FD-Score:2.84|P-value:9.07E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:5.85|P-value:6.76E-11 ID:SGTC_216|Compound:k038-0035|FD-Score:5.50|P-value:7.77E-10 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.38|P-value:1.10E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.12|P-value:2.99E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:-2.88|P-value:8.16E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.09|P-value:3.48E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:-3.12|P-value:3.20E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.50|P-value:5.99E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:2.94|P-value:6.15E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.43|P-value:8.77E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:6.32|P-value:2.04E-12 ID:SGTC_1171|Compound:0368-0077|FD-Score:2.87|P-value:7.92E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.18|P-value:2.48E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.43|P-value:8.56E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.62|P-value:1.90E-7 ID:SGTC_1305|Compound:1181-0477|FD-Score:2.82|P-value:9.63E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:2.84|P-value:8.87E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.34|P-value:1.22E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:4.11|P-value:3.22E-6 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.27|P-value:1.64E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:2.87|P-value:8.13E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:2.87|P-value:7.96E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.76|P-value:1.85E-5 ID:SGTC_1757|Compound:st041620|FD-Score:-2.97|P-value:5.73E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.54|P-value:5.02E-5 ID:SGTC_2081|Compound:5214970|FD-Score:4.01|P-value:5.26E-6 ID:SGTC_2353|Compound:9059630|FD-Score:3.19|P-value:2.33E-4 ID:SGTC_2361|Compound:9034121|FD-Score:-2.91|P-value:7.30E-4 ID:SGTC_2366|Compound:9070441|FD-Score:2.97|P-value:5.39E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-2.94|P-value:6.56E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.31|P-value:1.39E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-2.84|P-value:9.52E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.28|P-value:1.60E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-2.98|P-value:5.59E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.32|P-value:1.33E-4 ID:SGTC_3246|Compound:9135460|FD-Score:3.09|P-value:3.40E-4 ID:SGTC_3297|Compound:9117502|FD-Score:3.12|P-value:3.01E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.95|P-value:7.05E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:6.16|P-value:6.61E-12 ID:SGTC_88|Compound:0180-0332|FD-Score:-2.83|P-value:9.97E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:-3.00|P-value:5.06E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:3.01|P-value:4.65E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:3.60|P-value:3.83E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.58|P-value:4.18E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.31|P-value:1.35E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:2.96|P-value:5.73E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:4.70|P-value:1.21E-7 ID:SGTC_206|Compound:4546-0025|FD-Score:2.84|P-value:9.07E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:5.85|P-value:6.76E-11 ID:SGTC_216|Compound:k038-0035|FD-Score:5.50|P-value:7.77E-10 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.38|P-value:1.10E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.12|P-value:2.99E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:-2.88|P-value:8.16E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.09|P-value:3.48E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:-3.12|P-value:3.20E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.50|P-value:5.99E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:2.94|P-value:6.15E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.43|P-value:8.77E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:6.32|P-value:2.04E-12 ID:SGTC_1171|Compound:0368-0077|FD-Score:2.87|P-value:7.92E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.18|P-value:2.48E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.43|P-value:8.56E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.62|P-value:1.90E-7 ID:SGTC_1305|Compound:1181-0477|FD-Score:2.82|P-value:9.63E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:2.84|P-value:8.87E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.34|P-value:1.22E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:4.11|P-value:3.22E-6 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.27|P-value:1.64E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:2.87|P-value:8.13E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:2.87|P-value:7.96E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.76|P-value:1.85E-5 ID:SGTC_1757|Compound:st041620|FD-Score:-2.97|P-value:5.73E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.54|P-value:5.02E-5 ID:SGTC_2081|Compound:5214970|FD-Score:4.01|P-value:5.26E-6 ID:SGTC_2353|Compound:9059630|FD-Score:3.19|P-value:2.33E-4 ID:SGTC_2361|Compound:9034121|FD-Score:-2.91|P-value:7.30E-4 ID:SGTC_2366|Compound:9070441|FD-Score:2.97|P-value:5.39E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-2.94|P-value:6.56E-4 ID:SGTC_2461|Compound:5755302|FD-Score:3.31|P-value:1.39E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-2.84|P-value:9.52E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.28|P-value:1.60E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-2.98|P-value:5.59E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.32|P-value:1.33E-4 ID:SGTC_3246|Compound:9135460|FD-Score:3.09|P-value:3.40E-4 ID:SGTC_3297|Compound:9117502|FD-Score:3.12|P-value:3.01E-4

Top fitness defect scores for YLR007W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1106 tegaserod maleate 6.32 11.7 µM 2.04E-12 1 1.33E-10 1.14
2 SGTC_67 0335-0847 6.16 266.0 µM 6.61E-12 ubiquinone biosynthesis & proteasome 9 3.55E-10 0.73
3 SGTC_211 3455-0679 5.85 143.5 µM 6.76E-11 3 2.47E-9 0.30
4 SGTC_216 k038-0035 5.50 28.4 µM 7.77E-10 ubiquinone biosynthesis & proteasome 6 1.89E-8 0.01
5 SGTC_158 k038-0087 4.70 26.4 µM 1.21E-7 ubiquinone biosynthesis & proteasome 23 1.28E-6 0.16
6 SGTC_1203 3992-3522 4.62 103.0 µM 1.90E-7 8 1.87E-6 0.43
7 SGTC_1470 k295-0292 4.11 231.0 µM 3.22E-6 2 2.00E-5 0.11
8 SGTC_2081 5214970 4.01 32.3 µM 5.26E-6 2 3.01E-5 0.54
9 SGTC_64 000l-0018 3.95 272.1 µM 7.05E-6 ubiquinone biosynthesis & proteasome 46 3.85E-5 0.04
10 SGTC_1723 st034307 3.76 2.5 µM 1.85E-5 mitochondrial processes 17 8.63E-5 0.05
11 SGTC_110 0850-0284 3.60 111.6 µM 3.83E-5 5 1.59E-4 0.07
12 SGTC_142 0335-0849 3.58 62.7 µM 4.18E-5 ubiquinone biosynthesis & proteasome 22 1.71E-4 0.01
13 SGTC_1885 st057546 3.54 99.9 µM 5.02E-5 3 2.00E-4 0.01
14 SGTC_938 3126-1755 3.50 342.0 µM 5.99E-5 4 2.32E-4 0.22
15 SGTC_1364 1653-0028 3.34 37.6 µM 1.22E-4 6 4.20E-4 0.06
16 SGTC_3151 9099821 3.32 49.5 µM 1.33E-4 7 4.53E-4 0.08
17 SGTC_151 3013-0144 3.31 2.3 µM 1.35E-4 iron homeostasis 19 4.59E-4 0.17
18 SGTC_2461 5755302 3.31 26.1 µM 1.39E-4 9 4.69E-4 0.11
19 SGTC_2964 9083345 3.28 53.4 µM 1.60E-4 20 5.27E-4 0.00
20 SGTC_1499 4480-0877 3.27 67.3 µM 1.64E-4 3 5.39E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.334 4.22E-88 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.297 1.79E-69 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.290 2.91E-66 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.279 4.03E-61 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.275 2.45E-59 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.275 2.20E-59 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.269 1.08E-56 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.266 1.26E-55 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.259 2.15E-52 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.255 8.69E-51 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.251 2.42E-49 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.250 4.19E-49 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.241 1.56E-45 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.235 2.02E-43 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.219 8.85E-38 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated