YLR010C / TEN1

Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR010C / TEN1

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:3.49|P-value:4.69E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.80|P-value:1.44E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.43|P-value:5.72E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:4.37|P-value:1.69E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.74|P-value:1.80E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-4.27|P-value:2.34E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:3.73|P-value:2.00E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.53|P-value:4.08E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:-3.55|P-value:3.52E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.95|P-value:8.45E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:3.68|P-value:2.45E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:5.21|P-value:3.93E-7 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.65|P-value:2.69E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.81|P-value:1.51E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.71|P-value:2.06E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.31|P-value:8.55E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.87|P-value:1.22E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:4.14|P-value:4.30E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-4.20|P-value:3.11E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.46|P-value:4.93E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.47|P-value:4.64E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-4.19|P-value:3.28E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.53|P-value:4.10E-4 ID:SGTC_1721|Compound:st082152|FD-Score:4.05|P-value:6.19E-5 ID:SGTC_1769|Compound:st044406|FD-Score:5.77|P-value:2.23E-8 ID:SGTC_1772|Compound:st048439|FD-Score:-4.27|P-value:2.42E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.30|P-value:8.72E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.35|P-value:7.57E-4 ID:SGTC_1982|Compound:st072467|FD-Score:4.03|P-value:6.54E-5 ID:SGTC_2066|Compound:5222451|FD-Score:4.27|P-value:2.61E-5 ID:SGTC_2068|Compound:5226020|FD-Score:-4.54|P-value:7.58E-6 ID:SGTC_2264|Compound:7948757|FD-Score:4.62|P-value:5.99E-6 ID:SGTC_2265|Compound:7929201|FD-Score:5.00|P-value:1.07E-6 ID:SGTC_2266|Compound:7929956|FD-Score:4.11|P-value:4.93E-5 ID:SGTC_2274|Compound:7947094|FD-Score:4.80|P-value:2.69E-6 ID:SGTC_2344|Compound:7990960|FD-Score:4.11|P-value:4.82E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.35|P-value:7.41E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.38|P-value:1.63E-5 ID:SGTC_2421|Compound:5690543|FD-Score:4.57|P-value:7.24E-6 ID:SGTC_2433|Compound:5607874|FD-Score:-5.37|P-value:1.56E-7 ID:SGTC_2493|Compound:resveratrol|FD-Score:-3.60|P-value:3.02E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.11|P-value:4.93E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:5.21|P-value:3.89E-7 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.61|P-value:3.07E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.68|P-value:2.27E-4 ID:SGTC_2787|Compound:5284540|FD-Score:5.02|P-value:9.54E-7 ID:SGTC_2816|Compound:7982706|FD-Score:4.01|P-value:7.08E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-3.35|P-value:6.98E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.46|P-value:4.80E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.94|P-value:9.29E-5 ID:SGTC_2928|Compound:9011484|FD-Score:5.53|P-value:7.75E-8 ID:SGTC_3030|Compound:9087619|FD-Score:3.47|P-value:5.09E-4 ID:SGTC_3058|Compound:9093861|FD-Score:5.64|P-value:4.28E-8 ID:SGTC_3062|Compound:9077494|FD-Score:-3.46|P-value:4.90E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-3.29|P-value:8.61E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.93|P-value:9.71E-5 ID:SGTC_3303|Compound:9125618|FD-Score:3.92|P-value:1.01E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.65|P-value:2.70E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.49|P-value:4.69E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.80|P-value:1.44E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.43|P-value:5.72E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:4.37|P-value:1.69E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.74|P-value:1.80E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-4.27|P-value:2.34E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:3.73|P-value:2.00E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.53|P-value:4.08E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:-3.55|P-value:3.52E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.95|P-value:8.45E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:3.68|P-value:2.45E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:5.21|P-value:3.93E-7 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.65|P-value:2.69E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.81|P-value:1.51E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.71|P-value:2.06E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.31|P-value:8.55E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.87|P-value:1.22E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:4.14|P-value:4.30E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-4.20|P-value:3.11E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.46|P-value:4.93E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.47|P-value:4.64E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-4.19|P-value:3.28E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.53|P-value:4.10E-4 ID:SGTC_1721|Compound:st082152|FD-Score:4.05|P-value:6.19E-5 ID:SGTC_1769|Compound:st044406|FD-Score:5.77|P-value:2.23E-8 ID:SGTC_1772|Compound:st048439|FD-Score:-4.27|P-value:2.42E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.30|P-value:8.72E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.35|P-value:7.57E-4 ID:SGTC_1982|Compound:st072467|FD-Score:4.03|P-value:6.54E-5 ID:SGTC_2066|Compound:5222451|FD-Score:4.27|P-value:2.61E-5 ID:SGTC_2068|Compound:5226020|FD-Score:-4.54|P-value:7.58E-6 ID:SGTC_2264|Compound:7948757|FD-Score:4.62|P-value:5.99E-6 ID:SGTC_2265|Compound:7929201|FD-Score:5.00|P-value:1.07E-6 ID:SGTC_2266|Compound:7929956|FD-Score:4.11|P-value:4.93E-5 ID:SGTC_2274|Compound:7947094|FD-Score:4.80|P-value:2.69E-6 ID:SGTC_2344|Compound:7990960|FD-Score:4.11|P-value:4.82E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.35|P-value:7.41E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.38|P-value:1.63E-5 ID:SGTC_2421|Compound:5690543|FD-Score:4.57|P-value:7.24E-6 ID:SGTC_2433|Compound:5607874|FD-Score:-5.37|P-value:1.56E-7 ID:SGTC_2493|Compound:resveratrol|FD-Score:-3.60|P-value:3.02E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.11|P-value:4.93E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:5.21|P-value:3.89E-7 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.61|P-value:3.07E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.68|P-value:2.27E-4 ID:SGTC_2787|Compound:5284540|FD-Score:5.02|P-value:9.54E-7 ID:SGTC_2816|Compound:7982706|FD-Score:4.01|P-value:7.08E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-3.35|P-value:6.98E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.46|P-value:4.80E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.94|P-value:9.29E-5 ID:SGTC_2928|Compound:9011484|FD-Score:5.53|P-value:7.75E-8 ID:SGTC_3030|Compound:9087619|FD-Score:3.47|P-value:5.09E-4 ID:SGTC_3058|Compound:9093861|FD-Score:5.64|P-value:4.28E-8 ID:SGTC_3062|Compound:9077494|FD-Score:-3.46|P-value:4.90E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-3.29|P-value:8.61E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.93|P-value:9.71E-5 ID:SGTC_3303|Compound:9125618|FD-Score:3.92|P-value:1.01E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.65|P-value:2.70E-4

Top fitness defect scores for YLR010C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1769 st044406 5.77 64.4 µM 2.23E-8 1 4.06E-9 0.71
2 SGTC_3058 9093861 5.64 49.5 µM 4.28E-8 1 8.35E-9 1.03
3 SGTC_2928 9011484 5.53 9.8 µM 7.75E-8 heme biosynthesis & mitochondrial translocase 15 1.61E-8 0.01
4 SGTC_2516 gossypol 5.21 71.5 µM 3.89E-7 5 9.57E-8 0.20
5 SGTC_966 1300-0360 5.21 30.2 µM 3.93E-7 heme requiring 6 9.67E-8 0.24
6 SGTC_2787 5284540 5.02 71.4 µM 9.54E-7 5 2.58E-7 0.11
7 SGTC_2265 7929201 5.00 200.0 µM 1.07E-6 3 2.92E-7 0.53
8 SGTC_2274 7947094 4.80 46.1 µM 2.69E-6 3 8.11E-7 0.36
9 SGTC_2264 7948757 4.62 110.8 µM 5.99E-6 2 1.96E-6 0.69
10 SGTC_2421 5690543 4.57 90.7 µM 7.24E-6 1 2.42E-6 0.65
11 SGTC_2396 5342950 4.38 42.8 µM 1.63E-5 RSC complex & mRNA processing 27 5.94E-6 0.01
12 SGTC_342 k048-0088 4.37 23.3 µM 1.69E-5 RSC & ERG11 7 6.16E-6 0.09
13 SGTC_2066 5222451 4.27 176.0 µM 2.61E-5 heme biosynthesis & mitochondrial translocase 20 9.96E-6 0.05
14 SGTC_1093 fluphenazine 4.14 8.0 µM 4.30E-5 2 1.73E-5 0.08
15 SGTC_2344 7990960 4.11 77.0 µM 4.82E-5 36 1.96E-5 0.02
16 SGTC_2504 purpurogallin 4.11 52.3 µM 4.93E-5 RPP1 & pyrimidine depletion 3 2.01E-5 0.35
17 SGTC_2266 7929956 4.11 200.0 µM 4.93E-5 3 2.01E-5 0.24
18 SGTC_1721 st082152 4.05 9.3 µM 6.19E-5 60S ribosome export 10 2.58E-5 0.27
19 SGTC_1982 st072467 4.03 71.9 µM 6.54E-5 7 2.75E-5 0.17
20 SGTC_2816 7982706 4.01 58.4 µM 7.08E-5 azole & statin 11 3.00E-5 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.38E-13 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.104 1.73E-9 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.092 9.18E-8 YER103W SSA4 hom Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication
0.083 1.49E-6 YIL075C RPN2 het Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress
0.082 1.96E-6 YJL167W ERG20 het Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
0.082 2.14E-6 YLR089C ALT1 hom Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive
0.077 8.09E-6 YPL224C MMT2 hom Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
0.074 1.93E-5 YDR016C DAD1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.072 3.06E-5 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.070 5.28E-5 YER022W SRB4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination
0.069 5.67E-5 YMR218C TRS130 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
0.068 7.68E-5 YOR378W_p YOR378W_p hom Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
0.068 8.26E-5 YLR100W ERG27 het 3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs
0.065 1.83E-4 YGL224C SDT1 hom Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives
0.064 2.11E-4 YDR303C RSC3 het Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p