Putative protein of unknown function; YLR012C is not an essential gene
Zygosity: Homozygous strain
fixedexpanded
![]() ![]() Click on Significant Values for Screen Details |
Top fitness defect scores for YLR012C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.105 | 9.72E-10 | YJR022W | LSM8 | het | Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA |
0.093 | 7.18E-8 | YOR376W_d | YOR376W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene. |
0.087 | 4.74E-7 | YGR227W | DIE2 | hom | Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1 |
0.081 | 2.93E-6 | YNR031C | SSK2 | hom | MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress |
0.079 | 4.98E-6 | YDL223C | HBT1 | hom | Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis |
0.078 | 5.75E-6 | YOL035C_d | YOL035C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.078 | 6.16E-6 | YOR131C | YOR131C | hom | Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress |
0.077 | 7.67E-6 | YPL175W | SPT14 | het | UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins |
0.077 | 7.72E-6 | YLR080W | EMP46 | hom | Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport |
0.077 | 8.30E-6 | YFL011W | HXT10 | hom | Putative hexose transporter, expressed at low levels and expression is repressed by glucose |
0.074 | 2.10E-5 | YDR218C | SPR28 | hom | Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation |
0.073 | 2.31E-5 | YBR215W | HPC2 | hom | Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes |
0.071 | 3.72E-5 | YOR316C | COT1 | hom | Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication |
0.071 | 3.83E-5 | YNR021W_p | YNR021W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene |
0.070 | 5.25E-5 | YJR017C | ESS1 | het | Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3 |