YLR012C_p

Putative protein of unknown function; YLR012C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR012C / YLR012C

Click on Significant Values for Screen Details ID:SGTC_252|Compound:miconazole|FD-Score:-5.13|P-value:1.80E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.87|P-value:3.03E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:5.53|P-value:4.42E-7 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.45|P-value:8.97E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.88|P-value:2.21E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.86|P-value:3.11E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:-3.69|P-value:4.14E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.48|P-value:8.09E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:4.05|P-value:1.64E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.93|P-value:2.49E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:4.34|P-value:5.85E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.80|P-value:1.01E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:-4.39|P-value:3.67E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.87|P-value:3.05E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.87|P-value:7.44E-6 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.68|P-value:5.48E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.00|P-value:4.49E-6 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.26|P-value:7.75E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.69|P-value:5.37E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:5.43|P-value:6.71E-7 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.90|P-value:2.70E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:4.98|P-value:4.72E-6 ID:SGTC_1521|Compound:st012942|FD-Score:3.98|P-value:2.06E-4 ID:SGTC_1522|Compound:st012842|FD-Score:8.20|P-value:1.33E-13 ID:SGTC_1679|Compound:4130-1276|FD-Score:-4.54|P-value:2.07E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-4.34|P-value:4.43E-5 ID:SGTC_1893|Compound:st059353|FD-Score:3.94|P-value:2.39E-4 ID:SGTC_1906|Compound:st060206|FD-Score:-4.22|P-value:6.82E-5 ID:SGTC_1970|Compound:st070122|FD-Score:4.63|P-value:1.94E-5 ID:SGTC_2049|Compound:5262831|FD-Score:-4.53|P-value:2.15E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-3.63|P-value:5.09E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-4.56|P-value:1.92E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.24|P-value:8.45E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-5.15|P-value:1.67E-6 ID:SGTC_2793|Compound:7325131|FD-Score:-3.56|P-value:6.38E-4 ID:SGTC_2796|Compound:7949634|FD-Score:5.07|P-value:3.27E-6 ID:SGTC_2801|Compound:7907800|FD-Score:4.06|P-value:1.58E-4 ID:SGTC_2803|Compound:7707263|FD-Score:4.37|P-value:5.19E-5 ID:SGTC_2888|Compound:9058547|FD-Score:5.07|P-value:3.24E-6 ID:SGTC_2969|Compound:9091408|FD-Score:3.63|P-value:6.44E-4 ID:SGTC_2970|Compound:9090938|FD-Score:8.32|P-value:6.00E-14 ID:SGTC_2975|Compound:9084847|FD-Score:-5.43|P-value:4.94E-7 ID:SGTC_3040|Compound:9091894|FD-Score:4.27|P-value:7.44E-5 ID:SGTC_3153|Compound:9100258|FD-Score:4.08|P-value:1.46E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-4.22|P-value:6.73E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.60|P-value:7.07E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.62|P-value:6.71E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.80|P-value:3.83E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.60|P-value:5.50E-4 ID:SGTC_252|Compound:miconazole|FD-Score:-5.13|P-value:1.80E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.87|P-value:3.03E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:5.53|P-value:4.42E-7 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.45|P-value:8.97E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.88|P-value:2.21E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.86|P-value:3.11E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:-3.69|P-value:4.14E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.48|P-value:8.09E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:4.05|P-value:1.64E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.93|P-value:2.49E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:4.34|P-value:5.85E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.80|P-value:1.01E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:-4.39|P-value:3.67E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.87|P-value:3.05E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.87|P-value:7.44E-6 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.68|P-value:5.48E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.00|P-value:4.49E-6 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.26|P-value:7.75E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.69|P-value:5.37E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:5.43|P-value:6.71E-7 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.90|P-value:2.70E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:4.98|P-value:4.72E-6 ID:SGTC_1521|Compound:st012942|FD-Score:3.98|P-value:2.06E-4 ID:SGTC_1522|Compound:st012842|FD-Score:8.20|P-value:1.33E-13 ID:SGTC_1679|Compound:4130-1276|FD-Score:-4.54|P-value:2.07E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-4.34|P-value:4.43E-5 ID:SGTC_1893|Compound:st059353|FD-Score:3.94|P-value:2.39E-4 ID:SGTC_1906|Compound:st060206|FD-Score:-4.22|P-value:6.82E-5 ID:SGTC_1970|Compound:st070122|FD-Score:4.63|P-value:1.94E-5 ID:SGTC_2049|Compound:5262831|FD-Score:-4.53|P-value:2.15E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-3.63|P-value:5.09E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-4.56|P-value:1.92E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.24|P-value:8.45E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-5.15|P-value:1.67E-6 ID:SGTC_2793|Compound:7325131|FD-Score:-3.56|P-value:6.38E-4 ID:SGTC_2796|Compound:7949634|FD-Score:5.07|P-value:3.27E-6 ID:SGTC_2801|Compound:7907800|FD-Score:4.06|P-value:1.58E-4 ID:SGTC_2803|Compound:7707263|FD-Score:4.37|P-value:5.19E-5 ID:SGTC_2888|Compound:9058547|FD-Score:5.07|P-value:3.24E-6 ID:SGTC_2969|Compound:9091408|FD-Score:3.63|P-value:6.44E-4 ID:SGTC_2970|Compound:9090938|FD-Score:8.32|P-value:6.00E-14 ID:SGTC_2975|Compound:9084847|FD-Score:-5.43|P-value:4.94E-7 ID:SGTC_3040|Compound:9091894|FD-Score:4.27|P-value:7.44E-5 ID:SGTC_3153|Compound:9100258|FD-Score:4.08|P-value:1.46E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-4.22|P-value:6.73E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.60|P-value:7.07E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.62|P-value:6.71E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.80|P-value:3.83E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.60|P-value:5.50E-4

Top fitness defect scores for YLR012C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2970 9090938 8.32 41.9 µM 6.00E-14 RNA processing & uracil transport 1 4.44E-17
2 SGTC_1522 st012842 8.20 45.6 µM 1.33E-13 RNA pol III & RNase P/MRP 2 1.20E-16
3 SGTC_425 3825-7017 5.53 13.1 µM 4.42E-7 8 1.63E-8
4 SGTC_1340 1486-1359 5.43 257.0 µM 6.71E-7 5 2.74E-8
5 SGTC_2888 9058547 5.07 13.0 µM 3.24E-6 2 1.95E-7
6 SGTC_2796 7949634 5.07 45.5 µM 3.27E-6 9 1.97E-7
7 SGTC_1107 amlodipine 5.00 47.0 µM 4.49E-6 16 2.93E-7
8 SGTC_1505 k297-0037 4.98 20.6 µM 4.72E-6 8 3.12E-7
9 SGTC_1055 3448-0672 4.87 86.0 µM 7.44E-6 16 5.49E-7
10 SGTC_1012 4112-3522 4.80 18.0 µM 1.01E-5 12 7.99E-7
11 SGTC_1970 st070122 4.63 35.8 µM 1.94E-5 TSC3-RPN4 16 1.80E-6
12 SGTC_2803 7707263 4.37 71.4 µM 5.19E-5 23 6.15E-6
13 SGTC_968 1309-0633 4.34 340.0 µM 5.85E-5 8 7.15E-6
14 SGTC_3040 9091894 4.27 49.5 µM 7.44E-5 DNA intercalators 17 9.63E-6
15 SGTC_1313 1220-0047 4.26 237.0 µM 7.75E-5 30 1.01E-5
16 SGTC_2753 fluvastatin 4.24 17.1 µM 8.45E-5 azole & statin 26 1.13E-5
17 SGTC_3153 9100258 4.08 49.5 µM 1.46E-4 18 2.22E-5
18 SGTC_2801 7907800 4.06 81.8 µM 1.58E-4 25 2.45E-5
19 SGTC_836 0330-0104 4.05 1.4 µM 1.64E-4 13 2.58E-5
20 SGTC_1521 st012942 3.98 49.4 µM 2.06E-4 30 3.42E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 9.72E-10 YJR022W LSM8 het Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
0.093 7.18E-8 YOR376W_d YOR376W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
0.087 4.74E-7 YGR227W DIE2 hom Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1
0.081 2.93E-6 YNR031C SSK2 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
0.079 4.98E-6 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.078 5.75E-6 YOL035C_d YOL035C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.078 6.16E-6 YOR131C YOR131C hom Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress
0.077 7.67E-6 YPL175W SPT14 het UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins
0.077 7.72E-6 YLR080W EMP46 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.077 8.30E-6 YFL011W HXT10 hom Putative hexose transporter, expressed at low levels and expression is repressed by glucose
0.074 2.10E-5 YDR218C SPR28 hom Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation
0.073 2.31E-5 YBR215W HPC2 hom Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes
0.071 3.72E-5 YOR316C COT1 hom Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication
0.071 3.83E-5 YNR021W_p YNR021W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene
0.070 5.25E-5 YJR017C ESS1 het Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3