YLR015W / BRE2

Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR015W / BRE2

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:4.00|P-value:2.92E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:4.35|P-value:8.96E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:4.63|P-value:3.43E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:8.93|P-value:7.62E-15 ID:SGTC_91|Compound:0417-1751|FD-Score:4.84|P-value:1.54E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.82|P-value:5.10E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.19|P-value:1.54E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:6.06|P-value:9.00E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:4.37|P-value:8.44E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.10|P-value:2.10E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.19|P-value:1.57E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:5.92|P-value:1.76E-7 ID:SGTC_467|Compound:ro 31-8220|FD-Score:8.58|P-value:7.86E-14 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.66|P-value:8.26E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:9.25|P-value:8.43E-16 ID:SGTC_545|Compound:4218-0007|FD-Score:3.59|P-value:9.91E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.93|P-value:3.62E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.84|P-value:4.75E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:4.90|P-value:1.24E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:3.92|P-value:3.70E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.96|P-value:3.28E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:4.15|P-value:1.75E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.53|P-value:9.82E-7 ID:SGTC_822|Compound:1487-0950|FD-Score:3.73|P-value:6.69E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.65|P-value:8.44E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:4.73|P-value:2.37E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.72|P-value:6.82E-4 ID:SGTC_918|Compound:glabranin|FD-Score:4.22|P-value:1.40E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.44|P-value:6.65E-5 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.63|P-value:8.97E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.69|P-value:2.75E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.41|P-value:7.40E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.57|P-value:4.14E-5 ID:SGTC_1745|Compound:st081495|FD-Score:8.17|P-value:1.05E-12 ID:SGTC_2192|Compound:5915882|FD-Score:5.73|P-value:4.02E-7 ID:SGTC_2342|Compound:7990637|FD-Score:4.13|P-value:1.90E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-4.02|P-value:2.72E-4 ID:SGTC_2488|Compound:5268135|FD-Score:5.04|P-value:7.08E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.38|P-value:8.27E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.48|P-value:5.77E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:5.44|P-value:1.42E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.77|P-value:3.43E-7 ID:SGTC_2593|Compound:nobiletin|FD-Score:-5.16|P-value:4.47E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.00|P-value:8.40E-6 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.94|P-value:3.51E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.94|P-value:3.49E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.70|P-value:7.30E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.92|P-value:3.67E-4 ID:SGTC_2902|Compound:5787006|FD-Score:4.20|P-value:1.50E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.35|P-value:9.14E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.75|P-value:6.32E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.72|P-value:6.76E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.62|P-value:3.51E-5 ID:SGTC_3138|Compound:9097216|FD-Score:4.66|P-value:3.07E-5 ID:SGTC_3193|Compound:9111931|FD-Score:4.30|P-value:1.06E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.68|P-value:7.77E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.65|P-value:8.35E-4 ID:SGTC_3281|Compound:9140613|FD-Score:3.70|P-value:7.23E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:4.00|P-value:2.92E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:4.35|P-value:8.96E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:4.63|P-value:3.43E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:8.93|P-value:7.62E-15 ID:SGTC_91|Compound:0417-1751|FD-Score:4.84|P-value:1.54E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.82|P-value:5.10E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.19|P-value:1.54E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:6.06|P-value:9.00E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:4.37|P-value:8.44E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:4.10|P-value:2.10E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.19|P-value:1.57E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:5.92|P-value:1.76E-7 ID:SGTC_467|Compound:ro 31-8220|FD-Score:8.58|P-value:7.86E-14 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.66|P-value:8.26E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:9.25|P-value:8.43E-16 ID:SGTC_545|Compound:4218-0007|FD-Score:3.59|P-value:9.91E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.93|P-value:3.62E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.84|P-value:4.75E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:4.90|P-value:1.24E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:3.92|P-value:3.70E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.96|P-value:3.28E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:4.15|P-value:1.75E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.53|P-value:9.82E-7 ID:SGTC_822|Compound:1487-0950|FD-Score:3.73|P-value:6.69E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.65|P-value:8.44E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:4.73|P-value:2.37E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.72|P-value:6.82E-4 ID:SGTC_918|Compound:glabranin|FD-Score:4.22|P-value:1.40E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:4.44|P-value:6.65E-5 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.63|P-value:8.97E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.69|P-value:2.75E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.41|P-value:7.40E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.57|P-value:4.14E-5 ID:SGTC_1745|Compound:st081495|FD-Score:8.17|P-value:1.05E-12 ID:SGTC_2192|Compound:5915882|FD-Score:5.73|P-value:4.02E-7 ID:SGTC_2342|Compound:7990637|FD-Score:4.13|P-value:1.90E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-4.02|P-value:2.72E-4 ID:SGTC_2488|Compound:5268135|FD-Score:5.04|P-value:7.08E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.38|P-value:8.27E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.48|P-value:5.77E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:5.44|P-value:1.42E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.77|P-value:3.43E-7 ID:SGTC_2593|Compound:nobiletin|FD-Score:-5.16|P-value:4.47E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.00|P-value:8.40E-6 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.94|P-value:3.51E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.94|P-value:3.49E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.70|P-value:7.30E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.92|P-value:3.67E-4 ID:SGTC_2902|Compound:5787006|FD-Score:4.20|P-value:1.50E-4 ID:SGTC_2924|Compound:9010168|FD-Score:4.35|P-value:9.14E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.75|P-value:6.32E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.72|P-value:6.76E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.62|P-value:3.51E-5 ID:SGTC_3138|Compound:9097216|FD-Score:4.66|P-value:3.07E-5 ID:SGTC_3193|Compound:9111931|FD-Score:4.30|P-value:1.06E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.68|P-value:7.77E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.65|P-value:8.35E-4 ID:SGTC_3281|Compound:9140613|FD-Score:3.70|P-value:7.23E-4

Top fitness defect scores for YLR015W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_539 4859-0462 9.25 2.5 µM 8.43E-16 RNA pol III & RNase P/MRP 1 1.09E-20
2 SGTC_86 0417-1630 8.93 471.9 µM 7.62E-15 ubiquinone biosynthesis & proteasome 50 2.10E-19
3 SGTC_467 ro 31-8220 8.58 72.8 µM 7.86E-14 calcium & mitochondrial duress 13 4.85E-18
4 SGTC_1745 st081495 8.17 74.0 µM 1.05E-12 RNA processing & uracil transport 12 1.58E-16
5 SGTC_142 0335-0849 6.06 62.7 µM 9.00E-8 ubiquinone biosynthesis & proteasome 61 6.62E-10
6 SGTC_363 0455-0021 5.92 3.1 µM 1.76E-7 azole & statin 32 1.63E-9
7 SGTC_2582 agaric acid 5.77 100.0 µM 3.43E-7 redox potentiating 173 3.96E-9
8 SGTC_2192 5915882 5.73 198.5 µM 4.02E-7 RNA processing & uracil transport 15 4.92E-9
9 SGTC_794 k038-0031 5.53 316.0 µM 9.82E-7 ubiquinone biosynthesis & proteasome 68 1.62E-8
10 SGTC_2578 7,8-dihydroxyflavone 5.44 64.4 µM 1.42E-6 12 2.65E-8
11 SGTC_2488 5268135 5.04 45.7 µM 7.08E-6 27 2.28E-7
12 SGTC_2651 1327-0036 5.00 5.0 µM 8.40E-6 108 2.86E-7
13 SGTC_711 k292-0785 4.90 179.0 µM 1.24E-5 DNA intercalators 9 4.81E-7
14 SGTC_91 0417-1751 4.84 58.4 µM 1.54E-5 Golgi 28 6.44E-7
15 SGTC_899 1083-0020 4.73 478.0 µM 2.37E-5 11 1.14E-6
16 SGTC_1313 1220-0047 4.69 237.0 µM 2.75E-5 22 1.39E-6
17 SGTC_3138 9097216 4.66 49.5 µM 3.07E-5 8 1.61E-6
18 SGTC_36 0335-0881 4.63 14.2 µM 3.43E-5 ubiquinone biosynthesis & proteasome 92 1.87E-6
19 SGTC_3078 9116413 4.62 49.5 µM 3.51E-5 unfolded protein response 22 1.92E-6
20 SGTC_1364 1653-0028 4.57 37.6 µM 4.14E-5 10 2.40E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.225 1.11E-39 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.214 5.88E-36 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.212 2.98E-35 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.208 5.05E-34 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.206 2.23E-33 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.204 7.20E-33 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.197 1.19E-30 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.194 7.42E-30 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.191 6.66E-29 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.189 3.14E-28 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.185 3.03E-27 YLR420W URA4 hom Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
0.185 3.78E-27 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.184 6.42E-27 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.182 2.50E-26 YEL031W SPF1 hom P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
0.181 4.33E-26 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication