YLR017W / MEU1

Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR017W / MEU1

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:-5.10|P-value:9.31E-8 ID:SGTC_49|Compound:0717-0965|FD-Score:3.32|P-value:2.74E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.24|P-value:3.70E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.24|P-value:4.93E-4 ID:SGTC_271|Compound:rotenone|FD-Score:4.05|P-value:1.31E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:3.41|P-value:1.93E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.37|P-value:2.22E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-4.63|P-value:1.15E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:3.35|P-value:2.39E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.21|P-value:4.18E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.00|P-value:1.60E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.99|P-value:1.71E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.39|P-value:2.81E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:4.43|P-value:2.11E-6 ID:SGTC_890|Compound:0929-0006|FD-Score:3.01|P-value:8.50E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.19|P-value:4.51E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.25|P-value:3.61E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.11|P-value:5.99E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.15|P-value:5.18E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.44|P-value:1.71E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.01|P-value:8.46E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-4.21|P-value:8.82E-6 ID:SGTC_1676|Compound:st018489|FD-Score:-3.36|P-value:3.16E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.58|P-value:9.97E-5 ID:SGTC_1800|Compound:st050079|FD-Score:2.98|P-value:9.54E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.55|P-value:1.11E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-3.92|P-value:3.18E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.56|P-value:1.08E-4 ID:SGTC_2043|Compound:5101342|FD-Score:-4.92|P-value:2.51E-7 ID:SGTC_2060|Compound:5238662|FD-Score:3.59|P-value:9.44E-5 ID:SGTC_2067|Compound:5224629|FD-Score:-4.44|P-value:2.96E-6 ID:SGTC_2081|Compound:5214970|FD-Score:-3.37|P-value:3.04E-4 ID:SGTC_2223|Compound:6903751|FD-Score:-3.80|P-value:5.31E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.53|P-value:1.22E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.12|P-value:5.82E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:3.16|P-value:4.95E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.84|P-value:4.51E-5 ID:SGTC_2860|Compound:9025725|FD-Score:3.80|P-value:3.95E-5 ID:SGTC_2867|Compound:9039098|FD-Score:-5.06|P-value:1.18E-7 ID:SGTC_2875|Compound:9039966|FD-Score:-4.47|P-value:2.48E-6 ID:SGTC_2971|Compound:9092186|FD-Score:3.42|P-value:1.86E-4 ID:SGTC_3010|Compound:9080089|FD-Score:4.53|P-value:1.30E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:-5.10|P-value:9.31E-8 ID:SGTC_49|Compound:0717-0965|FD-Score:3.32|P-value:2.74E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.24|P-value:3.70E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.24|P-value:4.93E-4 ID:SGTC_271|Compound:rotenone|FD-Score:4.05|P-value:1.31E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:3.41|P-value:1.93E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.37|P-value:2.22E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-4.63|P-value:1.15E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:3.35|P-value:2.39E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.21|P-value:4.18E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:4.00|P-value:1.60E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.99|P-value:1.71E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.39|P-value:2.81E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:4.43|P-value:2.11E-6 ID:SGTC_890|Compound:0929-0006|FD-Score:3.01|P-value:8.50E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.19|P-value:4.51E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.25|P-value:3.61E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.11|P-value:5.99E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.15|P-value:5.18E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.44|P-value:1.71E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.01|P-value:8.46E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-4.21|P-value:8.82E-6 ID:SGTC_1676|Compound:st018489|FD-Score:-3.36|P-value:3.16E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.58|P-value:9.97E-5 ID:SGTC_1800|Compound:st050079|FD-Score:2.98|P-value:9.54E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.55|P-value:1.11E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-3.92|P-value:3.18E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.56|P-value:1.08E-4 ID:SGTC_2043|Compound:5101342|FD-Score:-4.92|P-value:2.51E-7 ID:SGTC_2060|Compound:5238662|FD-Score:3.59|P-value:9.44E-5 ID:SGTC_2067|Compound:5224629|FD-Score:-4.44|P-value:2.96E-6 ID:SGTC_2081|Compound:5214970|FD-Score:-3.37|P-value:3.04E-4 ID:SGTC_2223|Compound:6903751|FD-Score:-3.80|P-value:5.31E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.53|P-value:1.22E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.12|P-value:5.82E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:3.16|P-value:4.95E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.84|P-value:4.51E-5 ID:SGTC_2860|Compound:9025725|FD-Score:3.80|P-value:3.95E-5 ID:SGTC_2867|Compound:9039098|FD-Score:-5.06|P-value:1.18E-7 ID:SGTC_2875|Compound:9039966|FD-Score:-4.47|P-value:2.48E-6 ID:SGTC_2971|Compound:9092186|FD-Score:3.42|P-value:1.86E-4 ID:SGTC_3010|Compound:9080089|FD-Score:4.53|P-value:1.30E-6

Top fitness defect scores for YLR017W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3010 9080089 4.53 71.4 µM 1.30E-6 6 2.97E-6
2 SGTC_764 1951-2361 4.43 146.0 µM 2.11E-6 25 4.69E-6
3 SGTC_271 rotenone 4.05 740.0 µM 1.31E-5 19 2.61E-5
4 SGTC_584 0986-0246 4.00 15.4 µM 1.60E-5 heme requiring 12 3.13E-5
5 SGTC_706 4262-0057 3.99 46.9 µM 1.71E-5 fatty acid desaturase (OLE1) 32 3.34E-5
6 SGTC_2860 9025725 3.80 39.0 µM 3.95E-5 RPP1 & pyrimidine depletion 12 7.34E-5
7 SGTC_2060 5238662 3.59 140.0 µM 9.44E-5 36 1.66E-4
8 SGTC_1754 st042065 3.58 16.1 µM 9.97E-5 NEO1-PIK1 210 1.75E-4
9 SGTC_2038 4100038 3.56 31.0 µM 1.08E-4 plasma membrane duress 67 1.89E-4
10 SGTC_1933 st074711 3.55 15.9 µM 1.11E-4 57 1.94E-4
11 SGTC_2663 amphotericin b 3.53 100.0 µM 1.22E-4 19 2.11E-4
12 SGTC_1500 4488-1866 3.44 171.0 µM 1.71E-4 RPP1 & pyrimidine depletion 36 2.90E-4
13 SGTC_2971 9092186 3.42 9.9 µM 1.86E-4 ergosterol biosynthesis 49 3.14E-4
14 SGTC_334 1502-1024 3.41 68.5 µM 1.93E-4 24 3.25E-4
15 SGTC_343 4130-2827 3.37 29.8 µM 2.22E-4 50 3.70E-4
16 SGTC_536 3852-0578 3.35 10.6 µM 2.39E-4 50 3.97E-4
17 SGTC_49 0717-0965 3.32 32.1 µM 2.74E-4 60S ribosome export 44 4.51E-4
18 SGTC_925 2064-1272 3.25 59.6 µM 3.61E-4 45 5.84E-4
19 SGTC_50 0929-0078 3.24 56.4 µM 3.70E-4 84 5.98E-4
20 SGTC_580 1123-0028 3.21 41.0 µM 4.18E-4 DNA damage response 70 6.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.088 3.12E-7 YOR230W WTM1 hom Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
0.083 1.51E-6 YBR128C ATG14 hom Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor
0.082 1.71E-6 YHR117W TOM71 hom Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication
0.081 2.93E-6 YJL167W ERG20 het Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
0.079 5.24E-6 YPR014C_d YPR014C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
0.077 7.84E-6 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.072 2.64E-5 YHL024W RIM4 hom Putative RNA-binding protein required for the expression of early and middle sporulation genes
0.071 3.77E-5 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.071 3.81E-5 YLR438C-A LSM3 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.070 4.58E-5 YDR418W RPL12B hom Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication
0.069 5.69E-5 YNL332W THI12 hom Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
0.069 5.69E-5 YOR045W TOM6 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.068 7.18E-5 YBR113W_d YBR113W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
0.067 1.10E-4 YDR022C ATG31 hom Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
0.067 1.14E-4 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin