YLR018C / POM34

Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR018C / POM34

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.01|P-value:3.23E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:-2.94|P-value:9.92E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.23|P-value:1.26E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:2.90|P-value:4.84E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.28|P-value:1.02E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.78|P-value:2.99E-5 ID:SGTC_564|Compound:3555-0129|FD-Score:3.07|P-value:2.54E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.17|P-value:1.64E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:2.79|P-value:7.56E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.74|P-value:1.27E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:6.30|P-value:1.14E-12 ID:SGTC_1032|Compound:k061-1018|FD-Score:2.84|P-value:6.24E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:-2.95|P-value:9.56E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.10|P-value:2.18E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:2.77|P-value:7.96E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:2.85|P-value:5.98E-4 ID:SGTC_1712|Compound:st032288|FD-Score:2.75|P-value:8.74E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.51|P-value:3.68E-5 ID:SGTC_1820|Compound:st053765|FD-Score:4.12|P-value:1.89E-6 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.38|P-value:1.73E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.88|P-value:6.29E-6 ID:SGTC_2007|Compound:4011539|FD-Score:-3.14|P-value:4.70E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.03|P-value:2.99E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.04|P-value:2.78E-4 ID:SGTC_2205|Compound:7238770|FD-Score:2.76|P-value:8.55E-4 ID:SGTC_2221|Compound:6807166|FD-Score:2.76|P-value:8.52E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.00|P-value:7.93E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.19|P-value:1.51E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.78|P-value:2.96E-5 ID:SGTC_2591|Compound:skatole|FD-Score:2.99|P-value:3.42E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-5.37|P-value:4.48E-9 ID:SGTC_2803|Compound:7707263|FD-Score:4.55|P-value:1.68E-7 ID:SGTC_2859|Compound:9028643|FD-Score:3.41|P-value:5.95E-5 ID:SGTC_2983|Compound:9022671|FD-Score:2.78|P-value:7.89E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-2.97|P-value:8.96E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-3.16|P-value:4.29E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.01|P-value:3.23E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:-2.94|P-value:9.92E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.23|P-value:1.26E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:2.90|P-value:4.84E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.28|P-value:1.02E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.78|P-value:2.99E-5 ID:SGTC_564|Compound:3555-0129|FD-Score:3.07|P-value:2.54E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.17|P-value:1.64E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:2.79|P-value:7.56E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.74|P-value:1.27E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:6.30|P-value:1.14E-12 ID:SGTC_1032|Compound:k061-1018|FD-Score:2.84|P-value:6.24E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:-2.95|P-value:9.56E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.10|P-value:2.18E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:2.77|P-value:7.96E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:2.85|P-value:5.98E-4 ID:SGTC_1712|Compound:st032288|FD-Score:2.75|P-value:8.74E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.51|P-value:3.68E-5 ID:SGTC_1820|Compound:st053765|FD-Score:4.12|P-value:1.89E-6 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.38|P-value:1.73E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.88|P-value:6.29E-6 ID:SGTC_2007|Compound:4011539|FD-Score:-3.14|P-value:4.70E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.03|P-value:2.99E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.04|P-value:2.78E-4 ID:SGTC_2205|Compound:7238770|FD-Score:2.76|P-value:8.55E-4 ID:SGTC_2221|Compound:6807166|FD-Score:2.76|P-value:8.52E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.00|P-value:7.93E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.19|P-value:1.51E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.78|P-value:2.96E-5 ID:SGTC_2591|Compound:skatole|FD-Score:2.99|P-value:3.42E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-5.37|P-value:4.48E-9 ID:SGTC_2803|Compound:7707263|FD-Score:4.55|P-value:1.68E-7 ID:SGTC_2859|Compound:9028643|FD-Score:3.41|P-value:5.95E-5 ID:SGTC_2983|Compound:9022671|FD-Score:2.78|P-value:7.89E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-2.97|P-value:8.96E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-3.16|P-value:4.29E-4

Top fitness defect scores for YLR018C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_919 tnp00227 6.30 403.6 nM 1.14E-12 RNA pol III & RNase P/MRP 7 1.46E-10
2 SGTC_2803 7707263 4.55 71.4 µM 1.68E-7 21 2.65E-6
3 SGTC_1820 st053765 4.12 18.6 µM 1.89E-6 RPP1 & pyrimidine depletion 13 1.93E-5
4 SGTC_1948 st076329 3.88 66.6 µM 6.29E-6 30 5.20E-5
5 SGTC_913 3487-1245 3.74 167.0 µM 1.27E-5 39 9.27E-5
6 SGTC_1746 st038117 3.51 42.0 µM 3.68E-5 47 2.22E-4
7 SGTC_2859 9028643 3.41 45.5 µM 5.95E-5 28 3.29E-4
8 SGTC_427 1354-0053 3.28 47.3 µM 1.02E-4 46 5.11E-4
9 SGTC_290 2043-6722 3.23 48.1 µM 1.26E-4 35 6.09E-4
10 SGTC_2335 9018011 3.19 154.2 µM 1.51E-4 58 7.08E-4
11 SGTC_565 1418-0001 3.17 44.5 µM 1.64E-4 55 7.56E-4
12 SGTC_1408 3909-7976 3.10 48.8 µM 2.18E-4 Golgi 60 9.53E-4
13 SGTC_564 3555-0129 3.07 330.0 µM 2.54E-4 26 0.00108
14 SGTC_2201 6605497 3.04 169.9 µM 2.78E-4 ergosterol biosynthesis 28 0.00116
15 SGTC_2010 4012422 3.03 159.0 µM 2.99E-4 67 0.00124
16 SGTC_4 0960-0234 3.01 25.7 µM 3.23E-4 Golgi 45 0.00132
17 SGTC_2591 skatole 2.99 100.0 µM 3.42E-4 69 0.00138
18 SGTC_320 4092-0846 2.90 5.3 µM 4.84E-4 ergosterol depletion effects on membrane 97 0.00184
19 SGTC_1440 4100-1550 2.85 40.0 µM 5.98E-4 27 0.00219
20 SGTC_1032 k061-1018 2.84 98.7 µM 6.24E-4 89 0.00226

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.180 9.85E-26 YOL028C YAP7 hom Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.120 3.29E-12 YAL062W GDH3 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication
0.106 7.88E-10 YDR183W PLP1 hom Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators
0.100 6.40E-9 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.100 6.67E-9 YDL171C GLT1 hom NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
0.100 6.92E-9 YGL221C NIF3 hom Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.097 2.04E-8 YNL031C HHT2 hom Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation
0.096 2.41E-8 YOR378W_p YOR378W_p hom Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
0.092 8.64E-8 YCL044C MGR1 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.092 1.00E-7 YLL004W ORC3 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.091 1.32E-7 YER143W DDI1 hom DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains
0.090 1.64E-7 YER142C MAG1 hom 3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress
0.089 2.40E-7 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.087 5.13E-7 YJL190C RPS22A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication
0.087 5.17E-7 YLR336C SGD1 het Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia