YLR019W / PSR2

Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR019W / PSR2

Click on Significant Values for Screen Details ID:SGTC_136|Compound:0097-0015|FD-Score:-5.77|P-value:2.09E-9 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.68|P-value:8.76E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:-5.22|P-value:5.10E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:-4.09|P-value:1.50E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.10|P-value:8.38E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.52|P-value:1.80E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:3.07|P-value:9.18E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.07|P-value:8.54E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.73|P-value:7.19E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:3.07|P-value:9.37E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.23|P-value:5.21E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:3.32|P-value:3.74E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:4.21|P-value:9.74E-6 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.12|P-value:7.81E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.72|P-value:7.52E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.25|P-value:4.98E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.97|P-value:2.79E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.55|P-value:1.57E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.91|P-value:3.71E-5 ID:SGTC_1607|Compound:st000305|FD-Score:3.58|P-value:1.41E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.38|P-value:3.03E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.40|P-value:2.84E-4 ID:SGTC_2098|Compound:5376439|FD-Score:4.65|P-value:1.16E-6 ID:SGTC_2252|Compound:omeprazole|FD-Score:-3.33|P-value:3.39E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.85|P-value:4.76E-5 ID:SGTC_2341|Compound:7987486|FD-Score:3.30|P-value:4.10E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.52|P-value:1.65E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:5.13|P-value:9.74E-8 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.99|P-value:2.62E-5 ID:SGTC_2790|Compound:5423970|FD-Score:5.25|P-value:5.05E-8 ID:SGTC_2829|Compound:7992743|FD-Score:-3.07|P-value:8.71E-4 ID:SGTC_2863|Compound:9028737|FD-Score:-3.94|P-value:2.97E-5 ID:SGTC_2866|Compound:9034245|FD-Score:-3.06|P-value:8.96E-4 ID:SGTC_2872|Compound:9044037|FD-Score:3.37|P-value:3.17E-4 ID:SGTC_2875|Compound:9039966|FD-Score:3.20|P-value:5.87E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.20|P-value:1.02E-5 ID:SGTC_3056|Compound:9094900|FD-Score:-3.47|P-value:2.03E-4 ID:SGTC_3161|Compound:9100388|FD-Score:3.62|P-value:1.19E-4 ID:SGTC_3162|Compound:9099653|FD-Score:3.46|P-value:2.29E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-5.77|P-value:2.09E-9 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.68|P-value:8.76E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:-5.22|P-value:5.10E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:-4.09|P-value:1.50E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.10|P-value:8.38E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.52|P-value:1.80E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:3.07|P-value:9.18E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.07|P-value:8.54E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.73|P-value:7.19E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:3.07|P-value:9.37E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.23|P-value:5.21E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:3.32|P-value:3.74E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:4.21|P-value:9.74E-6 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.12|P-value:7.81E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.72|P-value:7.52E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.25|P-value:4.98E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.97|P-value:2.79E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.55|P-value:1.57E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.91|P-value:3.71E-5 ID:SGTC_1607|Compound:st000305|FD-Score:3.58|P-value:1.41E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.38|P-value:3.03E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.40|P-value:2.84E-4 ID:SGTC_2098|Compound:5376439|FD-Score:4.65|P-value:1.16E-6 ID:SGTC_2252|Compound:omeprazole|FD-Score:-3.33|P-value:3.39E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.85|P-value:4.76E-5 ID:SGTC_2341|Compound:7987486|FD-Score:3.30|P-value:4.10E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.52|P-value:1.65E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:5.13|P-value:9.74E-8 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.99|P-value:2.62E-5 ID:SGTC_2790|Compound:5423970|FD-Score:5.25|P-value:5.05E-8 ID:SGTC_2829|Compound:7992743|FD-Score:-3.07|P-value:8.71E-4 ID:SGTC_2863|Compound:9028737|FD-Score:-3.94|P-value:2.97E-5 ID:SGTC_2866|Compound:9034245|FD-Score:-3.06|P-value:8.96E-4 ID:SGTC_2872|Compound:9044037|FD-Score:3.37|P-value:3.17E-4 ID:SGTC_2875|Compound:9039966|FD-Score:3.20|P-value:5.87E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.20|P-value:1.02E-5 ID:SGTC_3056|Compound:9094900|FD-Score:-3.47|P-value:2.03E-4 ID:SGTC_3161|Compound:9100388|FD-Score:3.62|P-value:1.19E-4 ID:SGTC_3162|Compound:9099653|FD-Score:3.46|P-value:2.29E-4

Top fitness defect scores for YLR019W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2790 5423970 5.25 71.4 µM 5.05E-8 endomembrane recycling 34 7.80E-8
2 SGTC_2753 fluvastatin 5.13 17.1 µM 9.74E-8 azole & statin 13 1.48E-7
3 SGTC_2098 5376439 4.65 882.5 nM 1.16E-6 5 1.62E-6
4 SGTC_1111 tnp00062 4.21 510.7 nM 9.74E-6 7 1.28E-5
5 SGTC_2930 9013230 4.20 14.9 µM 1.02E-5 heme biosynthesis & mitochondrial translocase 26 1.34E-5
6 SGTC_2757 clomiphene 3.99 4.2 µM 2.62E-5 fatty acid desaturase (OLE1) 40 3.35E-5
7 SGTC_1578 josamycin 3.97 24.2 µM 2.79E-5 14 3.56E-5
8 SGTC_1592 4',5'-dihydroxyflavone 3.91 8.8 µM 3.71E-5 60S ribosome export 10 4.69E-5
9 SGTC_2253 7938677 3.85 135.8 µM 4.76E-5 11 5.98E-5
10 SGTC_3161 9100388 3.62 49.5 µM 1.19E-4 iron homeostasis 11 1.46E-4
11 SGTC_1607 st000305 3.58 50.6 µM 1.41E-4 22 1.72E-4
12 SGTC_1580 hydrocortisone 21-hemisuccinate 3.55 43.2 µM 1.57E-4 29 1.91E-4
13 SGTC_602 3130-1533 3.52 38.1 µM 1.80E-4 29 2.17E-4
14 SGTC_3162 9099653 3.46 49.5 µM 2.29E-4 11 2.75E-4
15 SGTC_2093 5331342 3.40 194.4 µM 2.84E-4 36 3.39E-4
16 SGTC_1974 st069448 3.38 26.9 µM 3.03E-4 44 3.61E-4
17 SGTC_2872 9044037 3.37 26.0 µM 3.17E-4 14 3.77E-4
18 SGTC_985 1493-0307 3.32 8.7 µM 3.74E-4 TSC3-RPN4 36 4.42E-4
19 SGTC_2341 7987486 3.30 176.7 µM 4.10E-4 36 4.84E-4
20 SGTC_1267 0828-0272 3.25 9.5 µM 4.98E-4 47 5.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 6.38E-10 YLR356W ATG33 hom Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes
0.099 8.02E-9 YBR094W PBY1 hom Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress
0.098 1.54E-8 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.094 4.39E-8 YNL285W_d YNL285W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093 7.91E-8 YMR163C INP2 hom Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene
0.085 7.87E-7 YCL023C_d YCL023C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
0.083 1.43E-6 YOR316C-A_p YOR316C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.082 2.06E-6 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.082 2.16E-6 YJR096W YJR096W hom Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.072 2.85E-5 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.072 2.77E-5 YOL151W GRE2 hom 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
0.072 3.11E-5 YGL230C_p YGL230C_p hom Putative protein of unknown function; non-essential gene
0.071 4.34E-5 YLR221C RSA3 hom Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus
0.070 4.58E-5 YGL229C SAP4 hom Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
0.070 5.02E-5 YGR177C ATF2 hom Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking