YLR020C / YEH2

Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR020C / YEH2

Click on Significant Values for Screen Details ID:SGTC_78|Compound:0336-0123|FD-Score:-2.92|P-value:8.51E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:2.99|P-value:7.51E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:3.32|P-value:2.11E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:5.39|P-value:5.16E-9 ID:SGTC_221|Compound:trifluoperazine|FD-Score:11.40|P-value:2.74E-34 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.05|P-value:6.02E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:2.92|P-value:9.76E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:5.93|P-value:1.38E-10 ID:SGTC_313|Compound:3474-0040|FD-Score:3.02|P-value:6.81E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.93|P-value:1.53E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:3.09|P-value:5.18E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:5.13|P-value:2.53E-8 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.73|P-value:3.80E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:4.04|P-value:9.07E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:3.94|P-value:1.42E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:5.05|P-value:4.04E-8 ID:SGTC_535|Compound:2293-4129|FD-Score:3.68|P-value:4.64E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:2.92|P-value:9.92E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:5.44|P-value:3.57E-9 ID:SGTC_743|Compound:1275-0778|FD-Score:3.54|P-value:8.76E-5 ID:SGTC_759|Compound:3486-0358|FD-Score:3.55|P-value:8.31E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:3.25|P-value:2.81E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.36|P-value:1.79E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.33|P-value:2.07E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.09|P-value:4.54E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.12|P-value:4.00E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.58|P-value:6.23E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:4.51|P-value:8.16E-7 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.83|P-value:2.01E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.13|P-value:3.91E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.05|P-value:5.28E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.03|P-value:5.80E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-3.41|P-value:1.27E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.05|P-value:6.03E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.32|P-value:2.12E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:2.95|P-value:9.00E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:2.94|P-value:9.31E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.03|P-value:6.54E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:4.22|P-value:3.76E-6 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.99|P-value:7.74E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.10|P-value:5.13E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.36|P-value:1.80E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.11|P-value:4.17E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.08|P-value:5.55E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.50|P-value:8.61E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.54|P-value:1.76E-12 ID:SGTC_1652|Compound:st011932|FD-Score:4.38|P-value:1.67E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.66|P-value:3.74E-7 ID:SGTC_1687|Compound:st020778|FD-Score:3.29|P-value:2.44E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.24|P-value:2.90E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.31|P-value:2.28E-4 ID:SGTC_1719|Compound:st032227|FD-Score:5.62|P-value:1.18E-9 ID:SGTC_1723|Compound:st034307|FD-Score:-2.97|P-value:7.25E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-2.90|P-value:9.33E-4 ID:SGTC_1750|Compound:st081859|FD-Score:6.52|P-value:2.06E-12 ID:SGTC_1754|Compound:st042065|FD-Score:12.90|P-value:2.60E-43 ID:SGTC_1760|Compound:st045453|FD-Score:19.30|P-value:1.68E-94 ID:SGTC_1800|Compound:st050079|FD-Score:6.77|P-value:3.05E-13 ID:SGTC_1801|Compound:st050089|FD-Score:11.70|P-value:3.71E-36 ID:SGTC_1803|Compound:st050068|FD-Score:11.50|P-value:5.57E-35 ID:SGTC_1818|Compound:st052136|FD-Score:7.28|P-value:4.76E-15 ID:SGTC_2021|Compound:4019055|FD-Score:5.71|P-value:6.19E-10 ID:SGTC_2073|Compound:5212005|FD-Score:2.97|P-value:8.29E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.04|P-value:6.41E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.76|P-value:3.28E-13 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.63|P-value:1.07E-9 ID:SGTC_2257|Compound:7960413|FD-Score:3.36|P-value:1.83E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.34|P-value:1.99E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-3.36|P-value:1.53E-4 ID:SGTC_2349|Compound:9023730|FD-Score:-3.40|P-value:1.30E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.09|P-value:7.01E-6 ID:SGTC_2469|Compound:5655019|FD-Score:3.38|P-value:1.65E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.19|P-value:3.61E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.68|P-value:4.62E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.50|P-value:1.48E-34 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.12|P-value:4.68E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.40|P-value:1.52E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.09|P-value:5.30E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:13.50|P-value:1.78E-47 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.74|P-value:3.08E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.14|P-value:5.61E-6 ID:SGTC_2864|Compound:9034755|FD-Score:-3.29|P-value:2.04E-4 ID:SGTC_2896|Compound:9052656|FD-Score:11.20|P-value:4.54E-33 ID:SGTC_2905|Compound:7799065|FD-Score:3.02|P-value:6.77E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.04|P-value:5.50E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.01|P-value:6.08E-4 ID:SGTC_2949|Compound:9072542|FD-Score:2.92|P-value:9.87E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.41|P-value:1.47E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.49|P-value:9.18E-7 ID:SGTC_3148|Compound:9097893|FD-Score:3.95|P-value:1.38E-5 ID:SGTC_3154|Compound:9100113|FD-Score:-3.09|P-value:4.62E-4 ID:SGTC_3188|Compound:9110789|FD-Score:-2.94|P-value:7.85E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.11|P-value:4.85E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.46|P-value:1.01E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-3.64|P-value:4.67E-5 ID:SGTC_3327|Compound:9140648|FD-Score:4.17|P-value:4.75E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:-2.92|P-value:8.51E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:2.99|P-value:7.51E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:3.32|P-value:2.11E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:5.39|P-value:5.16E-9 ID:SGTC_221|Compound:trifluoperazine|FD-Score:11.40|P-value:2.74E-34 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.05|P-value:6.02E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:2.92|P-value:9.76E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:5.93|P-value:1.38E-10 ID:SGTC_313|Compound:3474-0040|FD-Score:3.02|P-value:6.81E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.93|P-value:1.53E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:3.09|P-value:5.18E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:5.13|P-value:2.53E-8 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.73|P-value:3.80E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:4.04|P-value:9.07E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:3.94|P-value:1.42E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:5.05|P-value:4.04E-8 ID:SGTC_535|Compound:2293-4129|FD-Score:3.68|P-value:4.64E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:2.92|P-value:9.92E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:5.44|P-value:3.57E-9 ID:SGTC_743|Compound:1275-0778|FD-Score:3.54|P-value:8.76E-5 ID:SGTC_759|Compound:3486-0358|FD-Score:3.55|P-value:8.31E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:3.25|P-value:2.81E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.36|P-value:1.79E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.33|P-value:2.07E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.09|P-value:4.54E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.12|P-value:4.00E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.58|P-value:6.23E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:4.51|P-value:8.16E-7 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.83|P-value:2.01E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.13|P-value:3.91E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.05|P-value:5.28E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.03|P-value:5.80E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-3.41|P-value:1.27E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.05|P-value:6.03E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.32|P-value:2.12E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:2.95|P-value:9.00E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:2.94|P-value:9.31E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.03|P-value:6.54E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:4.22|P-value:3.76E-6 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.99|P-value:7.74E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.10|P-value:5.13E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.36|P-value:1.80E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.11|P-value:4.17E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.08|P-value:5.55E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.50|P-value:8.61E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.54|P-value:1.76E-12 ID:SGTC_1652|Compound:st011932|FD-Score:4.38|P-value:1.67E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.66|P-value:3.74E-7 ID:SGTC_1687|Compound:st020778|FD-Score:3.29|P-value:2.44E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.24|P-value:2.90E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.31|P-value:2.28E-4 ID:SGTC_1719|Compound:st032227|FD-Score:5.62|P-value:1.18E-9 ID:SGTC_1723|Compound:st034307|FD-Score:-2.97|P-value:7.25E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-2.90|P-value:9.33E-4 ID:SGTC_1750|Compound:st081859|FD-Score:6.52|P-value:2.06E-12 ID:SGTC_1754|Compound:st042065|FD-Score:12.90|P-value:2.60E-43 ID:SGTC_1760|Compound:st045453|FD-Score:19.30|P-value:1.68E-94 ID:SGTC_1800|Compound:st050079|FD-Score:6.77|P-value:3.05E-13 ID:SGTC_1801|Compound:st050089|FD-Score:11.70|P-value:3.71E-36 ID:SGTC_1803|Compound:st050068|FD-Score:11.50|P-value:5.57E-35 ID:SGTC_1818|Compound:st052136|FD-Score:7.28|P-value:4.76E-15 ID:SGTC_2021|Compound:4019055|FD-Score:5.71|P-value:6.19E-10 ID:SGTC_2073|Compound:5212005|FD-Score:2.97|P-value:8.29E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.04|P-value:6.41E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.76|P-value:3.28E-13 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.63|P-value:1.07E-9 ID:SGTC_2257|Compound:7960413|FD-Score:3.36|P-value:1.83E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.34|P-value:1.99E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-3.36|P-value:1.53E-4 ID:SGTC_2349|Compound:9023730|FD-Score:-3.40|P-value:1.30E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.09|P-value:7.01E-6 ID:SGTC_2469|Compound:5655019|FD-Score:3.38|P-value:1.65E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.19|P-value:3.61E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.68|P-value:4.62E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.50|P-value:1.48E-34 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.12|P-value:4.68E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.40|P-value:1.52E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.09|P-value:5.30E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:13.50|P-value:1.78E-47 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.74|P-value:3.08E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.14|P-value:5.61E-6 ID:SGTC_2864|Compound:9034755|FD-Score:-3.29|P-value:2.04E-4 ID:SGTC_2896|Compound:9052656|FD-Score:11.20|P-value:4.54E-33 ID:SGTC_2905|Compound:7799065|FD-Score:3.02|P-value:6.77E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.04|P-value:5.50E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.01|P-value:6.08E-4 ID:SGTC_2949|Compound:9072542|FD-Score:2.92|P-value:9.87E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.41|P-value:1.47E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.49|P-value:9.18E-7 ID:SGTC_3148|Compound:9097893|FD-Score:3.95|P-value:1.38E-5 ID:SGTC_3154|Compound:9100113|FD-Score:-3.09|P-value:4.62E-4 ID:SGTC_3188|Compound:9110789|FD-Score:-2.94|P-value:7.85E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.11|P-value:4.85E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.46|P-value:1.01E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-3.64|P-value:4.67E-5 ID:SGTC_3327|Compound:9140648|FD-Score:4.17|P-value:4.75E-6

Top fitness defect scores for YLR020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1760 st045453 19.30 10.4 µM 1.68E-94 NEO1-PIK1 8 1.88E-83
2 SGTC_2651 1327-0036 13.50 5.0 µM 1.78E-47 12 4.52E-42
3 SGTC_1754 st042065 12.90 16.1 µM 2.60E-43 NEO1-PIK1 13 2.10E-38
4 SGTC_1801 st050089 11.70 28.4 µM 3.71E-36 NEO1-PIK1 9 4.18E-32
5 SGTC_1803 st050068 11.50 52.4 µM 5.57E-35 NEO1-PIK1 18 4.53E-31
6 SGTC_2582 agaric acid 11.50 100.0 µM 1.48E-34 redox potentiating 45 1.07E-30
7 SGTC_221 trifluoperazine 11.40 10.3 µM 2.74E-34 NEO1-PIK1 43 1.84E-30
8 SGTC_2896 9052656 11.20 71.4 µM 4.54E-33 endomembrane recycling 7 2.19E-29
9 SGTC_1818 st052136 7.28 56.3 µM 4.76E-15 NEO1-PIK1 6 1.68E-13
10 SGTC_1800 st050079 6.77 29.1 µM 3.05E-13 NEO1-PIK1 28 6.62E-12
11 SGTC_2249 haloperidol 6.76 116.4 µM 3.28E-13 ergosterol depletion effects on membrane 34 7.05E-12
12 SGTC_1597 7-benzyloxygramine 6.54 47.5 µM 1.76E-12 calcium & mitochondrial duress 44 3.10E-11
13 SGTC_1750 st081859 6.52 2.4 µM 2.06E-12 endomembrane recycling 96 3.57E-11
14 SGTC_312 4092-0653 5.93 6.8 µM 1.38E-10 ergosterol depletion effects on membrane 40 1.47E-9
15 SGTC_2021 4019055 5.71 173.0 µM 6.19E-10 endomembrane recycling 45 5.53E-9
16 SGTC_2250 alverine citrate 5.63 130.0 µM 1.07E-9 67 8.97E-9
17 SGTC_1719 st032227 5.62 49.2 µM 1.18E-9 6 9.80E-9
18 SGTC_649 1123-0311 5.44 367.0 µM 3.57E-9 endomembrane recycling 32 2.60E-8
19 SGTC_207 4185-0010 5.39 4.5 µM 5.16E-9 endomembrane recycling 51 3.61E-8
20 SGTC_377 3970-0964 5.13 33.1 µM 2.53E-8 26 1.47E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.492 7.18E-204 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.471 2.02E-185 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.466 6.29E-180 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.457 3.57E-173 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.454 2.33E-170 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.452 1.21E-168 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.450 3.33E-167 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.439 1.81E-158 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.439 2.39E-158 YKL191W DPH2 hom Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
0.438 3.13E-157 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.434 1.62E-154 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.424 1.45E-146 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.416 1.02E-140 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.395 1.79E-125 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.383 2.00E-117 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern