YLR022C / SDO1

Essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR022C / SDO1

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:6.77|P-value:3.61E-12 ID:SGTC_72|Compound:0744-0168|FD-Score:6.20|P-value:1.72E-10 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.19|P-value:5.86E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.14|P-value:7.51E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.09|P-value:9.13E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.54|P-value:1.74E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.08|P-value:8.69E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:-3.46|P-value:2.17E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.36|P-value:3.21E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.58|P-value:1.41E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:-6.04|P-value:4.28E-10 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.86|P-value:4.72E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.08|P-value:8.59E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.38|P-value:3.16E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.59|P-value:1.43E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.52|P-value:1.72E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.25|P-value:4.75E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.54|P-value:1.71E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.84|P-value:5.11E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:-3.80|P-value:5.72E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.28|P-value:4.53E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.25|P-value:5.15E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.29|P-value:4.50E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.77|P-value:6.89E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.37|P-value:3.27E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.11|P-value:7.93E-4 ID:SGTC_1713|Compound:st033146|FD-Score:4.99|P-value:2.29E-7 ID:SGTC_1714|Compound:st033236|FD-Score:-4.92|P-value:2.99E-7 ID:SGTC_1716|Compound:st033144|FD-Score:3.55|P-value:1.65E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.68|P-value:9.45E-5 ID:SGTC_1743|Compound:st037606|FD-Score:-5.62|P-value:5.89E-9 ID:SGTC_1747|Compound:st037496|FD-Score:-3.49|P-value:1.96E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.73|P-value:7.64E-5 ID:SGTC_1821|Compound:st053465|FD-Score:3.30|P-value:4.20E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.55|P-value:1.66E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.36|P-value:3.19E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.48|P-value:2.96E-6 ID:SGTC_2013|Compound:4024628|FD-Score:-4.17|P-value:1.17E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.18|P-value:6.54E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.24|P-value:4.99E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.81|P-value:5.98E-5 ID:SGTC_2477|Compound:5967686|FD-Score:4.61|P-value:1.56E-6 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.18|P-value:6.50E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.67|P-value:1.06E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.49|P-value:2.07E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.34|P-value:3.49E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.96|P-value:3.18E-5 ID:SGTC_2861|Compound:9024595|FD-Score:3.16|P-value:7.08E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.19|P-value:6.40E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-7.63|P-value:5.06E-15 ID:SGTC_3288|Compound:9119690|FD-Score:-3.58|P-value:1.40E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:6.77|P-value:3.61E-12 ID:SGTC_72|Compound:0744-0168|FD-Score:6.20|P-value:1.72E-10 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.19|P-value:5.86E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.14|P-value:7.51E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.09|P-value:9.13E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.54|P-value:1.74E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.08|P-value:8.69E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:-3.46|P-value:2.17E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.36|P-value:3.21E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.58|P-value:1.41E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:-6.04|P-value:4.28E-10 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.86|P-value:4.72E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.08|P-value:8.59E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.38|P-value:3.16E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.59|P-value:1.43E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.52|P-value:1.72E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.25|P-value:4.75E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.54|P-value:1.71E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.84|P-value:5.11E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:-3.80|P-value:5.72E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.28|P-value:4.53E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.25|P-value:5.15E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.29|P-value:4.50E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.77|P-value:6.89E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.37|P-value:3.27E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.11|P-value:7.93E-4 ID:SGTC_1713|Compound:st033146|FD-Score:4.99|P-value:2.29E-7 ID:SGTC_1714|Compound:st033236|FD-Score:-4.92|P-value:2.99E-7 ID:SGTC_1716|Compound:st033144|FD-Score:3.55|P-value:1.65E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.68|P-value:9.45E-5 ID:SGTC_1743|Compound:st037606|FD-Score:-5.62|P-value:5.89E-9 ID:SGTC_1747|Compound:st037496|FD-Score:-3.49|P-value:1.96E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.73|P-value:7.64E-5 ID:SGTC_1821|Compound:st053465|FD-Score:3.30|P-value:4.20E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.55|P-value:1.66E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.36|P-value:3.19E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.48|P-value:2.96E-6 ID:SGTC_2013|Compound:4024628|FD-Score:-4.17|P-value:1.17E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.18|P-value:6.54E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.24|P-value:4.99E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.81|P-value:5.98E-5 ID:SGTC_2477|Compound:5967686|FD-Score:4.61|P-value:1.56E-6 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.18|P-value:6.50E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.67|P-value:1.06E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.49|P-value:2.07E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.34|P-value:3.49E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.96|P-value:3.18E-5 ID:SGTC_2861|Compound:9024595|FD-Score:3.16|P-value:7.08E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.19|P-value:6.40E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-7.63|P-value:5.06E-15 ID:SGTC_3288|Compound:9119690|FD-Score:-3.58|P-value:1.40E-4

Top fitness defect scores for YLR022C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_67 0335-0847 6.77 266.0 µM 3.61E-12 ubiquinone biosynthesis & proteasome 4 6.35E-12 0.07
2 SGTC_72 0744-0168 6.20 198.4 µM 1.72E-10 RPP1 & pyrimidine depletion 1 2.75E-10 0.61
3 SGTC_1713 st033146 4.99 12.8 µM 2.29E-7 4 3.08E-7 0.37
4 SGTC_2477 5967686 4.61 25.2 µM 1.56E-6 3 2.01E-6 0.04
5 SGTC_1978 st071761 4.48 42.0 µM 2.96E-6 TSC3-RPN4 4 3.76E-6 0.38
6 SGTC_2849 9019321 3.96 13.0 µM 3.18E-5 9 3.82E-5 0.24
7 SGTC_1017 4239-0030 3.86 168.0 µM 4.72E-5 2 5.62E-5 0.05
8 SGTC_1245 0418-0076 3.84 17.2 µM 5.11E-5 ERG2 9 6.08E-5 0.19
9 SGTC_2430 5571206 3.81 200.0 µM 5.98E-5 21 7.08E-5 0.02
10 SGTC_1541 2',3',6-trimethoxyflavone 3.77 64.0 µM 6.89E-5 5 8.14E-5 0.11
11 SGTC_2659 sanguinarine 3.67 24.2 µM 1.06E-4 12 1.23E-4 0.06
12 SGTC_1026 k007-1105 3.59 30.6 µM 1.43E-4 ERAD & cell cycle 28 1.66E-4 0.06
13 SGTC_1716 st033144 3.55 30.6 µM 1.65E-4 9 1.91E-4 0.29
14 SGTC_1829 berberine 3.55 14.4 µM 1.66E-4 60S ribosome export 15 1.92E-4 0.10
15 SGTC_1188 1403-0014 3.54 4.6 µM 1.71E-4 mitochondrial stress 15 1.98E-4 0.03
16 SGTC_340 k038-0059 3.54 454.0 µM 1.74E-4 ubiquinone biosynthesis & proteasome 11 2.01E-4 0.15
17 SGTC_2791 5663188 3.49 71.4 µM 2.07E-4 RPP1 & pyrimidine depletion 13 2.38E-4 0.00
18 SGTC_1023 4482-3888 3.38 16.0 µM 3.16E-4 TSC3-RPN4 15 3.61E-4 0.00
19 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 3.37 66.5 µM 3.27E-4 3 3.72E-4 0.12
20 SGTC_1821 st053465 3.30 65.6 µM 4.20E-4 6 4.77E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.12E-20 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.155 1.72E-19 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.136 3.21E-15 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.131 2.89E-14 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.110 1.62E-10 YPR194C OPT2 hom Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles
0.110 1.87E-10 YOR213C SAS5 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
0.108 3.42E-10 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.105 1.15E-9 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.105 1.25E-9 YNL148C ALF1 hom Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
0.100 7.46E-9 YGL254W FZF1 hom Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress
0.099 9.61E-9 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.098 1.27E-8 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.097 2.08E-8 YKL034W TUL1 hom Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1
0.096 2.28E-8 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.095 3.84E-8 YPL155C KIP2 hom Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle