YLR026C / SED5

cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR026C / SED5

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.26|P-value:6.57E-6 ID:SGTC_27|Compound:0485-0001|FD-Score:3.22|P-value:4.84E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.65|P-value:9.05E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:-3.07|P-value:9.22E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.17|P-value:6.57E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.53|P-value:2.08E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:3.27|P-value:3.94E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.10|P-value:8.34E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.28|P-value:4.42E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-6.65|P-value:6.37E-12 ID:SGTC_533|Compound:1222-0222|FD-Score:3.04|P-value:9.26E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.42|P-value:2.26E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.29|P-value:3.72E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.90|P-value:3.15E-7 ID:SGTC_751|Compound:0833-0568|FD-Score:4.24|P-value:7.02E-6 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.29|P-value:4.23E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.06|P-value:8.44E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.67|P-value:4.05E-9 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.50|P-value:1.67E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.49|P-value:1.75E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.57|P-value:1.43E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.95|P-value:3.04E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.38|P-value:3.05E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.05|P-value:8.67E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.03|P-value:9.57E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.35|P-value:3.41E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.15|P-value:6.84E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.10|P-value:7.32E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.50|P-value:1.91E-4 ID:SGTC_1866|Compound:st057638|FD-Score:-3.25|P-value:4.80E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-3.45|P-value:2.28E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.80|P-value:5.76E-5 ID:SGTC_2257|Compound:7960413|FD-Score:-3.06|P-value:9.52E-4 ID:SGTC_2487|Compound:5918373|FD-Score:4.13|P-value:1.20E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-6.14|P-value:2.10E-10 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.10|P-value:2.25E-10 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-4.86|P-value:3.84E-7 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.02|P-value:9.76E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-4.20|P-value:9.89E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.98|P-value:2.61E-5 ID:SGTC_2694|Compound:st077685|FD-Score:3.11|P-value:7.10E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.10|P-value:7.36E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.75|P-value:6.06E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.21|P-value:4.93E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.29|P-value:4.15E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.35|P-value:2.96E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-4.38|P-value:4.17E-6 ID:SGTC_3062|Compound:9077494|FD-Score:-3.76|P-value:6.73E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.29|P-value:3.77E-4 ID:SGTC_3227|Compound:9130768|FD-Score:3.23|P-value:4.60E-4 ID:SGTC_3234|Compound:9132280|FD-Score:-3.13|P-value:7.55E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-3.29|P-value:4.19E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.06|P-value:9.51E-4 ID:SGTC_3257|Compound:9139206|FD-Score:4.86|P-value:3.35E-7 ID:SGTC_3258|Compound:9138477|FD-Score:3.84|P-value:4.19E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:4.26|P-value:6.57E-6 ID:SGTC_27|Compound:0485-0001|FD-Score:3.22|P-value:4.84E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.65|P-value:9.05E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:-3.07|P-value:9.22E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:-3.17|P-value:6.57E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.53|P-value:2.08E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:3.27|P-value:3.94E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.10|P-value:8.34E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.28|P-value:4.42E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-6.65|P-value:6.37E-12 ID:SGTC_533|Compound:1222-0222|FD-Score:3.04|P-value:9.26E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.42|P-value:2.26E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.29|P-value:3.72E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.90|P-value:3.15E-7 ID:SGTC_751|Compound:0833-0568|FD-Score:4.24|P-value:7.02E-6 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.29|P-value:4.23E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.06|P-value:8.44E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.67|P-value:4.05E-9 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.50|P-value:1.67E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.49|P-value:1.75E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.57|P-value:1.43E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.95|P-value:3.04E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.38|P-value:3.05E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.05|P-value:8.67E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.03|P-value:9.57E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.35|P-value:3.41E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.15|P-value:6.84E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.10|P-value:7.32E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.50|P-value:1.91E-4 ID:SGTC_1866|Compound:st057638|FD-Score:-3.25|P-value:4.80E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-3.45|P-value:2.28E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.80|P-value:5.76E-5 ID:SGTC_2257|Compound:7960413|FD-Score:-3.06|P-value:9.52E-4 ID:SGTC_2487|Compound:5918373|FD-Score:4.13|P-value:1.20E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-6.14|P-value:2.10E-10 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.10|P-value:2.25E-10 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-4.86|P-value:3.84E-7 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.02|P-value:9.76E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-4.20|P-value:9.89E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.98|P-value:2.61E-5 ID:SGTC_2694|Compound:st077685|FD-Score:3.11|P-value:7.10E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.10|P-value:7.36E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.75|P-value:6.06E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.21|P-value:4.93E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.29|P-value:4.15E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.35|P-value:2.96E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-4.38|P-value:4.17E-6 ID:SGTC_3062|Compound:9077494|FD-Score:-3.76|P-value:6.73E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.29|P-value:3.77E-4 ID:SGTC_3227|Compound:9130768|FD-Score:3.23|P-value:4.60E-4 ID:SGTC_3234|Compound:9132280|FD-Score:-3.13|P-value:7.55E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-3.29|P-value:4.19E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.06|P-value:9.51E-4 ID:SGTC_3257|Compound:9139206|FD-Score:4.86|P-value:3.35E-7 ID:SGTC_3258|Compound:9138477|FD-Score:3.84|P-value:4.19E-5

Top fitness defect scores for YLR026C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 6.10 3.7 µM 2.25E-10 2 5.42E-10 0.86
2 SGTC_3257 9139206 4.86 33.0 µM 3.35E-7 2 5.99E-7 0.83
3 SGTC_1222 0366-0074 4.57 1.2 µM 1.43E-6 TSC3-RPN4 1 2.41E-6 0.41
4 SGTC_6 0844-0013 4.26 19.8 µM 6.57E-6 3 1.04E-5 0.15
5 SGTC_751 0833-0568 4.24 350.0 µM 7.02E-6 1 1.11E-5 0.35
6 SGTC_2487 5918373 4.13 44.0 µM 1.20E-5 4 1.85E-5 0.15
7 SGTC_3258 9138477 3.84 49.5 µM 4.19E-5 2 6.15E-5 0.84
8 SGTC_2709 st078560 3.75 56.0 µM 6.06E-5 7 8.77E-5 0.04
9 SGTC_81 0411-0046 3.65 10.0 µM 9.05E-5 44 1.29E-4 0.05
10 SGTC_1207 2099-0101 3.50 141.0 µM 1.67E-4 6 2.33E-4 0.29
11 SGTC_1211 1056-0033 3.49 32.3 µM 1.75E-4 6 2.43E-4 0.10
12 SGTC_597 k018-0003 3.42 82.8 µM 2.26E-4 RNA pol III & RNase P/MRP 8 3.11E-4 0.18
13 SGTC_2904 7225135 3.35 42.0 µM 2.96E-4 4 4.02E-4 0.03
14 SGTC_637 1181-0519 3.29 7.3 µM 3.72E-4 fatty acid desaturase (OLE1) 20 5.00E-4 0.31
15 SGTC_3192 9110362 3.29 49.5 µM 3.77E-4 mitochondrial processes 10 5.07E-4 0.02
16 SGTC_168 3970-0862 3.27 530.5 µM 3.94E-4 61 5.29E-4 0.03
17 SGTC_3227 9130768 3.23 49.5 µM 4.60E-4 1 6.13E-4 0.15
18 SGTC_27 0485-0001 3.22 32.6 µM 4.84E-4 RPP1 & pyrimidine depletion 2 6.44E-4 0.14
19 SGTC_2823 7987624 3.21 58.4 µM 4.93E-4 27 6.55E-4 0.16
20 SGTC_2694 st077685 3.11 81.9 µM 7.10E-4 endomembrane recycling 11 9.30E-4 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.211 3.98E-35 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.200 1.67E-31 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.191 5.28E-29 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.184 8.07E-27 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.174 2.99E-24 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.165 5.14E-22 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.164 1.60E-21 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.163 2.36E-21 YDL008W APC11 het Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
0.162 3.97E-21 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.157 6.18E-20 YOR283W YOR283W hom Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene
0.154 2.36E-19 YGR032W GSC2 hom Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
0.153 3.90E-19 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.151 1.92E-18 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.150 2.06E-18 YKL022C CDC16 het Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
0.150 2.76E-18 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress