YLR029C / RPL15A

Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR029C / RPL15A

Click on Significant Values for Screen Details ID:SGTC_517|Compound:1365-0151|FD-Score:3.79|P-value:8.00E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.72|P-value:9.90E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:3.77|P-value:8.46E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:4.90|P-value:2.20E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.66|P-value:9.42E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.84|P-value:7.05E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.74|P-value:9.22E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.74|P-value:7.53E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.83|P-value:7.08E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.79|P-value:8.04E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:29.90|P-value:2.17E-139 ID:SGTC_1189|Compound:1431-2119|FD-Score:7.20|P-value:8.79E-10 ID:SGTC_1191|Compound:1487-1166|FD-Score:-4.56|P-value:5.71E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:6.19|P-value:1.17E-7 ID:SGTC_1214|Compound:0358-0031|FD-Score:5.68|P-value:1.05E-6 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.95|P-value:5.10E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:4.09|P-value:3.26E-4 ID:SGTC_1668|Compound:st014914|FD-Score:4.67|P-value:4.99E-5 ID:SGTC_1727|Compound:st034309|FD-Score:-3.73|P-value:7.74E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-4.51|P-value:6.77E-5 ID:SGTC_1745|Compound:st081495|FD-Score:4.24|P-value:2.06E-4 ID:SGTC_1803|Compound:st050068|FD-Score:-4.47|P-value:7.67E-5 ID:SGTC_1814|Compound:st052110|FD-Score:11.10|P-value:8.63E-21 ID:SGTC_1941|Compound:st076221|FD-Score:-3.64|P-value:9.92E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.74|P-value:9.26E-4 ID:SGTC_2136|Compound:5328288|FD-Score:6.88|P-value:4.45E-9 ID:SGTC_2144|Compound:5628481|FD-Score:4.12|P-value:3.00E-4 ID:SGTC_2192|Compound:5915882|FD-Score:4.70|P-value:4.39E-5 ID:SGTC_2215|Compound:7188065|FD-Score:4.43|P-value:1.10E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-7.61|P-value:6.59E-11 ID:SGTC_2284|Compound:7945075|FD-Score:-4.85|P-value:2.02E-5 ID:SGTC_2302|Compound:7771753|FD-Score:-4.23|P-value:1.68E-4 ID:SGTC_2351|Compound:9026858|FD-Score:4.60|P-value:6.32E-5 ID:SGTC_2358|Compound:9037157|FD-Score:5.20|P-value:7.05E-6 ID:SGTC_2472|Compound:5377652|FD-Score:4.33|P-value:1.55E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.59|P-value:6.42E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.53|P-value:8.02E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:11.50|P-value:2.62E-22 ID:SGTC_2841|Compound:9004761|FD-Score:5.52|P-value:2.00E-6 ID:SGTC_2905|Compound:7799065|FD-Score:4.77|P-value:3.49E-5 ID:SGTC_2923|Compound:7992654|FD-Score:4.13|P-value:2.89E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-6.26|P-value:6.17E-8 ID:SGTC_3055|Compound:9094636|FD-Score:-4.29|P-value:1.39E-4 ID:SGTC_3118|Compound:9124250|FD-Score:5.62|P-value:1.34E-6 ID:SGTC_3132|Compound:9126706|FD-Score:6.30|P-value:7.01E-8 ID:SGTC_3138|Compound:9097216|FD-Score:4.24|P-value:2.09E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-4.45|P-value:8.14E-5 ID:SGTC_3167|Compound:9103034|FD-Score:6.37|P-value:5.05E-8 ID:SGTC_3173|Compound:9105693|FD-Score:3.76|P-value:8.74E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.92|P-value:5.50E-4 ID:SGTC_3220|Compound:9131269|FD-Score:-3.91|P-value:4.60E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.99|P-value:4.49E-4 ID:SGTC_3305|Compound:9127027|FD-Score:4.63|P-value:5.77E-5 ID:SGTC_3306|Compound:9127676|FD-Score:4.58|P-value:6.63E-5 ID:SGTC_3307|Compound:9126885|FD-Score:4.17|P-value:2.61E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.79|P-value:8.00E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.72|P-value:9.90E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:3.77|P-value:8.46E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:4.90|P-value:2.20E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.66|P-value:9.42E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.84|P-value:7.05E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.74|P-value:9.22E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.74|P-value:7.53E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.83|P-value:7.08E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.79|P-value:8.04E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:29.90|P-value:2.17E-139 ID:SGTC_1189|Compound:1431-2119|FD-Score:7.20|P-value:8.79E-10 ID:SGTC_1191|Compound:1487-1166|FD-Score:-4.56|P-value:5.71E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:6.19|P-value:1.17E-7 ID:SGTC_1214|Compound:0358-0031|FD-Score:5.68|P-value:1.05E-6 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.95|P-value:5.10E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:4.09|P-value:3.26E-4 ID:SGTC_1668|Compound:st014914|FD-Score:4.67|P-value:4.99E-5 ID:SGTC_1727|Compound:st034309|FD-Score:-3.73|P-value:7.74E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-4.51|P-value:6.77E-5 ID:SGTC_1745|Compound:st081495|FD-Score:4.24|P-value:2.06E-4 ID:SGTC_1803|Compound:st050068|FD-Score:-4.47|P-value:7.67E-5 ID:SGTC_1814|Compound:st052110|FD-Score:11.10|P-value:8.63E-21 ID:SGTC_1941|Compound:st076221|FD-Score:-3.64|P-value:9.92E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.74|P-value:9.26E-4 ID:SGTC_2136|Compound:5328288|FD-Score:6.88|P-value:4.45E-9 ID:SGTC_2144|Compound:5628481|FD-Score:4.12|P-value:3.00E-4 ID:SGTC_2192|Compound:5915882|FD-Score:4.70|P-value:4.39E-5 ID:SGTC_2215|Compound:7188065|FD-Score:4.43|P-value:1.10E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-7.61|P-value:6.59E-11 ID:SGTC_2284|Compound:7945075|FD-Score:-4.85|P-value:2.02E-5 ID:SGTC_2302|Compound:7771753|FD-Score:-4.23|P-value:1.68E-4 ID:SGTC_2351|Compound:9026858|FD-Score:4.60|P-value:6.32E-5 ID:SGTC_2358|Compound:9037157|FD-Score:5.20|P-value:7.05E-6 ID:SGTC_2472|Compound:5377652|FD-Score:4.33|P-value:1.55E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.59|P-value:6.42E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.53|P-value:8.02E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:11.50|P-value:2.62E-22 ID:SGTC_2841|Compound:9004761|FD-Score:5.52|P-value:2.00E-6 ID:SGTC_2905|Compound:7799065|FD-Score:4.77|P-value:3.49E-5 ID:SGTC_2923|Compound:7992654|FD-Score:4.13|P-value:2.89E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-6.26|P-value:6.17E-8 ID:SGTC_3055|Compound:9094636|FD-Score:-4.29|P-value:1.39E-4 ID:SGTC_3118|Compound:9124250|FD-Score:5.62|P-value:1.34E-6 ID:SGTC_3132|Compound:9126706|FD-Score:6.30|P-value:7.01E-8 ID:SGTC_3138|Compound:9097216|FD-Score:4.24|P-value:2.09E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-4.45|P-value:8.14E-5 ID:SGTC_3167|Compound:9103034|FD-Score:6.37|P-value:5.05E-8 ID:SGTC_3173|Compound:9105693|FD-Score:3.76|P-value:8.74E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.92|P-value:5.50E-4 ID:SGTC_3220|Compound:9131269|FD-Score:-3.91|P-value:4.60E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.99|P-value:4.49E-4 ID:SGTC_3305|Compound:9127027|FD-Score:4.63|P-value:5.77E-5 ID:SGTC_3306|Compound:9127676|FD-Score:4.58|P-value:6.63E-5 ID:SGTC_3307|Compound:9126885|FD-Score:4.17|P-value:2.61E-4

Top fitness defect scores for YLR029C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1104 tacrolimus 29.90 29.8 µM 2.17E-139 1 6.09E-197 10.20
2 SGTC_2689 tacrolimus 11.50 100.0 µM 2.62E-22 1 5.63E-31 2.93
3 SGTC_1814 st052110 11.10 31.5 µM 8.63E-21 RNA processing & uracil transport 1 7.95E-29 2.79
4 SGTC_1189 1431-2119 7.20 7.3 µM 8.79E-10 3 3.02E-13 1.46
5 SGTC_2136 5328288 6.88 199.3 µM 4.45E-9 1 2.98E-12 1.03
6 SGTC_3167 9103034 6.37 49.5 µM 5.05E-8 RPP1 & pyrimidine depletion 1 9.20E-11 1.27
7 SGTC_3132 9126706 6.30 49.5 µM 7.01E-8 1 1.46E-10 0.68
8 SGTC_1202 1988-0068 6.19 29.6 µM 1.17E-7 RNA processing & uracil transport 2 3.03E-10 0.76
9 SGTC_1214 0358-0031 5.68 63.7 µM 1.05E-6 1 6.69E-9 1.14
10 SGTC_3118 9124250 5.62 49.5 µM 1.34E-6 3 9.36E-9 0.78
11 SGTC_2841 9004761 5.52 39.0 µM 2.00E-6 amide catabolism 3 1.65E-8 0.66
12 SGTC_2358 9037157 5.20 4.0 µM 7.05E-6 6 9.73E-8 0.04
13 SGTC_861 0443-0273 4.90 110.0 µM 2.20E-5 3 4.83E-7 1.37
14 SGTC_2905 7799065 4.77 20.1 µM 3.49E-5 4 9.22E-7 0.06
15 SGTC_2192 5915882 4.70 198.5 µM 4.39E-5 RNA processing & uracil transport 10 1.27E-6 0.00
16 SGTC_1668 st014914 4.67 51.6 µM 4.99E-5 RPP1 & pyrimidine depletion 2 1.52E-6 0.27
17 SGTC_3305 9127027 4.63 53.8 µM 5.77E-5 1 1.87E-6 0.34
18 SGTC_2351 9026858 4.60 72.3 µM 6.32E-5 RNA processing & uracil transport 7 2.12E-6 0.20
19 SGTC_2580 diallyl disulphide 4.59 81.4 µM 6.42E-5 3 2.17E-6 0.46
20 SGTC_3306 9127676 4.58 59.8 µM 6.63E-5 2 2.27E-6 0.34

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.430 5.97E-151 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.143 1.10E-16 YBR021W FUR4 hom Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation
0.141 2.45E-16 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.116 1.68E-11 YCR009C RVS161 hom Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
0.115 2.12E-11 YDR245W MNN10 hom Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family
0.108 4.20E-10 YMR226C YMR226C hom NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments
0.098 1.50E-8 YLL037W_d YLL037W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor
0.097 1.87E-8 YHR079C-A SAE3 hom Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p
0.091 1.20E-7 YDL132W CDC53 het Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
0.091 1.40E-7 YBR142W MAK5 het Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
0.088 3.22E-7 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.087 5.04E-7 YER175C TMT1 hom Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
0.086 5.21E-7 YER142C MAG1 hom 3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress
0.086 5.52E-7 YLR406C RPL31B hom Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication
0.084 1.19E-6 YBL059W_p YBL059W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication