YLR030W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR030W / YLR030W

Click on Significant Values for Screen Details ID:SGTC_147|Compound:4466-0538|FD-Score:3.25|P-value:4.17E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.20|P-value:5.04E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.73|P-value:6.59E-5 ID:SGTC_199|Compound:4063-0024|FD-Score:3.91|P-value:3.00E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:-3.20|P-value:7.54E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:4.87|P-value:3.24E-7 ID:SGTC_342|Compound:k048-0088|FD-Score:3.22|P-value:4.55E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:4.67|P-value:9.04E-7 ID:SGTC_385|Compound:1494-0393|FD-Score:4.67|P-value:8.82E-7 ID:SGTC_672|Compound:1441-0018|FD-Score:3.77|P-value:5.56E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.30|P-value:9.18E-6 ID:SGTC_677|Compound:0929-0063|FD-Score:-3.50|P-value:2.57E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:-3.62|P-value:1.64E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.51|P-value:1.59E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.09|P-value:7.24E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.60|P-value:1.29E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.17|P-value:8.39E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.65|P-value:8.95E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.29|P-value:5.63E-6 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:5.16|P-value:6.82E-8 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.41|P-value:2.25E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-4.31|P-value:8.80E-6 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.68|P-value:7.80E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:-3.39|P-value:3.79E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:-3.61|P-value:1.65E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:-3.15|P-value:8.94E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.30|P-value:3.41E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.17|P-value:8.38E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.76|P-value:5.57E-7 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.60|P-value:1.11E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.91|P-value:3.03E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.92|P-value:2.93E-5 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:5.75|P-value:2.19E-9 ID:SGTC_1574|Compound:spiramycin|FD-Score:5.40|P-value:1.80E-8 ID:SGTC_1609|Compound:st001574|FD-Score:3.24|P-value:4.27E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.44|P-value:2.04E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-3.73|P-value:1.04E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.29|P-value:5.45E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.63|P-value:1.08E-6 ID:SGTC_1721|Compound:st082152|FD-Score:5.09|P-value:9.71E-8 ID:SGTC_1726|Compound:st035556|FD-Score:3.55|P-value:1.32E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-4.77|P-value:9.72E-7 ID:SGTC_1772|Compound:st048439|FD-Score:3.66|P-value:8.50E-5 ID:SGTC_1866|Compound:st057638|FD-Score:3.23|P-value:4.53E-4 ID:SGTC_1870|Compound:st057514|FD-Score:4.06|P-value:1.60E-5 ID:SGTC_1882|Compound:5615643|FD-Score:3.86|P-value:3.84E-5 ID:SGTC_2063|Compound:5246145|FD-Score:3.72|P-value:6.86E-5 ID:SGTC_2077|Compound:5212015|FD-Score:3.28|P-value:3.72E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.02|P-value:3.12E-5 ID:SGTC_2702|Compound:st077768|FD-Score:3.11|P-value:6.79E-4 ID:SGTC_2716|Compound:st080858|FD-Score:4.24|P-value:7.02E-6 ID:SGTC_2726|Compound:cimetidine|FD-Score:-3.64|P-value:1.47E-4 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:-4.11|P-value:2.15E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:3.69|P-value:7.70E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.89|P-value:3.30E-5 ID:SGTC_2947|Compound:9072639|FD-Score:-4.75|P-value:1.08E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-4.69|P-value:1.49E-6 ID:SGTC_3058|Compound:9093861|FD-Score:3.46|P-value:1.89E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.17|P-value:5.54E-4 ID:SGTC_3220|Compound:9131269|FD-Score:-4.20|P-value:1.46E-5 ID:SGTC_3307|Compound:9126885|FD-Score:-3.77|P-value:9.02E-5 ID:SGTC_3315|Compound:9136395|FD-Score:3.05|P-value:8.36E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.13|P-value:6.36E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.25|P-value:4.17E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.20|P-value:5.04E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.73|P-value:6.59E-5 ID:SGTC_199|Compound:4063-0024|FD-Score:3.91|P-value:3.00E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:-3.20|P-value:7.54E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:4.87|P-value:3.24E-7 ID:SGTC_342|Compound:k048-0088|FD-Score:3.22|P-value:4.55E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:4.67|P-value:9.04E-7 ID:SGTC_385|Compound:1494-0393|FD-Score:4.67|P-value:8.82E-7 ID:SGTC_672|Compound:1441-0018|FD-Score:3.77|P-value:5.56E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.30|P-value:9.18E-6 ID:SGTC_677|Compound:0929-0063|FD-Score:-3.50|P-value:2.57E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:-3.62|P-value:1.64E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.51|P-value:1.59E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.09|P-value:7.24E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.60|P-value:1.29E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.17|P-value:8.39E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.65|P-value:8.95E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.29|P-value:5.63E-6 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:5.16|P-value:6.82E-8 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.41|P-value:2.25E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-4.31|P-value:8.80E-6 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.68|P-value:7.80E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:-3.39|P-value:3.79E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:-3.61|P-value:1.65E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:-3.15|P-value:8.94E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.30|P-value:3.41E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.17|P-value:8.38E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.76|P-value:5.57E-7 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.60|P-value:1.11E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.91|P-value:3.03E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.92|P-value:2.93E-5 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:5.75|P-value:2.19E-9 ID:SGTC_1574|Compound:spiramycin|FD-Score:5.40|P-value:1.80E-8 ID:SGTC_1609|Compound:st001574|FD-Score:3.24|P-value:4.27E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.44|P-value:2.04E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-3.73|P-value:1.04E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.29|P-value:5.45E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.63|P-value:1.08E-6 ID:SGTC_1721|Compound:st082152|FD-Score:5.09|P-value:9.71E-8 ID:SGTC_1726|Compound:st035556|FD-Score:3.55|P-value:1.32E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-4.77|P-value:9.72E-7 ID:SGTC_1772|Compound:st048439|FD-Score:3.66|P-value:8.50E-5 ID:SGTC_1866|Compound:st057638|FD-Score:3.23|P-value:4.53E-4 ID:SGTC_1870|Compound:st057514|FD-Score:4.06|P-value:1.60E-5 ID:SGTC_1882|Compound:5615643|FD-Score:3.86|P-value:3.84E-5 ID:SGTC_2063|Compound:5246145|FD-Score:3.72|P-value:6.86E-5 ID:SGTC_2077|Compound:5212015|FD-Score:3.28|P-value:3.72E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.02|P-value:3.12E-5 ID:SGTC_2702|Compound:st077768|FD-Score:3.11|P-value:6.79E-4 ID:SGTC_2716|Compound:st080858|FD-Score:4.24|P-value:7.02E-6 ID:SGTC_2726|Compound:cimetidine|FD-Score:-3.64|P-value:1.47E-4 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:-4.11|P-value:2.15E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:3.69|P-value:7.70E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.89|P-value:3.30E-5 ID:SGTC_2947|Compound:9072639|FD-Score:-4.75|P-value:1.08E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-4.69|P-value:1.49E-6 ID:SGTC_3058|Compound:9093861|FD-Score:3.46|P-value:1.89E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.17|P-value:5.54E-4 ID:SGTC_3220|Compound:9131269|FD-Score:-4.20|P-value:1.46E-5 ID:SGTC_3307|Compound:9126885|FD-Score:-3.77|P-value:9.02E-5 ID:SGTC_3315|Compound:9136395|FD-Score:3.05|P-value:8.36E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.13|P-value:6.36E-4

Top fitness defect scores for YLR030W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 5.75 61.9 µM 2.19E-9 1 4.42E-9
2 SGTC_1574 spiramycin 5.40 23.7 µM 1.80E-8 7 3.42E-8
3 SGTC_1099 5-nonyloxytryptamine 5.16 2.9 µM 6.82E-8 5 1.25E-7
4 SGTC_1721 st082152 5.09 9.3 µM 9.71E-8 60S ribosome export 7 1.76E-7
5 SGTC_211 3455-0679 4.87 143.5 µM 3.24E-7 6 5.65E-7
6 SGTC_1254 0550-0035 4.76 264.0 µM 5.57E-7 7 9.57E-7
7 SGTC_385 1494-0393 4.67 12.4 µM 8.82E-7 9 1.49E-6
8 SGTC_346 4513-0042 4.67 7.2 µM 9.04E-7 azole & statin 22 1.53E-6
9 SGTC_1716 st033144 4.63 30.6 µM 1.08E-6 11 1.82E-6
10 SGTC_892 0929-0076 4.60 29.0 µM 1.29E-6 TRP & mitochondrial translation 24 2.16E-6
11 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 4.29 15.5 µM 5.63E-6 21 9.01E-6
12 SGTC_2716 st080858 4.24 38.6 µM 7.02E-6 60S ribosome export 13 1.12E-5
13 SGTC_1870 st057514 4.06 26.5 µM 1.60E-5 RSC & ERG11 21 2.48E-5
14 SGTC_1451 4152-0210 3.92 104.0 µM 2.93E-5 28 4.45E-5
15 SGTC_199 4063-0024 3.91 41.6 µM 3.00E-5 6 4.55E-5
16 SGTC_1449 4112-4002 3.91 201.0 µM 3.03E-5 RPP1 & pyrimidine depletion 17 4.59E-5
17 SGTC_2753 fluvastatin 3.89 17.1 µM 3.30E-5 azole & statin 39 4.99E-5
18 SGTC_1882 5615643 3.86 20.0 µM 3.84E-5 TRP & mitochondrial translation 28 5.78E-5
19 SGTC_672 1441-0018 3.77 53.7 µM 5.56E-5 22 8.28E-5
20 SGTC_198 3454-2873 3.73 16.2 µM 6.59E-5 60S ribosome export 17 9.75E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.081 2.37E-6 YPL245W_p YPL245W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.077 8.64E-6 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.069 5.85E-5 YMR175W-A_p YMR175W-A_p hom Putative protein of unknown function
0.068 8.90E-5 YIL034C CAP2 hom Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress
0.067 1.15E-4 YPR003C_p YPR003C_p hom Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene
0.065 1.72E-4 YBL054W TOD6 hom PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication
0.064 2.05E-4 YPL221W FLC1 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
0.064 2.08E-4 YIL007C NAS2 hom Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress
0.061 4.07E-4 YLR453C RIF2 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.060 4.95E-4 YNL292W PUS4 hom Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)
0.060 5.15E-4 YDL012C YDL012C hom Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication
0.060 5.34E-4 YNL212W VID27 hom Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth
0.060 5.58E-4 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.059 5.82E-4 YLR368W MDM30 hom F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains
0.059 5.92E-4 YMR010W_p YMR010W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1