HIPHOP chemogenomics database

YLR030W_p

Putative protein of unknown function

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR030W / YLR030W

Click on Significant Values for Screen Details

Top fitness defect scores for YLR030W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1536	cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid	5.75	61.9 µM	2.19E-9		1	4.42E-9
2	SGTC_1574	spiramycin	5.40	23.7 µM	1.80E-8		7	3.42E-8
3	SGTC_1099	5-nonyloxytryptamine	5.16	2.9 µM	6.82E-8		5	1.25E-7
4	SGTC_1721	st082152	5.09	9.3 µM	9.71E-8	60S ribosome export	7	1.76E-7
5	SGTC_211	3455-0679	4.87	143.5 µM	3.24E-7		6	5.65E-7
6	SGTC_1254	0550-0035	4.76	264.0 µM	5.57E-7		7	9.57E-7
7	SGTC_385	1494-0393	4.67	12.4 µM	8.82E-7		9	1.49E-6
8	SGTC_346	4513-0042	4.67	7.2 µM	9.04E-7	azole & statin	22	1.53E-6
9	SGTC_1716	st033144	4.63	30.6 µM	1.08E-6		11	1.82E-6
10	SGTC_892	0929-0076	4.60	29.0 µM	1.29E-6	TRP & mitochondrial translation	24	2.16E-6
11	SGTC_1095	3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran	4.29	15.5 µM	5.63E-6		21	9.01E-6
12	SGTC_2716	st080858	4.24	38.6 µM	7.02E-6	60S ribosome export	13	1.12E-5
13	SGTC_1870	st057514	4.06	26.5 µM	1.60E-5	RSC & ERG11	21	2.48E-5
14	SGTC_1451	4152-0210	3.92	104.0 µM	2.93E-5		28	4.45E-5
15	SGTC_199	4063-0024	3.91	41.6 µM	3.00E-5		6	4.55E-5
16	SGTC_1449	4112-4002	3.91	201.0 µM	3.03E-5	RPP1 & pyrimidine depletion	17	4.59E-5
17	SGTC_2753	fluvastatin	3.89	17.1 µM	3.30E-5	azole & statin	39	4.99E-5
18	SGTC_1882	5615643	3.86	20.0 µM	3.84E-5	TRP & mitochondrial translation	28	5.78E-5
19	SGTC_672	1441-0018	3.77	53.7 µM	5.56E-5		22	8.28E-5
20	SGTC_198	3454-2873	3.73	16.2 µM	6.59E-5	60S ribosome export	17	9.75E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.081	2.37E-6	YPL245W_p	YPL245W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.077	8.64E-6	YER087W	AIM10	hom	Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.069	5.85E-5	YMR175W-A_p	YMR175W-A_p	hom	Putative protein of unknown function
0.068	8.90E-5	YIL034C	CAP2	hom	Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress
0.067	1.15E-4	YPR003C_p	YPR003C_p	hom	Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene
0.065	1.72E-4	YBL054W	TOD6	hom	PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication
0.064	2.05E-4	YPL221W	FLC1	hom	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
0.064	2.08E-4	YIL007C	NAS2	hom	Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress
0.061	4.07E-4	YLR453C	RIF2	hom	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.060	4.95E-4	YNL292W	PUS4	hom	Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)
0.060	5.15E-4	YDL012C	YDL012C	hom	Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication
0.060	5.34E-4	YNL212W	VID27	hom	Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth
0.060	5.58E-4	YIL123W	SIM1	hom	Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.059	5.82E-4	YLR368W	MDM30	hom	F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains
0.059	5.92E-4	YMR010W_p	YMR010W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1