YLR031W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR031W / YLR031W

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:-3.34|P-value:5.78E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.65|P-value:2.26E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.65|P-value:1.97E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.34|P-value:6.84E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:4.46|P-value:9.05E-6 ID:SGTC_230|Compound:MPP+|FD-Score:3.78|P-value:1.42E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.22|P-value:9.94E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.56|P-value:5.75E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.78|P-value:1.41E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:5.00|P-value:7.68E-7 ID:SGTC_733|Compound:4069-0007|FD-Score:4.62|P-value:4.44E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:-3.48|P-value:3.55E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-3.97|P-value:5.69E-5 ID:SGTC_899|Compound:1083-0020|FD-Score:4.93|P-value:1.08E-6 ID:SGTC_900|Compound:1112-0045|FD-Score:3.31|P-value:7.50E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:5.15|P-value:3.54E-7 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.21|P-value:8.92E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.42|P-value:5.10E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:4.42|P-value:1.06E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.33|P-value:6.96E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.43|P-value:1.03E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:3.99|P-value:6.31E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:-4.59|P-value:4.20E-6 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.70|P-value:1.91E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.01|P-value:5.86E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.91|P-value:1.16E-6 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.26|P-value:2.13E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.67|P-value:3.47E-6 ID:SGTC_1530|Compound:rhein|FD-Score:4.28|P-value:1.94E-5 ID:SGTC_1554|Compound:st069299|FD-Score:3.25|P-value:9.01E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.99|P-value:6.34E-5 ID:SGTC_2055|Compound:5235184|FD-Score:3.86|P-value:1.04E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.96|P-value:7.13E-5 ID:SGTC_2123|Compound:5259487|FD-Score:3.48|P-value:4.12E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-3.36|P-value:5.34E-4 ID:SGTC_2505|Compound:galangin|FD-Score:3.52|P-value:3.61E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.84|P-value:1.58E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:4.27|P-value:2.05E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.22|P-value:8.64E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-4.99|P-value:6.42E-7 ID:SGTC_2625|Compound:euphol|FD-Score:-3.70|P-value:1.59E-4 ID:SGTC_2712|Compound:st079126|FD-Score:-3.22|P-value:8.73E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.49|P-value:3.41E-4 ID:SGTC_2841|Compound:9004761|FD-Score:5.40|P-value:1.02E-7 ID:SGTC_3124|Compound:9127567|FD-Score:-4.80|P-value:1.62E-6 ID:SGTC_3127|Compound:9126946|FD-Score:-3.85|P-value:9.09E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-3.55|P-value:2.83E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.29|P-value:1.86E-5 ID:SGTC_3144|Compound:9087057|FD-Score:-5.77|P-value:1.11E-8 ID:SGTC_3187|Compound:9109394|FD-Score:3.59|P-value:2.79E-4 ID:SGTC_3220|Compound:9131269|FD-Score:3.61|P-value:2.63E-4 ID:SGTC_3289|Compound:9119912|FD-Score:6.14|P-value:1.65E-9 ID:SGTC_3296|Compound:9122258|FD-Score:5.14|P-value:3.81E-7 ID:SGTC_3345|Compound:9148410|FD-Score:-3.40|P-value:4.67E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.38|P-value:5.80E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.34|P-value:5.78E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.65|P-value:2.26E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.65|P-value:1.97E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.34|P-value:6.84E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:4.46|P-value:9.05E-6 ID:SGTC_230|Compound:MPP+|FD-Score:3.78|P-value:1.42E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.22|P-value:9.94E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.56|P-value:5.75E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.78|P-value:1.41E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:5.00|P-value:7.68E-7 ID:SGTC_733|Compound:4069-0007|FD-Score:4.62|P-value:4.44E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:-3.48|P-value:3.55E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-3.97|P-value:5.69E-5 ID:SGTC_899|Compound:1083-0020|FD-Score:4.93|P-value:1.08E-6 ID:SGTC_900|Compound:1112-0045|FD-Score:3.31|P-value:7.50E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:5.15|P-value:3.54E-7 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.21|P-value:8.92E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.42|P-value:5.10E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:4.42|P-value:1.06E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.33|P-value:6.96E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.43|P-value:1.03E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:3.99|P-value:6.31E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:-4.59|P-value:4.20E-6 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.70|P-value:1.91E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.01|P-value:5.86E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.91|P-value:1.16E-6 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.26|P-value:2.13E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.67|P-value:3.47E-6 ID:SGTC_1530|Compound:rhein|FD-Score:4.28|P-value:1.94E-5 ID:SGTC_1554|Compound:st069299|FD-Score:3.25|P-value:9.01E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.99|P-value:6.34E-5 ID:SGTC_2055|Compound:5235184|FD-Score:3.86|P-value:1.04E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.96|P-value:7.13E-5 ID:SGTC_2123|Compound:5259487|FD-Score:3.48|P-value:4.12E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-3.36|P-value:5.34E-4 ID:SGTC_2505|Compound:galangin|FD-Score:3.52|P-value:3.61E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.84|P-value:1.58E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:4.27|P-value:2.05E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.22|P-value:8.64E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-4.99|P-value:6.42E-7 ID:SGTC_2625|Compound:euphol|FD-Score:-3.70|P-value:1.59E-4 ID:SGTC_2712|Compound:st079126|FD-Score:-3.22|P-value:8.73E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.49|P-value:3.41E-4 ID:SGTC_2841|Compound:9004761|FD-Score:5.40|P-value:1.02E-7 ID:SGTC_3124|Compound:9127567|FD-Score:-4.80|P-value:1.62E-6 ID:SGTC_3127|Compound:9126946|FD-Score:-3.85|P-value:9.09E-5 ID:SGTC_3137|Compound:9097352|FD-Score:-3.55|P-value:2.83E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.29|P-value:1.86E-5 ID:SGTC_3144|Compound:9087057|FD-Score:-5.77|P-value:1.11E-8 ID:SGTC_3187|Compound:9109394|FD-Score:3.59|P-value:2.79E-4 ID:SGTC_3220|Compound:9131269|FD-Score:3.61|P-value:2.63E-4 ID:SGTC_3289|Compound:9119912|FD-Score:6.14|P-value:1.65E-9 ID:SGTC_3296|Compound:9122258|FD-Score:5.14|P-value:3.81E-7 ID:SGTC_3345|Compound:9148410|FD-Score:-3.40|P-value:4.67E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.38|P-value:5.80E-4

Top fitness defect scores for YLR031W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3289 9119912 6.14 71.4 µM 1.65E-9 3 4.00E-10
2 SGTC_2841 9004761 5.40 39.0 µM 1.02E-7 amide catabolism 7 3.35E-8
3 SGTC_904 1141-0088 5.15 396.0 µM 3.54E-7 6 1.27E-7
4 SGTC_3296 9122258 5.14 64.0 µM 3.81E-7 redox potentiating 12 1.38E-7
5 SGTC_588 3970-1144 5.00 52.9 µM 7.68E-7 11 2.92E-7
6 SGTC_899 1083-0020 4.93 478.0 µM 1.08E-6 7 4.22E-7
7 SGTC_1428 4049-0204 4.91 61.7 µM 1.16E-6 2 4.55E-7
8 SGTC_2546 rhodinyl acetate 4.84 100.0 µM 1.58E-6 5 6.34E-7
9 SGTC_1483 3453-0561 4.67 55.9 µM 3.47E-6 9 1.48E-6
10 SGTC_733 4069-0007 4.62 56.1 µM 4.44E-6 ERAD & cell cycle 63 1.92E-6
11 SGTC_444 curcumin 4.56 90.4 µM 5.75E-6 iron homeostasis 15 2.54E-6
12 SGTC_140 0062-0056 4.46 502.5 µM 9.05E-6 13 4.12E-6
13 SGTC_995 3931-2021 4.43 34.6 µM 1.03E-5 RPP1 & pyrimidine depletion 14 4.72E-6
14 SGTC_975 1335-0046 4.42 28.5 µM 1.06E-5 RPP1 & pyrimidine depletion 23 4.90E-6
15 SGTC_3142 9086498 4.29 49.5 µM 1.86E-5 iron homeostasis 30 8.92E-6
16 SGTC_1530 rhein 4.28 70.4 µM 1.94E-5 13 9.35E-6
17 SGTC_2610 ononetin 4.27 44.2 µM 2.05E-5 30 9.91E-6
18 SGTC_1430 4049-0248 4.26 69.1 µM 2.13E-5 13 1.03E-5
19 SGTC_1203 3992-3522 4.01 103.0 µM 5.86E-5 28 3.06E-5
20 SGTC_1123 mangostin 3.99 811.3 nM 6.31E-5 mitochondrial response to ROS 39 3.31E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.091 1.43E-7 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.087 4.31E-7 YBR010W HHT1 hom Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation
0.085 8.62E-7 YDL130W RPP1B hom Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component
0.084 1.06E-6 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.083 1.48E-6 YIR001C SGN1 hom Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation
0.080 3.25E-6 YGL014W PUF4 hom Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors
0.078 5.95E-6 YOL038C-A_p YOL038C-A_p hom Putative protein of unknown function; identified by SAGE analysis
0.074 1.71E-5 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.073 2.42E-5 YOL073C YOL073C hom Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2
0.072 2.85E-5 YOL036W_p YOL036W_p hom Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication
0.071 3.46E-5 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.071 3.72E-5 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.070 5.00E-5 YGR108W CLB1 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
0.070 5.36E-5 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.066 1.17E-4 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W