YLR036C_p

Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR036C / YLR036C

Click on Significant Values for Screen Details ID:SGTC_119|Compound:0121-0043|FD-Score:-3.29|P-value:3.33E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.25|P-value:4.67E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:2.98|P-value:9.09E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.22|P-value:3.85E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.23|P-value:4.31E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.73|P-value:5.80E-5 ID:SGTC_681|Compound:1642-0006|FD-Score:-3.20|P-value:4.79E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:3.70|P-value:5.72E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:4.60|P-value:8.17E-7 ID:SGTC_729|Compound:4092-0585|FD-Score:5.83|P-value:6.19E-10 ID:SGTC_950|Compound:1165-0508|FD-Score:3.04|P-value:7.56E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:5.25|P-value:2.29E-8 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.27|P-value:3.15E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.61|P-value:8.41E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.37|P-value:2.21E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.27|P-value:3.70E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.28|P-value:3.10E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.27|P-value:3.19E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.57|P-value:9.81E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.37|P-value:2.17E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-4.23|P-value:6.16E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.25|P-value:3.51E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:4.76|P-value:3.46E-7 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.35|P-value:2.35E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.63|P-value:7.53E-5 ID:SGTC_1704|Compound:st028805|FD-Score:3.18|P-value:4.47E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.08|P-value:6.38E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-3.51|P-value:1.43E-4 ID:SGTC_1902|Compound:st060212|FD-Score:4.29|P-value:3.92E-6 ID:SGTC_1914|Compound:st062367|FD-Score:3.39|P-value:2.01E-4 ID:SGTC_2003|Compound:4023581|FD-Score:-4.76|P-value:4.20E-7 ID:SGTC_2009|Compound:4012297|FD-Score:3.44|P-value:1.62E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.58|P-value:9.51E-5 ID:SGTC_2024|Compound:5144227|FD-Score:3.05|P-value:7.21E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.54|P-value:1.08E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.64|P-value:7.24E-5 ID:SGTC_2333|Compound:9017922|FD-Score:3.34|P-value:2.48E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.01|P-value:8.20E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.10|P-value:6.76E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.76|P-value:4.42E-5 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.14|P-value:5.17E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-3.15|P-value:5.65E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.20|P-value:4.73E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.81|P-value:3.44E-5 ID:SGTC_2883|Compound:9059145|FD-Score:3.18|P-value:4.42E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.02|P-value:7.93E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.19|P-value:4.98E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.30|P-value:2.85E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.03|P-value:7.88E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.29|P-value:3.33E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.25|P-value:4.67E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:2.98|P-value:9.09E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.22|P-value:3.85E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.23|P-value:4.31E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.73|P-value:5.80E-5 ID:SGTC_681|Compound:1642-0006|FD-Score:-3.20|P-value:4.79E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:3.70|P-value:5.72E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:4.60|P-value:8.17E-7 ID:SGTC_729|Compound:4092-0585|FD-Score:5.83|P-value:6.19E-10 ID:SGTC_950|Compound:1165-0508|FD-Score:3.04|P-value:7.56E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:5.25|P-value:2.29E-8 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.27|P-value:3.15E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.61|P-value:8.41E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.37|P-value:2.21E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.27|P-value:3.70E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.28|P-value:3.10E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.27|P-value:3.19E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.57|P-value:9.81E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.37|P-value:2.17E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-4.23|P-value:6.16E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.25|P-value:3.51E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:4.76|P-value:3.46E-7 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.35|P-value:2.35E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.63|P-value:7.53E-5 ID:SGTC_1704|Compound:st028805|FD-Score:3.18|P-value:4.47E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.08|P-value:6.38E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-3.51|P-value:1.43E-4 ID:SGTC_1902|Compound:st060212|FD-Score:4.29|P-value:3.92E-6 ID:SGTC_1914|Compound:st062367|FD-Score:3.39|P-value:2.01E-4 ID:SGTC_2003|Compound:4023581|FD-Score:-4.76|P-value:4.20E-7 ID:SGTC_2009|Compound:4012297|FD-Score:3.44|P-value:1.62E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.58|P-value:9.51E-5 ID:SGTC_2024|Compound:5144227|FD-Score:3.05|P-value:7.21E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.54|P-value:1.08E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.64|P-value:7.24E-5 ID:SGTC_2333|Compound:9017922|FD-Score:3.34|P-value:2.48E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.01|P-value:8.20E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-3.10|P-value:6.76E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.76|P-value:4.42E-5 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.14|P-value:5.17E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-3.15|P-value:5.65E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.20|P-value:4.73E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.81|P-value:3.44E-5 ID:SGTC_2883|Compound:9059145|FD-Score:3.18|P-value:4.42E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.02|P-value:7.93E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.19|P-value:4.98E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.30|P-value:2.85E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.03|P-value:7.88E-4

Top fitness defect scores for YLR036C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_729 4092-0585 5.83 94.1 µM 6.19E-10 4 2.74E-9
2 SGTC_963 1269-2853 5.25 151.0 µM 2.29E-8 9 7.76E-8
3 SGTC_1348 1493-0373 4.76 93.8 µM 3.46E-7 7 9.60E-7
4 SGTC_722 3534-0461 4.60 190.0 µM 8.17E-7 PDR1 23 2.13E-6
5 SGTC_1902 st060212 4.29 70.5 µM 3.92E-6 7 9.10E-6
6 SGTC_128 0906-2981 4.25 13.4 µM 4.67E-6 11 1.07E-5
7 SGTC_2880 9042983 3.81 58.4 µM 3.44E-5 fatty acid desaturase (OLE1) 30 6.81E-5
8 SGTC_2502 avocadyne acetate 3.76 18.6 µM 4.42E-5 29 8.60E-5
9 SGTC_709 3807-1509 3.70 243.0 µM 5.72E-5 RSC complex & mRNA processing 21 1.09E-4
10 SGTC_2108 5365811 3.64 200.0 µM 7.24E-5 25 1.36E-4
11 SGTC_1475 4092-1048 3.63 11.7 µM 7.53E-5 plasma membrane duress 40 1.41E-4
12 SGTC_1027 k015-0025 3.61 8.7 µM 8.41E-5 34 1.56E-4
13 SGTC_2011 4012611 3.58 177.0 µM 9.51E-5 mitochondrial processes 43 1.75E-4
14 SGTC_1114 scopoletin 3.57 1.7 µM 9.81E-5 26 1.80E-4
15 SGTC_2050 5263056 3.54 171.0 µM 1.08E-4 fatty acid desaturase (OLE1) 63 1.97E-4
16 SGTC_2009 4012297 3.44 12.1 µM 1.62E-4 cell wall signaling 87 2.86E-4
17 SGTC_1914 st062367 3.39 72.6 µM 2.01E-4 37 3.50E-4
18 SGTC_1133 3473-0247 3.37 50.0 µM 2.17E-4 RSC complex & mRNA processing 77 3.75E-4
19 SGTC_1045 1348-1485 3.37 165.0 µM 2.21E-4 60 3.81E-4
20 SGTC_1470 k295-0292 3.35 231.0 µM 2.35E-4 28 4.05E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 7.40E-15 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.094 4.76E-8 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.091 1.17E-7 YDR217C RAD9 hom DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate
0.091 1.45E-7 YGL238W CSE1 het Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
0.087 4.45E-7 YPR200C ARR2 hom Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p
0.083 1.40E-6 YGR012W YGR012W hom Putative cysteine synthase, localized to the mitochondrial outer membrane
0.076 1.08E-5 YDR503C LPP1 hom Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA
0.073 2.25E-5 YGL260W_p YGL260W_p hom Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium
0.069 7.07E-5 YML109W ZDS2 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication
0.068 8.82E-5 YOR011W AUS1 hom Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen
0.067 9.85E-5 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.066 1.29E-4 YDR112W_d IRC2_d hom Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
0.066 1.45E-4 YJR135C MCM22 hom Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4
0.065 1.49E-4 YIR038C GTT1 hom ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p
0.065 1.49E-4 YOR367W SCP1 hom Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin