YLR037C / PAU23

Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR037C / PAU23

Click on Significant Values for Screen Details ID:SGTC_145|Compound:3737-0113|FD-Score:5.67|P-value:8.71E-9 ID:SGTC_190|Compound:3970-0790|FD-Score:-4.34|P-value:8.54E-6 ID:SGTC_194|Compound:1486-1323|FD-Score:3.46|P-value:2.93E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.64|P-value:1.48E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:-4.86|P-value:7.19E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:-3.81|P-value:7.85E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:3.58|P-value:1.90E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.34|P-value:4.54E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:4.27|P-value:1.11E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:3.12|P-value:9.59E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.42|P-value:3.32E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.87|P-value:5.99E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:3.28|P-value:5.60E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:5.65|P-value:1.02E-8 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.18|P-value:8.12E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.54|P-value:2.17E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.86|P-value:6.20E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.24|P-value:6.37E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.19|P-value:7.57E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.21|P-value:1.42E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.33|P-value:4.69E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.90|P-value:5.53E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:15.00|P-value:2.15E-50 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.27|P-value:1.12E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:4.27|P-value:1.11E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:4.85|P-value:7.17E-7 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.23|P-value:6.52E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.31|P-value:4.91E-4 ID:SGTC_1640|Compound:st009078|FD-Score:4.00|P-value:3.58E-5 ID:SGTC_1658|Compound:st012944|FD-Score:3.16|P-value:8.31E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-3.51|P-value:2.53E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.28|P-value:5.54E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.28|P-value:5.49E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.56|P-value:2.03E-4 ID:SGTC_2196|Compound:6573537|FD-Score:4.61|P-value:2.32E-6 ID:SGTC_2257|Compound:7960413|FD-Score:3.20|P-value:7.25E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.12|P-value:9.56E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.83|P-value:7.00E-5 ID:SGTC_2692|Compound:st077426|FD-Score:3.36|P-value:4.20E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.49|P-value:2.61E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.12|P-value:9.63E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.51|P-value:2.46E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.67|P-value:8.71E-9 ID:SGTC_190|Compound:3970-0790|FD-Score:-4.34|P-value:8.54E-6 ID:SGTC_194|Compound:1486-1323|FD-Score:3.46|P-value:2.93E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.64|P-value:1.48E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:-4.86|P-value:7.19E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:-3.81|P-value:7.85E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:3.58|P-value:1.90E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.34|P-value:4.54E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:4.27|P-value:1.11E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:3.12|P-value:9.59E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.42|P-value:3.32E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.87|P-value:5.99E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:3.28|P-value:5.60E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:5.65|P-value:1.02E-8 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.18|P-value:8.12E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.54|P-value:2.17E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.86|P-value:6.20E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.24|P-value:6.37E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.19|P-value:7.57E-4 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.21|P-value:1.42E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.33|P-value:4.69E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.90|P-value:5.53E-5 ID:SGTC_1305|Compound:1181-0477|FD-Score:15.00|P-value:2.15E-50 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.27|P-value:1.12E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:4.27|P-value:1.11E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:4.85|P-value:7.17E-7 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.23|P-value:6.52E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.31|P-value:4.91E-4 ID:SGTC_1640|Compound:st009078|FD-Score:4.00|P-value:3.58E-5 ID:SGTC_1658|Compound:st012944|FD-Score:3.16|P-value:8.31E-4 ID:SGTC_1740|Compound:st038286|FD-Score:-3.51|P-value:2.53E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.28|P-value:5.54E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.28|P-value:5.49E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.56|P-value:2.03E-4 ID:SGTC_2196|Compound:6573537|FD-Score:4.61|P-value:2.32E-6 ID:SGTC_2257|Compound:7960413|FD-Score:3.20|P-value:7.25E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.12|P-value:9.56E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.83|P-value:7.00E-5 ID:SGTC_2692|Compound:st077426|FD-Score:3.36|P-value:4.20E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.49|P-value:2.61E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.12|P-value:9.63E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.51|P-value:2.46E-4

Top fitness defect scores for YLR037C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1305 1181-0477 15.00 144.0 µM 2.15E-50 1 4.42E-51
2 SGTC_145 3737-0113 5.67 38.4 µM 8.71E-9 DNA intercalators 33 7.05E-9
3 SGTC_978 1416-0512 5.65 87.4 µM 1.02E-8 redox potentiating 6 8.23E-9
4 SGTC_1418 3966-3099 4.85 2.4 µM 7.17E-7 9 6.16E-7
5 SGTC_2196 6573537 4.61 42.7 µM 2.32E-6 copper-dependent oxidative stress 5 2.02E-6
6 SGTC_699 0375-0592 4.27 111.0 µM 1.11E-5 iron homeostasis 13 9.84E-6
7 SGTC_1314 1222-0010 4.27 41.1 µM 1.11E-5 8 9.85E-6
8 SGTC_1313 1220-0047 4.27 237.0 µM 1.12E-5 29 9.93E-6
9 SGTC_1222 0366-0074 4.21 1.2 µM 1.42E-5 TSC3-RPN4 8 1.27E-5
10 SGTC_1640 st009078 4.00 66.4 µM 3.58E-5 8 3.23E-5
11 SGTC_790 1575-0012 3.87 79.1 µM 5.99E-5 TSC3-RPN4 31 5.45E-5
12 SGTC_1137 ixabepilone 3.86 100.0 µM 6.20E-5 26 5.64E-5
13 SGTC_2628 lathosterol 3.83 100.0 µM 7.00E-5 35 6.38E-5
14 SGTC_205 1486-1330 3.64 71.9 µM 1.48E-4 23 1.36E-4
15 SGTC_274 sirtinol 3.58 40.1 µM 1.90E-4 32 1.75E-4
16 SGTC_2150 5556613 3.56 200.0 µM 2.03E-4 26 1.88E-4
17 SGTC_1129 3453-1384 3.54 223.0 µM 2.17E-4 56 2.00E-4
18 SGTC_3324 9138759 3.51 60.8 µM 2.46E-4 30 2.28E-4
19 SGTC_2938 9059746 3.49 27.3 µM 2.61E-4 fatty acid desaturase (OLE1) 56 2.42E-4
20 SGTC_194 1486-1323 3.46 56.9 µM 2.93E-4 35 2.72E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.11E-17 YLR177W_p YLR177W_p hom Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication
0.146 1.88E-17 YLR298C YHC1 het Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
0.140 3.36E-16 YNL125C ESBP6 hom Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
0.136 2.20E-15 YBR182C SMP1 hom Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication
0.134 5.99E-15 YIR036C_p IRC24_p hom Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci
0.109 2.29E-10 YBR056W YBR056W hom Putative glycoside hydrolase of the mitochondrial intermembrane space
0.098 1.52E-8 YPL112C PEX25 hom Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
0.097 1.77E-8 YNL052W COX5A hom Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication
0.096 2.39E-8 YPL214C THI6 hom Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
0.096 3.02E-8 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.094 4.91E-8 YIL136W OM45 hom Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; protein abundance increases in response to DNA replication stress
0.090 1.58E-7 YIR025W MND2 hom Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase
0.088 3.57E-7 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.82E-7 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.92E-7 YIR005W IST3 hom Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing